-
1
-
-
0033616590
-
Unusual phenotypic alteration of beta amyloid precursor protein (beta APP) maturation by a new Val-715 → Met beta APP-770 mutation responsible for probable early-onset Alzheimer's disease
-
Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, et al. 1999. Unusual phenotypic alteration of beta amyloid precursor protein (beta APP) maturation by a new Val-715 → Met beta APP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc. Natl. Acad. Sci. USA 96:4119-24
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4119-4124
-
-
Ancolio, K.1
Dumanchin, C.2
Barelli, H.3
Warter, J.M.4
Brice, A.5
-
2
-
-
0033151572
-
Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation
-
Ando K, Oishi M, Takeda S, Iijima K, Isohara T, et al. 1999. Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J. Neurosci. 19:4421-27
-
(1999)
J. Neurosci.
, vol.19
, pp. 4421-4427
-
-
Ando, K.1
Oishi, M.2
Takeda, S.3
Iijima, K.4
Isohara, T.5
-
3
-
-
0033214675
-
Presenilins: Molecular switches between proteolysis and signal transduction
-
Annaert W, De Strooper B. 1999. Presenilins: Molecular switches between proteolysis and signal transduction. Trends Neurosci. 22:439-43
-
(1999)
Trends Neurosci.
, vol.22
, pp. 439-443
-
-
Annaert, W.1
De Strooper, B.2
-
4
-
-
0035923750
-
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
-
Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, et al. 2001. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron 32:579-89
-
(2001)
Neuron
, vol.32
, pp. 579-589
-
-
Annaert, W.G.1
Esselens, C.2
Baert, V.3
Boeve, C.4
Snellings, G.5
-
5
-
-
0032720496
-
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
-
Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, et al. 1999. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons, J. Cell Biol. 147:277-94
-
(1999)
J. Cell Biol.
, vol.147
, pp. 277-294
-
-
Annaert, W.G.1
Levesque, L.2
Craessaerts, K.3
Dierinck, I.4
Snellings, G.5
-
6
-
-
0032415249
-
The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis
-
Arduengo PM, Appleberry OK, Chuang P, Lhernaul SW. 1998. The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis. J. Cell Sci. 111:3645-54
-
(1998)
J. Cell Sci.
, vol.111
, pp. 3645-3654
-
-
Arduengo, P.M.1
Appleberry, O.K.2
Chuang, P.3
Lhernaul, S.W.4
-
7
-
-
0031108103
-
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
-
Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C. 1997. Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct. 1:149-59
-
(1997)
Genes Funct.
, vol.1
, pp. 149-159
-
-
Baumeister, R.1
Leimer, U.2
Zweckbronner, I.3
Jakubek, C.4
Grunberg, J.5
Haass, C.6
-
8
-
-
0035815635
-
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
-
Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, et al. 2001. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem. 276:10879-87
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10879-10887
-
-
Benjannet, S.1
Elagoz, A.2
Wickham, L.3
Mamarbachi, M.4
Munzer, J.S.5
-
9
-
-
0034529080
-
A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase
-
Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, et al. 2000. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase. J. Biol. Chem. 275:37712-17
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37712-37717
-
-
Bennett, B.D.1
Denis, P.2
Haniu, M.3
Teplow, D.B.4
Kahn, S.5
-
10
-
-
0037040977
-
Identification and characterization of presenilin-independent Notch signaling
-
Berechid BE, Kitzmann M, Foltz DR, Roach AH, Seiffert D, et al. 2002. Identification and characterization of presenilin-independent Notch signaling. J. Biol. Chem. 277:3154-65
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3154-3165
-
-
Berechid, B.E.1
Kitzmann, M.2
Foltz, D.R.3
Roach, A.H.4
Seiffert, D.5
-
11
-
-
8044257704
-
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
-
Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, et al. 1997. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385:729-33
-
(1997)
Nature
, vol.385
, pp. 729-733
-
-
Black, R.A.1
Rauch, C.T.2
Kozlosky, C.J.3
Peschon, J.J.4
Slack, J.L.5
-
12
-
-
0032510834
-
The X11 alpha protein slows cellular amyloid precursor protein processing and reduces A beta 40 and A beta 42 secretion
-
Borg JP, Yang Y, De Taddeo-Borg M, Margolis B, Turner RS. 1998. The X11 alpha protein slows cellular amyloid precursor protein processing and reduces A beta 40 and A beta 42 secretion. J. Biol. Chem. 273:14761-66
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14761-14766
-
-
Borg, J.P.1
Yang, Y.2
De Taddeo-Borg, M.3
Margolis, B.4
Turner, R.S.5
-
13
-
-
0033868818
-
A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
-
Brou C, Logeat F, Gupta N, Bessia C, LeBail O, et al. 2000. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE. Mol. Cell 5:207-16
-
(2000)
Mol. Cell
, vol.5
, pp. 207-216
-
-
Brou, C.1
Logeat, F.2
Gupta, N.3
Bessia, C.4
LeBail, O.5
-
14
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL. 2000. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 100:391-98
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
15
-
-
14444272986
-
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, et al. 1998. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273:27765-67
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
-
16
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of A beta peptides by neurons
-
Cai HB, Wang YS, McCarthy D, Wen HJ, Borchelt DR, et al. 2001. BACE1 is the major beta-secretase for generation of A beta peptides by neurons. Nat. Neurosci. 4:233-34
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 233-234
-
-
Cai, H.B.1
Wang, Y.S.2
McCarthy, D.3
Wen, H.J.4
Borchelt, D.R.5
-
17
-
-
0035816661
-
A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Südhof TC. 2001. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293:115-20
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Südhof, T.C.2
-
18
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, et al. 1998. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J. Biol. Chem, 273:3205-11
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
-
19
-
-
0037085453
-
Apical sorting of beta-secretase limits amyloid beta-peptide production
-
Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C. 2002. Apical sorting of beta-secretase limits amyloid beta-peptide production. J. Biol. Chem. 277:5637-43
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5637-5643
-
-
Capell, A.1
Meyn, L.2
Fluhrer, R.3
Teplow, D.B.4
Walter, J.5
Haass, C.6
-
20
-
-
0033783140
-
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch
-
Capell A, Steiner H, Romig H, Keck S, Baader M, et al. 2000. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nat. Cell Biol. 2:205-11
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 205-211
-
-
Capell, A.1
Steiner, H.2
Romig, H.3
Keck, S.4
Baader, M.5
-
21
-
-
0035204206
-
Nicastrin is required for presenilin-mediated transmembrane cleavage in Drosophila
-
Chung HM, Struhl G. 2001. Nicastrin is required for presenilin-mediated transmembrane cleavage in Drosophila. Nat. Cell Biol. 3:1129-32
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1129-1132
-
-
Chung, H.M.1
Struhl, G.2
-
22
-
-
0035449016
-
The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate
-
Cinar HN, Sweet KL, Hosemann KE, Earley K, Newman AP. 2001. The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate. Dev. Biol. 237:173-82
-
(2001)
Dev. Biol.
