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Volumn 75, Issue 5, 1997, Pages 327-340

The β cell transcription factors and development of the pancreas

Author keywords

cell; development; insulin; islet; pancreas; PDX 1; transcription

Indexed keywords

INSULIN; TRANSCRIPTION FACTOR;

EID: 0030927342     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050118     Document Type: Review
Times cited : (287)

References (129)
  • 2
    • 0021111938 scopus 로고
    • Expression of the human insulin gene in an alternate mammalian cell and in cell extracts
    • Laub O, Rall L, Bell GI, Rutter WJ (1983) Expression of the human insulin gene in an alternate mammalian cell and in cell extracts. J Biol Chem 258:6037-6042
    • (1983) J Biol Chem , vol.258 , pp. 6037-6042
    • Laub, O.1    Rall, L.2    Bell, G.I.3    Rutter, W.J.4
  • 3
    • 0020633329 scopus 로고
    • Expression of the human insulin gene and cDNA in a heterologous mammalian system
    • Laub O, Rutter WJ (1983) Expression of the human insulin gene and cDNA in a heterologous mammalian system. J Biol Chem 258:6043-6050
    • (1983) J Biol Chem , vol.258 , pp. 6043-6050
    • Laub, O.1    Rutter, W.J.2
  • 4
    • 0021024216 scopus 로고
    • Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
    • Moore HP, Walker MD, Lee F, Kelly RB (1983) Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Cell 35:531-538
    • (1983) Cell , vol.35 , pp. 531-538
    • Moore, H.P.1    Walker, M.D.2    Lee, F.3    Kelly, R.B.4
  • 8
  • 9
    • 0019456804 scopus 로고
    • The insulin gene is located on the short arm of chromosome 11 in humans
    • Owerbach D, Bell GI, Rutter WJ, Brown JA, Shows TB (1981) The insulin gene is located on the short arm of chromosome 11 in humans. Diabetes 30:267-270
    • (1981) Diabetes , vol.30 , pp. 267-270
    • Owerbach, D.1    Bell, G.I.2    Rutter, W.J.3    Brown, J.A.4    Shows, T.B.5
  • 11
    • 0002466710 scopus 로고
    • Insulin gene structure and regulation
    • Draznin B, Leroith D (eds) Humana. Totowa
    • German M (1994) Insulin gene structure and regulation. In: Draznin B, Leroith D (eds) Molecular biology of diabetes. Humana. Totowa, pp 91-117
    • (1994) Molecular Biology of Diabetes , pp. 91-117
    • German, M.1
  • 12
    • 0013591906 scopus 로고
    • Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus
    • Laimins L, Holmgren-Konig M, Khoury G (1986) Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus. Proc Natl Acad Sci USA 83:3151-3155
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3151-3155
    • Laimins, L.1    Holmgren-Konig, M.2    Khoury, G.3
  • 14
    • 0021071029 scopus 로고
    • Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes
    • Walker MD, Edlund T, Boulet AM, Rutter WJ (1983) Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature 306:557-561
    • (1983) Nature , vol.306 , pp. 557-561
    • Walker, M.D.1    Edlund, T.2    Boulet, A.M.3    Rutter, W.J.4
  • 15
    • 0022377642 scopus 로고
    • Cell-specific expression of the rat insulin gene: Evidence for role of two distinct 5′ flanking elements
    • Edlund T, Walker MD, Barr PJ, Rutter WJ (1985) Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science 230:912-916
    • (1985) Science , vol.230 , pp. 912-916
    • Edlund, T.1    Walker, M.D.2    Barr, P.J.3    Rutter, W.J.4
  • 16
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • Hanahan D (1985) Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115-122
    • (1985) Nature , vol.315 , pp. 115-122
    • Hanahan, D.1
  • 17
    • 0023477391 scopus 로고
    • A mutational analysis of the insulin gene transcription control region: Expression in beta cells is dependent on two related sequences within the enhancer
    • Karlsson O, Edlund T, Moss JB, Rutter WJ, Walker MD (1987) A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci USA 84:8819-8823
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8819-8823
    • Karlsson, O.1    Edlund, T.2    Moss, J.B.3    Rutter, W.J.4    Walker, M.D.5
  • 19
    • 0024596435 scopus 로고
    • Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT cells
    • Crowe DT, Tsai MJ (1989) Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT cells. Mol Cell Biol 9:1784-1789
    • (1989) Mol Cell Biol , vol.9 , pp. 1784-1789
    • Crowe, D.T.1    Tsai, M.J.2
  • 20
    • 0024328366 scopus 로고
    • Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements
    • Whelan J, Poon D, Weil PA, Stein R (1989) Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements. Mol Cell Biol 9:3253-3259
    • (1989) Mol Cell Biol , vol.9 , pp. 3253-3259
    • Whelan, J.1    Poon, D.2    Weil, P.A.3    Stein, R.4
  • 21
    • 0025361461 scopus 로고
    • Positive and negative regulation of the human insulin gene by multiple trans-acting factors
    • Boam DS, Clark AR, Docherty K (1990) Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J Biol Chem 265:8285-8296
    • (1990) J Biol Chem , vol.265 , pp. 8285-8296
    • Boam, D.S.1    Clark, A.R.2    Docherty, K.3
  • 22
    • 0030070145 scopus 로고    scopus 로고
    • Function of the human insulin promoter in primary cultured islet cells
    • Odagiri H, Wang J, German MS (1996) Function of the human insulin promoter in primary cultured islet cells. J Biol Chem 271:1909-1915
