Intracellular site of γ-secretase cleavage for Aβ42 generation in neuro 2a cells, harbouring a presenilin 1 mutation

European Journal of Biochemistry

Volumn 267, Issue 7, 2000, Pages 2036-2045

  Sudoh, Shinji ^a,c   Hua, Gang ^a,d   Kawamura, Yuuki ^a   Maruyama, Kei ^b   Komano, Hiroto ^a   Yanagisawa, Katsuhiko ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

Author keywords

A 42 secretase cleavage; Alzheimer's disease; Amyloid protein; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BREFELDIN A; COMPLEMENTARY DNA; GAMMA SECRETASE; MONENSIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE MUTATION; GOLGI COMPLEX; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; BREFELDIN A; DNA PRIMERS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HYDROLYSIS; MEMBRANE PROTEINS; MICE; MONENSIN; MUTATION; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN SORTING SIGNALS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034069575     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01206.x     Document Type: Article

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