, vol.237
, pp. 173-182
-
-
Cinar, H.N.1
Sweet, K.L.2
Hosemann, K.E.3
Earley, K.4
Newman, A.P.5
-
23
-
-
0035830897
-
Processing of beta-secretase by furin and other members of the proprotein convertase family
-
Creemers JWM, Dominguez DI, Plets E, Serneels L, Taylor NA, et al. 2001. Processing of beta-secretase by furin and other members of the proprotein convertase family. J. Biol. Chem. 276:4211-17
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4211-4217
-
-
Creemers, J.W.M.1
Dominguez, D.I.2
Plets, E.3
Serneels, L.4
Taylor, N.A.5
-
24
-
-
0035798269
-
Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease
-
Cruts M, Dermaut B, Rademakers R, Roks G, Van den Broeck M, et al. 2001. Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease. Neurosci. Lett. 313:105-7
-
(2001)
Neurosci. Lett.
, vol.313
, pp. 105-107
-
-
Cruts, M.1
Dermaut, B.2
Rademakers, R.3
Roks, G.4
Van den Broeck, M.5
-
25
-
-
0035921427
-
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
-
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, et al. 2001a. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. J. Cell Biol. 154:731-40
-
(2001)
J. Cell Biol.
, vol.154
, pp. 731-740
-
-
Cupers, P.1
Bentahir, M.2
Craessaerts, K.3
Orlans, I.4
Vanderstichele, H.5
-
26
-
-
0034839287
-
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
-
Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. 2001b. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J. Neurochem. 78:1168-78
-
(2001)
J. Neurochem.
, vol.78
, pp. 1168-1178
-
-
Cupers, P.1
Orlans, I.2
Craessaerts, K.3
Annaert, W.4
De Strooper, B.5
-
27
-
-
0032032019
-
An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos
-
Davis JA, Naruse S, Chen H, Eckman C, Younkin S, et al. 1998. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron 20:603-9
-
(1998)
Neuron
, vol.20
, pp. 603-609
-
-
Davis, J.A.1
Naruse, S.2
Chen, H.3
Eckman, C.4
Younkin, S.5
-
28
-
-
0033851020
-
Tau pathology: A marker of neurodegenerative disorders
-
Delacourte A, Buee L. 2000. Tau pathology: A marker of neurodegenerative disorders. Curr. Opin. Neurol. 13:371-76
-
(2000)
Curr. Opin. Neurol.
, vol.13
, pp. 371-376
-
-
Delacourte, A.1
Buee, L.2
-
29
-
-
0034049944
-
Proteolytic processing and cell biological functions of the amyloid precursor protein
-
De Strooper B, Annaert W. 2000. Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci. 113:1857-70
-
(2000)
J. Cell Sci.
, vol.113
, pp. 1857-1870
-
-
De Strooper, B.1
Annaert, W.2
-
30
-
-
0035911161
-
Where Notch and Wnt signaling meet. The presenilin hub
-
De Strooper B, Annaert W. 2001. Where Notch and Wnt signaling meet. The presenilin hub. J. Cell Biol. 152:F17-20
-
(2001)
