Rab5-stimulated up-regulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production

Journal of Biological Chemistry

Volumn 278, Issue 33, 2003, Pages 31261-31268

  Grbovic, Olivera M ^a,e   Mathews, Paul M ^a,b   Jiang, Ying ^a   Schmidt, Stephen D ^a   Dinakar, Ravi ^a   Summers Terio, Nicole B ^a   Ceresa, Brian P ^c   Nixon, Ralph A ^a,b   Cataldo, Anne M ^a,d  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d MCLEAN HOSPITAL   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL BONDS; CYTOLOGY; IMMUNOLOGY; NEUROLOGY; PATHOLOGY; REACTION KINETICS;

ENDOCYTOSIS;

PROTEINS;

AMYLOID PRECURSOR PROTEIN; GENE PRODUCT; RAB5 PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIBODY LABELING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE MODEL; ENDOCYTOSIS; ENDOSOME; GENE OVEREXPRESSION; GOLGI COMPLEX; HUMAN; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE; DOWN SYNDROME; ENDOCYTOSIS; ENDOSOMES; FIBROBLASTS; GENE EXPRESSION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RAB5 GTP-BINDING PROTEINS; TRANSFECTION; UP-REGULATION;

ANIMALIA; MURINAE;

EID: 0042733013     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304122200     Document Type: Article

References (72)

1. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-786
2. De Strooper, B., and Annaert, W. (2000) J. Cell Sci. 113, 1857-1870
3. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
4. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., and Tang, J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1456-1460
5. Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., and Tonegawa, S. (1997) Cell 89, 629-639
6. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
7. Soriano, S., Chyung, A. S., Chen, X., Stokin, G. B., Lee, V. M., and Koo, E. H. (1999) J. Biol. Chem. 274, 32295-32300
8. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B., and Koo, E. H. (1999) J. Biol. Chem. 274, 18851-18856
9. Koo, E. H., and Squazzo, S. L. (1994) J. Biol. Chem. 269, 17386-17389
10. Petanceska, S. S., Seeger, M., Checler, F., and Gandy, S. (2000) J. Neurochem. 74, 1878-1884
11. Xu, H., Sweeney, D., Wang, R., Thinakaran, G., Lo, A. C., Sisodia, S. S., Greengard, P., and Gandy, S. (1997) Proc. Natl. Acad. Sci. U. S. A, 94, 3748-3752
12. Hartmann, T., Bieger, S. C., Bruhl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K., and Beyreuther, K. (1997) Nat. Med. 3, 1016-1020
13. Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Cheeler, F., Sisodia, S. S., Greengard, P., and Xu, H. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 742-747
14. Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., and Haass, C. (2000) J. Biol. Chem. 275, 30849-30854
15. Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G., and Haass, C. (2001) J. Biol. Chem. 276, 14634-14641
16. Yan, R., Han, P., Miao, H., Greengard, P., and Xu, H. (2001) J. Biol. Chem. 276, 36788-36796
17. Huse, J. T., Liu, K., Pijak, D. S., Carlin, D., Lee, V. M., and Doms, R. W. (2002) J. Biol. Chem. 277, 16278-16284
18. Annaert, W. G., Levesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D., St. George-Hyslop, P., Cordell, B., Fraser, P., and De Strooper, B. (1999) J. Cell Biol. 147, 277-294
19. Cook, D. G., Sung, J. C., Golde, T. E., Felsenstein, K. M., Wojczyk, B. S., Tanzi, R. E., Trojanowski, J. Q., Lee, V. M., and Doms, R. W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9223-9228
20. De Strooper, B., Beullens, M., Contreras, B., Levesque, L., Craessaerts, K., Cordell, B., Moechars, D., Bollen, M., Fraser, P., St. George-Hyslop, P., and Van Leuven, F. (1997) J. Biol. Chem. 272, 3590-3598
21. Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T. W., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., Hyman, B. T., Tanzi, R. E., and Waseo, W. (1996) Nat. Med. 2, 224-229
22. Lah, J. J., Heilman, C. J., Nash, N. R., Rees, H. D., Yi, H., Counts, S. E., and Levey, A. I. (1997) J. Neurosci. 17, 1971-1980
23. Zhang, J., Kang, D. E., Xia, W., Okochi, M., Mori, H., Selkoe, D. J., and Koo, E. H. (1998) J. Biol. Chem. 273, 12436-12442
24. Kaether, C., Lammich, S., Edbauer, D., Ertl, M., Rietdorf, J., Capell, A., Steiner, H., and Haass, C. (2002) J. Cell Biol. 158, 551-561
25. Cupers, P., Bentahir, M., Craessaerts, K., Orlans, I., Vanderstichele, H., Saftig, P., De Strooper, B., and Annaert, W. (2001) J. Cell Biol. 154, 731-740
26. Georgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, H. C., Schutte, M., Gordon, R., Holstein, G. R., Martinelli, G., Mehta, P., Friedrich, V. L., Jr., and Robakis, N. K. (1999) Mol. Cell. 4, 893-902
27. Ray, W. J., Yao, M., Mumm, J., Schroeter, E. H., Saftig, P., Wolfe, M., Selkoe, D. J., Kopan, R., and Goate, A. M. (1999) J. Biol. Chem. 274, 36801-36807
28. Yang, D. S., Tandon, A., Chen, F., Yu, G., Yu, H., Arawaka, S., Hasegawa, H., Duthie, M., Schmidt, S. D., Ramabhadran, T. V., Nixon, R. A., Mathews, P. M., Gandy, S. E., Mount, H. T., St. George-Hyslop, P., and Fraser, P. E. (2002) J. Biol. Chem. 277, 28135-28142
29. Cataldo, A. M., Peterhoff, C. M., Troncoso, J. C., Gomez-Isla, T., Hyman, B. T., and Nixon, R. A. (2000) Am. J. Pathol. 157, 277-286
30. Cataldo, A. M., Barnett, J. L., Pieroni, C., and Nixon, R. A. (1997) J. Neurosci. 17, 6142-6151
31. Mathews, P. M., Guerra, C. B., Jiang, Y., Grbovic, O. M., Kao, B. H., Schmidt, S. D., Dinakar, R., Mercken, M., Hille-Rehfeld, A., Rohrer, J., Mehta, P., Cataldo, A. M., and Nixon, R. A. (2002) J. Biol. Chem. 277, 5299-5307
32. Chavrier, P., Parton, R. G., Hauri, H. P., Simons, K., and Zerial, M. (1990) Cell 62, 317-329
33. Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., and Zerial, M. (1992) Cell 70, 715-728
34. Deneka, M., and van der Sluijs, P. (2002) Nat. Cell Biol. 4, E33-E35
35. Vitale, G., Rybin, V., Christoforidis, S., Thornqvist, P., McCaffrey, M., Stenmark, H., and Zerial, M. (1998) EMBO J. 17, 1941-1951
36. Stenmark, H., Vitale, G., Ullrich, O., and Zerial, M. (1995) Cell 83, 423-432
37. Horiuchi, H., Lippe, R., MeBride, H. M., Rubino, M., Woodman, P., Stenmark, H., Rybin, V., Wilm, M., Ashman, K., Mann, M., and Zerial, M. (1997) Cell 90, 1149-1159
38. Patki, V., Virbasius, J., Lane, W. S., Toh, B. H., Shpetner, H. S., and Corvera, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 7326-7330
39. Mu, F. T., Callaghan, J. M., Steele-Mortimer, O., Stenmark, H., Parton, R. G., Campbell, P. L., McCluskey, J., Yeo, J. P., Tock, E. P., and Toh, B. H. (1995) J. Biol. Chem. 270, 13503-13511
40. Simonsen, A., Lippe, R., Christoforidis, S., Gaullier, J. M., Brech, A., Callaghan, J., Toh, B. H., Murphy, C., Zerial, M., and Stenmark, H. (1998) Nature 394, 494-498
41. Gorvel, J. P., Chavrier, P., Zerial, M., and Gruenberg, J. (1991) Cell 64, 915-925
42. Mathews, P. M., Jiang, Y., Schmidt, S. D., Grbovic, O. M., Mercken, M., and Nixon, R. A. (2002) J. Biol. Chem. 277, 36415-36424
43. Lawe, D. C., Patki, V., Heller-Harrison, R., Lambright, D., and Corvera, S. (2000) J. Biol. Chem. 275, 3699-3705
44. Vandermeeren, M., Geraerts, M., Pype, S., Dillen, L., Van Hove, C., and Mercken, M. (2001) Neurosci. Lett. 315, 145-148
45. Cataldo, A. M., Hamilton, D. J., Barnett J. L., Paskevich, P. A., and Nixon, R. A. (1996) J. Neurosci. 16, 186-199
46. Islam, K., and Levy, E. (1997) Am. J. Pathol. 151, 265-271
47. Ehehalt, R., Keller, P., Haass, C., Thiele, C., and Simons, K. (2003) J. Cell Biol. 160, 113-123
48. Corvera, S., D'Arrigo, A., and Stenmark, H. (1999) Curr. Opin. Cell Biol. 11, 460-465
49. Van Der Sluijs, P., Hull, M., Zahraoui, A., Tavitian, A., Goud, B., and Mellman, I. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 6313-6317
50. van der Sluijs, P., Hull, M., Webster, P., Male, P., Goud, B., and Mellman, I. (1992) Cell 70, 729-740
51. Cataldo, A., Rebeck, G. W., Ghetri, B., Hulette, C., Lippa, C., Van Broeckhoven, C., van Duijn, C., Cras, P., Bogdanovic, N., Bird, T., Peterhoff, C., and Nixon, R. (2001) Ann. Neurol. 50, 661-665
52. Cataldo, A. (2000) Neurobiol. Aging 293, Suppl. 65, 293
53. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) J. Biol. Chem. 273, 27765-27767
54. Slack, B. E., Ma, L. K., and Seah, C. C. (2001) Biochem. J. 357, 787-794
55. Lopez-Perez, E., Zhang, Y., Frank, S. J., Creemers, J., Seidah, N., and Checler, F. (2001) J. Neurochem. 76, 1532-1539
56. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenholz, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3922-3927
57. Parvathy, S., Hussain, I., Karran, E. H., Turner, A. J., and Hooper, N. M. (1999) Biochemistry 38, 9728-9734
58. Sisodia, S. S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6075-6079
59. Gandy, S. (1999) Trends Endocrinol. Metab. 10, 273-279
60. Jaffe, A. B., Toran-Allerand, C. D., Greengard, P., and Gandy, S. E. (1994) J. Biol. Chem. 269, 13065-13068
61. Gandy, S., Caporaso, G., Buxbaum, J., Frangione, B., and Greengard, P. (1994) Neurobiol. Aging 15, 253-256
62. Caporaso, G. L., Gandy, S. E., Buxbaum, J. D., Ramabhadran, T. V., and Greengard, P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3055-3059
63. Vassar, R., and Citron, M. (2000) Neuron 27, 419-422
64. Refolo, L. M., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., Duff, K., and Pappolla, M. A. (2000) Neurobiol. Dis. 7, 321-331
65. Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5856-5861
66. Kojro, E., Gimpl, G., Lammich, S., Marz, W., and Fahrenholz, F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5815-5820
67. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
68. Cedazo-Minguez, A., and Cowburn, R. F. (2001) J. Cell Mol. Med. 5, 254-266
69. Simons, M., Keller, P., Dichgans, J., and Schulz, J. B. (2001) Neurology 57, 1089-1093
70. Mann, D. M. Yates P. O. Marcyniuk B., and Ravindra, C. R. (1987) J. Neurol. Sci. 80, 79-89
71. Hyman, B. T. (1992) Prog. Clin. Biol. Res. 379, 123-142
72. Van Nostrand, W. E., Wagner, S. L., Suzuki, M., Choi, B. H., Farrow, J. S., Geddes, J. W., Cotman, C. W., and Cunningham, D. D. (1989) Nature 341, 546-549