Trafficking of cell-surface amyloid β-protein precursor I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

Journal of Cell Science

Volumn 109, Issue 5, 1996, Pages 991-998

  Koo, Edward H ^a,b   Squazzo, Sharon L ^b   Selkoe, Dennis J ^a,b   Koo, Catherine H ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CALDWELL UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Amyloid protein precursor ( PP); Endocytosis; Trafficking

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELL SURFACE PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY LABELING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; DNA TRANSFECTION; ENDOCYTOSIS; INTERNALIZATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT; RADIOASSAY; RADIOIODINATION; STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BIOLOGICAL TRANSPORT; CHO CELLS; CRICETINAE; ENDOCYTOSIS; KINETICS; MEMBRANE PROTEINS; TRANSFECTION;

ANIMALIA;

EID: 0029950149     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Anderson, R. G. W., Brown, M. S., Beisiegel, U. and Goldstein, J. L. (1982). Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies. J. Cell Biol. 93, 523-531.
2. Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G. W. and Brown, M. S. (1981). Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. J. Biol. Chem. 256, 11923-11931.
3. Bretscher, M. S. and Lutter, R. (1988). A new method for detecting endocytosed proteins. EMBO J. 7, 4087-4092.
4. Brown, M. S. and Goldstein, J. L. (1979). Receptor-mediated endocytosis: Insights from the lipoprotein receptor system. Proc. Natl. Acad. Sci. USA 76, 3330-3337.
5. Chen, W.-J., Goldstein, J. L. and Brown, M. S. (1990). NPXY, a sequence often found in cytoplasmic tails, is required for coated-pit mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265, 3116-3123.
6. Ciechanover, A., Schwartz, A. L., Dautry-Varsat, A. and Lodish, H. F. (1983). Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line: effects of lysosomotropic agents. J. Biol. Chem. 258, 9681-9689.
7. De Strooper, B., Umans, L., Van Leuven, F. and Van Den Berghe, H. (1993). Study of the synthesis and secretion of normal and artifical mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretory pathway. J. Cell Biol. 121, 295-304.
8. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D. and Ward, P. J. (1990). Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248, 1122-1124.
9. Golde, T. E., Estus, S., Selkoe, D. J. and Younkin, S. G. (1992). Endosomal/lysosomal processing of the Alzheimer β-amyloid protein precursor generates potentially amyloidogenic carboxyl terminal derivates. Science 255, 728-730.
10. Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U. and Gajdusek, D. C. (1987). Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
11. Haass, C., Koo, E. H., Mellon, A., Hung, A. Y. and Selkoe, D. J. (1992) Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
12. Haass, C., Hung, A. Y., Schlossmacher, M. G., Teplow, D. B. and Selkoe, D. J. (1993). β-amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J. Biol. Chem. 268, 3021-3024.
13. Haass, C., Koo, E. H., Capell, A., Teplow, D. B. and Selkoe, D. J. (1995) Polarized sorting of β-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J. Cell Biol. 128, 537-547.
14. 125I-epidermal growth factor in BALB 3T3 cells. J. Biol. Chem. 255, 1239-1241.
15. Hopkins, C. R. and Trowbridge, I. S. (1983). Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells. J. Cell Biol. 97, 508-521.
16. Jacobsen, J. S., Spruyt, M. A., Brown, A. M., Sahasrabudhe, S. R., Blume, A. J., Vitek, M. P., Muenkel, H. A. and Sonnenberg-Reines, J. (1994). The release of Alzheimer's disease β amyloid peptide is reduced by phorbol treatment. J. Biol. Chem. 269, 8376-8382.
17. Kang, J., Lemaire, H., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K., Multhaup, G., Beyreuther, K. and Muller-Hill, B. (1987). The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