J. Cell Biol.
, vol.152
-
-
De Strooper, B.1
Annaert, W.2
-
31
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, et al. 1999. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518-22
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
-
32
-
-
15444341611
-
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins
-
De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, et al. 1997. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem. 272:3590-98
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3590-3598
-
-
De Strooper, B.1
Beullens, M.2
Contreras, B.3
Levesque, L.4
Craessaerts, K.5
-
33
-
-
0035829817
-
An inflammatory drug prospect
-
De Strooper B, Konig G. 2001. An inflammatory drug prospect. Nature 414:159-60
-
(2001)
Nature
, vol.414
, pp. 159-160
-
-
De Strooper, B.1
Konig, G.2
-
34
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, et al. 1998. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391:387-90
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
-
35
-
-
0030293854
-
Protein topology of presenilin 1
-
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, et al. 1996. Protein topology of presenilin 1. Neuron 17:1023-30
-
(1996)
Neuron
, vol.17
, pp. 1023-1030
-
-
Doan, A.1
Thinakaran, G.2
Borchelt, D.R.3
Slunt, H.H.4
Ratovitsky, T.5
-
36
-
-
0035979234
-
Presenilin-dependent gamma-secretase activity modulates thymocyte development
-
Doerfler P, Shearman MS, Perlmutter RM. 2001. Presenilin-dependent gamma-secretase activity modulates thymocyte development. Proc. Natl. Acad. Sci. USA 98:9312-17
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9312-9317
-
-
Doerfler, P.1
Shearman, M.S.2
Perlmutter, R.M.3
-
37
-
-
0011714196
-
From the theory towards the therapy of Alzheimer's disease: Novel therapeutic strategies provide the real test for the amyloid hypothesis
-
In press
-
Dominguez DI, De Strooper B. 2002. From the theory towards the therapy of Alzheimer's disease: Novel therapeutic strategies provide the real test for the amyloid hypothesis. Trends Pharmacol. Sci. In press
-
(2002)
Trends Pharmacol. Sci.
-
-
Dominguez, D.I.1
De Strooper, B.2
-
38
-
-
0032728957
-
Mice lacking both presenilin genes exhibit early embryonic patterning defects
-
Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, Bernstein A. 1999. Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 13:2801-10
-
(1999)
Genes Dev.
, vol.13
, pp. 2801-2810
-
-
Donoviel, D.B.1
Hadjantonakis, A.K.2
Ikeda, M.3
Zheng, H.4
Hyslop, P.S.5
Bernstein, A.6
-
39
-
-
0037122805
-
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
-
Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. 2002. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415:287-94
-
(2002)
Nature
, vol.415
, pp. 287-294
-
-
Dutzler, R.1
Campbell, E.B.2
Cadene, M.3
Chait, B.T.4
MacKinnon, R.5
-
40
-
-
0033780472
-
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
-
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, et al. 2000. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat. Cell Biol. 2:428-34
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
-
41
-
-
0034662929
-
BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
-
Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H. 2000. BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. USA 97:9712-17
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9712-9717
-
-
Farzan, M.1
Schnitzler, C.E.2
Vasilieva, N.3
Leung, D.4
Choe, H.5
-
42
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides A beta 42 and A beta 40 in vitro and in vivo
-
Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, et al. 2001. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides A beta 42 and A beta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98:5856-61
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
Stroick, M.4
Lutjohann, D.5
-
43
-
-
18244391974
-
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces
-
Feng R, Rampon C, Tang YP, Shrom D, Jin J, et al. 2001. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32:911-26
-
(2001)
Neuron
, vol.32
, pp. 911-926
-
-
Feng, R.1
Rampon, C.2
Tang, Y.P.3
Shrom, D.4
Jin, J.5
-
44
-
-
0035909901
-
The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
-
Gao Y, Pimplikar SW. 2001. The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc. Natl. Acad. Sci. USA 98:14979-84
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14979-14984
-
-
Gao, Y.1
Pimplikar, S.W.2
-
45
-
-
0035912767
-
Kinesin molecular motors: Transport pathways, receptors, and human disease
-
Goldstein LS. 2001. Kinesin molecular motors: Transport pathways, receptors, and human disease. Proc. Natl. Acad. Sci. USA 98:6999-7003
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6999-7003
-
-
Goldstein, L.S.1
-
46
-
-
0035943436
-
Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by A beta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. 2001. Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by A beta 42 fibrils. Science 293:1491-95
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
47
-
-
0034080403
-
Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C, Hepler W, Mickey KM, Priess JR. 2000. Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127:2481-92
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
48
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA, Priess JR. 2002. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA 99:775-79
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
49
-
-
0035829720
-
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
-
Gunawardena S, Goldstein LS. 2001. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32:389401
-
(2001)
Neuron
, vol.32
, pp. 389-401
-
-
Gunawardena, S.1
Goldstein, L.S.2
-
50
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
Haass C, Schlossmacher MG, Hung AY, VigoPelfrey C, Mellon A, et al. 1992. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359:322-25
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
-
51
-
-
0035912829
-
Gamma-secretase inhibitors repress thymocyte development
-
Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, et al. 2001. Gamma-secretase inhibitors repress thymocyte development. Proc. Natl. Acad. Sci. USA 98:7487-91
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 7487-7491
-
-
Hadland, B.K.1
Manley, N.R.2
Su, D.3
Longmore, G.D.4
Moore, C.L.5
-
52
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy J. 1997. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20:154-59
-
(1997)
Trends Neurosci.
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
53
-
-
0035968117
-
Presenilin mutations line up along transmembrane alpha-helices
-
Hardy J, Crook R. 2001. Presenilin mutations line up along transmembrane alpha-helices. Neurosci. Lett. 306:203-5
-
(2001)
Neurosci. Lett.
, vol.306
, pp. 203-205
-
-
Hardy, J.1
Crook, R.2
-
54
-
-
0033565962
-
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
-
Hartmann D, De Strooper B, Saftig P. 1999. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Curr. Biol. 9:719-27
-
(1999)
Curr. Biol.
