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Volumn 10, Issue 10, 2003, Pages 875-889

Gene- and cell-based therapeutics for type I diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; CATALASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS LIGAND; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOKINASE; GLUCOSE TRANSPORTER 2; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; I KAPPA B ALPHA; INDOLEAMINE 2,3 DIOXYGENASE; INSULIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MANGANESE SUPEROXIDE DISMUTASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE C DELTA; PROTEIN P40; PYRUVATE KINASE; SOMATOMEDIN C; STREPTOZOCIN; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VIRUS PROTEIN; VIRUS VECTOR;

EID: 0038621437     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302015     Document Type: Review
Times cited : (66)

References (275)
  • 1
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • Atkinson MA, Leiter EH. The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 1999; 5: 601-604.
    • (1999) Nat. Med. , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 2
    • 0036165756 scopus 로고    scopus 로고
    • Progression to insulin-requiring diabetes in seronegative prediabetic subjects: The role of two HLA-DQ high-risk haplotypes
    • Pietropaolo M et al. Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes. Diabetologia 2002; 45: 66-76.
    • (2002) Diabetologia , vol.45 , pp. 66-76
    • Pietropaolo, M.1
  • 3
    • 0001919817 scopus 로고    scopus 로고
    • Major histocompatibility locus and other genes that determine risk of development of insulin-dependent Diabetes mellitus
    • LeRoith D, Taylor S, Olefsky JM (eds.), J.B. Lippincott & Co.; Philadelphia, PA
    • Pietropaolo M, Trucco M. Major histocompatibility locus and other genes that determine risk of development of insulin-dependent Diabetes mellitus. In: LeRoith D, Taylor S, Olefsky JM (eds.), Diabetes Mellitus: A fundamental and Clinical Text. J.B. Lippincott & Co.; Philadelphia, PA, 2000, pp. 399-410.
    • (2000) Diabetes Mellitus: A Fundamental and Clinical Text , pp. 399-410
    • Pietropaolo, M.1    Trucco, M.2
  • 4
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997; 15: 289-292.
    • (1997) Nat. Genet. , vol.15 , pp. 289-292
    • Vafiadis, P.1
  • 5
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997; 15: 293-297.
    • (1997) Nat. Genet. , vol.15 , pp. 293-297
    • Pugliese, A.1
  • 6
    • 0036315824 scopus 로고    scopus 로고
    • Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
    • Chentoufi AA, Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 2002; 51: 1383-1390.
    • (2002) Diabetes , vol.51 , pp. 1383-1390
    • Chentoufi, A.A.1    Polychronakos, C.2
  • 7
    • 17144452354 scopus 로고    scopus 로고
    • A search for type 1 diabetes susceptibility genes in families from the United Kingdom
    • Mein CA et al. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet 1998; 19: 297-300.
    • (1998) Nat. Genet. , vol.19 , pp. 297-300
    • Mein, C.A.1
  • 8
    • 17344372511 scopus 로고    scopus 로고
    • A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
    • Concannon P et al. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet 1998; 19: 292-296.
    • (1998) Nat. Genet. , vol.19 , pp. 292-296
    • Concannon, P.1
  • 9
    • 0027933734 scopus 로고
    • A genome-wide search for human type 1 diabetes susceptibility genes
    • Davies JL et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-136.
    • (1994) Nature , vol.371 , pp. 130-136
    • Davies, J.L.1
  • 10
    • 0031664697 scopus 로고    scopus 로고
    • Molecular mimicry and immune-mediated diseases
    • Oldstone MB. Molecular mimicry and immune-mediated diseases. Faseb J 1998; 12: 1255-1265.
    • (1998) Faseb J. , vol.12 , pp. 1255-1265
    • Oldstone, M.B.1
  • 12
    • 0031874342 scopus 로고    scopus 로고
    • Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
    • Horwitz MS et al. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med 1998; 4: 781-785.
    • (1998) Nat. Med. , vol.4 , pp. 781-785
    • Horwitz, M.S.1
  • 13
    • 0030999981 scopus 로고    scopus 로고
    • Immunological aspects of nutritional diabetes prevention in NOD mice: A pilot study for the cow's milk-based IDDM prevention trial
    • Karges W et al. Immunological aspects of nutritional diabetes prevention in NOD mice: a pilot study for the cow's milk-based IDDM prevention trial. Diabetes 1997; 46: 557-564.
    • (1997) Diabetes , vol.46 , pp. 557-564
    • Karges, W.1
  • 14
    • 0026542241 scopus 로고
    • Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
    • Kaufman DL et al. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 1992; 89: 283-292.
    • (1992) J. Clin. Invest. , vol.89 , pp. 283-292
    • Kaufman, D.L.1
  • 15
    • 0028641482 scopus 로고
    • Superantigens as etiopathogenetic factors in the development of insulin-dependent diabetes mellitus
    • Conrad B, Trucco M. Superantigens as etiopathogenetic factors in the development of insulin-dependent diabetes mellitus. Diabetes Metab Rev 1994; 10: 309-338.
    • (1994) Diabetes Metab. Rev. , vol.10 , pp. 309-338
    • Conrad, B.1    Trucco, M.2
  • 16
    • 0027959188 scopus 로고
    • Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology
    • Conrad B et al. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology Nature 1994; 371: 351-355.
    • (1994) Nature , vol.371 , pp. 351-355
    • Conrad, B.1
  • 17
    • 0031594619 scopus 로고    scopus 로고
    • Coeliac disease in children and adolescents with IDDM: Clinical characteristics and response to gluten-free diet
    • Acerini CL et al. Coeliac disease in children and adolescents with IDDM: clinical characteristics and response to gluten-free diet. Diabet Med 1998; 15: 38-44.
    • (1998) Diabet. Med. , vol.15 , pp. 38-44
    • Acerini, C.L.1
  • 18
    • 0028328306 scopus 로고
    • Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children
    • Childhood Diabetes in Finland Study Group
    • Virtanen SM et al. Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children. Childhood Diabetes in Finland Study Group. Diabetologia 1994; 37: 381-387.
    • (1994) Diabetologia , vol.37 , pp. 381-387
    • Virtanen, S.M.1
  • 19
    • 0026591739 scopus 로고
    • Early infant diet and risk of IDDM in blacks and whites. A matched case-control study
    • Kostraba JN et al. Early infant diet and risk of IDDM in blacks and whites. A matched case-control study. Diabetes Care 1992; 15: 626-631.
    • (1992) Diabetes Care , vol.15 , pp. 626-631
    • Kostraba, J.N.1
  • 20
    • 0027482258 scopus 로고
    • Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic β-cell destruction in insulin-dependent diabetes mellitus
    • Mandrup-Poulsen T et al. Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic β-cell destruction in insulin-dependent diabetes mellitus. Cytokine 1993; 5: 185-191.
    • (1993) Cytokine , vol.5 , pp. 185-191
    • Mandrup-Poulsen, T.1
  • 21
    • 0030030057 scopus 로고    scopus 로고
    • Cytokines and nitric oxide in islet inflammation and diabetes
    • McDaniel ML et al. Cytokines and nitric oxide in islet inflammation and diabetes. Proc Soc Exp Biol Med 1996; 211: 24-32.
    • (1996) Proc. Soc. Exp. Biol. Med. , vol.211 , pp. 24-32
    • McDaniel, M.L.1
  • 22
    • 0032146564 scopus 로고    scopus 로고
    • IL-1 produced and released endogenously within human islets inhibits β-cell function
    • Arnush M et al. IL-1 produced and released endogenously within human islets inhibits β-cell function. J Clin Invest 1998; 102: 516-526.
    • (1998) J. Clin. Invest. , vol.102 , pp. 516-526
    • Arnush, M.1
  • 23
    • 0032521025 scopus 로고    scopus 로고
    • Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes
    • Arnush M et al. Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J Immunol 1998; 160: 2684-2691.
    • (1998) J. Immunol. , vol.160 , pp. 2684-2691
    • Arnush, M.1
  • 24
    • 0028206337 scopus 로고
    • The intraislet macrophage and type I diabetes
    • Lacy PE. The intraislet macrophage and type I diabetes. Mt Sinai J Med 1994; 61: 170-174.
    • (1994) Mt Sinai J. Med. , vol.61 , pp. 170-174
    • Lacy, P.E.1
  • 25
    • 0036316723 scopus 로고    scopus 로고
    • Clearance of apoptotic β-cells is reduced in neonatal autoimmune diabetes-prone rats
    • O'Brien BA, Fieldus WE, Field CJ, Finegood DT. Clearance of apoptotic β-cells is reduced in neonatal autoimmune diabetes-prone rats. Cell Death Differ 2002; 9: 457-464.
    • (2002) Cell Death Differ. , vol.9 , pp. 457-464
    • O'Brien, B.A.1    Fieldus, W.E.2    Field, C.J.3    Finegood, D.T.4
  • 26
    • 0033985277 scopus 로고    scopus 로고
    • Neonatal β-cell apoptosis: A trigger for autoimmune diabetes?
    • Trudeau JD et al. Neonatal β-cell apoptosis: a trigger for autoimmune diabetes? Diabetes 2000; 49: 1-7.
    • (2000) Diabetes , vol.49 , pp. 1-7
    • Trudeau, J.D.1
  • 27
    • 0030903840 scopus 로고    scopus 로고
    • Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
    • Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S. Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 1997; 138: 1736-1741.
    • (1997) Endocrinology , vol.138 , pp. 1736-1741
    • Scaglia, L.1    Cahill, C.J.2    Finegood, D.T.3    Bonner-Weir, S.4
  • 31
    • 0037117550 scopus 로고    scopus 로고
    • A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
    • Sui G et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 2002; 99: 5515-5520.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 5515-5520
    • Sui, G.1
  • 32
    • 0035375601 scopus 로고    scopus 로고
    • Targeted integration of foreign DNA into a defined locus on chromosome 19 in K562 cells using AAV-derived components
    • Kogure K et al. Targeted integration of foreign DNA into a defined locus on chromosome 19 in K562 cells using AAV-derived components. Int J Hematol 2001; 73, 469-475.
    • (2001) Int. J. Hematol. , vol.73 , pp. 469-475
    • Kogure, K.1
  • 33
    • 0032581938 scopus 로고    scopus 로고
    • Targeted integration of adeno-associated virus-derived plasmids in transfected human cells
    • Pieroni L et al. Targeted integration of adeno-associated virus-derived plasmids in transfected human cells. Virology 1998; 249: 249-259.
    • (1998) Virology , vol.249 , pp. 249-259
    • Pieroni, L.1
  • 34
    • 0036323162 scopus 로고    scopus 로고
    • Gene transduction efficiency in cells of different species by HIV and EIAV vectors
    • Ikeda Y et al. Gene transduction efficiency in cells of different species by HIV and EIAV vectors. Gene Therapy 2002; 9: 932-938.
    • (2002) Gene Therapy , vol.9 , pp. 932-938
    • Ikeda, Y.1
  • 35
    • 0036147521 scopus 로고    scopus 로고
    • Comparison of gene transfer efficiencies and gene expression levels achieved with equine infectious anemia virus-and human immunodeficiency virus type 1-derived lentivirus vectors
    • O'Rourke JP et al. Comparison of gene transfer efficiencies and gene expression levels achieved with equine infectious anemia virus-and human immunodeficiency virus type 1-derived lentivirus vectors. J Virol 2002; 76: 1510-1515.
    • (2002) J. Virol. , vol.76 , pp. 1510-1515
    • O'Rourke, J.P.1
  • 36
    • 0031738707 scopus 로고    scopus 로고
    • Gene transfer vectors derived from equine infectious anemia virus
    • Olsen JC. Gene transfer vectors derived from equine infectious anemia virus. Gene Therapy 1998; 5: 1481-1487.
