Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion

Gene Therapy

Volumn 6, Issue 6, 1999, Pages 1160-1169

  Dupraz, P ^a   Rinsch, C ^b   Pralong, W F ^c   Rolland, E ^c   Zufferey, R ^d   Trono, D ^d   Thorens, B ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b University of Lausanne Medical Center   (Switzerland)

^c Modex Therapeutiques   (Switzerland)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Diabetes; Gene therapy; Hypoxia; Insulin; Lentiviral vector

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INSULIN; INTERLEUKIN 1BETA; PROTEIN BCL 2; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL TRANSPLANTATION; GENE THERAPY; GENETIC ENGINEERING; HYPERGLYCEMIA; HYPOXIA; INSULIN RELEASE; KIDNEY CAPSULE; LENTIVIRINAE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTO ONCOGENE; STREPTOZOCIN DIABETES;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BLOTTING, WESTERN; CELL HYPOXIA; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, TYPE 1; GENETIC VECTORS; HUMANS; INSULIN; LENTIVIRUS; MALE; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2;

ANIMALIA; LENTIVIRUS; MURINAE; RNA VIRUSES;

EID: 0032984806     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300922     Document Type: Article

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