, vol.9
, pp. 719-727
-
-
Hartmann, D.1
De Strooper, B.2
Saftig, P.3
-
55
-
-
0034329291
-
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members
-
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, et al. 2000. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J. Neurosci. 20:7951-63
-
(2000)
J. Neurosci.
, vol.20
, pp. 7951-7963
-
-
Heber, S.1
Herms, J.2
Gajic, V.3
Hainfellner, J.4
Aguzzi, A.5
-
56
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, et al. 1999. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. USA 96:11872-77
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
-
57
-
-
0033775709
-
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells
-
Herreman A, Semeels L, Annaert W, Collen D, Schoonjans L, De Strooper B. 2000. Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nat. Cell Biol. 2:461-62
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 461-462
-
-
Herreman, A.1
Semeels, L.2
Annaert, W.3
Collen, D.4
Schoonjans, L.5
De Strooper, B.6
-
58
-
-
0034613320
-
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
-
Hong L, Koelsch G, Lin X, Wu S, Terzyan S, et al. 2000. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 290:150-53
-
(2000)
Science
, vol.290
, pp. 150-153
-
-
Hong, L.1
Koelsch, G.2
Lin, X.3
Wu, S.4
Terzyan, S.5
-
59
-
-
0036007117
-
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
-
Hu Y, Ye Y, Fortini ME. 2002. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell. 2:69-78
-
(2002)
Dev. Cell.
, vol.2
, pp. 69-78
-
-
Hu, Y.1
Ye, Y.2
Fortini, M.E.3
-
60
-
-
0034702303
-
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
-
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, et al. 2000. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405:966-70
-
(2000)
Nature
, vol.405
, pp. 966-970
-
-
Huppert, S.S.1
Le, A.2
Schroeter, E.H.3
Mumm, J.S.4
Saxena, M.T.5
-
61
-
-
0034721842
-
Maturation and endosomal targeting of BACE: The Alzheimer's disease beta-secretase
-
Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW. 2000. Maturation and endosomal targeting of BACE: The Alzheimer's disease beta-secretase. J. Biol. Chem. 275:33729-37
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.4
Doms, R.W.5
-
62
-
-
0035968173
-
Prodomain processing of Asp1 (BACE2) is autocatalytic
-
Hussain I, Christie G, Schneider K, Moore S, Dingwall C. 2001. Prodomain processing of Asp1 (BACE2) is autocatalytic. J. Biol. Chem. 276:23322-28
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23322-23328
-
-
Hussain, I.1
Christie, G.2
Schneider, K.3
Moore, S.4
Dingwall, C.5
-
63
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, et al. 1999. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14:419-27
-
(1999)
Mol. Cell. Neurosci.
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
-
64
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
Jarrett JT, Lansbury PT Jr. 1993. Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73:1055-58
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury P.T., Jr.2
-
65
-
-
0032576605
-
Aggresomes: A cellular response to misfolded proteins
-
Johnston JA, Ward CL, Kopito RR. 1998. Aggresomes: A cellular response to misfolded proteins. J. Cell Biol. 143:1883-98
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
66
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
-
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. 2001. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414:643-48
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.5
-
67
-
-
0035900686
-
Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein
-
Kim SM, Leem JY, Cah JJ, Slunt HH, Levey AI, et al. 2001. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. J. Biol. Chem. 276:4343-50
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4343-4350
-
-
Kim, S.M.1
Leem, J.Y.2
Cah, J.J.3
Slunt, H.H.4
Levey, A.I.5
-
68
-
-
0030890399
-
Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
-
Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. 1997. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272:11006-10
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11006-11010
-
-
Kim, T.W.1
Pettingell, W.H.2
Hallmark, O.G.3
Moir, R.D.4
Wasco, W.5
Tanzi, R.E.6
-
69
-
-
0035955693
-
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
-
Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ. 2001. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J. Biol. Chem. 276:40288-92
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40288-40292
-
-
Kimberly, W.T.1
Zheng, J.B.2
Guenette, S.Y.3
Selkoe, D.J.4
-
70
-
-
0035923502
-
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyl-transferase
-
Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y. 2001. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyl-transferase. Proc. Natl. Acad. Sci. USA 98:13554-59
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13554-13559
-
-
Kitazume, S.1
Tachida, Y.2
Oka, R.3
Shirotani, K.4
Saido, T.C.5
Hashimoto, Y.6
-
71
-
-
0033569653
-
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
-
Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, et al. 1999. Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem. J. 343:371-75
-
(1999)
Biochem. J.
, vol.343
, pp. 371-375
-
-
Koike, H.1
Tomioka, S.2
Sorimachi, H.3
Saido, T.C.4
Maruyama, K.5
-
72
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
-
Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F. 2001. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc. Natl. Acad. Sci. USA 98:5815-20
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
Gimpl, G.2
Lammich, S.3
Marz, W.4
Fahrenholz, F.5
-
73
-
-
0034212710
-
Notch signaling is essential for vascular morphogenesis in mice
-
Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, et al. 2000. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 14:1343-52
-
(2000)
Genes Dev.