    • (1998) Gene Therapy , vol.5 , pp. 1481-1487
    • Olsen, J.C.1
  • 37
    • 0036204263 scopus 로고    scopus 로고
    • Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors
    • Lotery AJ et al. Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors. Hum Gene Ther 2002; 13: 689-696.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 689-696
    • Lotery, A.J.1
  • 38
    • 0034663147 scopus 로고    scopus 로고
    • Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein
    • Kelly PF et al. Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein. Blood 2000; 96: 1206-1214.
    • (2000) Blood , vol.96 , pp. 1206-1214
    • Kelly, P.F.1
  • 39
    • 0033642822 scopus 로고    scopus 로고
    • Efficient transduction of nondividing cells by optimized feline immunodeficiency virus vectors
    • Curran MA, Kaiser SM, Achacoso PL, Nolan GP. Efficient transduction of nondividing cells by optimized feline immunodeficiency virus vectors. Mol Ther 2000; 1: 31-38.
    • (2000) Mol. Ther. , vol.1 , pp. 31-38
    • Curran, M.A.1    Kaiser, S.M.2    Achacoso, P.L.3    Nolan, G.P.4
  • 40
    • 0031953134 scopus 로고    scopus 로고
    • Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
    • Poeschla EM, Wong-Staal F, Looney DJ. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat Med 1998; 4: 354-357.
    • (1998) Nat. Med. , vol.4 , pp. 354-357
    • Poeschla, E.M.1    Wong-Staal, F.2    Looney, D.J.3
  • 41
    • 0020063583 scopus 로고
    • Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneic bone marrow cells
    • Britt LD, Scharp DW, Lacy PE, Slavin S. Transplantation of islet cells across major histocompatibility barriers after total lymphoid irradiation and infusion of allogeneic bone marrow cells. Diabetes 1982; 31(Suppl 4): 63-68.
    • (1982) Diabetes , vol.31 , Issue.SUPPL. 4 , pp. 63-68
    • Britt, L.D.1    Scharp, D.W.2    Lacy, P.E.3    Slavin, S.4
  • 43
    • 0029919866 scopus 로고    scopus 로고
    • Induction of immunological tolerance to islet allografts
    • Rossini AA et al. Induction of immunological tolerance to islet allografts. Cell Transplant 1996; 5: 49-52.
    • (1996) Cell Transplant. , vol.5 , pp. 49-52
    • Rossini, A.A.1
  • 44
    • 0034998737 scopus 로고    scopus 로고
    • Impact of bone marrow transplantation on type I diabetes
    • Domenick MA, Ildstad ST. Impact of bone marrow transplantation on type I diabetes. World J Surg 2001; 25: 474-480.
    • (2001) World J. Surg. , vol.25 , pp. 474-480
    • Domenick, M.A.1    Ildstad, S.T.2
  • 45
    • 0035073827 scopus 로고    scopus 로고
    • Historical and current perspectives on bone marrow transplantation for prevention and treatment of immunodeficiencies and autoimmunities
    • Good RA, Verjee T. Historical and current perspectives on bone marrow transplantation for prevention and treatment of immunodeficiencies and autoimmunities. Biol Blood Marrow Transplant 2001; 7: 123-135.
    • (2001) Biol. Blood Marrow Transplant. , vol.7 , pp. 123-135
    • Good, R.A.1    Verjee, T.2
  • 46
    • 0028859072 scopus 로고
    • Induction of mixed bone marrow chimerism as potential therapy for autoimmune (type I) diabetes: Experience in the NOD model
    • Mathieu C, Bouillon R, Rutgeerts O, Waer M. Induction of mixed bone marrow chimerism as potential therapy for autoimmune (type I) diabetes: experience in the NOD model. Transplant Proc 1995; 27: 640-641.
    • (1995) Transplant. Proc. , vol.27 , pp. 640-641
    • Mathieu, C.1    Bouillon, R.2    Rutgeerts, O.3    Waer, M.4
  • 47
    • 0027447559 scopus 로고
    • Protection against autoimmune diabetes by induction of mixed bone marrow chimerism
    • Mathieu C, Vandeputte M, Bouillon R, Waer M. Protection against autoimmune diabetes by induction of mixed bone marrow chimerism. Transplant Proc 1993; 25: 1266-1267.
    • (1993) Transplant. Proc. , vol.25 , pp. 1266-1267
    • Mathieu, C.1    Vandeputte, M.2    Bouillon, R.3    Waer, M.4
  • 48
    • 0029083441 scopus 로고
    • Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice
    • discussion 197-198
    • Li H, Kaufman CL, Ildstad ST. Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice. Surgery 1995; 118: 192-197; discussion 197-198.
    • (1995) Surgery , vol.118 , pp. 192-197
    • Li, H.1    Kaufman, C.L.2    Ildstad, S.T.3
  • 49
    • 0345490808 scopus 로고    scopus 로고
    • Chimerism-induced remission of overt diabetes in nonobese diabetic mice
    • Li H, Inverardi L, Ricordi C. Chimerism-induced remission of overt diabetes in nonobese diabetic mice. Transplant Proc 1999; 31: 640.
    • (1999) Transplant. Proc. , vol.31 , pp. 640
    • Li, H.1    Inverardi, L.2    Ricordi, C.3
  • 50
    • 0035987925 scopus 로고    scopus 로고
    • Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes
    • Zorina TD et al. Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes. Cell Transplant 2002; 11: 113-123.
    • (2002) Cell Transplant. , vol.11 , pp. 113-123
    • Zorina, T.D.1
  • 51
    • 0033513456 scopus 로고    scopus 로고
    • Immunotherapy of NOD mice with bone marrow-derived dendritic cells
    • Feili-Hariri M et al. Immunotherapy of NOD mice with bone marrow-derived dendritic cells. Diabetes 1999; 48: 2300-2308.
    • (1999) Diabetes , vol.48 , pp. 2300-2308
    • Feili-Hariri, M.1
  • 52
    • 0026700060 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer
    • Clare-Salzler MJ et al. Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest 1992; 90: 741-748.
    • (1992) J. Clin. Invest. , vol.90 , pp. 741-748
    • Clare-Salzler, M.J.1
  • 53
    • 84984763849 scopus 로고    scopus 로고
    • Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides
    • Giannoukakis N et al. Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides. Mol Ther 2000; 1: 430-437.
    • (2000) Mol. Ther. , vol.1 , pp. 430-437
    • Giannoukakis, N.1
  • 54
    • 0037080938 scopus 로고    scopus 로고
    • Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease
    • Lu L, Thomson AW. Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease. Transplantation 2002; 73: S19-22.
    • (2002) Transplantation , vol.73
    • Lu, L.1    Thomson, A.W.2
  • 55
    • 0032587080 scopus 로고    scopus 로고
    • Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients
    • Lu L et al. Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients. Gene Therapy 1999; 6: 554-563.
    • (1999) Gene Therapy , vol.6 , pp. 554-563
    • Lu, L.1
  • 56
    • 0032797186 scopus 로고    scopus 로고
    • Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-β, and CTLA4Ig)
    • Lu L et al. Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-β, and CTLA4Ig). J Leukoc Biol 1999; 66: 293-296.
    • (1999) J. Leukoc. Biol. , vol.66 , pp. 293-296
    • Lu, L.1
  • 57
    • 0033565530 scopus 로고    scopus 로고
    • Dendritic cells as regulators of immune reactivity: Implications for transplantation
    • Thomson AW, Lu L. Dendritic cells as regulators of immune reactivity: implications for transplantation. Transplantation 1999; 68: 1-8.
    • (1999) Transplantation , vol.68 , pp. 1-8
    • Thomson, A.W.1    Lu, L.2
  • 58
    • 0032573680 scopus 로고    scopus 로고
    • Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-β
    • Lee WC et al. Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-β. Transplantation 1998; 66: 1810-1817.
    • (1998) Transplantation , vol.66 , pp. 1810-1817
    • Lee, W.C.1
  • 59
    • 0032573692 scopus 로고    scopus 로고
    • Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness
    • Takayama T et al. Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness. Transplantation 1998; 66: 1567-1574.
    • (1998) Transplantation , vol.66 , pp. 1567-1574
    • Takayama, T.1
  • 60
    • 0037160160 scopus 로고    scopus 로고
    • Transplantation of islets of Langerhans: New developments
    • Berney T et al. Transplantation of islets of Langerhans: new developments. Swiss Med Wkly 2001; 131: 671-680.
    • (2001) Swiss Med. Wkly. , vol.131 , pp. 671-680
    • Berney, T.1
  • 61
    • 0035016543 scopus 로고    scopus 로고
    • Human islet transplantation: Update
    • Boker A et al. Human islet transplantation: update. World J Surg 2001; 25: 481-486.
    • (2001) World J. Surg. , vol.25 , pp. 481-486
    • Boker, A.1
  • 62
    • 0033736567 scopus 로고    scopus 로고
    • Islet cell transplantation: The future?
    • Berney T, Ricordi C. Islet cell transplantation: the future? Langenbecks Arch Surg 2000; 385: 373-378.
    • (2000) Langenbecks Arch. Surg. , vol.385 , pp. 373-378
    • Berney, T.1    Ricordi, C.2
  • 64
    • 0037739476 scopus 로고    scopus 로고
    • Therapeutic controversy: Prevention and treatment of diabetes in children
    • Rosenbloom AL et al. Therapeutic controversy: prevention and treatment of diabetes in children. J Clin Endocrinol Metab 2000; 85: 494-522.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 494-522
    • Rosenbloom, A.L.1
  • 65
    • 0025349596 scopus 로고
    • Immunopathogenesis and immunotherapy of type 1 diabetes
    • Wilson K, Eisenbarth GS. Immunopathogenesis and immunotherapy of type 1 diabetes. Annu Rev Med 1990; 41: 497-508.
    • (1990) Annu. Rev. Med. , vol.41 , pp. 497-508
    • Wilson, K.1    Eisenbarth, G.S.2
  • 66
    • 0025084894 scopus 로고
    • Probability of remission in individual in early adult insulin dependent diabetic patients
    • Results from the Cyclosporine Diabetes French Study Group
    • Papoz L et al. Probability of remission in individual in early adult insulin dependent diabetic patients. Results from the Cyclosporine Diabetes French Study Group. Diabetes Metab 1990; 16: 303-310.
    • (1990) Diabetes Metab. , vol.16 , pp. 303-310
    • Papoz, L.1
  • 67
    • 0033035851 scopus 로고    scopus 로고
    • T-cell insulitis found in anti-GAD65+ diabetes with residual β-cell function. A case report
    • Shimada A et al. T-cell insulitis found in anti-GAD65+ diabetes with residual β-cell function. A case report. Diabetes Care 1999; 22: 615-617.
    • (1999) Diabetes Care , vol.22 , pp. 615-617
    • Shimada, A.1
  • 68
    • 0035860238 scopus 로고    scopus 로고
    • Recovery of function and mass of endogenous β-cells in streptozotocin-induced diabetic rats treated with islet transplantation
    • Hamamoto Y et al. Recovery of function and mass of endogenous β-cells in streptozotocin-induced diabetic rats treated with islet transplantation. Biochem Biophys Res Commun 2001; 287: 104-109.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 104-109
    • Hamamoto, Y.1
  • 69
    • 0033840593 scopus 로고    scopus 로고
    • Functional rest through intensive treatment with insulin and potassium channel openers preserves residual β-cell function and mass in acutely diabetic BB rats
    • Rasmussen SB et al. Functional rest through intensive treatment with insulin and potassium channel openers preserves residual β-cell function and mass in acutely diabetic BB rats. Horm Metab Res 2000; 32: 294-300.
