Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides

Molecular Therapy

Volumn 1, Issue 5, 2000, Pages 430-437

  Giannoukakis, Nick ^a   Bonham, C Andrew ^b   Qian, Shiguang ^b   Zhou, Zhongyou ^b   Peng, Lansha ^b   Harnaha, Jo ^b   Li, Wei ^b   Thomson, Angus W ^a,b   Fung, John J ^b   Robbins, Paul D ^a   Lu, Lina ^b,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

Costimulation; Dendritic cells; NF kB; Oligodeoxyribonucleotide; Tolerance; Transplantation

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OLIGODEOXYRIBONUCLEOTIDE;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BIOSYNTHESIS; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; DENDRITIC CELL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGY; MALE; METABOLISM; MOUSE; PHYSIOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; BONE MARROW CELLS; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; GRAFT SURVIVAL; HEART TRANSPLANTATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 84984763849     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0060     Document Type: Article

References (24)

1. Banchereau, J., and Steinman, R. M. (1998). Dendritic cells and the control of immunity. Nature 392: 245-252.
2. Thomson, A. W., and Lu, L. (1999). Dendritic cells as regulators of immune reactivity: Implications for transplantation. Transplantation 68: 1-8.
3. Lu, L., McCaslin, D., Starzl, T. E., and Thomson, A. W. (1995). Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 60: 1539-1545.
4. Lu, L., Bonham, C. A., Chambers, F. G., Watkins, S. C., Hoffman, R. A., Simmons, R. L., and Thomson, A. W. (1996). Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: Nitric oxide production is associated with dendritic cell apoptosis. J. Immunol. 157: 3577-3586.
5. Fu, F., Lim Y., Qian, S., Lu, L., Chambers, F., Starzl, T. E., Fung, J. J., and Thomson, A. W. (1996). Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 62: 659-665.
6. Rastellini, C., Lu, L., Ricordi, C., Starzl, T. E., Rao, A. S., and Thomson, A. W. (1995). Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation 60: 1366-1370.
7. Rescigno, M., Martino, M., Sutherland, C. L., Gold, M. R., and Ricciardi-Castagnoli, P. (1998). Dendritic cell survival and maturation are regulated by different signaling pathways. J. Exp. Med. 188: 2175-2180.
8. Burkly, L., Hession, C., Ogata, L., Reilly, C., Marconi, L. A., Olson, D., Tizard, R., Cate, R., and Lo, D. (1995). Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373: 531-536.
9. Baeuerle, P. A., and Henkel, T. (1994). Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12: 141-179.
10. Xie, Q. W., Kashiwabara, Y., and Nathan, C. (1994). Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Bol. Chem. 269: 4705-4708.
11. Lee, J. I., Ganster, R. W., Geller, D. A., Burckart, G. J., Thomson, A. W., and Lu, L. (1999). Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: Association with reduced nuclear translocation of nuclear factor kappa B. Transplantation 68: 1255-1263.
12. Bielinska, A., Shivdasani, R. A., Zhang, L. Q., and Nabel, G. J. (1990). Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science 250: 997-1000.
13. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., and Steinman, R. M. (1992). Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176: 1693-1702.
14. Lu, L., Li, W., Fu, F., Chambers, F. G., Qian, S., Fung, J. J., and Thomson, A. W. (1997). Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation 64: 1808-1815.
15. Lu, L., Rudert, W. A., Qian, S., McCaslin, D., Fu, F., Rao, A. S., Trucco, M., Fung, J. J., Starzl, T. E., and Thomson, A. W. (1995). Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 182: 379-387.
16. Andrews, N. C., and Faller, D. V. (1991). A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19: 2499.
17. Billiar, T. R., Curran, R. D., Stuehr, D. J., West, M. A., Bentz, B. G., and Simmons, R. L. (1989). An l-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J. Exp. Med. 169: 1467-1472.
18. Fu, F., Li, Y., Qian, S., Lu, L., Chambers, F. D., Starzl, T. E., Fung, J. J., and Thomson, A. W. (1997). Costimulatory molecule-deficient dendritic cell progenitors induce T cell hyporesponsiveness in vitro and prolong the survival of vascularized cardiac allografts. Transplant. Proc. 29: 1310.
19. Lu, L., Lee, W. C., Gambotto, A., Zhong, C., Robbins, P. D., Qian, S., Fung, J. J., and Thomson, A. W. (1999). Transduction of dendritic cells with adenoviral vectors encoding CTLA4-lg markedly reduces their allostimulatory activity. Transplant. Proc. 31: 797.
20. Jenkins, M. K., Schwartz, R. H., and Pardoll, D. M. (1988). Effects of cyclosporine A on T cell development and clonal deletion. Science 241: 1655-1658.
21. Lee, W. C., Zhong, C., Qian, S., Wan, Y., Gauldie, J., Mi, Z., Robbins, P. D., Thomson, A. W., and Lu, L. (1998). Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-beta. Transplantation 66: 1810-1817.
22. Stepkowski, S. M., Wang, M. E., Condon, T. P., Cheng-Flournoy, S., Stecker, K., Graham, M., Qu, X., Tian, L., Chen, W., Kahan, B. D., and Bennett, C. F. (1998). Protection against allograft rejection with intercellular adhesion molecule-1 antisense oligodeoxynucleotides. Transplantation 66: 699-707.
23. Stepkowski, S. M., Tu, Y., Condon, T. P., and Bennett, C. F. (1994). Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities. J. Immunol. 153: 5336-5346.
24. Thomas, J. M., Contreras, J. L., Jang, X. L., Eckhoff, D. E., Wang, P. X., Hubbard, W. J., Lobashevsky, A. L., Wang, W., Asiedu, C., Stavrou, S., Cook, W. J., Robbin, M. L., Thomas, F. T., and Neville, D. M., Jr. (1999). Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin. Transplantation 68: 1660-1673.