Adenoviral transfection of isolated pancreatic islets: A study of programmed cell death (apoptosis) and islet function

Journal of Surgical Research

Volumn 69, Issue 1, 1997, Pages 23-32

  Weber, Markus ^a   Deng, Shaoping ^a   Kucher, Taras ^a   Shaked, Abraham ^a   Ketchum, Robert J ^a   Brayman, Kenneth L ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GENE PRODUCT;

APOPTOSIS; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; CONFERENCE PAPER; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; PANCREAS ISLET; PRIORITY JOURNAL; TARGET CELL; VIRUS INFECTION;

EID: 0031127357     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1997.4995     Document Type: Conference Paper

References (48)

1. 1. Kolodka, T. M., Finegold, M., Moss, L., and Woo, S. L. C. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc. Natl. Acad. Sci. USA 92: 3293, 1995.
2. 2. Kay, M. A., and Woo, S. L. C. Gene therapy for metabolic disorders. Trends Genet. 10: 253, 1994.
3. 3. Csete, M. E., Drazan, K. E., Van Bree, M., McIntee, D. F., McBride, W. H., Bett, A., Graham, F. L., Busuttil, W. R., Berk, A. J., and Shaked, A. Adenovirus-mediated gene transfer in the transplant setting. I. Conditions for expression of transferred genes in cold-preserved hepatocytes. Transplantation 57: 1502, 1994.
4. 4. Shaked, A., Csete, M. E., Drazan, K. E., Bullington, D., Wu, L., Busuttil, W. R., and Berk, A. J. Adenovirus-mediated gene transfer in the transplant setting. II. Successful expression of transferred cDNA in syngeneic liver grafts. Transplantation 57: 1508, 1994.
5. 5. Qin, L., Chavin, K. D., Ding, Y. D., Woodward, J. E., Favaro, J. P., Lin, J., and Bromberg, J. Gene transfer for transplantation - Prolongation of allograft survival with transforming growth factor-β1. Ann. Surg. 220: 508, 1994.
6. 6. Marshall, E., et al. Gene therapy's growing pains. Science 269: 1050-1055, 1995.
7. 7. Wilson, J. A. M. Adenoviruses as gene-delivery vehicles. N. Engl. J. Med. 334: 1185, 1996.
8. 8. Zhang, W. W., Alemany, R., Wang, J., Koch, P. E., Ordonez, N. G., and Roth, J. A. Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Hum. Gene Ther. 6: 155, 1995.
9. 9. Mittereder, N., Yei, S., Bachurski, C., Cuppoletti, J., Whitsett, J. A., Tolstoshev, P., and Trapnell, B. C. Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5: 717, 1994.
10. 10. Leiden, J. M. Gene therapy - Promise, pitfalls, and prognosis. N. Engl. J. Med. 333: 871, 1995.
11. 11. Tropea, F., Troiano, L., Monti, D., Lovato, E., Malorni, W., Rainaldi, G., Mattana, P., Viscomi, G., Ingletti, M. C., Portolani, M., Cermelli, C., Cossarizza, A., and Franceschi, C. Sendai virus and herpes virus type 1 induce apoptosis in human peripheral blood mononuclear cells. Exp. Cell Res. 218: 63, 1995.
12. 12. Hinshaw, V. S., Olsen, C. W., Dybdahl-Sissoko, N., and Evans, D. Apoptosis: A mechanism of cell killing by influenza A and B viruses. J. Virol. 68: 3667, 1994.
13. 13. Ho, D. Y., Fink, S. L., Lawrence, M. S., Meier, T. J., Saydam, T. C., Dash, R., and Sapolsky, R. M. Herpes simplex virus vector system: Analysis of its in vivo and in vitro cytopathic effects. J. Neurosci. Methods 57: 205, 1995.
14. 14. Korbutt, G. S., Smith, D. K., Rajotte, R. V., and Elliott, J. F. Expression of β-Galactosidase in mouse pancreatic islets by adenoviral-mediated gene transfer. Transplant. Proc. 27: 3414, 1995.