    • (2000) Horm. Metab. Res. , vol.32 , pp. 294-300
    • Rasmussen, S.B.1
  • 70
    • 0033305760 scopus 로고    scopus 로고
    • The relationship between peripheral T-cell reactivity to insulin, clinical remissions and cytokine production in type 1 (insulin-dependent) diabetes mellitus
    • Mayer A et al. The relationship between peripheral T-cell reactivity to insulin, clinical remissions and cytokine production in type 1 (insulin-dependent) diabetes mellitus. J Clin Endocrinol Metab 1999; 84: 2419-2424.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 2419-2424
    • Mayer, A.1
  • 71
    • 0033045376 scopus 로고    scopus 로고
    • Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
    • Finegood DT, Weir GC, Bonner-Weir S. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am J Physiol 1999; 276: E822-827.
    • (1999) Am. J. Physiol. , vol.276
    • Finegood, D.T.1    Weir, G.C.2    Bonner-Weir, S.3
  • 72
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 1994; 91: 123-127.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3    Bach, J.F.4
  • 73
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • Herold KC et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002; 346: 1692-1698.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1692-1698
    • Herold, K.C.1
  • 74
    • 0028900805 scopus 로고
    • Intraislet release of interleukin 1 inhibits β-cell function by inducing β-cell expression of inducible nitric oxide synthase
    • Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits β-cell function by inducing β-cell expression of inducible nitric oxide synthase. J Exp Med 1995; 181: 559-568.
    • (1995) J. Exp. Med. , vol.181 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 75
    • 0030997703 scopus 로고    scopus 로고
    • Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1
    • Heitmeier MR, Scarim AL, Corbett JA. Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1. J Biol Chem 1997; 272: 13697-13704.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13697-13704
    • Heitmeier, M.R.1    Scarim, A.L.2    Corbett, J.A.3
  • 76
    • 0030667121 scopus 로고    scopus 로고
    • Evidence for the presence of type I IL-1 receptors on β-cells of islets of Langerhans
    • 1361
    • Scarim AL et al. Evidence for the presence of type I IL-1 receptors on β-cells of islets of Langerhans. Biochim Biophys Acta 1997; 1361: 313-320.
    • (1997) Biochim. Biophys. Acta , pp. 313-320
    • Scarim, A.L.1
  • 77
    • 0036297935 scopus 로고    scopus 로고
    • Reversal of established autoimmune diabetes by in situ β-cell regeneration
    • Faustman DL. Reversal of established autoimmune diabetes by in situ β-cell regeneration. Ann N Y Acad Sci 2002; 961: 40.
    • (2002) Ann. N. Y. Acad. Sci. , vol.961 , pp. 40
    • Faustman, D.L.1
  • 78
    • 0036023129 scopus 로고    scopus 로고
    • Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies
    • Mottram PL et al. Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies. Transpl Immunol 2002; 10: 63-72.
    • (2002) Transpl. Immunol. , vol.10 , pp. 63-72
    • Mottram, P.L.1
  • 79
    • 0031025574 scopus 로고    scopus 로고
    • Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
    • French MB et al. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1997; 46: 34-39.
    • (1997) Diabetes , vol.46 , pp. 34-39
    • French, M.B.1
  • 80
    • 0026781403 scopus 로고
    • Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules
    • Miyazaki T et al. Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules. Proc Natl Acad Sci USA 1992; 89: 9519-9523.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9519-9523
    • Miyazaki, T.1
  • 81
    • 0032433125 scopus 로고    scopus 로고
    • Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T-cell response
    • Ridgway WM et al. Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T-cell response. J Exp Med 1998; 188: 2267-2275.
    • (1998) J. Exp. Med. , vol.188 , pp. 2267-2275
    • Ridgway, W.M.1
  • 82
    • 0031984204 scopus 로고    scopus 로고
    • The association of MHC with autoimmune diseases: Understanding the pathogenesis of autoimmune diabetes
    • Ridgway WM, Fathman CG. The association of MHC with autoimmune diseases: understanding the pathogenesis of autoimmune diabetes. Clin Immunol Immunopathol 1998; 86: 3-10.
    • (1998) Clin. Immunol. Immunopathol. , vol.86 , pp. 3-10
    • Ridgway, W.M.1    Fathman, C.G.2
  • 83
    • 0035881246 scopus 로고    scopus 로고
    • Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: Additive, but unequal, involvement of multiple APC subtypes
    • Johnson EA et al. Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: additive, but unequal, involvement of multiple APC subtypes. J Immunol 2001; 167: 2404-2410.
    • (2001) J. Immunol. , vol.167 , pp. 2404-2410
    • Johnson, E.A.1
  • 84
    • 0026545730 scopus 로고
    • Intrathymic islet cell transplantation reduces β-cell autoimmunity and prevents diabetes in NOD/Lt mice
    • Gerling IC, Serreze DV, Christianson SW, Leiter EH. Intrathymic islet cell transplantation reduces β-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes 1992; 41: 1672-1676.
    • (1992) Diabetes , vol.41 , pp. 1672-1676
    • Gerling, I.C.1    Serreze, D.V.2    Christianson, S.W.3    Leiter, E.H.4
  • 85
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-49.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1
  • 86
    • 0036106054 scopus 로고    scopus 로고
    • Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
    • Schwartz RE et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002; 109: 1291-1302.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1291-1302
    • Schwartz, R.E.1
  • 87
    • 0034937823 scopus 로고    scopus 로고
    • Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells
    • discussion 233-235
    • Reyes M, Verfaillie CM. Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells. Ann N Y Acad Sci 2001; 938: 231-233; discussion 233-235.
    • (2001) Ann. N. Y. Acad. Sci. , vol.938 , pp. 231-233
    • Reyes, M.1    Verfaillie, C.M.2
  • 89
    • 0035077484 scopus 로고    scopus 로고
    • Mixed bone marrow chimerism as a treatment for autoimmune diabetes
    • Leykin I, Nikolic B, Sykes M. Mixed bone marrow chimerism as a treatment for autoimmune diabetes. Transplant Proc 2001; 33: 120.
    • (2001) Transplant. Proc. , vol.33 , pp. 120
    • Leykin, I.1    Nikolic, B.2    Sykes, M.3
  • 90
    • 0029795112 scopus 로고    scopus 로고
    • Dendritic cells and tolerance induction
    • Steptoe RJ, Thomson AW. Dendritic cells and tolerance induction. Clin Exp Immunol 1996; 105: 397-402.
    • (1996) Clin. Exp. Immunol. , vol.105 , pp. 397-402
    • Steptoe, R.J.1    Thomson, A.W.2
  • 91
    • 0032573692 scopus 로고    scopus 로고
    • Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness
    • Takayama T et al. Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness. Transplantation 1998; 66: 1567-1574.
    • (1998) Transplantation , vol.66 , pp. 1567-1574
    • Takayama, T.1
  • 92
    • 0344766065 scopus 로고    scopus 로고
    • Transduction of dendritic cells with adenoviral vectors encoding CTLA4-Ig markedly reduces their allostimulatory activity
    • Lu L et al. Transduction of dendritic cells with adenoviral vectors encoding CTLA4-Ig markedly reduces their allostimulatory activity. Transplant Proc 1999; 31(1-2): 797.
    • (1999) Transplant. Proc. , vol.31 , Issue.1-2 , pp. 797
    • Lu, L.1
  • 93
    • 0032573680 scopus 로고    scopus 로고
    • Phenotype, function and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-β
    • Lee WC et al. Phenotype, function and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-β. Transplantation 1998; 66(12): 1810-1817.
    • (1998) Transplantation , vol.66 , Issue.12 , pp. 1810-1817
    • Lee, W.C.1
  • 94
    • 0036268008 scopus 로고    scopus 로고
    • Regulatory natural killer T cells protect against spontaneous and recurrent type 1 diabetes
    • Sharif S, Arreaza GA, Zucker P, Delovitch TL. Regulatory natural killer T cells protect against spontaneous and recurrent type 1 diabetes. Ann NY Acad Sci 2002; 958: 77-88.
    • (2002) Ann. NY Acad. Sci. , vol.958 , pp. 77-88
    • Sharif, S.1    Arreaza, G.A.2    Zucker, P.3    Delovitch, T.L.4
  • 95
    • 0035923675 scopus 로고    scopus 로고
    • Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets
    • Naumov YN et al. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci USA 2001; 98: 13838-13843.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13838-13843
    • Naumov, Y.N.1
  • 97
    • 0034799397 scopus 로고    scopus 로고
    • Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes
    • Sharif S et al. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med 2001; 7: 1057-1062.
    • (2001) Nat. Med. , vol.7 , pp. 1057-1062
    • Sharif, S.1
  • 98
    • 0034786013 scopus 로고    scopus 로고
    • The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice
    • Hong S et al. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med 2001; 7: 1052-1056.
    • (2001) Nat. Med. , vol.7 , pp. 1052-1056
    • Hong, S.1
  • 99
    • 0035089893 scopus 로고    scopus 로고
    • Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
    • Pugliese A et al. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J Clin Invest 2001; 107: 555-564.
    • (2001) J. Clin. Invest. , vol.107 , pp. 555-564
    • Pugliese, A.1
  • 100
    • 84984763849 scopus 로고    scopus 로고
    • Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides
    • Giannoukakis N et al. Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides. Mol Ther 2000; 1: 430-437.
    • (2000) Mol. Ther. , vol.1 , pp. 430-437
    • Giannoukakis, N.1
  • 101
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 230-238
    • Shapiro, A.M.1
  • 104
    • 0035085643 scopus 로고    scopus 로고
    • Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    • Ryan EA et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50: 710-719.
    • (2001) Diabetes , vol.50 , pp. 710-719
    • Ryan, E.A.1
  • 105
    • 0036328572 scopus 로고    scopus 로고
    • Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound
    • Bottino R et al. Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes 2002; 51: 2561-2567.
    • (2002) Diabetes , vol.51 , pp. 2561-2567
    • Bottino, R.1
  • 106
    • 84907034896 scopus 로고
    • Vascular oxidant stress and hepatic ischemia/reperfusion injury
    • Jaeschke H. Vascular oxidant stress and hepatic ischemia/reperfusion injury. Free Radic Res Commun 1991; 121-3: 737-743.
    • (1991) Free Radic. Res. Commun. , vol.121-123 , pp. 737-743
    • Jaeschke, H.1
  • 107
    • 0025745032 scopus 로고
    • Reactive oxygen and ischemia/reperfusion injury of the liver
    • Jaeschke H. Reactive oxygen and ischemia/reperfusion injury of the liver. Chem Biol Interact 1991; 79: 115-136.
    • (1991) Chem. Biol. Interact. , vol.79 , pp. 115-136
    • Jaeschke, H.1
  • 108
    • 0034063364 scopus 로고    scopus 로고
    • Cell loss in isolated human islets occurs by apoptosis
    • Paraskevas S et al. Cell loss in isolated human islets occurs by apoptosis. Pancreas 2000; 20: 270-276.
    • (2000) Pancreas , vol.20 , pp. 270-276
    • Paraskevas, S.1
  • 109
    • 0032870660 scopus 로고    scopus 로고
    • Structural and functional changes resulting from islet isolation lead to islet cell death
    • Rosenberg L, Wang R, Paraskevas S, Maysinger D. Structural and functional changes resulting from islet isolation lead to islet cell death. Surgery 1999; 126: 393-398.