18. Koo, E. H. and Squazzo, S. L. (1994). Evidence that production and release of amyloid β-protein involves the endocytic pathway. J. Biol Chem. 269, 17386-17389.
19. Kuntzel, S. L., Ali, S. M., Altman, R. A., Greenberg, B. D. and Raub, T. J. (1993). The Alzheimer beta-amyloid protein precursor protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells. Biochem. J. 295, 367-378.
20. Lai, A., Sisodia, S. S. and Trowbridge, I. S. (1995). Characterization of sorting signals in the β-amyloid precursor protein cytoplasmic domain. J. Biol. Chem. 270, 3565-3573.
21. Mellman, I. S., Plutner, H., Steinman, R. M., Unkeless, J. C. and Cohn, Z. A. (1983). Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis. J. Cell Biol. 96, 887-895.
22. Müller-Hill, B. and Beyreuther, K. (1989). Molecular biology of Alzheimer's disease. Annu. Rev. Biochem. 58, 287-307.
23. Nordstedt, C., Caporaso, G. L., Thyberg, J., Gandy, S. E. and Greengard, P. (1993). Identification of the Alzheimer β/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. J. Biol. Chem. 268, 608-612.
24. Pelchen-Matthews, A., Armes, J. E. and Marsh, M. (1989). Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells. EMBO J. 8, 3641-3649.
25. Roberts, S. B., Ripellino, J. A., Ingalls, K. M., Robakis, N. K. and Felsenstein, K. M. (1994). Non-amyloidogenic cleavage of the β-amyloid precursor protein by an integral membrane metalloendopeptidase. J. Biol Chem. 269, 3111-3116.
26. Sambamurti, K., Shioi, J., Anderson, J. P., Pappolla, M. A. and Robakis, N. K. (1992). Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J. Neurosci. Res. 33, 319-329.
27. Schoenenberger, C.-A., Zuk, A., Zinkl, G. M., Kendall, D. and Matlin, K. S. (1994). Integrin expression and localization in normal MDCK cells and transformed MDCK cells lacking apical polarity. J. Cell Sci. 107, 527-541.
28. Schwartz, A. L., Fridovich, S. E. and Lodish, H. F. (1982). Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line. J. Biol. Chem. 257, 4230-4237.
29. Shyng, S.-L., Huber, M. T. and Harris, D. A. (1993). A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells. J. Biol. Chem. 268, 15922-15928.
30. Sinha, S. and Lieberburg, I. (1992). Normal metabolism of the amyloid precursor protein (APP). Neurodegeneration 1, 169-175.
31. Sisodia, S. S., Koo, E. H., Beyreuther, K., Unterbeck, A. and Price, D. L. (1990). Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-495.
32. Sisodia, S. S. (1992). β-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Nat. Acad. Sci. USA 89, 6075-6079.
33. Sisodia, S. S., Koo, E. H., Hoffman, P. N., Perry, G. and Price, D. L. (1993). Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13, 3136-3142.
34. Trowbridge, I. S., Collawn, J. F. and Hopkins, C. R. (1993). Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell Biol. 9, 129-161.
35. Ukkonen, P., Lewis, V., Marsh, M., Helenius, A. and Mellman, I. (1986) Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes. J. Exp. Med. 163, 952-971.
36. von Figura, K., Gieselmann, V. and Hasilik, A. (1984). Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts. EMBO J. 3, 1281-1286.
37. Weidemann, A., Konig, G., Bunke, D., Fischer, P., Salbaum, J. M., Masters, C. L. and Beyreuther, K. (1989). Identification, biogenesis, and localization of precursor of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
38. Yamazaki, T., Selkoe, D. J. and Koo, E. H. (1995). Trafficking of cell surface β-amyloid precursor protein: Retrograde and transcytotic transport in cultured neurons. J. Cell Biol. 129, 431-442.
39. Yamazaki, T., Koo, E. H. and Selkoe, D. J. (1996). Trafficking of cell-surface amyloid β-protein precursor II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization. J. Cell Science 109 (in press).
40. Zurzolo, C., Le Bivic, A. L. and Rodriguez-Boulan, E. (1994). Cell surface biotinylation techniques. In Cell Biology: A Laboratory Manual (ed. J. E. Celis), pp. 185-192. Academic Press, San Diego.