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Volumn 61, Issue 7, 2002, Pages 640-650

Intracellular deposition, microtubule destabilization, and transport failure: An "early" pathogenic cascade leading to synaptic decline

Author keywords

Acetylated tubulin; Alzheimer disease; Hippocampal slice culture; Neurodegeneration; Paired helical filaments; Tau

Indexed keywords

CHLOROQUINE;

EID: 0036293375     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.7.640     Document Type: Article
Times cited : (57)

References (71)
  • 12
    • 0028171520 scopus 로고
    • Induction of β-amyloid-containing polypeptides in hippocampus: Evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin
    • (1994) Exp Neurol , vol.129 , pp. 81-94
    • Bahr, B.A.1    Abai, B.2    Gall, C.M.3
  • 13
    • 0032551528 scopus 로고    scopus 로고
    • Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein
    • (1998) J Comp Neurol , vol.397 , pp. 139-147
    • Bahr, B.A.1    Hoffman, K.B.2    Yang, A.J.3
  • 14
  • 15
    • 0034711207 scopus 로고    scopus 로고
    • Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
    • (2000) J Biol Chem , vol.275 , pp. 36794-36802
    • Chen, F.1    Yang, D.S.2    Petanceska, S.3
  • 19
    • 0027081792 scopus 로고
    • Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain
    • (1992) Ann NY Acad Sci , vol.674 , pp. 89-102
    • Ivy, G.O.1
  • 21
    • 0028864852 scopus 로고
    • Long-term hippocampal slices: A model system for investigating synaptic mechanisms and pathologic processes
    • (1995) J Neurosci Res , vol.42 , pp. 294-305
    • Bahr, B.A.1
  • 23
    • 0032837802 scopus 로고    scopus 로고
    • Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease
    • (1999) Exp Neurol , vol.158 , pp. 312-327
    • Bi, X.1    Zhou, J.2    Lynch, G.3
  • 38
    • 0016255812 scopus 로고
    • Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1
    • (1974) J Cell Biol , vol.63 , pp. 430-440
    • Wibo, M.1    Poole, B.2
  • 42
    • 0025284610 scopus 로고
    • Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins
    • (1990) Acta Neuropathol (Berl) , vol.80 , pp. 111-117
    • Delacourte, A.1    Flament, S.2    Dibe, E.M.3
  • 47
    • 0035884954 scopus 로고    scopus 로고
    • Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
    • (2001) J Neurosci Res , vol.65 , pp. 471-476
    • Pasinetti, G.M.1
  • 55
    • 0031812256 scopus 로고    scopus 로고
    • Chloroquine myopathy suggests that tau is degraded in lysosomes: Implication for the formation of paired helical filaments in Alzheimer's disease
    • (1998) Neurosci Res , vol.31 , pp. 1-8
    • Oyama, F.1    Murakami, N.2    Ihara, Y.3
  • 59
    • 0021225006 scopus 로고
    • Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells
    • (1984) J Cell Physiol , vol.121 , pp. 257-262
    • Scornik, O.A.1
  • 61
    • 0029812897 scopus 로고    scopus 로고
    • Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis
    • (1996) Neurology , vol.47 , pp. 535-540
    • Sasaki, S.1    Iwata, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.