, vol.14
, pp. 1343-1352
-
-
Krebs, L.T.1
Xue, Y.2
Norton, C.R.3
Shutter, J.R.4
Maguire, M.5
-
74
-
-
0034327364
-
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease
-
Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, et al. 2000. Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Hum. Mol. Genet. 9:2589-98
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2589-2598
-
-
Kumar-Singh, S.1
De Jonghe, C.2
Cruts, M.3
Kleinert, R.4
Wang, R.5
-
75
-
-
0033616716
-
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, et al. 1999. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. USA 96:3922-27
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
Gilbert, S.4
Pfeiffer, R.5
-
76
-
-
0034626631
-
Fe65 and X11 beta co-localize with and compete for binding to the amyloid precursor protein
-
Lau KF, McLoughlin DM, Standen CL, Irving NG, Miller CC. 2000. Fe65 and X11 beta co-localize with and compete for binding to the amyloid precursor protein. NeuroReport 11:3607-10
-
(2000)
NeuroReport
, vol.11
, pp. 3607-3610
-
-
Lau, K.F.1
McLoughlin, D.M.2
Standen, C.L.3
Irving, N.G.4
Miller, C.C.5
-
77
-
-
0031746979
-
A detergent-insoluble membrane compartment contains A beta in vivo
-
Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT Jr, Kosik KS. 1998. A detergent-insoluble membrane compartment contains A beta in vivo. Nat. Med. 4:730-34
-
(1998)
Nat. Med.
, vol.4
, pp. 730-734
-
-
Lee, S.J.1
Liyanage, U.2
Bickel, P.E.3
Xia, W.4
Lansbury P.T., Jr.5
Kosik, K.S.6
-
78
-
-
0033231262
-
Neurodegenerative tauopathies: Human disease and transgenic mouse models
-
Lee VM, Trojanowski JQ. 1999. Neurodegenerative tauopathies: Human disease and transgenic mouse models. Neuron 24:507-10
-
(1999)
Neuron
, vol.24
, pp. 507-510
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
79
-
-
0034657414
-
Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice
-
Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. 2000. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J. Cell Biol. 149:793-98
-
(2000)
J. Cell Biol.
, vol.149
, pp. 793-798
-
-
Leissring, M.A.1
Akbari, Y.2
Fanger, C.M.3
Cahalan, M.D.4
Mattson, M.P.5
LaFerla, F.M.6
-
80
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
-
Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, et al. 1996. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93:14940-44
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
Lee, M.K.4
Thinakaran, G.5
-
81
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I. 1995. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-54
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
82
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-77
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
-
83
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, et al. 2001. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293:1487-91
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
-
84
-
-
0030671560
-
HOP-l, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
-
Li X, Greenwald I. 1997. HOP-l, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. USA 94:12204-9
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12204-12209
-
-
Li, X.1
Greenwald, I.2
-
85
-
-
0032499750
-
Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
-
Li X, Greenwald I. 1998. Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins. Proc. Natl. Acad. Sci. USA 95:7109-14
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7109-7114
-
-
Li, X.1
Greenwald, I.2
-
86
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li YM, Xu M, Lai MT, Huang Q, Castro JL, et al. 2000. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405:689-94
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
-
87
-
-
0032981558
-
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
-
Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. 1999. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 96:3053-58
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3053-3058
-
-
Lichtenthaler, S.F.1
Wang, R.2
Grimm, H.3
Uljon, S.N.4
Masters, C.L.5
Beyreuther, K.6
-
88
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
-
Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. 2000. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc. Natl. Acad. Sci. USA 97:1456-60
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
89
-
-
0036007118
-
Drosophila nicastrin is essential for the intramembranous cleavage of Notch
-
Lopez-Schier H, Johnston DS. 2002. Drosophila nicastrin is essential for the intramembranous cleavage of Notch. Dev. Cell. 2:79-89
-
(2002)
Dev. Cell.
, vol.2
, pp. 79-89
-
-
Lopez-Schier, H.1
Johnston, D.S.2
-
90
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo Y, Bolon B, Kahn S, Bennett BD, BabuKhan S, et al. 2001. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat. Neurosci. 4:231-32
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
Bennett, B.D.4
Babu-Khan, S.5
-
91
-
-
0035827702
-
Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide
-
Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, et al. 2001. Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide. J. Biol. Chem. 276:20267-79
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20267-20279
-
-
Maltese, W.A.1
Wilson, S.2
Tan, Y.3
Suomensaari, S.4
Sinha, S.5
-
92
-
-
0035794182
-
The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation
-
Minopoli G, de Candia P, Bonetti A, Faraonio R, Zambrano N, Russo T. 2001. The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation. J. Biol. Chem. 276:6545-50
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6545-6550
-
-
Minopoli, G.1
De Candia, P.2
Bonetti, A.3
Faraonio, R.4
Zambrano, N.5
Russo, T.6
-
93
-
-
0035979241
-
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
-
Mizutani T, Taniguchi Y, Aoki T, Hashimoto N, Honjo T. 2001. Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. Proc. Natl. Acad. Sci. USA 98:9026-31
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9026-9031
-
-
Mizutani, T.1
Taniguchi, Y.2
Aoki, T.3
Hashimoto, N.4
Honjo, T.5
-
94
-
-
0033867521
-
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch 1
-
Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian XL, et al. 2000. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch 1. Mol. Cell 5:197-206
-
(2000)
Mol. Cell
, vol.5
, pp. 197-206
-
-
Mumm, J.S.1
Schroeter, E.H.2
Saxena, M.T.3
Griesemer, A.4
Tian, X.L.5
-
95
-
-
0030296851
-
Presenilin mutations in Alzheimer's disease: Molecular models suggest a potential functional locus
-
Murgolo NJ, Brown JE, Bayne ML, Strader CD. 1996. Presenilin mutations in Alzheimer's disease: Molecular models suggest a potential functional locus. Trends Pharmacol. Sci. 17:389-93
-
(1996)
Trends Pharmacol. Sci.
