A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

Nature Genetics

Volumn 19, Issue 3, 1998, Pages 292-296

  Concannon, Patrick ^a,b   Gogolin Ewens, Kathryn J ^c   Hinds, David A ^d   Wapelhorst, Beth ^a,b   Morrison, V Anne ^a,b   Stirling, Brigid ^a,b   Mitra, Mirna ^e   Farmer, Jennifer ^c   Williams, Sloan R ^c   Cox, Nancy J ^e   Bell, Graeme I ^e   Risch, Neil ^d   Spielman, Richard S ^c  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d STANFORD UNIVERSITY   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 1Q; CHROMOSOME 6P; CHROMOSOME 6Q; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 1; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOME, HUMAN; HUMANS; LINKAGE (GENETICS);

EID: 17344372511     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/985     Document Type: Article

References (33)

1. Davies, J.L. et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371, 130-135 (1994).
2. Hashimoto, L. et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371, 161-164 (1994).
3. Thomson, G., Robinson, W.P., Kuhner, M.K., Joe, S. & Klitz, W. HLA, insulin gene, and Gm associations with IDDM. Genet. Epidemiol. 6, 155-160 (1989).
4. Julier, C. et al. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 354, 155-159 (1991).
5. Morahan, G., Huang, D., Tait, B.D., Colman, P.G. & Harrison, L.C. Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. Science 272, 1811-1813 (1996)
6. Nisticò, L. et al. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Hum. Mol. Genet. 5, 1075-1080 (1996).
7. Field, L.L, Tobias, R. & Magnus, T. A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. Nature Genet. 8, 189-194 (1994).
8. Luo, D.-F. et al. Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-27. Am. J. Hum. Genet. 57, 911-919 (1995).
9. Field, L.L, Tobias, R., Thomson, G. & Plon, S. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (1DDM11) on human chromosome 14q24.3-q31. Genomics 33, 1-8 (1996).
10. Delépine, M. et al. Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. Am. J. Hum. Genet. 60, 174-187 (1997).
11. Laporte, R.E., Matsushima, M. & Chang, Y.-F. Prevalence and incidence of insulin-dependent diabetes, in Diabetes in America, (eds Harris, M.I. et al.) 37-45 (NIH Publication No. 95-1468, 1995).
12. Nerup, J. et al. HL-A antigens and diabetes mellitus. Lancet 2, 864-866 (1974).
13. Cudworth, A.G. & Woodrow, J.C Evidence for HLA linked genes in juvenile diabetes mellitus. B.M.J. 3, 133-135 (1975).
14. Thomson, G. A two locus model for juvenile diabetes. Ann. Hum. Genet. 43, 383-398 (1980).
15. Risch, N. Assessing the role of HLA-linked and unlinked determinants of disease. Am. J. Hum. Genet. 40, 1-14 (1987).
16. Bell, G.I., Horita, S. & Karam, J.H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33, 176-183 (1984).
17. Owerbach, D. & Gabbay, K.H. The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes. Diabetes 44, 132-136 (1995).
18. Rowe. R.E. et al. Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Nature Genet. 10, 240-242 (1995).
19. Luo, D.-F. et al. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4. IDDM5 and IDDM8. Hum. Mol. Genet. 5, 693-698 (1996).
20. Davies, J.L. et al. Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes. Hum. Mol. Genet. 5, 1071-1074 (1996).
21. Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
22. Spielman, R.S., McGinnis, R.E. & Ewens, W.J. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus. Am. J. Hum. Genet. 52, 506-516 (1993).
23. Copeman, J.B. et al. Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nature Genet. 9, 80-85 (1995).
24. Owerbach, D. et al. Analysis of candidate genes for susceptibility to type 1 diabetes. A case-control and family association study of genes on chromosome 2q31-35. Diabetes 46, 1069-1074 (1997).
25. Zamani, M., Pociot, F., Raeymaekers, P., Nerup, J. & Cassiman, J.J. Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population. Hum. Genet. 98, 491-496 (1996).
26. Risch, N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am. J. Hum. Genet. 46, 242-253 (1990).
27. Rich, S.S. Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 39, 1315-1319 (1990).
28. Lernmark, A. et al. Family cell lines available for research. Am. J. Hum. Genet. 47, 1028-1030 (1990).
29. Bain, S.C., Todd, J.A. & Barnett, A.H. The British Diabetic Association - Warren Repository. Autoimmunity 7, 83-85 (1990).
30. Cox, N.J., Baker, L. & Spielman, R.S. Insulin gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage. Am. J. Hum. Genet. 42, 167-172 (1988).
31. Holmans, P. & Craddock, N. Efficient strategies for genome scanning using maximum- likelihood affected-sib-pair analysis. Am. J. Hum. Genet. 60, 657-666 (1997).
32. Schwab, S.G. et al. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genet. 11, 325-327 (1995).
33. Hauser, E.R., Boehnke, M., Guo, S.-W. & Risch, N. Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet. Epidemiol. 13, 117-137 (1996).