    • (1999) Surgery , vol.126 , pp. 393-398
    • Rosenberg, L.1    Wang, R.2    Paraskevas, S.3    Maysinger, D.4
  • 110
    • 0030915659 scopus 로고    scopus 로고
    • Chronic allograft failure: The clinical problem
    • Nagano H, Tilney NL. Chronic allograft failure: the clinical problem. Am J Med Sci 1997; 313: 305-309.
    • (1997) Am. J. Med. Sci. , vol.313 , pp. 305-309
    • Nagano, H.1    Tilney, N.L.2
  • 111
    • 0023360005 scopus 로고
    • Free radical-mediated reperfusion injury: A selective review
    • Bulkley GB. Free radical-mediated reperfusion injury: a selective review. Br J Cancer Suppl 1987; 8: 66-73.
    • (1987) Br. J. Cancer Suppl. , vol.8 , pp. 66-73
    • Bulkley, G.B.1
  • 112
    • 0035458338 scopus 로고    scopus 로고
    • Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation
    • Pileggi A et al. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 2001; 50: 1983-1991.
    • (2001) Diabetes , vol.50 , pp. 1983-1991
    • Pileggi, A.1
  • 113
    • 0035179294 scopus 로고    scopus 로고
    • Heme oxygenase-1 protects pancreatic β-cells from apoptosis caused by various stimuli
    • Tobiasch E, Gunther L, Bach FH. Heme oxygenase-1 protects pancreatic β-cells from apoptosis caused by various stimuli. J Investig Med 2001; 49, 566-571.
    • (2001) J. Investig. Med. , vol.49 , pp. 566-571
    • Tobiasch, E.1    Gunther, L.2    Bach, F.H.3
  • 114
    • 0034902165 scopus 로고    scopus 로고
    • Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement
    • Contreras JL et al. Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement. Surgery 2001; 130: 166-174.
    • (2001) Surgery , vol.130 , pp. 166-174
    • Contreras, J.L.1
  • 115
    • 0035039750 scopus 로고    scopus 로고
    • Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene
    • Contreras JL et al. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation 2001; 71: 1015-1023.
    • (2001) Transplantation , vol.71 , pp. 1015-1023
    • Contreras, J.L.1
  • 116
    • 0033921459 scopus 로고    scopus 로고
    • Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes
    • Lortz S et al. Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes 2000; 49: 1123-1130.
    • (2000) Diabetes , vol.49 , pp. 1123-1130
    • Lortz, S.1
  • 117
    • 0032547768 scopus 로고    scopus 로고
    • Pancreatic β-cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes
    • Hotta M et al. Pancreatic β-cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med 1998; 188: 1445-1451.
    • (1998) J. Exp. Med. , vol.188 , pp. 1445-1451
    • Hotta, M.1
  • 118
    • 0035432970 scopus 로고    scopus 로고
    • Proteins linked to a protein transduction domain efficiently transduce pancreatic islets
    • Embury J et al. Proteins linked to a protein transduction domain efficiently transduce pancreatic islets. Diabetes 2001; 50: 1706-1713.
    • (2001) Diabetes , vol.50 , pp. 1706-1713
    • Embury, J.1
  • 119
    • 0036061614 scopus 로고    scopus 로고
    • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone
    • Piganelli JD et al. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 2002; 51: 347-355.
    • (2002) Diabetes , vol.51 , pp. 347-355
    • Piganelli, J.D.1
  • 120
    • 0030220572 scopus 로고    scopus 로고
    • Mechanisms of inflammatory liver injury: Adhesion molecules and cytotoxicity of neutrophils
    • Jaeschke H et al. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 1996; 139: 213-226.
    • (1996) Toxicol. Appl. Pharmacol. , vol.139 , pp. 213-226
    • Jaeschke, H.1
  • 121
    • 0030330722 scopus 로고    scopus 로고
    • Chemokines, neutrophils, and inflammatory liver injury
    • Jaeschke H. Chemokines, neutrophils, and inflammatory liver injury. Shock 1996; 6: 403-404.
    • (1996) Shock , vol.6 , pp. 403-404
    • Jaeschke, H.1
  • 122
    • 0033618444 scopus 로고    scopus 로고
    • HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines
    • Dairaghi DJ et al. HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem 1999; 274: 21569-21574.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21569-21574
    • Dairaghi, D.J.1
  • 123
    • 0032884283 scopus 로고    scopus 로고
    • Chemokines as molecular targets for therapeutic intervention
    • Howard OM, Oppenheim JJ, Wang JM. Chemokines as molecular targets for therapeutic intervention. J Clin Immunol 1999; 19: 280-292.
    • (1999) J. Clin. Immunol. , vol.19 , pp. 280-292
    • Howard, O.M.1    Oppenheim, J.J.2    Wang, J.M.3
  • 124
    • 0035656779 scopus 로고    scopus 로고
    • Hepatic insulin production for type 1 diabetes
    • Dong H, Woo SL. Hepatic insulin production for type 1 diabetes. Trends Endocrinol Metab 2001; 12: 441-446.
    • (2001) Trends Endocrinol. Metab. , vol.12 , pp. 441-446
    • Dong, H.1    Woo, S.L.2
  • 125
    • 0035032259 scopus 로고    scopus 로고
    • Hepatic insulin expression improves glycemic control in type 1 diabetic rats
    • Dong H et al. Hepatic insulin expression improves glycemic control in type 1 diabetic rats. Diabetes Res Clin Pract 2001; 52: 153-163.
    • (2001) Diabetes Res. Clin. Pract. , vol.52 , pp. 153-163
    • Dong, H.1
  • 126
    • 0033765795 scopus 로고    scopus 로고
    • Regulated hepatic insulin gene therapy of STZ-diabetic rats
    • Thule PM, Liu JM. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Therapy 2000; 7: 1744-1752.
    • (2000) Gene Therapy , vol.7 , pp. 1744-1752
    • Thule, P.M.1    Liu, J.M.2
  • 127
    • 0034907229 scopus 로고    scopus 로고
    • 5-Oxoprolinuria: A cause of neonatal metabolic acidosis
    • Mitanchez D et al. 5-Oxoprolinuria: a cause of neonatal metabolic acidosis. Acta Paediatr 2001; 90: 827-828.
    • (2001) Acta Paediatr. , vol.90 , pp. 827-828
    • Mitanchez, D.1
  • 128
    • 0032536095 scopus 로고    scopus 로고
    • Regulated expression of mature human insulin in the liver of transgenic mice
    • Mitanchez D et al. Regulated expression of mature human insulin in the liver of transgenic mice. FEBS Lett 1998; 421: 285-289.
    • (1998) FEBS Lett. , vol.421 , pp. 285-289
    • Mitanchez, D.1
  • 129
    • 0030751585 scopus 로고    scopus 로고
    • Glucose-stimulated genes and prospects of gene therapy for type I diabetes
    • Mitanchez D, Doiron B, Chen R, Kahn A. Glucose-stimulated genes and prospects of gene therapy for type I diabetes. Endocrinol Rev 1997; 18: 520-540.
    • (1997) Endocrinol. Rev. , vol.18 , pp. 520-540
    • Mitanchez, D.1    Doiron, B.2    Chen, R.3    Kahn, A.4
  • 130
    • 0035127574 scopus 로고    scopus 로고
    • Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors
    • Flotte T et al. Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes 2001; 50: 515-520.
    • (2001) Diabetes , vol.50 , pp. 515-520
    • Flotte, T.1
  • 131
    • 0034707028 scopus 로고    scopus 로고
    • Remission in models of type 1 diabetes by gene therapy using a single- chain insulin analogue
    • Lee HC et al. Remission in models of type 1 diabetes by gene therapy using a single- chain insulin analogue. Nature 2000; 408: 483-488.
    • (2000) Nature , vol.408 , pp. 483-488
    • Lee, H.C.1
  • 132
    • 0033766932 scopus 로고    scopus 로고
    • Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors
    • Yang YW, Kotin RM. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharm Res 2000; 17: 1056-1061.
    • (2000) Pharm. Res. , vol.17 , pp. 1056-1061
    • Yang, Y.W.1    Kotin, R.M.2
  • 133
    • 0035043950 scopus 로고    scopus 로고
    • Regulated secretion of proinsulin/insulin from human hepatoma cells transduced by recombinant adeno-associated virus
    • Yang YW, Hsieh YC. Regulated secretion of proinsulin/insulin from human hepatoma cells transduced by recombinant adeno-associated virus. Biotechnol Appl Biochem 2001; 33: 133-140.
    • (2001) Biotechnol. Appl. Biochem. , vol.33 , pp. 133-140
    • Yang, Y.W.1    Hsieh, Y.C.2
  • 134
    • 0031978015 scopus 로고    scopus 로고
    • Stable transduction of human pancreatic adenocarcinoma cells, rat fibroblasts, and bone marrow-derived stem cells with recombinant adeno-associated virus containing the rat preproinsulin II gene
    • Bochan MR et al. Stable transduction of human pancreatic adenocarcinoma cells, rat fibroblasts, and bone marrow-derived stem cells with recombinant adeno-associated virus containing the rat preproinsulin II gene. Transplant Proc 1998; 30: 453-454.
    • (1998) Transplant. Proc. , vol.30 , pp. 453-454
    • Bochan, M.R.1
  • 135
    • 0030904210 scopus 로고    scopus 로고
    • Reversal of hyperglycemia in diabetic NOD mice by human proinsulin gene therapy
    • Kasten-Jolly J et al. Reversal of hyperglycemia in diabetic NOD mice by human proinsulin gene therapy Transplant Proc 1997; 29: 2216-2218.
    • (1997) Transplant. Proc. , vol.29 , pp. 2216-2218
    • Kasten-Jolly, J.1
  • 136
    • 0031968445 scopus 로고    scopus 로고
    • Toward engineering skeletal muscle to release peptide hormone from the human pre-proinsulin gene
    • Bartlett RJ et al. Toward engineering skeletal muscle to release peptide hormone from the human pre-proinsulin gene. Transplant Proc 1998; 30: 451.
    • (1998) Transplant. Proc. , vol.30 , pp. 451
    • Bartlett, R.J.1
  • 137
    • 0030832862 scopus 로고    scopus 로고
    • Gene therapy of diabetes: Glucose-stimulated insulin secretion in a human hepatoma cell line (HEP G2ins/g)
    • Simpson AM et al. Gene therapy of diabetes: glucose-stimulated insulin secretion in a human hepatoma cell line (HEP G2ins/g). Gene Therapy 1997; 4: 1202-1215.
    • (1997) Gene Therapy , vol.4 , pp. 1202-1215
    • Simpson, A.M.1
  • 138
    • 0029922307 scopus 로고    scopus 로고
    • Synthesis and processing of genetically modified human proinsulin by rat myoblast primary cultures
    • Simonson GD, Groskreutz DJ, Gorman CM, MacDonald MJ. Synthesis and processing of genetically modified human proinsulin by rat myoblast primary cultures. Hum Gene Ther 1996; 7: 71-78.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 71-78
    • Simonson, G.D.1    Groskreutz, D.J.2    Gorman, C.M.3    MacDonald, M.J.4
  • 139
    • 0027380787 scopus 로고
    • Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells
    • Vollenweider F, Irminger JC, Halban PA. Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells. Diabetologia 1993; 36: 1322-1325.
