Apoptosis and Alzheimer's disease

Journal of Neural Transmission

Volumn 107, Issue 11, 2000, Pages 1325-1344

  Behl, C ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Alzheimer's disease; Apoptosis; Caspase; Necrosis

Indexed keywords

CASPASE; DNA;

ALZHEIMER DISEASE; APOPTOSIS; CELL DEATH; DEGENERATIVE DISEASE; DNA DAMAGE; ENZYME ACTIVATION; HUMAN; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ALZHEIMER DISEASE; APOPTOSIS; DNA FRAGMENTATION; HUMANS; NECROSIS;

EID: 0033739282     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020070021     Document Type: Review

References (132)

1. The Bcl-2 Protein Family - Arbiters of cell survival
2. Uber eine eigenartige Erkrankung der Hirnrinde
3. Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): Association of c-Jun with A beta-induced apoptosis
4. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
5. The NF-κB and IκB proteins: New discoveries and insights
6. Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor
7. An essential role for NF-κB in preventing TNF-α induced cell death
8. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease
9. Neurobiology of corticotropin releasing factor (CRH) receptors and CRH-binding protein: Implications for the treatment of CNS disorders
10. Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches
11. The female sex hormone as a neuroprotectant
12. Vitamin E protects nerve cells from amyloid β protein toxicity
13. Amyloid β peptide induces necrosis rather than apoptosis
14. Hydrogen peroxide mediates amyloid beta protein toxicity
15. Haloperidol-induced cell death-mechanism and protection with vitamin E in vitro
16. 17-β Estradiol protects from oxidative stress-induced cell death in vitro
17. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship
18. A node between proliferation, apoptosis, and growth arrest
19. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
20. Programmed cell death in the developing nervous system
21. Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles
22. A cautionary note on the use of the TUNEL stain to determine apoptosis
23. Conversion of Bcl-2 to a Bax-like death effector by caspases
24. A potential role for apoptosis in neurodegeneration and Alzheimer's disease
25. Proteases to die for
26. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
27. IAP family proteins-suppressors of apoptosis
28. Reciprocal changes in corticotropin-releasing factor (CRH)-like immunoreactivity and CRH receptors in cerebral cortex of Alzheimer's disease
29. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry
30. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
31. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons
32. A caspase-activated DNASE that degrades DNA during apoptosis, and its inhibitor ICAD
33. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
34. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
35. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
36. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
37. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
38. Apoptosis in neuronal cells: Role of caspases
39. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
40. Phenolic a ring for the neuroprotective effects of steroids
41. Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent
42. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
43. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals
44. Presenilins: Genes for life and death
45. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
46. Proteolysis by presenilins and the renaissance of tau
47. Amyloid, the presenilins and Alzheimer's disease
48. Genetic classification of primary neurodegenerative disease
49. Direct evidence of oxidative injury produced by the Alzheimer's β-amyloid peptide (1-40) in cultured hippocampal neurons
50. Insulin-like growth factor-l-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kappaB
51. The epidemiology of estrogen replacement therapy and Alzheimer's disease
52. Estrogen replacement therapy in older women
53. Antidepressants and hypothalamic-pituitary-adrenocortical regulation
54. Risk factors for Alzheimer's disease during aging. Impacts of glucose/energy metabolism
55. Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells
56. Programmed cell death and Bcl-2 protection in the absence of a nucleus
57. Transcription factor NF-κB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease
58. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
59. Caspase-3-generated fragment of gelsolin - Effector of morphological change in apoptosis
60. Cholinesterase inhibitors: A therapeutic strategy for Alzheimer disease
61. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
62. Methylmercury induces apoptosis of rat cerebellar neurons in primary culture
63. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
64. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
65. Nicotinic acetylcholine involvement in cognitive function in animals
66. Transcription factor NF-κB: Friend or foe of neurons?
67. High constitutive NF-κB activity mediates resistance to oxidative stress in neuronal cells
68. Corticotropin-releasing hormone-mediated neuroprotection is associated with an increased release of non-amyloidogenic amyloid protein precursor and with the suppression of NF-κB
69. Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients
70. Janus faces of NF-?B: Neurodestruction versus neuroprotection
71. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger dna fragmentation during apoptosis
72. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
73. Apoptosis is induced by beta-amyloidin cultured central nervous system neurons
74. DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology
75. Oxidative stress hypothesis in Alzheimer's disease
76. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease
77. Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease
78. Amyloid plaque core protein in Alzheimer disease and Down syndrome
79. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
80. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
81. Methods for detecting and quantifying apoptosis
82. Calcium-activated DNA fragmentation kills immature thymocytes
83. Estrogen actions in the central nervous system
84. Mechanisms of cell death in Alzheimer disease - Immunopathology
85. Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons
86. The role of the Caspase family of cysteine proteases in apoptosis
87. A direct association of presenilin-1 with beta-catenin
88. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
89. Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death
90. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
91. Death substrates came alive
92. Programmed cell death and the control of cell survival: Lessons from the nervous system
93. Free radicals in Alzheimer's disease
94. Complement activation by β-amyloid in Alzheimer disease
95. A controlled trial of selegiline, alphatocopherol, or both as treatment for Alzheimer's disease
96. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB
97. Translating cell biology into therapeutic advances in Alzheimer's disease
98. In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease
99. Simultaneous determination of cell surface antigens and apoptosis
100. The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease
101. Purification and cloning of amyloid precursor protein beta-secretase from human brain
102. Evidence for apoptotic cell death in Alzheimer's disease
103. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
104. Molecular genetics of Alzheimer disease
105. Immunohistochemical evidence for apoptosis in Alzheimer's disease
106. Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression, and brain pathology
107. Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus
108. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention
109. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells
110. Effect of oestrogen during menopause on risk and age of onset of Alzheimer's disease
111. Some morphometric aspects of the brain in senile dementia of the Alzheimer type
112. Caspases: Enemies within
113. In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: Correlations with senile plaques and disease progression
114. Suppression of TNFα-induced apoptosis
115. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
116. Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system
117. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage
118. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of apoptosis
119. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
120. Molecular regulation of apoptosis: Genetic controls on cell death
121. Cytochemical methods for the detection of apoptosis
122. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
123. Inhibition of NF-κB/rel induces apoptosis of murine B cells
124. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
125. Cell death: The significance of apoptosis
126. Caenorhabditis elegans ced-9 protein is a bifunctional cell-death inhibitor
127. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
128. Mechanism of neuronal degeneration in Alzheimer's disease
129. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
130. Proteins that regulate dynamic actin remodeling in response to membrane signaling minireview series
131. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
132. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells