Sustained proliferation of PDX-1+ cells derived from human islets

Diabetes

Volumn 48, Issue 5, 1999, Pages 1013-1019

  Beattie, Gillian M ^b   Itkin Ansari, Pamela ^a   Cirulli, Vincenzo ^b   Leibowitz, Gil ^a   Lopez, Ana D ^b   Bossie, Stuart ^a   Mally, Martin I ^b   Levine, Fred ^a   Hayek, Alberto ^b  

^a Whittier Institute for Diabetes   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN; INSULIN; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL;

CELL COUNT; CELL DIVISION; CELLS, CULTURED; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; KERATINS; KINETICS; MICROSCOPY, CONFOCAL; PANCREATIC DUCTS; PHENOTYPE;

EID: 0032932851     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.5.1013     Document Type: Article

References (27)

1. Hayek A, Beattie GM, Cirulli V, Lopez AD, Ricordi C, Rubin JS: Growth factor/matrix-induced proliferation of human adult β-cells. Diabetes 44:1458-1460, 1995
2. Beattie GM, Rubin JS, Mally MI, Otonkoski T, Hayek A: Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes 45:1223-1228, 1996
3. Brelje TC, Scharp DW, Lacy PE, O'Gren L, Talamantes F, Robertson M, Friesen HG, Sorenson RL Effect of homologous placental lactogens, prolactins, and growth hormones on islet β-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology 132:879-887, 1993
4. Tyrberg B, Eizirik DL, Hellerstrom C, Pipeleers DG, Andersson A: Human pancreatic β-cell deoxyribonucleic acid synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro. Endocrinology 137:5694-5699, 1996
5. Lefebvre VH, Otonkoski T, Ustinov J, Huotari MA, Pipeleers DG, Bouwens L: Culture of adult islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for β-cells. Diabetes 47:134-137, 1998
6. Beattie GM, Cirulli V, Lopez AD, Hayek A: Ex vivo expansion of human pancreatic endocrine cells. J Clin Endocrinol Metab 82:1852-1856, 1997
7. Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW: Automated method for isolation of human pancreatic islets. Diabetes 37:413-420, 1988
8. Latif ZA, Noel J, Alejandro R: A simple method of staining fresh and cultured islets. Transplantation 45:827-830, 1988
9. Mally MI, Otonkoski T, Lopez AD, Hayek A: Developmental gene expression in the human fetal pancreas. Pediatr Res 36:537-544, 1994
10. Rouiller DG, Cirulli V, Halban PA: Differences in aggregation properties and levels of the neural cell adhesion molecule (N-CAM) between islet cell types. Exp Cell Res 191:305-312, 1990
11. Shimizu H, Shimizu C, Burns JC: Detection of novel RNA viruses: morbilliviruses as a model system. Mol Cell Probes 8:209-214, 1994
12. Erber WN, Mason DY: Immunoalkaline phosphatase labeling of terminal transferase in hematologic samples. Am J Clin Pathol 88:43-50, 1987
13. Beattie GM, Levine F, Mally M, Otonkoski T, O'Brien JS, Salomon DR, Hayek A: Acid β-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. J Clin Endocrinol Metab 78:1232-1240, 1994
14. Cirulli V, Crisa L, Beattie GM, Mally MI, Lopez AD, Fannon A, Ptasznik A, Inverardi L, Ricordi C, Deerinck T, Ellisman M, Reisfeld RA, Hayek A: KSA antigen (Ep-CAM) mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development. J Cell Biol 140: 1519-1534, 1998
15. Litvinov SV, Velders MP, Bakker HAM, Fleuren GJ, Warnaar SO: Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125:437-446, 1994
16. Yoshida K, Kagawa S, Murakoso K, Haito K, Shimizu S, Matsuoka A: Long-term effect of 2-deoxy-2-fluoroglucose on maintenance in culture of the neonatal β-cell of the rat. Biochem Biophys Res Commun 108:279-285, 1982
17. Rabinovitch A, Blondel B, Murray T, Mintz D: Cyclic AMP stimulates islet β-cell replication in neonatal rat pancreatic monolayer cultures. J Clin Invest 66:1065-1071, 1980
18. Kaiser N, Corcos AP, Tur-Sinai A, Ariav Y, Cerasi E: Monolayer culture of adult rat pancreatic islets on extracellular matrix: long-term maintenance of differentiated β-cell function. Endocrinology 123:834-840, 1988
19. Shimizu S, Kagawa S, Nakao K, Wakabayashi S, Mimura K, Matsuoka A: Effect of iodoacetic acid on maintenance of pancreatic endocrine cells of the neonatal rat. Endocrinol Jpn 31:253-261, 1984
20. Beattie GM, Lappi DA, Baird A, Hayek A: Functional impact of attachment and purification in the short-term culture of human pancreatic islets. J Clin Endocrinol Metab 73:93-98, 1991
21. Beattie GM, Butler C, Hayek A: Morphology and function of cultured human fetal pancreatic cells transplanted into athymic mice: a longitudinal study. Cell Transplant 3:421-425, 1994
22. Cirulli V, Baetens D, Rutishauser U, Halban PA, Orci L, Rouiller DG: Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J Cell Sci 107:1429-1436, 1994
23. Otonkoski T, Cirulli V, Beattie GM, Mally MI, Soto G, Rubin JS, Hayek A: A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic β-cell growth. Endocrinology 137:3131-3139, 1996
24. Stoffel M, Stein R, Wright CVE, Espinoza R III, Le Beau MM, Bell GI: Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1. Genomics 28:125-126, 1995
25. Bouwens L, Wang R, DeBlay E, Pipeleers DG, Kloppel G: Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 43:1279-1283, 1994
26. Cattoretti G, Becker MHG, Key G, Duchrow M, Schluter C, Gallet J, Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:357-363, 1992
27. Viac J, Reano A, Brochier J, Staquet MJ, Thivolet J: Reactivity pattern of a monoclonal antikeratin antibody, KL1. J Invest Dermatol 81:351-354, 1983