Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

Journal of Clinical Investigation

Volumn 107, Issue 5, 2001, Pages 555-564

  Pugliese, Alberto ^a   Brown, Douglas ^a   Garza, David ^a   Murchison, Djanira ^a   Zeller, Markus ^a   Redondo, Maria ^b   Diez, Juan ^a   Eisenbarth, George S ^b   Patel, Dhavalkumar D ^c   Ricordi, Camillo ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; INSULIN; PROTEIN TYROSINE PHOSPHATASE;

ADOLESCENT; ADULT; AGED; ANTIGEN PRESENTING CELL; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DIABETES MELLITUS; DISEASE PREDISPOSITION; FEMALE; FETUS; HUMAN; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOID ORGAN; MACROPHAGE; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; THYMUS; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

EID: 0035089893     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10860     Document Type: Article

References (48)

1. Immunological tolerance
2. T-cell tolerance
3. Intrathymic and extrathymic clonal deletion of T cells
4. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
5. A license to kill
6. Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
7. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells
8. Dendritic cells in the Tceil areas of lymphoid organs
9. Unraveling the generics of insulin-dependent type 1A diabetes: The search must go on
10. Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system
11. Insulin gene expression and insulin synthesis in mammalian neuronal cells
12. Preproinsulin messenger ribonucleic acid in the rat adrenal gland
13. Preproinsulin mRNA in the rat eye
14. Control of immune pathology by regulatory T cells
15. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-DM2 susceptibility locus for type 1 diabetes
16. Insulin expression in the thymus is modulated by INS VNTR alleles at the IDDM2 locus
17. Transcription of a broad range o f self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens
18. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus
19. Intrathymic expression of genes involved in organ specific autoimmune disease
20. Aberrant expression of tissue-specific proteins in the thymus: A hypothesis for the development of central tolerance
21. Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
22. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
23. Generation of functional thymocytes in the human adult
24. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla
25. Pancreatic gone expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
26. Pancreatic hormone expression in the murine thymus: Localization in dendritic cells and macrophages
27. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
28. Natural and induced apoptosis during lymphocyte development in the axolotl
29. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor
30. Role of CD8alpha+ and CD8alpha-dendritic cells in the induction of primary immune responses in vivo
31. Thymic dendritic cells
32. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse
33. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
34. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
35. Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes
36. An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis
37. Insulin gene expression and imprinting in pancreas and lymphoid organs
38. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
39. Escape from tolerance in the human x-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse
40. Positive and negative thymocyte selection induced by different concentrations of a single peptide
41. Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels
42. Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis
43. Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 IDDM autoantigen
44. Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer
45. Immunotherapy of NOD mice with bone marrow-derived dendritic cells
46. Transfer of dendritic cells (DC) ex vivo stimulated with interferongamma (1FN-gamma) down-modulates autoimmune diabetes in nonobese diabetic (NOD) mice
47. Progressive islet graft failure occurs significantly earlier in autoantibody-positive than in autoantibody-negative IDDM recipients of intrahepatic islet allografts
48. Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients