메뉴 건너뛰기




Volumn 301, Issue 1, 2003, Pages 119-126

Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes

Author keywords

Oligomerization; Presenilin; Protein dimerization; Western blotting; Yeast two hybrid; Secretase

Indexed keywords

DIMER; GAMMA SECRETASE; OLIGOMER; PRESENILIN 1;

EID: 0037474505     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02984-4     Document Type: Article
Times cited : (32)

References (38)
  • 4
    • 0033990169 scopus 로고    scopus 로고
    • Presenilins and Alzheimer's disease: Biological functions and pathogenic mechanisms
    • Czech C., Tremp G., Pradier L. Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms. Prog. Neurobiol. 60:2000;363-384.
    • (2000) Prog. Neurobiol. , vol.60 , pp. 363-384
    • Czech, C.1    Tremp, G.2    Pradier, L.3
  • 5
    • 0032576605 scopus 로고    scopus 로고
    • Aggresomes: A cellular response to misfolded proteins
    • Johnston J.A., Ward C.L., Kopito R.R. Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143:1998;1883-1898.
    • (1998) J. Cell Biol. , vol.143 , pp. 1883-1898
    • Johnston, J.A.1    Ward, C.L.2    Kopito, R.R.3
  • 6
    • 0032488995 scopus 로고    scopus 로고
    • The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
    • Capell A., Grunberg J., Pesold B., Diehlmann A., Citron M., Nixon R., Beyreuther K., Selkoe D.J., Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J. Biol. Chem. 273:1998;3205-3211.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3205-3211
    • Capell, A.1    Grunberg, J.2    Pesold, B.3    Diehlmann, A.4    Citron, M.5    Nixon, R.6    Beyreuther, K.7    Selkoe, D.J.8    Haass, C.9
  • 9
    • 0033610863 scopus 로고    scopus 로고
    • Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
    • Steiner H., Capell A., Pesold B., Citron M., Kloetzel P.M., Selkoe D.J., Romig H., Mendla K., Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J. Biol. Chem. 273:1998;32322-32331.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32322-32331
    • Steiner, H.1    Capell, A.2    Pesold, B.3    Citron, M.4    Kloetzel, P.M.5    Selkoe, D.J.6    Romig, H.7    Mendla, K.8    Haass, C.9
  • 14
    • 0034210793 scopus 로고    scopus 로고
    • Binding partners of Alzheimer's disease proteins: Are they physiologically relevant?
    • Van Gassen G., Annaert W., Van Broeckhoven C. Binding partners of Alzheimer's disease proteins: are they physiologically relevant? Neurobiol. Dis. 7:2000;135-151.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 135-151
    • Van Gassen, G.1    Annaert, W.2    Van Broeckhoven, C.3
  • 15
    • 0000792598 scopus 로고    scopus 로고
    • The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ -secretase activity and amyloid β -protein generation
    • Kimberly W.T., Xia W., Rahmati T., Wolfe M.S., Selkoe D.J. The transmembrane aspartates in presenilin 1 and 2 are obligatory for. γ -secretase activity and amyloid β -protein generation J. Biol. Chem. 275:2000;3173-3178.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3173-3178
    • Kimberly, W.T.1    Xia, W.2    Rahmati, T.3    Wolfe, M.S.4    Selkoe, D.J.5
  • 16
    • 0031768676 scopus 로고    scopus 로고
    • Missense mutation E318G of the presenilin-1 gene appears to be a nonpathogenic polymorphism
    • Aldudo J., Bullido M.J., Frank A., Valdivieso F. Missense mutation E318G of the presenilin-1 gene appears to be a nonpathogenic polymorphism. Ann. Neurol. 44:1998;985-986.
    • (1998) Ann. Neurol. , vol.44 , pp. 985-986
    • Aldudo, J.1    Bullido, M.J.2    Frank, A.3    Valdivieso, F.4
  • 17
    • 0030576937 scopus 로고    scopus 로고
    • Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant
    • Vidal R., Ghiso J., Wisniewski T., Frangione B. Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant. FEBS Lett. 393:1996;19-23.
    • (1996) FEBS Lett. , vol.393 , pp. 19-23
    • Vidal, R.1    Ghiso, J.2    Wisniewski, T.3    Frangione, B.4
  • 18
    • 0029813255 scopus 로고    scopus 로고
    • The presenilin genes: A new gene family involved in Alzheimer disease pathology
    • Cruts M., Hendriks L., Van Broeckhoven C. The presenilin genes: a new gene family involved in Alzheimer disease pathology. Hum. Mol. Genet. 5:1996;1449-1455.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1449-1455
    • Cruts, M.1    Hendriks, L.2    Van Broeckhoven, C.3
  • 20
    • 0033583047 scopus 로고    scopus 로고
    • The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing
    • Steiner H., Romig H., Grim M.G., Philipp U., Pesold B., Citron M., Baumeister R., Haass C. The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. J. Biol. Chem. 274:1999;7615-7618.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7615-7618
    • Steiner, H.1    Romig, H.2    Grim, M.G.3    Philipp, U.4    Pesold, B.5    Citron, M.6    Baumeister, R.7    Haass, C.8
  • 23
    • 0034704906 scopus 로고    scopus 로고
    • G-protein-coupled receptors function as oligomers in vivo
    • Overton M.C., Blumer K.J. G-protein-coupled receptors function as oligomers in vivo. Curr. Biol. 10:2000;341-344.
    • (2000) Curr. Biol. , vol.10 , pp. 341-344
    • Overton, M.C.1    Blumer, K.J.2
  • 26
    • 0030924177 scopus 로고    scopus 로고
    • Cell surface expression of the Alzheimer disease-related presenilin proteins
    • Dewji N.N., Singer S.J. Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc. Natl. Acad. Sci. USA. 94:1997;9926-9931.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9926-9931
    • Dewji, N.N.1    Singer, S.J.2
  • 28
    • 0031024228 scopus 로고    scopus 로고
    • Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques
    • Weber L.L., Leissring M.A., Yang A.J., Glabe C.G., Cribbs D.H., LaFerla F.M. Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Exp. Neurol. 143:1997;37-44.
    • (1997) Exp. Neurol. , vol.143 , pp. 37-44
    • Weber, L.L.1    Leissring, M.A.2    Yang, A.J.3    Glabe, C.G.4    Cribbs, D.H.5    LaFerla, F.M.6
  • 32
    • 0035823039 scopus 로고    scopus 로고
    • Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease
    • Cervantes S., Gonzalez-Duarte R., Marfany G. Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease. FEBS Lett. 505:2001;81-86.
    • (2001) FEBS Lett. , vol.505 , pp. 81-86
    • Cervantes, S.1    Gonzalez-Duarte, R.2    Marfany, G.3
  • 33
    • 0033553564 scopus 로고    scopus 로고
    • Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing
    • Saura C.A., Tomita T., Davenport F., Harris C.L., Iwatsubo T., Thinakaran G. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. J. Biol. Chem. 274:1999;13818-13823.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13818-13823
    • Saura, C.A.1    Tomita, T.2    Davenport, F.3    Harris, C.L.4    Iwatsubo, T.5    Thinakaran, G.6
  • 38
    • 0034966874 scopus 로고    scopus 로고
    • Presenilins as therapeutic targets for the treatment of Alzheimer's disease
    • Golde T.E., Younkin S.G. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol. Med. 7:2001;264-269.
    • (2001) Trends Mol. Med. , vol.7 , pp. 264-269
    • Golde, T.E.1    Younkin, S.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.