15. 15. Csete, M. E., Afra, R., Mullen, Y., Drazan, K. E., Benhamou, P. Y., and Shaked, A. Adenoviral-mediated gene transfer to pancreatic islets does not alter islet function. Transplant. Proc. 26: 756, 1994.
16. 16. Csete, M. E., Benhamou, P. Y., Drazan, K. E., Wu, L., McIntee, D. F., Afra, R., Mullen, Y., Busuttil, R. W., and Shaked, A. Efficient gene transfer to pancreatic islets mediated by adenoviral vectors. Transplantation 59: 263, 1995.
17. 17. Arends, J. M., Morris, R. G., and Wyllie, A. H. Apoptosis - The role of the endonuclease. Am. J. Pathol. 136: 593, 1990.
18. 18. Rao, L., Debbas, M., Sabbatini, P., Hockenbery, D., Korsmeyer, S., and White, E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl. Acad. Sci. USA 89: 7742, 1992.
19. 19. Shen, Y., and Shenk, T. E. Viruses and apoptosis. Curr. Opin. Genet. Dev. 5: 105, 1995.
20. 20. Teramoto, S., Johnson, G. L., Huang, W., Leigh, M. W., and Boucher, R. C. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Hum. Gene Ther. 6: 1045, 1995.
21. 21. Schulick, A. H., Newman, K. D., Virmani, R., and Dichek, D. A. In vivo gene transfer into injured carotid arteries: Optimization and evaluation of acute toxicity. Circulation 91: 2407, 1995.
22. 22. Markmann, J. F., Posselt, A. M., Bassiri, H., Brayman, K. L., Woehrle, M., Hickey, W. F., Silvers, W. K., Barker, C. F., and Naji, A. Major-histocompatibility-complex restricted and non-restricted autoimmune effector mechanism in BB rats. Transplantation 52: 662, 1991.
23. 23. Lacy, P. E., Walker, M. M., and Fink, C. J. Perifusion of isolated rat islets in vitro. Diabetes 21: 987, 1972.
24. 24. Holmes, M. A., Clayton, H. A., Chadwick, D. R., Bell, P. R. F., London, N. J. M., and James, R. F. Functional studies of rat, porcine, and human pancreatic islets cultured in ten commercially available media. Transplantation 60: 854, 1995.
25. 25. Wyllie, A. H. Cell death: A new calssification separating apoptosis from necrosis. In I. D. Bowen and R. A. Lockshin (Eds.), Cell Death in Biology and Pathology. New York: Chapman & Hall, 1981. Pp. 9-34.
26. 26. Takasu, N., Komiya, I., Asawa, T., Nagasawa, Y., and Yamada, T. Streptozocin- and alloxan-induced H2O2 Generation and DNA fragmentation in pancreatic islets. Diabetes 40: 1141, 1991.
27. 27. Ankarcrona, M., Dypbukt, J. M., Brune, B., and Nicotera, P. Interleukin-1β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp. Cell Res. 213: 172, 1994.
28. 28. Kaneto, H., Fujii, J., Seo, H. G., Suzuki, K., Matsuoka, T., Nakamura, M., Tatsumi, H., Yamasaki, Y., Kamada, T., and Taniguchi, N. Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 44: 733, 1995.
29. 29. Scaglia, L., Smith, F. E., and Bonner-Weir, S. Apoptosis contributes to the involution of β cell mass in the post partum rat pancreas. Endocrinology 136: 5461, 1995.
30. 30. Nagata, S., and Golstein, P. The Fas death factor. Science 267: 1449, 1995.
31. 31. Zheng, L., Fisher, G., Miller, R. E., Peschon, J., Lynch, D. H., and Lenardo, M. J. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature 377: 348, 1995.
32. 32. Dunger, A., Cunningham, J. M., Delaney, C. A., Lowe, J. E., Green, M. H. L., Bone, A. J., and Green, I. C. Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Diabetes 45: 183, 1996.