    • (1993) Diabetologia , vol.36 , pp. 1322-1325
    • Vollenweider, F.1    Irminger, J.C.2    Halban, P.A.3
  • 140
    • 0026769402 scopus 로고
    • Processing of proinsulin by transfected hepatoma (FAO) cells
    • Vollenweider F et al. Processing of proinsulin by transfected hepatoma (FAO) cells. J Biol Chem 1992; 267: 14629-14636.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14629-14636
    • Vollenweider, F.1
  • 141
    • 0028064783 scopus 로고
    • Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin
    • Groskreutz DJ, Sliwkowski MX, Gorman CM. Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J Biol Chem 1994; 269: 6241-6245.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6241-6245
    • Groskreutz, D.J.1    Sliwkowski, M.X.2    Gorman, C.M.3
  • 142
    • 0034004456 scopus 로고    scopus 로고
    • Glucose regulated production of human insulin in rat hepatocytes
    • Thule PM, Liu J, Phillips LS. Glucose regulated production of human insulin in rat hepatocytes. Gene Therapy 2000; 7: 205-214.
    • (2000) Gene Therapy , vol.7 , pp. 205-214
    • Thule, P.M.1    Liu, J.2    Phillips, L.S.3
  • 143
    • 0034984540 scopus 로고    scopus 로고
    • Auto-regulated hepatic insulin gene expression in type 1 diabetic rats
    • Chen R, Meseck ML, Woo SL. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol Ther 2001; 3: 584-590.
    • (2001) Mol. Ther. , vol.3 , pp. 584-590
    • Chen, R.1    Meseck, M.L.2    Woo, S.L.3
  • 144
    • 0033693585 scopus 로고    scopus 로고
    • Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells
    • Chen R, Meseck M, McEvoy RC, Woo SL. Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells. Gene Therapy 2000; 7: 1802-1809.
    • (2000) Gene Therapy , vol.7 , pp. 1802-1809
    • Chen, R.1    Meseck, M.2    McEvoy, R.C.3    Woo, S.L.4
  • 145
    • 0024791538 scopus 로고
    • Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system
    • Iynedjian PB et al. Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem 1989; 264: 21824-21829.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21824-21829
    • Iynedjian, P.B.1
  • 146
    • 0024342083 scopus 로고
    • Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans
    • Iynedjian PB et al. Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. Proc Natl Acad Sci USA 1989; 86: 7838-7842.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7838-7842
    • Iynedjian, P.B.1
  • 147
    • 0026047305 scopus 로고
    • Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements
    • Liu JS et al. Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. J Biol Chem 1991; 266: 19095-19102.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19095-19102
    • Liu, J.S.1
  • 148
    • 0025052002 scopus 로고
    • In vitro analysis of promoter elements regulating transcription of the phosphoenolpyruvate carboxykinase (GTP) gene
    • Klemm DJ et al. In vitro analysis of promoter elements regulating transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. Mol Cell Biol 1990; 10: 480-485.
    • (1990) Mol. Cell Biol. , vol.10 , pp. 480-485
    • Klemm, D.J.1
  • 149
    • 0029738626 scopus 로고    scopus 로고
    • Insulin-secreting non-islet cells are resistant to autoimmune destruction
    • Lipes MA et al. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci USA 1996; 93: 8595-8600.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8595-8600
    • Lipes, M.A.1
  • 150
    • 0030959913 scopus 로고    scopus 로고
    • Genetic engineering of insulin expression in nonislet cells: Implications for β-cell replacement therapy for insulin-dependent diabetes mellitus
    • Lipes MA, Davalli AM, Cooper EM. Genetic engineering of insulin expression in nonislet cells: implications for β-cell replacement therapy for insulin-dependent diabetes mellitus. Acta Diabetol 1997; 34: 2-5.
    • (1997) Acta Diabetol. , vol.34 , pp. 2-5
    • Lipes, M.A.1    Davalli, A.M.2    Cooper, E.M.3
  • 151
    • 0034623757 scopus 로고    scopus 로고
    • Glucose-dependent insulin release from genetically engineered K cells
    • Cheung AT et al. Glucose-dependent insulin release from genetically engineered K cells. Science 2000; 290: 1959-1962.
    • (2000) Science , vol.290 , pp. 1959-1962
    • Cheung, A.T.1
  • 152
    • 0030848123 scopus 로고    scopus 로고
    • In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas
    • Cornelius JG, Tchernev V, Kao KJ, Peck AB. In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas. Horm Metab Res 1997; 29: 271-277.
    • (1997) Horm. Metab. Res. , vol.29 , pp. 271-277
    • Cornelius, J.G.1    Tchernev, V.2    Kao, K.J.3    Peck, A.B.4
  • 153
    • 0029795884 scopus 로고    scopus 로고
    • Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact
    • Beattie GM et al. Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes 1996; 45: 1223-1228.
    • (1996) Diabetes , vol.45 , pp. 1223-1228
    • Beattie, G.M.1
  • 154
    • 0029560777 scopus 로고
    • In vivo maturation and growth potential of human fetal pancreases: Fresh versus cultured tissue
    • Beattie GM, Lopez AD, Hayek A. In vivo maturation and growth potential of human fetal pancreases: fresh versus cultured tissue. Transplant Proc 1995; 27: 3343.
    • (1995) Transplant. Proc. , vol.27 , pp. 3343
    • Beattie, G.M.1    Lopez, A.D.2    Hayek, A.3
  • 155
    • 0028609023 scopus 로고
    • Outcome of human fetal pancreatic transplants according to implantation site
    • Beattie GM, Hayek A. Outcome of human fetal pancreatic transplants according to implantation site. Transplant Proc 1994; 26, 3299.
    • (1994) Transplant. Proc. , vol.26 , pp. 3299
    • Beattie, G.M.1    Hayek, A.2
  • 157
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001; 292: 1389-1394.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1
  • 158
    • 0034721123 scopus 로고    scopus 로고
    • Stem cells-hype and hope
    • McKay R. Stem cells-hype and hope. Nature 2000; 406: 361-364.
    • (2000) Nature , vol.406 , pp. 361-364
    • McKay, R.1
  • 159
    • 0034192677 scopus 로고    scopus 로고
    • Therapeutic cloning: Concepts and practicalities
    • Colman A, Kind A. Therapeutic cloning: concepts and practicalities. Trends Biotechnol 2000; 18: 192-196.
    • (2000) Trends Biotechnol. , vol.18 , pp. 192-196
    • Colman, A.1    Kind, A.2
  • 160
    • 0033142804 scopus 로고    scopus 로고
    • Therapeutic cloning: Needs and prospects
    • Kind A, Colman A. Therapeutic cloning: needs and prospects. Semin Cell Dev Biol 1999; 10: 279-286.
    • (1999) Semin. Cell Dev. Biol. , vol.10 , pp. 279-286
    • Kind, A.1    Colman, A.2
  • 162
    • 0025374590 scopus 로고
    • Regulation of insulin secretion from β-cell lines derived from transgenic mice insulinomas resembles that of normal β-cells
    • D'Ambra R et al. Regulation of insulin secretion from β-cell lines derived from transgenic mice insulinomas resembles that of normal β-cells. Endocrinology 1990; 126: 2815-2822.
    • (1990) Endocrinology , vol.126 , pp. 2815-2822
    • D'Ambra, R.1
  • 163
    • 0028938747 scopus 로고
    • Conditional transformation of a pancreatic β-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene
    • Efrat S et al. Conditional transformation of a pancreatic β-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci USA 1995; 92: 3576-3580.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3576-3580
    • Efrat, S.1
  • 164
    • 0031951829 scopus 로고    scopus 로고
    • Cell-based therapy for insulin-dependent diabetes mellitus
    • Efrat S. Cell-based therapy for insulin-dependent diabetes mellitus. Eur J Endocrinol 1998; 138: 129-133.
    • (1998) Eur. J. Endocrinol. , vol.138 , pp. 129-133
    • Efrat, S.1
  • 165
    • 0031659962 scopus 로고    scopus 로고
    • Functional analysis of a conditionally transformed pancreatic β-cell line
    • Fleischer N et al. Functional analysis of a conditionally transformed pancreatic β-cell line. Diabetes 1998; 47: 1419-1425.
    • (1998) Diabetes , vol.47 , pp. 1419-1425
    • Fleischer, N.1
  • 166
    • 0028799972 scopus 로고
    • Growth factor/matrix-induced proliferation of human adult β-cells
    • Hayek A et al. Growth factor/matrix-induced proliferation of human adult β-cells. Diabetes 1995; 44: 1458-1460.
    • (1995) Diabetes , vol.44 , pp. 1458-1460
    • Hayek, A.1
  • 167
    • 0028284507 scopus 로고
    • Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells
    • Otonkoski T et al. Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 1994; 43: 947-953.
    • (1994) Diabetes , vol.43 , pp. 947-953
    • Otonkoski, T.1
  • 168
    • 0030015057 scopus 로고    scopus 로고
    • A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic β-cell growth
    • Otonkoski T et al. A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic β-cell growth. Endocrinology 1996; 137: 3131-3139.
    • (1996) Endocrinology , vol.137 , pp. 3131-3139
    • Otonkoski, T.1
  • 169
    • 0033120723 scopus 로고    scopus 로고
    • Towards gene therapy of diabetes mellitus
    • Levine F, Leibowitz G. Towards gene therapy of diabetes mellitus. Mol Med Today 1999; 5: 165-171.
    • (1999) Mol. Med. Today , vol.5 , pp. 165-171
    • Levine, F.1    Leibowitz, G.2
  • 170
    • 0032932851 scopus 로고    scopus 로고
    • Sustained proliferation of PDX-1+ cells derived from human islets
    • Beattie GM et al. Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes 1999; 48: 1013-1019.
    • (1999) Diabetes , vol.48 , pp. 1013-1019
    • Beattie, G.M.1
  • 171
    • 0031985396 scopus 로고    scopus 로고
    • A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus
    • Habener JF, Stoffers DA. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians 1998; 110: 12-21.
    • (1998) Proc. Assoc. Am. Physicians , vol.110 , pp. 12-21
    • Habener, J.F.1    Stoffers, D.A.2
  • 172
    • 8544284816 scopus 로고    scopus 로고
    • Transcription factors contributing to the pancreatic β-cell phenotype
    • Madsen OD et al. Transcription factors contributing to the pancreatic β-cell phenotype. Horm Metab Res 1997; 29: 265-270.
    • (1997) Horm. Metab. Res. , vol.29 , pp. 265-270
    • Madsen, O.D.1
  • 173
    • 0030927342 scopus 로고    scopus 로고
    • The β-cell transcription factors and development of the pancreas
    • Sander M, German MS. The β-cell transcription factors and development of the pancreas. J Mol Med 1997; 75: 327-340.
    • (1997) J. Mol. Med. , vol.75 , pp. 327-340
    • Sander, M.1    German, M.S.2
  • 174
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber S et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000; 6: 568-572.
    • (2000) Nat. Med. , vol.6 , pp. 568-572
    • Ferber, S.1
  • 175
    • 0030873949 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene
    • Wu KL et al. Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene. Mol Cell Biol 1997; 17: 6002-6013.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6002-6013
    • Wu, K.L.1
  • 176
    • 0031775277 scopus 로고    scopus 로고
    • Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)
    • Oster A et al. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J Histochem Cytochem 1998; 46: 707-715.
    • (1998) J. Histochem. Cytochem. , vol.46 , pp. 707-715
    • Oster, A.1
  • 177
    • 0025999697 scopus 로고
    • Growth factor control of pancreatic B cell hyperplasia
    • Hill DJ, Hogg J. Growth factor control of pancreatic B cell hyperplasia. Baillieres Clin Endocrinol Metab 1991; 5: 689-698.
