Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

Diabetes

Volumn 46, Issue 1, 1997, Pages 34-39

  French, Michelle B ^a   Allison, Janette ^a   Cram, David S ^a   Thomas, Helen E ^a   Dempsey Collier, Majella ^a   Silva, Anabel ^a   Georgiou, Harry M ^a   Kay, Thomas W ^a   Harrison, Leonard C ^a,b   Lew, Andrew M ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROINSULIN;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0031025574     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.1.34     Document Type: Article

References (35)

1. Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15:516-542, 1994
2. Kikutani H, Makino S: The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 51:285-322, 1992
3. Harrison LC: Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited. Immunol Today 13:348-352, 1992
4. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL: Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337-1339, 1983
5. Dean BM, Becker F, McNally JM, Tarn AC, Schwartz G, Gale EAM, Bottazzo GF: Insulin autoantibodies in the pre-diabetic period: correlation with islet cell antibodies and development of diabetes. Diabetologia 29:339-342, 1986
6. Vardi P, Ziegler AG, Mathews JH, Dib S, Keller RJ, Ricker AT, Wolfsdorf JI, Herskowitz RD, Rabizadeh A, Eisenbarth GS, Soeldner JS: Concentration of insulin autoantibodies at onset of type I diabetes: inverse log-linear correlation with age. Diabetes Care 11:736-739, 1988
7. Harrison LC, Chu SX, DeAizpurua HJ, Graham M, Honeyman MC, Colman PG: Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes. J Clin Invest 89:1161-1165, 1992
8. Rudy G, Stone N, Harrison LC, Colman PG, McNair P, Brusic V, French MB, Honeyman MC, Tait B, Lew AM: Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med 1:625-633, 1995
9. Ziegler AG, Vardi P, Ricker AT, Hattori M, Soeldner JS, Eisenbarth GS: Radioassay determination of insulin autoantibodies in NOD mice: correlation with increased risk of progression to overt diabetes. Diabetes 38:358-363, 1989
10. Wegmann DR, Norbury-Glaser M, Daniel D: Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 24:1853-1857, 1994
11. Daniel D, Gill RG, Schloot N, Wegmann D: Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 25:1056-1062, 1995
12. Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL: Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 88:10252-10256, 1991
13. Atkinson MA, Maclaren NK, Luchetta R: Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39:933-937, 1990
14. Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N: Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J Clin Invest 95:628-634, 1995
15. Miller JFAP, Heath WR: Self-ignorance in the peripheral T-cell pool. Immunol Rev 133:131-150, 1993
16. Kisielow P, von Boehmer H: Development and selection of T cells: fact and puzzles. Adv Immunol 58:87-209, 1995
17. Ziegler AG, Hillebrand B, Rabl W, Mayrhofer M, Hummel M, Mollenhauer U, Vordemann J, Lenz A, Standl E: On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia 36:402-408, 1993
18. Wentworth BM, Schaefer IM, Villa-Komaroff L, Chirgwin JM: Characterization of the two nonallelic genes encoding mouse preproinsulin. J Mol Evol 23:305-312, 1986
19. Alderuccio F, Toh BH, Tan SS, Gleeson PA, van Driel IR: An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. J Exp Med 178:419-426, 1993
20. Jolicoeur C, Hanahan D, Smith KM: T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc Natl Acad Sci USA 91:6707-6711, 1994
21. Steiner DF, Fox N, Smeekens SP, Ohagi S, Westermark G, Chan SJ: New molecular perspectives in islet hormone biosynthesis. Biochem Soc Trans 21:139-142, 1993
22. Galloway JA, Hooper SA, Spradlin CT, Howey DC, Frank BH, Bowsher RR, Anderson JH: Biosynthetic human proinsulin: review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience. Diabetes Care 15:666-692, 1992
23. Harada M, Makino S: Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide. Diabetologia 27:604-606, 1984
24. Charlton B, Bacelj A, Slattery RM, Mandel TE: Cyclophosphamide-induced diabetes in NOD/WEHI mice: evidence for suppression in spontaneous autoimmune diabetes mellitus. Diabetes 38:441-447, 1989
25. Nomura Y, Stein E, Mullen Y: Prevention of overt diabetes and insulitis by intrathymic injection of syngeneic islets in newborn nonobese diabetic (NOD) mice. Transplantation 56:638-642, 1993
26. Charlton B, Taylor-Edwards C, Tisch R, Fathman CG: Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD mice. J Autoimmunity 7:549-560, 1994
27. Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72-75, 1993
28. Birk OS, Douek DC, Elias D, Takacs K, Dewchand H, Gur SL, Walker MD, van der Zee R, Cohen IR, Altmann DM: The role of Hsp 60 in autoimmune diabetes: analysis of a transgenic model. Proc Natl Acad Sci USA 93:1032-1037, 1996
29. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GSP, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69-72, 1993
30. Chen SL, Whiteley PJ, Freed DC, Rothbard JB, Peterson LB, Wicker LS: Responses of NOD congenic mice to a glutamic acid decarboxylase-derived peptide. J Autoimmunity 7:635-641, 1994
31. Lohmann T, Leslie RDG, Hawa M, Geysen M, Rodda S, Londei M: Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet 343:1607-1608, 1994
32. Sprent J, Hurd M, Schaefer M, Heath W: Split tolerance in spleen chimeras. J Immunol 154:1198-1206, 1995
33. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:34-38, 1995
34. Katz JD, Beniost C, Mathis D: T helper cell subsets in insulin-dependent diabetes. Science 268:1185-1188, 1995
35. Harrison LC, Dempsey-Collier M: Aerosol insulin induces regulatory T cells that retard the development of insulin-dependent diabetes (Abstract). Autoimmunity 21:51, 1995