33. 33. Stassi, G., Todaro, M., Richiusa, P., Giordano, M., Mattina, A., Sbriglia, M. S., Lo Monte, A., Buscemi, G., Galluzzo, A., and Giordano, C. Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro. Trans. Proc. 27: 3271, 1995.
34. 34. Stassi, G., Todaro, M., Richiusa, P., De Maria, R., Giordano, M., Mattina, A., Sbriglia, M. S., Galluzzo, A., and Giordano, C. Triggering of Fas (Apo-1/CD95)-induced apoptosis in human pancreatic β-cells. Diabetes 45(Suppl. 2): 240A, 1996.
35. 35. White, E., and Gooding, L. R. Regulation of apoptosis by human adenovirus. In L. D. Tomei and F. O. Cope (Eds.), Apoptosis II: The Molecular Basis of Apoptosis in Disease. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1994. Pp. 111-141.
36. 36. White, E., Cipriani, R., Sabbatini, P., and Denton, A. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins. J. Virol. 65: 2968, 1991.
37. 37. Chen, M. J., Holskin, B., Strickler, J., Gorniak, J., Clark, M. A., Johnson, P. J., Mitcho, M., and Shalloway, D. Induction by E1A oncogen expression of cellular susceptibility to lysis by TNF. Nature 330: 581, 1987.
38. 38. Duerksen-Hughes, P. J., Wold, W. S. M., and Gooding, L. R. Adenovirus E1A renders infected cells sensitive to cylolysis by tumor necrosis factor. J. Immunol. 143: 4193, 1989.
39. 39. Duerksen-Hughes, P. J., Hermiston, T. W., Wold, W. S. M., and Gooding, L. R. The amino terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to TNF cytolysis in adenovirus infected mouse cells. J. Virol. 65: 1236, 1991.
40. 40. Gooding, L. R., Ranheim, R., Tollefson, A. E., Aquino, L., Duerksen-Hughes, P. J., Horton, T. M., and Wold, W. S. M. The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor. J. Virol. 65: 4114, 1991.
41. 41. Hashimoto, S., Ishii, A., and Yonehara, S. The E1B oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody. Int. Immunol. 3: 343, 1991.
42. 42. White, E., Sabbatini, P., Debbas, M., Wold, W. S. M., Kusher, D. I., and Gooding, L. The 19-kilodalton adenovirus E1B transforming proteins inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha. Mol. Cell. Biol. 12: 2570, 1992.
43. 43. Lochmueller, H., Jani, A., Huard, J., Prescott, S., Simoneau, M., Massie, B., Karpati, G., and Acsadi, G. Emergence of early region 1-containing replication-competent adenovirus in stocks of replication-defective adenovirus recombinants (E1 + E3) during multiple passages in 293 cells. Hum. Gene Ther. 5: 1485, 1994.
44. 44. Bursch, W., Kleine, L., and Tenniswood, M. The biochemistry of cell death by apoptosis. Biochem. Cell Biol. 68: 1071, 1990.
45. 45. Bursch, W., Paffe, S., Putz, B., Barthel, G., and Schulte-Hermann, R. Determination of length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carciogenesis 11: 847, 1990.
46. 46. Qin, L., Chavin, K. D., Ding, Y. D., Woodward, J. E., Favaro, J. P., Lin, J., and Bromberg, J. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model: Immunosuppression with TGF-β or vIL-10. Transplantation 59: 809, 1995.
47. 47. Qin, L., Chavin, K. D., Ding, Y. D., Woodward, J. E., Favaro, J. P., Lin, J., and Bromberg, J. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J. Immunol. 156: 2316, 1996.
48. 48. Deng, S., Ketchum, R. J., Kucher, T., Weber, M., Shaked, A., Naji, A., and Brayman, K. L. Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine gene abrogates primary non-function and prolongs graft survival. Trans. Proc. 29: 770, 1997.