    • (1991) Baillieres Clin. Endocrinol. Metab. , vol.5 , pp. 689-698
    • Hill, D.J.1    Hogg, J.2
  • 178
    • 0033039383 scopus 로고    scopus 로고
    • Pancreatic islet cell survival following islet isolation: The role of cellular interactions in the pancreas
    • Ilieva A et al. Pancreatic islet cell survival following islet isolation: the role of cellular interactions in the pancreas. J Endocrinol 1999; 161: 357-364.
    • (1999) J. Endocrinol. , vol.161 , pp. 357-364
    • Ilieva, A.1
  • 179
    • 0027236719 scopus 로고
    • Insulin-like growth factor-II and transforming growth factor-α in developing human fetal pancreatic islets
    • Miettinen PJ, Otonkoski T, Voutilainen R. Insulin-like growth factor-II and transforming growth factor-α in developing human fetal pancreatic islets. J Endocrinol 1993; 138: 127-136.
    • (1993) J. Endocrinol. , vol.138 , pp. 127-136
    • Miettinen, P.J.1    Otonkoski, T.2    Voutilainen, R.3
  • 180
    • 0031788728 scopus 로고    scopus 로고
    • Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor
    • Petrik J, Arany E, McDonald TJ, Hill DJ. Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor. Endocrinology 1998; 139: 2994-3004.
    • (1998) Endocrinology , vol.139 , pp. 2994-3004
    • Petrik, J.1    Arany, E.2    McDonald, T.J.3    Hill, D.J.4
  • 181
    • 0033323812 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia
    • Petrik J et al. Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia. Endocrinology 1999; 140: 2353-2363.
    • (1999) Endocrinology , vol.140 , pp. 2353-2363
    • Petrik, J.1
  • 182
    • 0025060783 scopus 로고
    • Effects of prolactin and glycosylated prolactin on (pro)insulin synthesis and insulin release from cultured rat pancreatic islets
    • Markoff E, Beattie GM, Hayek A, Lewis UJ. Effects of prolactin and glycosylated prolactin on (pro)insulin synthesis and insulin release from cultured rat pancreatic islets. Pancreas 1990; 5: 99-103.
    • (1990) Pancreas , vol.5 , pp. 99-103
    • Markoff, E.1    Beattie, G.M.2    Hayek, A.3    Lewis, U.J.4
  • 183
    • 0031039705 scopus 로고    scopus 로고
    • In vitro studies of the stimulation of insulin secretion and B-cell proliferation by rat placental lactogen-II during pregnancy in rats
    • Kawai M, Kishi K. In vitro studies of the stimulation of insulin secretion and B-cell proliferation by rat placental lactogen-II during pregnancy in rats. J Reprod Fertil 1997; 109: 145-152.
    • (1997) J. Reprod. Fertil. , vol.109 , pp. 145-152
    • Kawai, M.1    Kishi, K.2
  • 184
    • 0025954951 scopus 로고
    • The stimulatory effect of growth hormone, prolactin, and placental lactogen on β-cell proliferation is not mediated by insulin-like growth factor-I
    • Billestrup N, Nielsen JH. The stimulatory effect of growth hormone, prolactin, and placental lactogen on β-cell proliferation is not mediated by insulin-like growth factor-I. Endocrinology 1991; 129: 883-888.
    • (1991) Endocrinology , vol.129 , pp. 883-888
    • Billestrup, N.1    Nielsen, J.H.2
  • 185
    • 13344270898 scopus 로고    scopus 로고
    • Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia
    • Vasavada RC et al. Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. J Biol Chem 1996; 271: 1200-1208.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1200-1208
    • Vasavada, R.C.1
  • 186
    • 0031731218 scopus 로고    scopus 로고
    • Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse
    • Porter SE et al. Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. Endocrinology 1998; 139: 3743-3751.
    • (1998) Endocrinology , vol.139 , pp. 3743-3751
    • Porter, S.E.1
  • 187
    • 0030747583 scopus 로고    scopus 로고
    • Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats
    • Wang RN, Rehfeld JF, Nielsen FC, Kloppel G. Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 1997; 40: 887-893.
    • (1997) Diabetologia , vol.40 , pp. 887-893
    • Wang, R.N.1    Rehfeld, J.F.2    Nielsen, F.C.3    Kloppel, G.4
  • 188
    • 0027280261 scopus 로고
    • Transforming growth factor-α and epidermal growth factor expression in human fetal gastrointestinal tract
    • Miettinen PJ. Transforming growth factor-α and epidermal growth factor expression in human fetal gastrointestinal tract. Pediatr Res 1993; 33: 481-486.
    • (1993) Pediatr. Res. , vol.33 , pp. 481-486
    • Miettinen, P.J.1
  • 189
    • 0035122230 scopus 로고    scopus 로고
    • Insulin promoter factor-1 controls several aspects of β-cell identity
    • Baeza N, Hart A, Ahlgren U, Edlund H. Insulin promoter factor-1 controls several aspects of β-cell identity. Diabetes 2001; 50(Suppl 1): S36.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Baeza, N.1    Hart, A.2    Ahlgren, U.3    Edlund, H.4
  • 190
    • 0034649608 scopus 로고    scopus 로고
    • Attenuation of FGF signalling in mouse β-cells leads to diabetes
    • Hart AW, Baeza N, Apelqvist A, Edlund H. Attenuation of FGF signalling in mouse β-cells leads to diabetes. Nature 2000; 408: 864-868.
    • (2000) Nature , vol.408 , pp. 864-868
    • Hart, A.W.1    Baeza, N.2    Apelqvist, A.3    Edlund, H.4
  • 191
    • 0033085845 scopus 로고    scopus 로고
    • Development of pancreatic islets
    • (review)
    • Yamaoka T, Itakura M. Development of pancreatic islets (review). Int J Mol Med 1999; 3: 247-261.
    • (1999) Int. J. Mol. Med. , vol.3 , pp. 247-261
    • Yamaoka, T.1    Itakura, M.2
  • 192
    • 0028029181 scopus 로고
    • Developmental gene expression in the human fetal pancreas
    • Mally MI, Otonkoski T, Lopez AD, Hayek A. Developmental gene expression in the human fetal pancreas. Pediatr Res 1994; 36: 537-544.
    • (1994) Pediatr. Res. , vol.36 , pp. 537-544
    • Mally, M.I.1    Otonkoski, T.2    Lopez, A.D.3    Hayek, A.4
  • 193
    • 0026699872 scopus 로고
    • Islet β-cell regeneration and reg genes
    • Unno M et al. Islet β-cell regeneration and reg genes. Adv Exp Med Biol 1992; 321: 61-66.
    • (1992) Adv. Exp. Med. Biol. , vol.321 , pp. 61-66
    • Unno, M.1
  • 194
    • 0031774785 scopus 로고    scopus 로고
    • Characteristics of rat pancreatic regenerating protein
    • Zenilman ME, Chen J, Danesh B, Zheng QH. Characteristics of rat pancreatic regenerating protein. Surgery 1998; 124: 855-863.
    • (1998) Surgery , vol.124 , pp. 855-863
    • Zenilman, M.E.1    Chen, J.2    Danesh, B.3    Zheng, Q.H.4
  • 195
    • 0031662468 scopus 로고    scopus 로고
    • Effect of reg protein on rat pancreatic ductal cells
    • Zenilman ME, Chen J, Magnuson TH. Effect of reg protein on rat pancreatic ductal cells. Pancreas 1998; 17: 256-261.
    • (1998) Pancreas , vol.17 , pp. 256-261
    • Zenilman, M.E.1    Chen, J.2    Magnuson, T.H.3
  • 196
    • 0001072379 scopus 로고    scopus 로고
    • The REG gene and islet cell repair and renewal in type 1 diabetes
    • Bone AJ, Banister SH, Zhang S. The REG gene and islet cell repair and renewal in type 1 diabetes. Adv Exp Med Biol 1997; 426: 321-327.
    • (1997) Adv. Exp. Med. Biol. , vol.426 , pp. 321-327
    • Bone, A.J.1    Banister, S.H.2    Zhang, S.3
  • 197
    • 0030848124 scopus 로고    scopus 로고
    • Induction of pancreatic islet neogenesis
    • Vinik A et al. Induction of pancreatic islet neogenesis. Horm Metab Res 1997; 29: 278-293.
    • (1997) Horm. Metab. Res. , vol.29 , pp. 278-293
    • Vinik, A.1
  • 198
    • 0030912531 scopus 로고    scopus 로고
    • Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
    • Rafaeloff R et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 1997; 99: 2100-2109.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2100-2109
    • Rafaeloff, R.1
  • 199
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue
    • Bonner-Weir S et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 2000; 97: 7999-8004.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7999-8004
    • Bonner-Weir, S.1
  • 200
    • 0036009120 scopus 로고    scopus 로고
    • Targeted disruption of the α 1,3-galactosyltransferase gene in cloned pigs
    • Dai Y et al. Targeted disruption of the α 1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 2002; 20: 251-255.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 251-255
    • Dai, Y.1
  • 201
    • 0037155815 scopus 로고    scopus 로고
    • Molecular basis of evolutionary loss of the α 1,3-galactosyltransferase gene in higher primates
    • Koike C et al. Molecular basis of evolutionary loss of the α 1,3-galactosyltransferase gene in higher primates. J Biol Chem 2002; 277: 10114-10120.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10114-10120
    • Koike, C.1
  • 202
    • 0032558090 scopus 로고    scopus 로고
    • Improved survival of biolistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand
    • Gainer AL et al. Improved survival of biolistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand. Transplantation 1998; 66: 194-199.
    • (1998) Transplantation , vol.66 , pp. 194-199
    • Gainer, A.L.1
  • 203
    • 0030935124 scopus 로고    scopus 로고
    • Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival
    • Gainer AL et al. Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival. Transplantation 1997; 63: 1017-1021.
    • (1997) Transplantation , vol.63 , pp. 1017-1021
    • Gainer, A.L.1
  • 204
    • 0025639908 scopus 로고
    • Liposome mediated in vitro transfection of pancreatic islet cells
    • Welsh N, Oberg C, Hellerstrom C, Welsh M. Liposome mediated in vitro transfection of pancreatic islet cells. Biomed Biochim Acta 1990; 49: 1157-1164.
    • (1990) Biomed. Biochim. Acta , vol.49 , pp. 1157-1164
    • Welsh, N.1    Oberg, C.2    Hellerstrom, C.3    Welsh, M.4
  • 205
    • 0030925175 scopus 로고    scopus 로고
    • Standardization of procedure for efficient ex vivo gene transfer into porcine pancreatic islets with cationic liposomes
    • Benhamou PY et al. Standardization of procedure for efficient
    • (1997) Transplantation , vol.63 , pp. 1798-1803
    • Benhamou, P.Y.1
  • 206
    • 0030773969 scopus 로고    scopus 로고
    • Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent β-cell destruction in diabetic NOD mice
    • Smith DK et al. Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent β-cell destruction in diabetic NOD mice. Transplantation 1997; 64: 1040-1049.
    • (1997) Transplantation , vol.64 , pp. 1040-1049
    • Smith, D.K.1
  • 207
    • 7844230594 scopus 로고    scopus 로고
    • Local expression of immunoregulatory IL-12p4O gene prolonged syngeneic islet graft survival in diabetic NOD mice
    • Yasuda H et al. Local expression of immunoregulatory IL-12p4O gene prolonged syngeneic islet graft survival in diabetic NOD mice. J Clin Invest 1998; 102: 1807-1814.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1807-1814
    • Yasuda, H.1
  • 208
    • 0030449531 scopus 로고    scopus 로고
    • Decreased alloreactivity to human islets secreting recombinant viral interleukin 10
    • Benhamou PY et al. Decreased alloreactivity to human islets secreting recombinant viral interleukin 10. Transplantation 1996; 62: 1306-1312.
