Intramuscular Administration of Expression Plasmids Encoding Interferon-γ Receptor/IgG1 or IL-4/IgG1 Chimeric Proteins Protects from Autoimmunity

Journal of Gene Medicine

Volumn 1, Issue 6, 1999, Pages 415-423

  Chang, Yigang ^a   Prud'homme, Gérald J ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Autoimmunity; Diabetes; Interferon ; Interferon receptor; Interleukin 4; Intramuscular; Naked DNA

Indexed keywords

MURINAE;

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERFERON RECEPTOR; INTERLEUKIN 4; RECOMBINANT DNA; SYNTHETIC DNA;

ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; DRUG EFFECT; FEMALE; GENE THERAPY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; INTRAMUSCULAR DRUG ADMINISTRATION; MACROPHAGE; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PANCREATITIS; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DIABETES MELLITUS, TYPE 1; DNA, RECOMBINANT; FEMALE; GENE THERAPY; GENES, SYNTHETIC; GENETIC VECTORS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; INTERFERON TYPE II; INTERLEUKIN-4; ISLETS OF LANGERHANS; MACROPHAGES; MICE; MICE, INBRED NOD; PANCREATITIS; RECEPTORS, INTERFERON; RECOMBINANT FUSION PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSFECTION;

EID: 0033222419     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-2254(199911/12)1:6<415::AID-JGM66>3.0.CO;2-B     Document Type: Article

References (29)

1. De Maeyer E, De Maeyer-Guignard J. Interferons. In The Cytokine Handbook, Thomson A (ed). San Diego: Academic Press, 1998; 491-516.
2. Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infections, neoplastic, and inflammatory diseases. Clin Microbiol Rev 1996; 9: 532-562.
3. Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diab Metab Rev 1998; 14: 129-151.
4. Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1997; 7: 727-738.
5. O'Garra A, Steinman L, Gijbels K. CD4 + T-cell subsets in autoimmunity. Curr Opin Immunol 1997; 9: 872-883.
6. Nicoletti F, Zaccone P, Di Marco R, et al. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology 1996; 137: 5567-5575.
7. Prud'homme GJ, Chang Y. Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein. Gene Ther 1999; 6: 771-777.
8. Rothe H, Faust A, Schade U, et al. Cyclophosphamide treatment of female NOD mice causes enhanced expression of inducible nitric oxide synthase and interferon-γ, but not IL-4. Diabetologia 1994; 37: 1154-1158.
9. Piccirillo C, Chang Y, Prud'homme GJ. Transforming growth factor bera-1 (TGF-bera-1) somatic gene therapy prevents autoimmune disease in NOD mice. J Immunol 1998; 161: 3950-3956.
10. Cameron MJ, Arreaza GA, Zucker P, et al. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T-helper-2 cell function. J Immunol 1997; 159: 4686-4692.
11. Zheng XX, Steele AW, Hancock WW, et al. A noncytolytic IL-10/ Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J Immunol 1997; 158: 4507-4513.
12. Nitta Y, Tashiro F, Tokui M. Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum Gene Ther 1998; 9: 1701-1707.
13. Haworth C, Maini RN, Feldmann M. Cytokine and anti-cytokine therapy. In The Cytokine Handbook, Thomson A (ed). San Diego: Academic Press, 1998, 777-801.
14. Prud'homme GJ, Kono DH, Theofilopoulos AN. Quantitative polymerase chain reaction analysis reveals marked overexpression of IL-1-beta, IL-10, and interferon-γ in the lymph nodes of lupus-prone mice. Mol Immunol 1995; 32: 495-503.
15. Hartikka J, et al. An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum Gene Ther 1996; 7: 1205-1217.
16. Coligan JE, Kruisbeek AM, Margulies DH, et al. Current Protocols in Immunology. New York: John Wiley and Sons; 1991 (Suppl. 8), 8.10.1-8.10.17.
17. 2 production as a sensitive and rapid assay for quantitation of murine IFN-γ. J Immunol Methods 1991; 139: 107-114.
18. Prud'homme GJ, Bocarro DC, Luke ECH. Clonal deletion and autoreactivity in extrathymic CD4-CD8-(double negative) T-cell receptor alpha/beta T cells. J Immunol 1991; 147: 3314-3318.
19. Kürschner C, Ozmen L, Garotta G, Dembic Z. IFN-γ receptor-Ig fusion proteins. Half-life, immunogenecity and in vivo activity. J Immunol 1992; 144: 4096-4100.
20. Wang B, Andre I, Gonzalez A, et al. Interferon-γ impacts at multiple points during the progression of autoimmune diabetes. Proc Natl Acad Sci U S A 1997; 94: 13844-13849.
21. Hultgren B, Huang X, Dybdal N, Stewart TA. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 1996; 45: 812-817.
22. Campbell IL, Kay TW, Oxbrow L, Harrison LC. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest 1991; 87: 739-742.
23. Sarvetnick N, Shizuru J, Liggitt D, et al. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-γ. Nature 1990; 346: 844-847.
24. Yoon JW, Jun HS, Santamania P. Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 1998; 27: 109-122.
25. Mueller R, Krahl T, Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 1996; 184: 1093-1099.
26. Mueller R, Bradley LM, Krahl T, Sarvetnick N. Mechanism underlying counterregulation of autoimmune diabetes by IL-4. Immunity 1997; 7: 411-418.
27. Ishii KJ, Weiss WR, Ichino M, Verthelyi D, Klinman DM. Activity and safety of DNA plasmids encoding IL-4 and IFN gamma. Gene Ther 1999; 6: 237-244.
28. Haak-Frendscho M, et al. Inhibition of interferon-γ by an interferon-γ receptor immunoadhesin. Immunology 1993; 79: 594-599.
29. Kürschner C, Garotta G, Dembic Z. Construction, purification, and characterization of new interferon γ inhibitor proteins. J Biol Chem 1992; 267: 9354-9360.