Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies

Transplant Immunology

Volumn 10, Issue 1, 2002, Pages 63-72

  Mottram, Patricia L ^a   Murray Segal, Lisa J ^b   Han, Wenruo ^c   Maguire, Julie ^d   Stein Oakley, Alicia N ^d  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

Author keywords

Anti CD3; NOD; Pancreas transplants; Recent onset diabetes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 145 2C11; MONOCLONAL ANTIBODY 53 6 7; MONOCLONAL ANTIBODY CD3; MONOCLONAL ANTIBODY GK1 5; MONOCLONAL ANTIBODY H129 19; MONOCLONAL ANTIBODY KT3; OKT 4; OKT 8; UNCLASSIFIED DRUG; CD3 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; DEATH; DIABETES MELLITUS; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; GRAFT SURVIVAL; HISTOLOGY; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; ISOGRAFT; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET DISEASE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RECURRENT DISEASE; REMISSION; T LYMPHOCYTE ACTIVATION; VASCULAR DISEASE; ANIMAL; IMMUNOLOGY; NONOBESE DIABETIC MOUSE; NUDE MOUSE; PANCREAS ISLET; PANCREAS TRANSPLANTATION; PHYSIOLOGY;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; DIABETES MELLITUS, INSULIN-DEPENDENT; FEMALE; GRAFT SURVIVAL; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; MICE, NUDE; PANCREAS TRANSPLANTATION; SUPPORT, NON-U.S. GOV'T; TRANSPLANTATION, ISOGENEIC; ANIMALS; DIABETES MELLITUS, TYPE 1;

EID: 0036023129     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(02)00050-3     Document Type: Article

References (38)

1. Genetic control of autoimmunity in type 1 diabetes
2. What causes diabetes?
3. Tolerance to islet autoantigens in type 1 diabetes
4. The genetics and epidemiology of diabetes in NOD mice
5. Diabetes results from a late change in the autoimmune response of NOD mice
6. Anti-CD4 monoclonal antibodies in therapy: Creation of nonclassical tolerance in the adult
7. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
8. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
9. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: Studies using NOD/CIITA-deficient mice
10. The role of CD8+ cells, cell degeneration, and Fas ligand in insulitis after intraperitoneal transfer of NOD splenocytes
11. Over expression of natural killer T cells protects Valpha14-Jalpha281 transgenic nonobese diabetic mice against diabetes
12. Remission of established disease in diabetic NOD mice induced by anti-CD3 monoclonal antibody
13. Long-term abrogation of autoimmune diabetes in nonobese diabetic mice by immunotherapy with anti-lymphocyte serum
14. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
15. Identification of a monoclonal antibody specific for a murine T3 polypeptide
16. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex
17. Characterisation of the murine T cell surface molecule, designated L3T4, identified by the monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu-3/T4 molecule
18. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens
19. Microsurgical techniques for transplantation of vascularised organs in mice
20. Long-term survival of segmental pancreas isografts in NOD/Lt mice treated with anti-CD4 and anti-CD8 monoclonal antibodies
21. Idarubicin anti-CD3: A new immunoconjugate that induces alloantigen-specific tolerance in mice
22. A comparison of organ cultured fetal pancreas allo-, iso-, and xenografts (pig) in non-immunosuppressed non-obese diabetic mice
23. Positive versus negative signaling by lymphocyte antigen receptors
24. Beta cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model
25. Histochemical characterisation of monocytes-macrophages and dendritic calls involved in the initiation of insulitis and beta cell destruction in NOD mice
26. Autoimmune diabetes: Involvement of benign and malignant autoimmunity
27. Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice
28. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice
29. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice
30. B lymphocytes influence the shape of the mature preimmune CD4+ TCR repertoire
31. Impaired CD4 T cell activation due to reliance upon B cell-mediated costimulation in nonobese diabetic (NOD) mice
32. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis
33. Differential ability of T cell subsets to undergo activation-induced cell death
34. Constitutive impaired TCR/CD3-mediated activation of T cells in IDDM patients co-exist with normal co-stimulation pathways
35. Nondepleting anti-CD4 has an immediate action on diabetogenic effector cells, halting their destruction of pancreatic beta cells
36. Protective insulitis