    • (1996) Transplantation , vol.62 , pp. 1306-1312
    • Benhamou, P.Y.1
  • 209
    • 0032572797 scopus 로고    scopus 로고
    • Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival
    • Judge TA et al. Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation 1998; 66: 426-434.
    • (1998) Transplantation , vol.66 , pp. 426-434
    • Judge, T.A.1
  • 211
    • 0031127357 scopus 로고    scopus 로고
    • Adenoviral transfection of isolated pancreatic islets: A study of programmed cell death (apoptosis) and islet function
    • Weber M et al. Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function. I Surg Res 1997; 69: 23-32.
    • (1997) J. Surg. Res. , vol.69 , pp. 23-32
    • Weber, M.1
  • 212
    • 0028859143 scopus 로고
    • Efficient gene transfer to pancreatic islets mediated by adenoviral vectors
    • Csete ME et al. Efficient gene transfer to pancreatic islets mediated by adenoviral vectors. Transplantation 1995; 59: 263-268.
    • (1995) Transplantation , vol.59 , pp. 263-268
    • Csete, M.E.1
  • 213
    • 0029933105 scopus 로고    scopus 로고
    • Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas
    • Raper SE, DeMatteo RP. Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas. Pancreas 1996; 12: 401-410.
    • (1996) Pancreas , vol.12 , pp. 401-410
    • Raper, S.E.1    DeMatteo, R.P.2
  • 214
    • 0029845951 scopus 로고    scopus 로고
    • Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes
    • Saldeen J et al. Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes. Diabetes 1996; 45: 1197-1203.
    • (1996) Diabetes , vol.45 , pp. 1197-1203
    • Saldeen, J.1
  • 215
    • 0032830997 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1β-induced β-cell impairment and activation of islet cell apoptosis in vitro
    • Giannoukakis N et al. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1β-induced β-cell impairment and activation of islet cell apoptosis in vitro. Diabetes 1999; 48: 1730-1736.
    • (1999) Diabetes , vol.48 , pp. 1730-1736
    • Giannoukakis, N.1
  • 216
    • 0032745109 scopus 로고    scopus 로고
    • A20 inhibits cytokine-induced apoptosis and nuclear factor κ B-dependent gene activation in islets
    • Grey ST et al. A20 inhibits cytokine-induced apoptosis and nuclear factor κ B-dependent gene activation in islets. J Exp Med 1999; 190: 1135-1146.
    • (1999) J. Exp. Med. , vol.190 , pp. 1135-1146
    • Grey, S.T.1
  • 217
    • 0030743247 scopus 로고    scopus 로고
    • Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants
    • Muruve DA, Manfro RC, Strom TB, Libermann TA. Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants. Transplantation 1997; 64: 542-546.
    • (1997) Transplantation , vol.64 , pp. 542-546
    • Muruve, D.A.1    Manfro, R.C.2    Strom, T.B.3    Libermann, T.A.4
  • 218
    • 0027994097 scopus 로고
    • Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
    • Becker TC et al. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J Biol Chem 1994; 269: 21234-21238.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21234-21238
    • Becker, T.C.1
  • 219
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor
    • Giannoukakis N, Rudert WA, Trucco M, Robbins PD. Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor. J Biol Chem, 2000; 275(47): 36509-36513.
    • (2000) J. Biol Chem. , vol.275 , Issue.47 , pp. 36509-36513
    • Giannoukakis, N.1    Rudert, W.A.2    Trucco, M.3    Robbins, P.D.4
  • 220
    • 0036166305 scopus 로고    scopus 로고
    • Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector
    • Kapturczak M et al. Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Mol Ther 2002; 5: 154-160.
    • (2002) Mol. Ther. , vol.5 , pp. 154-160
    • Kapturczak, M.1
  • 221
    • 0034778099 scopus 로고    scopus 로고
    • Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia
    • Shifrin AL et al. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Therapy 2001; 8: 1480-1489.
    • (2001) Gene Therapy , vol.8 , pp. 1480-1489
    • Shifrin, A.L.1
  • 222
    • 0035995944 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes
    • Alexander AM et al. Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 2002; 51: 356-365.
    • (2002) Diabetes , vol.51 , pp. 356-365
    • Alexander, A.M.1
  • 223
    • 0033049684 scopus 로고    scopus 로고
    • Prevention of autoimmune recurrence and rejection by adenovirus-mediated CTLA4Ig gene transfer to the pancreatic graft in BB rat
    • Uchikoshi F et al. Prevention of autoimmune recurrence and rejection by adenovirus-mediated CTLA4Ig gene transfer to the pancreatic graft in BB rat. Diabetes 1999; 48: 652-657.
    • (1999) Diabetes , vol.48 , pp. 652-657
    • Uchikoshi, F.1
  • 224
    • 0034078138 scopus 로고    scopus 로고
    • Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells
    • Moriscot C et al. Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells. Diabetologia 2000; 43: 625-631.
    • (2000) Diabetologia , vol.43 , pp. 625-631
    • Moriscot, C.1
  • 225
    • 0033370606 scopus 로고    scopus 로고
    • Efficient gene transfer and expression in islets by an adenoviral vector that lacks all viral genes
    • Guo Z et al. Efficient gene transfer and expression in islets by an adenoviral vector that lacks all viral genes. Cell Transplant 1999; 8: 661-671.
    • (1999) Cell Transplant. , vol.8 , pp. 661-671
    • Guo, Z.1
  • 226
    • 0034509569 scopus 로고    scopus 로고
    • Prevention of β-cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I
    • Giannoukakis N et al. Prevention of β-cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. Gene Therapy 2000; 7: 2015-2022.
    • (2000) Gene Therapy , vol.7 , pp. 2015-2022
    • Giannoukakis, N.1
  • 227
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an Iκ B repressor
    • Giannoukakis N, Rudert WA, Trucco M, Robbins PD. Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an Iκ B repressor. J Biol Chem 2000; 275: 36509-36513.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36509-36513
    • Giannoukakis, N.1    Rudert, W.A.2    Trucco, M.3    Robbins, P.D.4
  • 228
    • 0032830997 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1β-induced β-cell impairment and activation of islet cell apoptosis in vitro
    • Giannoukakis N et al. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1β-induced β-cell impairment and activation of islet cell apoptosis in vitro. Diabetes 1999; 48: 1730-1736.
    • (1999) Diabetes , vol.48 , pp. 1730-1736
    • Giannoukakis, N.1
  • 229
    • 0033030446 scopus 로고    scopus 로고
    • Gene transfer to human pancreatic endocrine cells using viral vectors
    • Leibowitz G et al. Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes 1999; 48: 745-753.
    • (1999) Diabetes , vol.48 , pp. 745-753
    • Leibowitz, G.1
  • 230
    • 0032506750 scopus 로고    scopus 로고
    • Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis
    • Gallichan WS et al. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Ham Gene Ther 1998; 9: 2717-2726.
    • (1998) Ham. Gene Ther. , vol.9 , pp. 2717-2726
    • Gallichan, W.S.1
  • 231
    • 0031812835 scopus 로고    scopus 로고
    • Transduction of non-dividing adult human pancreatic β-cells by an integrating lentiviral vector
    • Ju Q et al. Transduction of non-dividing adult human pancreatic β-cells by an integrating lentiviral vector. Diabetologia 1998; 41: 736-739.
    • (1998) Diabetologia , vol.41 , pp. 736-739
    • Ju, Q.1
  • 232
    • 0032855209 scopus 로고    scopus 로고
    • Infection of intact human islets by a lentiviral vector
    • Giannoukakis N et al. Infection of intact human islets by a lentiviral vector. Gene Therapy 1999; 6: 1545-1551.
    • (1999) Gene Therapy , vol.6 , pp. 1545-1551
    • Giannoukakis, N.1
  • 233
    • 0029801229 scopus 로고    scopus 로고
    • Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic β-cells from apoptosis
    • Liu Y et al. Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic β-cells from apoptosis. Hum Gene Ther 1996; 7: 1719-1726.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1719-1726
    • Liu, Y.1
  • 234
    • 0345161818 scopus 로고    scopus 로고
    • Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β-cells from cytokine-induced destruction
    • Rabinovitch A et al. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β-cells from cytokine-induced destruction. Diabetes 1999; 48: 1223-1229.
    • (1999) Diabetes , vol.48 , pp. 1223-1229
    • Rabinovitch, A.1
  • 235
    • 0034296675 scopus 로고    scopus 로고
    • Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo
    • Mi Z, Mai J, Lu X, Robbins PD. Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo. Mol Ther 2000; 2: 339-347.
    • (2000) Mol. Ther. , vol.2 , pp. 339-347
    • Mi, Z.1    Mai, J.2    Lu, X.3    Robbins, P.D.4
  • 236
    • 0032984806 scopus 로고    scopus 로고
    • Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion
    • Dupraz P et al. Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. Gene Therapy 1999; 6: 1160-1169.
    • (1999) Gene Therapy , vol.6 , pp. 1160-1169
    • Dupraz, P.1
  • 237
    • 16744368499 scopus 로고    scopus 로고
    • Overexpression of Bcl-x(L) in β-cells prevents cell death but impairs mitochondrial signal for insulin secretion
    • Zhou YP et al. Overexpression of Bcl-x(L) in β-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab 2000; 278: E340-351.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Zhou, Y.P.1
  • 238
    • 15644379473 scopus 로고    scopus 로고
    • A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1β
    • Ye J, Laychock SG. A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1β. Endocrinology 1998; 139: 4155-4163.
    • (1998) Endocrinology , vol.139 , pp. 4155-4163
    • Ye, J.1    Laychock, S.G.2
  • 239
    • 0036061642 scopus 로고    scopus 로고
    • Inhibition of protein kinase Cδ protects rat INS-1 cells against interleukin-1β and streptozotocin-induced apoptosis
    • Carpenter L, Cordery D, Biden TJ. Inhibition of protein kinase Cδ protects rat INS-1 cells against interleukin-1β and streptozotocin-induced apoptosis. Diabetes 2002; 51: 317-324.
    • (2002) Diabetes , vol.51 , pp. 317-324
    • Carpenter, L.1    Cordery, D.2    Biden, T.J.3
  • 240
    • 0034532379 scopus 로고    scopus 로고
    • Dominant negative MyD88 proteins inhibit interleukin-1β/interferon-γ-mediated induction of nuclear factor κ B-dependent nitrite production and apoptosis in β-cells
    • Dupraz P et al. Dominant negative MyD88 proteins inhibit interleukin-1β/interferon-γ-mediated induction of nuclear factor κ B-dependent nitrite production and apoptosis in β-cells. J Biol Chem 2000; 275: 37672-37678.
    • (2000) J. Biol. Chem. , vol.275 , pp. 37672-37678
    • Dupraz, P.1
  • 241
    • 0034733644 scopus 로고    scopus 로고
    • Natural resistance of human β-cells toward nitric oxide is mediated by heat shock protein 70
    • Burkart V et al. Natural resistance of human β-cells toward nitric oxide is mediated by heat shock protein 70. J Biol Chem 2000; 275: 19521-19528.
    • (2000) J. Biol. Chem. , vol.275 , pp. 19521-19528
    • Burkart, V.1
  • 242
    • 0032847555 scopus 로고    scopus 로고
    • Overexpression of catalase provides partial protection to transgenic mouse β-cells
    • Xu B, Moritz JT, Epstein PN. Overexpression of catalase provides partial protection to transgenic mouse β-cells. Free Radic Biol Med 1999; 27: 830-837.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 830-837
    • Xu, B.1    Moritz, J.T.2    Epstein, P.N.3
  • 243
    • 15644375700 scopus 로고    scopus 로고
    • Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets
    • Benhamou PY et al. Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets. Diabetologia 1998; 41: 1093-1100.