, vol.17
, pp. 389-393
-
-
Murgolo, N.J.1
Brown, J.E.2
Bayne, M.L.3
Strader, C.D.4
-
96
-
-
0033597105
-
gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length
-
Murphy MP, Hickman LJ, Eckman CB, Uljon SN, Wang R, Golde TE. 1999. gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length. J. Biol. Chem. 274:11914-23
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11914-11923
-
-
Murphy, M.P.1
Hickman, L.J.2
Eckman, C.B.3
Uljon, S.N.4
Wang, R.5
Golde, T.E.6
-
97
-
-
0033551742
-
Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure
-
Nakai T, Yamasaki A, Sakaguchi M, Kosaka K, Mihara K, et al. 1999. Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure. J. Biol. Chem. 274:23647-58
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23647-23658
-
-
Nakai, T.1
Yamasaki, A.2
Sakaguchi, M.3
Kosaka, K.4
Mihara, K.5
-
98
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, et al. 1998. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21:1213-21
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
Kusiak, J.W.4
Tomita, T.5
-
99
-
-
0035824391
-
gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
-
Ni CY, Murphy MP, Golde TE, Carpenter G. 2001. gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294:2179-81
-
(2001)
Science
, vol.294
, pp. 2179-2181
-
-
Ni, C.Y.1
Murphy, M.P.2
Golde, T.E.3
Carpenter, G.4
-
100
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including A beta 42
-
Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia WM, et al. 1999. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including A beta 42. J. Biol. Chem. 274:18851-56
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
Ostaszewski, B.4
Xia, W.M.5
-
102
-
-
0032032847
-
Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates A beta1-42/43 expression
-
Qian S, Jiang P, Guan XM, Singh G, Trumbauer ME, et al. 1998. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates A beta1-42/43 expression. Neuron 20:611-17
-
(1998)
Neuron
, vol.20
, pp. 611-617
-
-
Qian, S.1
Jiang, P.2
Guan, X.M.3
Singh, G.4
Trumbauer, M.E.5
-
103
-
-
0031301274
-
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
-
Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, et al. 1997. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol. Cell 1:47-57
-
(1997)
Mol. Cell
, vol.1
, pp. 47-57
-
-
Rawson, R.B.1
Zelenski, N.G.2
Nijhawan, D.3
Ye, J.4
Sakai, J.5
-
104
-
-
0033579505
-
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of notch
-
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, et al. 1999. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of notch. J. Biol. Chem. 274:36801-7
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36801-36807
-
-
Ray, W.J.1
Yao, M.2
Mumm, J.3
Schroeter, E.H.4
Saftig, P.5
-
105
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, et al. 2000. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7:321-31
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 321-331
-
-
Refolo, L.M.1
Malester, B.2
LaFrancois, J.3
Bryant-Thomas, T.4
Wang, R.5
-
106
-
-
0035160066
-
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, et al. 2001. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8:890-99
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 890-899
-
-
Refolo, L.M.1
Pappolla, M.A.2
LaFrancois, J.3
Malester, B.4
Schmidt, S.D.5
-
107
-
-
0035928732
-
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
-
Riddell DR, Christie G, Hussain I, Dingwall C. 2001. Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr. Biol. 11:1288-93
-
(2001)
Curr. Biol.
, vol.11
, pp. 1288-1293
-
-
Riddell, D.R.1
Christie, G.2
Hussain, I.3
Dingwall, C.4
-
108
-
-
17344388652
-
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics
-
Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, et al. 2001. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 10:1317-24
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1317-1324
-
-
Roberds, S.L.1
Anderson, J.2
Basi, G.3
Bienkowski, M.J.4
Branstetter, D.G.5
-
109
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, et al. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-78
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
-
110
-
-
0032945805
-
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
-
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, et al. 1999. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat. Struct. Biol. 6:327-31
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 327-331
-
-
Rossjohn, J.1
Cappai, R.2
Feil, S.C.3
Henry, A.4
McKinstry, W.J.5
-
111
-
-
0035954426
-
The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement
-
Sabo SL, Ikin AF, Buxbaum JD, Greengard P. 2001. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J. Cell Biol. 153:1403-14
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1403-1414
-
-
Sabo, S.L.1
Ikin, A.F.2
Buxbaum, J.D.3
Greengard, P.4
-
112
-
-
0032575559
-
X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion
-
Sastre M, Turner RS, Levy E. 1998. X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. J. Biol. Chem. 273:22351-57
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22351-22357
-
-
Sastre, M.1
Turner, R.S.2
Levy, E.3
-
113
-
-
0034616960
-
Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase
-
Sauder JM, Arthur JW, Dunbrack RL Jr. 2000. Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase. J. Mol. Biol. 300:241-48
-
(2000)
J. Mol. Biol.
, vol.300
, pp. 241-248
-
-
Sauder, J.M.1
Arthur, J.W.2
Dunbrack R.L., Jr.3
-
114
-
-
0035955604
-
Murine notch homologs (n1-4) undergo presenilin-dependent proteolysis
-
Saxena MT, Schroeter EH, Mumm JS, Kopan R. 2001. Murine notch homologs (n1-4) undergo presenilin-dependent proteolysis. J. Biol. Chem. 276:40268-73
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40268-40273
-
-
Saxena, M.T.1
Schroeter, E.H.2
Mumm, J.S.3
Kopan, R.4
-
115
-
-
0035823495
-
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
-
Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, et al. 2001. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J. Biol. Chem. 276:33923-29
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33923-33929
-
-
Scheuermann, S.1
Hambsch, B.2
Hesse, L.3
Stumm, J.4
Schmidt, C.5
-
116
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, et al. 1996. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:864-70
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
-
117
-
-
0032741143
-
Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
-
Schlondorff J, Blobel CP. 1999. Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J. Cell Sci. 112:3603-17
-
(1999)
