A detergent-insoluble membrane compartment contains Aβ in vivo

Nature Medicine

Volumn 4, Issue 6, 1998, Pages 730-734

  Lee, Seung Jae ^a   Liyanage, Udaya ^a   Bickel, Perry E ^a,b   Xia, Weiming ^a   Lansbury Jr , Peter T ^a   Kosik, Kenneth S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CHO CELL; GRAY MATTER; IMMUNOGOLD STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; BRAIN CHEMISTRY; CAVEOLIN 1; CAVEOLINS; CELL COMPARTMENTATION; CELL MEMBRANE; CHO CELLS; CHOLESTEROL; CRICETINAE; DETERGENTS; ENDOPLASMIC RETICULUM; GLYCOLIPIDS; GOLGI APPARATUS; MEMBRANE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SUBCELLULAR FRACTIONS;

ANIMALIA;

EID: 0031746979     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0698-730     Document Type: Article

References (35)

1. Selkoe, D.J. Alzheimer's disease: genotypes, phenotypes and treatments. Science 275, 630-631 (1997).
2. Xu, H. et al. Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc. Natl. Acad. Sci. USA 94, 3748-3752 (1997).
3. Wild-Bode, C. et al. Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42. J. Biol. Chem. 272, 16085-16088 (1997).
4. Hartmann, T. et al. Distinct sites of intracellular production of Alzheimer's disease A beta 40/42 amyloid peptides. Nature Med. 3, 1016-1018 (1997).
5. Cook, D.G. et al. Alzheimer's A beta (1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nature Med. 3, 1021-1023 (1997).
6. Simons, K. & Ikonen, E. Functional rafts in cell membranes. Nature 387, 569-572 (1997).
7. Parton, R.G. Caveolae and caveolins. Curr. Opin. Cell Biol 8, 542-548 (1996).
8. Lisanti, M. et al. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich sourcer: implication for human disease. J. Cell Biol. 126, 111-126 (1994).
9. Tienari, P.J. et al. Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA 194, 4125-4130 (1997).
10. Wu, C., Butz, S., Ying, Y.-s. & Anderson, G.W. Tyrosine kinase receptors concentrated in caveolae-like domains from neuronal plasma membranes. J. Biol. Chem. 272, 3554-3559 (1997).
11. Bickel, P. et al. Flotillin and epidermal surface antigen define a new family of caveolae-assofiated integral membrane proteins. J. Biol. Chem. 272, 13793-13802 (1997).
12. Olive, S., Dubois, C., Schachner, M. & Rougon, G. The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized ot glycolipid-enriched membrane subdomains and interacts with L1 and Fyn kinase in cerebellum. J. Neurochem. 65, 2307-2317 (1995).
13. Bouillot, C., Prochiantz, A., Rougon, G. & Allinquant, B. Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties. J. Biol. Chem. 271, 7640-7644 (1996).
14. Schnitzer, J.E., McIntosh, D.P., Dvorak, A.M., Liu, J. & Oh, P. Separation of caveolae from associated microdomains of GPI-anchored proteins. Science 269, 1435-1439 (1995).
15. Hope, H.R. & Pike, L.J. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains. Mol. Biol. Cell 7, 843-851 (1996).
16. DeStrooper, B. et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390 (1998).
17. Kim, T.-W. Pettingell, W.H., Jung, Y.-K., Kovacs, D.M. & Tanzi, R.E. Alternative cleavage of Alzheimer's associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376 (1997).
18. Thinakaran, G. et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190 (1996).
19. Seeger, M. et al. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. USA 94, 5090-5094 (1997).
20. Zhang, W., et al. Characterization of beta-amyloid peptide precursor processing by the yeast YAP3 and MKC7 proteases. Biochim. Biophys. Acta 1359, 110-122 (1997).
21. Tettamanti, G. & Riboni, L. Gangliosides and modulation of the function of neural cells. Adv. Lipid Res. 25, 235-267 (1982).
22. Brown, D.A. & London, E. Structure of detergent-resistenat membrane domains: Does phase separation occur in biological membrane? Biochem. Biophys. Res. Commun. 240, 1-7 (1997).
23. Mason, R.P. Shoemaker, W.J., Shajenko, L., Chambers, T.C. & Herbette, L.G. Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol. Neurobiol. Aging 13, 413-419 (1992).
24. Nitsch, R.M. et al. Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci. USA 89, 1671-1675 (1992).
25. Weisgraber, K.H. & Mahley, R.W. Human apolipoprotein E: the Alzheimer's disease connection. FASEB J. 10, 1485-1494 (1996).
26. Avdulov, N.A. et al. Lipid binding to amyloid β-peptide aggregates: preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids. J. Neurochem. 69, 1746-1752 (1997).
27. Choo-Smith, L.-P., Garzon-Rodriguez, W., Glabe, C.G. & Surewicz, W.K. Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles. J. Biol. Chem. 272, 22987-22990 (1997).
28. Jones, D.H., Rigby, A.C., Barber, K.R. & Grant, C.W. Oligomerizatoin of the EGF receptor transmembrane domain: a 2H NMR study in lipid bilayers. Biochem. 36, 12616-12624 (1997).
29. Choo-Smith, L.i. & Surewicz, W.K. The interaction between Alzheimer amyloid β(1-40) peptide and ganglioside GM1-containing membranes. FEBS Lett. 402, 95-98 (1997).
30. Yanagisawa, K., Odaka, A., Suzuki, N. & Ihara, Y. GM1 ganglioside-bound amyloid β-protein (Aβ): a possible form of preamyloid in Alzheimer disease. Nature Med. 1, 998-999 (1995).
31. Koo, E.H. & Squazzo, S. Evidence that production and release of amyloid β-protein involves the endocytic pathway. J. Biol. Chem. 269, 17386-17389 (1994).
32. Zhou, J. et al. Presenilin 1 interacts in brain with a novel member of the armadillo family. Neurorep. 8, 1489-1494 (1997).
33. Johnson-Wood, K. et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 1550-1555 (1997).
34. Slusarewicz, P., Hui, N. & Warren, G. in Cell Biology: A Laboratory Handbook. Vol. (ed. Celis, J.E.) 509-516 (Academeic Press, 1994).
35. Xu, Y.H. & Slater, H.S. Immunocytochemical localization of endogenous antithrombin III in the vasculature of rat tissues reveals locations of anticoagulantly active heparan sulfate proteoglycans. J. Histochem. Cytochem. 42, 1365-1376 (1994).