    • (1998) Diabetologia , vol.41 , pp. 1093-1100
    • Benhamou, P.Y.1
  • 244
    • 0032080663 scopus 로고    scopus 로고
    • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1β-induced cytotoxicity and reduces nitric oxide production
    • Hohmeier HE et al. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1β-induced cytotoxicity and reduces nitric oxide production. J Clin Invest 1998; 101: 1811-1820.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1811-1820
    • Hohmeier, H.E.1
  • 245
    • 0032506750 scopus 로고    scopus 로고
    • Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis
    • Gallichan WS et al. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum Gene Ther 1998; 9: 2717-2726.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2717-2726
    • Gallichan, W.S.1
  • 246
    • 0030948708 scopus 로고    scopus 로고
    • IL-10 and TGF-β gene transfer to rodent islets: Effect on xenogeneic islet graft survival in naive and B-cell-deficient mice
    • Deng S et al. IL-10 and TGF-β gene transfer to rodent islets: effect on xenogeneic islet graft survival in naive and B-cell-deficient mice. Transplant Proc 1997; 29: 2207-2208.
    • (1997) Transplant. Proc. , vol.29 , pp. 2207-2208
    • Deng, S.1
  • 247
    • 0029621794 scopus 로고
    • Recombinant human transforming growth factor β does not inhibit the effects of interleukin-1β on pancreatic islet cells
    • Hao W, Palmer JP. Recombinant human transforming growth factor β does not inhibit the effects of interleukin-1β on pancreatic islet cells. J Interferon Cytokine Res 1995; 15: 1075-1081.
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 1075-1081
    • Hao, W.1    Palmer, J.P.2
  • 248
    • 0030842535 scopus 로고    scopus 로고
    • Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
    • Kang SM et al. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med 1997; 3: 738-743.
    • (1997) Nat. Med. , vol.3 , pp. 738-743
    • Kang, S.M.1
  • 249
    • 0031066658 scopus 로고    scopus 로고
    • Protection against autoimmune diabetes in mixed bone marrow chimeras: Mechanisms involved
    • Mathieu C, Casteels K, Bouillon R, Waer M. Protection against autoimmune diabetes in mixed bone marrow chimeras: mechanisms involved. J Immunol 1997; 158: 1453-1457.
    • (1997) J. Immunol. , vol.158 , pp. 1453-1457
    • Mathieu, C.1    Casteels, K.2    Bouillon, R.3    Waer, M.4
  • 250
    • 0035752674 scopus 로고    scopus 로고
    • The effect of bone marrow transplantation on survival of allogeneic pancreatic islets with short-term tacrolimus conditioning in rats
    • Girman P et al. The effect of bone marrow transplantation on survival of allogeneic pancreatic islets with short-term tacrolimus conditioning in rats. Ann Transplant 2001; 6: 43-45.
    • (2001) Ann. Transplant. , vol.6 , pp. 43-45
    • Girman, P.1
  • 251
    • 0034654374 scopus 로고    scopus 로고
    • Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice
    • Seung E et al. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 2000; 95: 2175-2182.
    • (2000) Blood , vol.95 , pp. 2175-2182
    • Seung, E.1
  • 252
    • 0029092748 scopus 로고
    • Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts
    • Li H, Colson YL, Ildstad ST. Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts. Transplantation 1995; 60: 523-529.
    • (1995) Transplantation , vol.60 , pp. 523-529
    • Li, H.1    Colson, Y.L.2    Ildstad, S.T.3
  • 253
    • 0028281701 scopus 로고
    • Mixed xenogeneic chimerism (mouse+rat → mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts
    • Li H et al. Mixed xenogeneic chimerism (mouse+rat → mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts. Transplantation 1994; 57: 592-598.
    • (1994) Transplantation , vol.57 , pp. 592-598
    • Li, H.1
  • 254
    • 0035960303 scopus 로고    scopus 로고
    • Islet cell transplantation tolerance
    • Rossini AA et al. Islet cell transplantation tolerance. Transplantation 2001; 72: S43-46.
    • (2001) Transplantation , vol.72
    • Rossini, A.A.1
  • 255
    • 0034719349 scopus 로고    scopus 로고
    • Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells
    • Ali A et al. Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells. Transplantation 2000; 69: 221-226.
    • (2000) Transplantation , vol.69 , pp. 221-226
    • Ali, A.1
  • 256
    • 0036533702 scopus 로고    scopus 로고
    • Long-term reversal of established autoimmunity upon transient blockade of the LFA-1/intercellular adhesion molecule-1 pathway
    • Bertry-Coussot L et al. Long-term reversal of established autoimmunity upon transient blockade of the LFA-1/intercellular adhesion molecule-1 pathway J Immunol 2002; 168: 3641-3648.
    • (2002) J. Immunol. , vol.168 , pp. 3641-3648
    • Bertry-Coussot, L.1
  • 257
    • 0031003713 scopus 로고    scopus 로고
    • Genetic modification of an islet tumor cell line inhibits its rejection
    • Georgiou HM, Brady JL, Silva A, Lew AM. Genetic modification of an islet tumor cell line inhibits its rejection. Transplant Proc 1997; 29: 1032-1033.
    • (1997) Transplant. Proc. , vol.29 , pp. 1032-1033
    • Georgiou, H.M.1    Brady, J.L.2    Silva, A.3    Lew, A.M.4
  • 258
    • 0029980798 scopus 로고    scopus 로고
    • Secretion of CTLA4Ig by an SV40 T antigen-transformed islet cell line inhibits graft rejection against the neoantigen
    • Lew AM et al. Secretion of CTLA4Ig by an SV40 T antigen-transformed islet cell line inhibits graft rejection against the neoantigen. Transplantation 1996; 62: 83-89.
    • (1996) Transplantation , vol.62 , pp. 83-89
    • Lew, A.M.1
  • 259
    • 0029968448 scopus 로고    scopus 로고
    • CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice
    • Weber CJ et al. CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice. Transplant Proc 1996; 28: 821-823.
    • (1996) Transplant. Proc. , vol.28 , pp. 821-823
    • Weber, C.J.1
  • 260
    • 0034654475 scopus 로고    scopus 로고
    • Additive efficacy of CTLA4Ig and OX40Ig secreted by genetically modified grafts
    • Brady JL, Lew AM. Additive efficacy of CTLA4Ig and OX40Ig secreted by genetically modified grafts. Transplantation 2000; 69: 724-730.
    • (2000) Transplantation , vol.69 , pp. 724-730
    • Brady, J.L.1    Lew, A.M.2
  • 261
    • 0034658452 scopus 로고    scopus 로고
    • Protective effect of CTLA4Ig secreted by transgenic fetal pancreas allografts
    • Sutherland RM et al. Protective effect of CTLA4Ig secreted by transgenic fetal pancreas allografts. Transplantation 2000; 69: 1806-1812.
    • (2000) Transplantation , vol.69 , pp. 1806-1812
    • Sutherland, R.M.1
  • 262
    • 0035923680 scopus 로고    scopus 로고
    • Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice
    • Goudy K et al. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc Natl Acad Sci USA 2001; 98: 13913-13918.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13913-13918
    • Goudy, K.1
  • 263
    • 0034760333 scopus 로고    scopus 로고
    • Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice
    • Ko KS, Lee M, Koh JJ, Kim SW. Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Mol Ther 2001; 4: 313-316.
    • (2001) Mol. Ther. , vol.4 , pp. 313-316
    • Ko, K.S.1    Lee, M.2    Koh, J.J.3    Kim, S.W.4
  • 264
    • 0034504234 scopus 로고    scopus 로고
    • Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice
    • Koh JJ et al. Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice. Gene Therapy 2000; 7: 2099-2104.
    • (2000) Gene Therapy , vol.7 , pp. 2099-2104
    • Koh, J.J.1
  • 265
    • 0037097550 scopus 로고    scopus 로고
    • Suppression of autoimmune diabetes by viral IL-10 gene transfer
    • Yang Z et al. Suppression of autoimmune diabetes by viral IL-10 gene transfer. J Immunol 2002; 168: 6479-6485.
    • (2002) J. Immunol. , vol.168 , pp. 6479-6485
    • Yang, Z.1
  • 266
    • 0036584901 scopus 로고    scopus 로고
    • A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats
    • Zipris D, Karnieli E. A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats. Jop 2002; 3: 76-82.
    • (2002) Jop , vol.3 , pp. 76-82
    • Zipris, D.1    Karnieli, E.2
  • 267
    • 0033222419 scopus 로고    scopus 로고
    • Intramuscular administration of expression plasmids encoding interferon-γ receptor/IgG1 or IL-4/IgG1 chimeric proteins protects from autoimmunity
    • Chang Y, Prud'homme GJ. Intramuscular administration of expression plasmids encoding interferon-γ receptor/IgG1 or IL-4/IgG1 chimeric proteins protects from autoimmunity. J Gene Med 1999; 1: 415-423.
    • (1999) J. Gene Med. , vol.1 , pp. 415-423
    • Chang, Y.1    Prud'homme, G.J.2
  • 268
    • 0033020168 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-γ receptor/IgG1 fusion protein
    • Prud'homme GJ, Chang Y. Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-γ receptor/IgG1 fusion protein. Gene Therapy 1999; 6: 771-777.
    • (1999) Gene Therapy , vol.6 , pp. 771-777
    • Prud'homme, G.J.1    Chang, Y.2
  • 269
    • 0032531423 scopus 로고    scopus 로고
    • TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
    • Piccirillo CA, Chang Y, Prud'homme GJ. TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol 1998; 161: 3950-3956.
    • (1998) J. Immunol. , vol.161 , pp. 3950-3956
    • Piccirillo, C.A.1    Chang, Y.2    Prud'homme, G.J.3
  • 270
    • 0035867792 scopus 로고    scopus 로고
    • Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection
    • Balasa B et al. Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection. Clin Immunol 2001; 99: 241-252.
    • (2001) Clin. Immunol. , vol.99 , pp. 241-252
    • Balasa, B.1
  • 271
    • 0035029840 scopus 로고    scopus 로고
    • Adenovirus early region 3(E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice
    • Efrat S et al. Adenovirus early region 3(E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes 2001; 50: 980-984.
    • (2001) Diabetes , vol.50 , pp. 980-984
    • Efrat, S.1
  • 272
    • 0028202792 scopus 로고
    • Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
    • Weiner HL et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 1994; 12: 809-837.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 809-837
    • Weiner, H.L.1
  • 273
    • 0031214341 scopus 로고    scopus 로고
    • Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines
    • Polanski M, Melican NS, Zhang J, Weiner HL. Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines. J Autoimmun 1997; 10: 339-346.
    • (1997) J. Autoimmun. , vol.10 , pp. 339-346
    • Polanski, M.1    Melican, N.S.2    Zhang, J.3    Weiner, H.L.4
  • 274
    • 0032877655 scopus 로고    scopus 로고
    • Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells
    • Bergerot I et al. Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells. Diabetes 1999; 48: 1720-1729.
    • (1999) Diabetes , vol.48 , pp. 1720-1729
    • Bergerot, I.1
  • 275
    • 0036202406 scopus 로고    scopus 로고
    • Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand
    • Prud'homme GJ, Chang Y, Li X. Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand. Hum Gene Ther 2002; 13: 395-406.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 395-406
    • Prud'homme, G.J.1    Chang, Y.2    Li, X.3


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