J. Cell Sci.
, vol.112
, pp. 3603-3617
-
-
Schlondorff, J.1
Blobel, C.P.2
-
118
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan R. 1998. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-86
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
119
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimer's disease
-
Selkoe DJ. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:A23-31
-
(1999)
Nature
, vol.399
-
-
Selkoe, D.J.1
-
120
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe DJ. 2001. Clearing the brain's amyloid cobwebs. Neuron 32:177-80
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
121
-
-
0026646605
-
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
-
Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, et al. 1992. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359:325-27
-
(1992)
Nature
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
Lee, M.4
Dovey, H.5
-
122
-
-
0030779784
-
Skeletal and CNS defects in presenilin-1-deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. 1997. Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89:629-39
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
123
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-40
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
-
124
-
-
0030949124
-
Functional rafts in cell membranes
-
Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387:569-72
-
(1997)
Nature
, vol.387
, pp. 569-572
-
-
Simons, K.1
Ikonen, E.2
-
125
-
-
0029935765
-
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons
-
Simons M, De Strooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K. 1996. Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J. Neurosci. 16:899-908
-
(1996)
J. Neurosci.
, vol.16
, pp. 899-908
-
-
Simons, M.1
De Strooper, B.2
Multhaup, G.3
Tienari, P.J.4
Dotti, C.G.5
Beyreuther, K.6
-
126
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, et al. 1999. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537-40
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
-
127
-
-
0035433962
-
Alzheimer's disease and A beta toxicity: From top to bottom
-
Small DH, Mok SS, Bornstein JC. 2001. Alzheimer's disease and A beta toxicity: From top to bottom. Nat. Rev. Neurosci. 2:595-98
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
128
-
-
0035911156
-
Presenilin 1 negatively regulates beta-catenin/LEF signaling independently of APP and Notch processing
-
Soriano S, Kang DE, Fu M, Pestall R, Chevalier N, et al. 2001. Presenilin 1 negatively regulates beta-catenin/LEF signaling independently of APP and Notch processing. J. Cell Biol. 152:785-94
-
(2001)
J. Cell Biol.
, vol.152
, pp. 785-794
-
-
Soriano, S.1
Kang, D.E.2
Fu, M.3
Pestall, R.4
Chevalier, N.5
-
129
-
-
0037128935
-
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
-
Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM. 2002. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J. Cell Biol. 156:1051-63
-
(2002)
J. Cell Biol.
, vol.156
, pp. 1051-1063
-
-
Stamer, K.1
Vogel, R.2
Thies, E.3
Mandelkow, E.4
Mandelkow, E.M.5
-
130
-
-
0033214070
-
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and Notch signaling
-
Steiner H, Duff K, Capell A, Romig H, Grim MG, et al. 1999. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and Notch signaling. J. Biol. Chem. 274:28669-73
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28669-28673
-
-
Steiner, H.1
Duff, K.2
Capell, A.3
Romig, H.4
Grim, M.G.5
-
131
-
-
0033778262
-
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
-
Steiner H, Kostka M, Romig H, Basset G, Pesold B, et al. 2000. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat. Cell Biol. 2:848-51
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 848-851
-
-
Steiner, H.1
Kostka, M.2
Romig, H.3
Basset, G.4
Pesold, B.5
-
132
-
-
0033639117
-
Requirements for presenilin-dependent cleavage of Notch and other transmembrane proteins
-
Struhl G, Adachi A. 2000. Requirements for presenilin-dependent cleavage of Notch and other transmembrane proteins. Mol. Cell 6:625-36
-
(2000)
Mol. Cell
, vol.6
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
133
-
-
0033535508
-
Presenilin is required for activity and nuclear access of Notch in Drosophila
-
Struhl G, Greenwald I. 1999. Presenilin is required for activity and nuclear access of Notch in Drosophila, Nature 398:522-25
-
(1999)
Nature
, vol.398
, pp. 522-525
-
-
Struhl, G.1
Greenwald, I.2
-
134
-
-
0034425701
-
Mesp2 initiates somite segmentation through the Notch signalling pathway
-
Takahashi Y, Koizumi K, Takagi A, Kitajima S, Inoue T, et al. 2000. Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat. Genet. 25:390-96
-
(2000)
Nat. Genet.
, vol.25
, pp. 390-396
-
-
Takahashi, Y.1
Koizumi, K.2
Takagi, A.3
Kitajima, S.4
Inoue, T.5
-
135
-
-
0035950188
-
New frontiers in Alzheimer's disease genetics
-
Tanzi RE, Bertram L. 2001. New frontiers in Alzheimer's disease genetics. Neuron 32:181-84
-
(2001)
Neuron
, vol.32
, pp. 181-184
-
-
Tanzi, R.E.1
Bertram, L.2
-
136
-
-
0030667426
-
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
-
Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, et al. 1997. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J. Biol. Chem. 272:28415-22
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28415-28422
-
-
Thinakaran, G.1
Harris, C.L.2
Ratovitski, T.3
Davenport, F.4
Slunt, H.H.5
-
137
-
-
0035980073
-
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins
-
Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, et al. 2001. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. J. Biol. Chem. 276:33273-81
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33273-33281
-
-
Tomita, T.1
Watabiki, T.2
Takikawa, R.3
Morohashi, Y.4
Takasugi, N.5
-
138
-
-
0031566256
-
Cloning of Xenopus presenilin-alpha and -beta cDNAs and their differential expression in oogenesis and embryogenesis
-
Tsujimura A, Yasojima K, Hashimoto-Gotoh T. 1997. Cloning of Xenopus presenilin-alpha and -beta cDNAs and their differential expression in oogenesis and embryogenesis. Biochem. Biophys. Res. Commun. 231:392-96
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.231
, pp. 392-396
-
-
Tsujimura, A.1
Yasojima, K.2
Hashimoto-Gotoh, T.3
-
139
-
-
0035913908
-
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
-
Urban S, Lee JR, Freeman M. 2001. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107:173-82
-
(2001)
Cell
, vol.107
, pp. 173-182
-
-
Urban, S.1
Lee, J.R.2
Freeman, M.3
-
140
-
-
0034210793
-
Binding partners of Alzheimer's disease proteins: Are they physiologically relevant?
-
Van Gassen G, Annaert W, Van Broeckhoven C. 2000. Binding partners of Alzheimer's disease proteins: Are they physiologically relevant? Neurobiol. Dis. 7:135-51
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 135-151
-
-
Van Gassen, G.1
Annaert, W.2
Van Broeckhoven, C.3
-
141
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, et al. 1999. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-41
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
-
142
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of beta-secretase
-
Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, et al. 2001. Phosphorylation regulates intracellular trafficking of beta-secretase. J. Biol. Chem. 276:14634-41
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
Willem, M.4
Kaether, C.5
-
143
-
-
0033514950
-
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in notch-pathway signaling
-
Westlund B, Parry D, Clover R, Basson M, Johnson CD. 1999. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in notch-pathway signaling. Proc. Natl. Acad. Sci. USA 96:2497-502
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2497-2502
-
-
Westlund, B.1
Parry, D.2
Clover, R.3
Basson, M.4
Johnson, C.D.5
-
144
-
-
0033621152
-
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
-
Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. 1999a. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry 38:11223-30
-
(1999)
Biochemistry
, vol.38
, pp. 11223-11230
-
-
Wolfe, M.S.1
De Los Angeles, J.2
Miller, D.D.3
Xia, W.4
Selkoe, D.J.5
-
145
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenelin endoproteolysis and gamma-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. 1999b. Two transmembrane aspartates in presenilin-1 required for presenelin endoproteolysis and gamma-secretase activity. Nature 398:513-17
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
146
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
-
Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, et al. 1996. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 274:1710-13
-
(1996)
Science
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
Iwasaki, K.2
Vito, P.3
Ganjei, J.K.4
Lacana, E.5
-
147
-
-
17744401440
-
Presenilin 1 is required for Notch 1 and DII1 expression in the paraxial mesoderm
-
Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, et al. 1997. Presenilin 1 is required for Notch 1 and DII1 expression in the paraxial mesoderm. Nature 387:288-92
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.5
-
148
-
-
0032416732
-
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
-
Wu GY, Hubbard EJA, Kitajewski JK, Greenwald I. 1998. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL- 12 presenilin. Proc. Natl. Acad. Sci. USA 95:15787-91
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15787-15791
-
-
Wu, G.Y.1
Hubbard, E.J.A.2
Kitajewski, J.K.3
Greenwald, I.4
-
149
-
-
0034255029
-
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
-
Xia WM, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, et al. 2000. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc. Natl. Acad. Sci. USA 97:9299-304
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9299-9304
-
-
Xia, W.M.1
Ray, W.J.2
Ostaszewski, B.L.3
Rahmati, T.4
Kimberly, W.T.5
-
150
-
-
0035845481
-
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis
-
Xia XF, Qian S, Soriano S, Wu Y, Fletcher AM, et al. 2001. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. USA 98:10863-68
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10863-10868
-
-
Xia, X.F.1
Qian, S.2
Soriano, S.3
Wu, Y.4
Fletcher, A.M.5
-
151
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan RQ, Bienkowski MJ, Shuck ME, Miao HY, Tory MC, et al. 1999. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402:533-37
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.Q.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.Y.4
Tory, M.C.5
-
152
-
-
0033535555
-
Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
-
Ye YH, Lukinova N, Fortini ME. 1999. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398:525-29
-
(1999)
Nature
, vol.398
, pp. 525-529
-
-
Ye, Y.H.1
Lukinova, N.2
Fortini, M.E.3
-
153
-
-
0034618715
-
Nicastrin modulates presenilin-mediated Notch/glp-1 signal transduction and beta APP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, et al. 2000. Nicastrin modulates presenilin-mediated Notch/glp-1 signal transduction and beta APP processing. Nature 407:48-54
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
-
154
-
-
17944376442
-
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice
-
Yu HK, Saura CA, Choi SY, Sun LD, Yang XD, et al. 2001. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 31:713-26
-
(2001)
Neuron
, vol.31
, pp. 713-726
-
-
Yu, H.K.1
Saura, C.A.2
Choi, S.Y.3
Sun, L.D.4
Yang, X.D.5
-
155
-
-
0033779635
-
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1
-
Zhang ZH, Nadeau P, Song WH, Donoviel D, Yuan ML, et al. 2000. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat. Cell Biol. 2:463-65
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 463-465
-
-
Zhang, Z.H.1
Nadeau, P.2
Song, W.H.3
Donoviel, D.4
Yuan, M.L.5
-
156
-
-
0028988801
-
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, et al. 1995. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-31
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.4
Hopkins, R.5
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