    • (1996) J Biol Chem , vol.271 , pp. 1909-1915
    • Odagiri, H.1    Wang, J.2    German, M.S.3
  • 23
    • 0028009846 scopus 로고
    • bHLH factors in muscle development: Dead lines and commitments, what to leave in and what to leave out
    • Olson EN, Klein WH (1994) bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev 8:1-8
    • (1994) Genes Dev , vol.8 , pp. 1-8
    • Olson, E.N.1    Klein, W.H.2
  • 24
    • 0023669153 scopus 로고
    • The achaete-scute gene complex of D. melanogaster: Conserved domains in a subset of genes required for neurogenesis and their homology to myc
    • Villares R, Cabrera CV (1987) The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 50:415-424
    • (1987) Cell , vol.50 , pp. 415-424
    • Villares, R.1    Cabrera, C.V.2
  • 25
    • 0024308990 scopus 로고
    • lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
    • Mellentin JD, Smith SD, Cleary ML (1989) lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58:77-83
    • (1989) Cell , vol.58 , pp. 77-83
    • Mellentin, J.D.1    Smith, S.D.2    Cleary, M.L.3
  • 26
    • 0024554495 scopus 로고
    • A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
    • Murre C, McCaw PS, Baltimore D (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777-783
    • (1989) Cell , vol.56 , pp. 777-783
    • Murre, C.1    McCaw, P.S.2    Baltimore, D.3
  • 27
    • 0028329080 scopus 로고
    • Crystal structure of transcription factor E47:E-box recognition by a basic region helix-loop-helix dimer
    • Ellenberger T, Fass D, Arnaud M, Harrison SC (1994) Crystal structure of transcription factor E47:E-box recognition by a basic region helix-loop-helix dimer. Genes Dev 8:970-980
    • (1994) Genes Dev , vol.8 , pp. 970-980
    • Ellenberger, T.1    Fass, D.2    Arnaud, M.3    Harrison, S.C.4
  • 28
    • 0024025198 scopus 로고
    • Systematic binding analysis of the insulin gene transcription control region: Insulin and immunoglobulin enhancers utilize similar transactivators
    • Moss LG, Moss JB, Rutter WJ (1988) Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators. Mol Cell Biol 8:2620-2627
    • (1988) Mol Cell Biol , vol.8 , pp. 2620-2627
    • Moss, L.G.1    Moss, J.B.2    Rutter, W.J.3
  • 29
    • 2642628564 scopus 로고
    • A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer
    • Ohlsson H, Karlsson O, Edlund T (1988) A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer. Proc Natl Acad Sci USA 85:4228-4231
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4228-4231
    • Ohlsson, H.1    Karlsson, O.2    Edlund, T.3
  • 30
    • 0025822963 scopus 로고
    • Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes
    • Aronheim A, Ohlsson H, Park CW, Edlund T, Walker MD (1991) Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes. Nucleic Acids Res 19:3893-3899
    • (1991) Nucleic Acids Res , vol.19 , pp. 3893-3899
    • Aronheim, A.1    Ohlsson, H.2    Park, C.W.3    Edlund, T.4    Walker, M.D.5
  • 31
    • 0025994835 scopus 로고
    • Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene
    • Shieh SY, Tsai MJ (1991) Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J Biol Chem 266:16708-16714
    • (1991) J Biol Chem , vol.266 , pp. 16708-16714
    • Shieh, S.Y.1    Tsai, M.J.2
  • 32
    • 0028136103 scopus 로고
    • Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription
    • Robinson GL, Peshavaria M, Henderson E, Shieh SY, Tsai MJ, Teitelman G, Stein R (1994) Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription. J Biol Chem 269:2452-2460
    • (1994) J Biol Chem , vol.269 , pp. 2452-2460
    • Robinson, G.L.1    Peshavaria, M.2    Henderson, E.3    Shieh, S.Y.4    Tsai, M.J.5    Teitelman, G.6    Stein, R.7
  • 33
    • 0025292710 scopus 로고
    • Pan: A transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs
    • Nelson C, Shen LP, Meister A, Fodor E, Rutter WJ (1990) Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev 4:1035-1043
    • (1990) Genes Dev , vol.4 , pp. 1035-1043
    • Nelson, C.1    Shen, L.P.2    Meister, A.3    Fodor, E.4    Rutter, W.J.5
  • 34
    • 0026016780 scopus 로고
    • Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind to the insulin enhancer
    • German MS, Blanar MA, Nelson C, Moss LG, Rutter WJ (1991) Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind to the insulin enhancer. Mol Endocinol 5:292-299
    • (1991) Mol Endocinol , vol.5 , pp. 292-299
    • German, M.S.1    Blanar, M.A.2    Nelson, C.3    Moss, L.G.4    Rutter, W.J.5
  • 35
    • 0026331306 scopus 로고
    • Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements
    • Cordle SR, Whelan J, Henderson E, Masuoka H, Weil PA, Stein R (1991) Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements. Mol Cell Biol 11:2881-2886
    • (1991) Mol Cell Biol , vol.11 , pp. 2881-2886
    • Cordle, S.R.1    Whelan, J.2    Henderson, E.3    Masuoka, H.4    Weil, P.A.5    Stein, R.6
  • 36
    • 0026512017 scopus 로고
    • HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
    • Hu JS, Olson EN, Kingston RE (1992) HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Mol Cell Biol 12:1031-1042
    • (1992) Mol Cell Biol , vol.12 , pp. 1031-1042
    • Hu, J.S.1    Olson, E.N.2    Kingston, R.E.3
  • 37
    • 0027960493 scopus 로고
    • Two distinct class A helix-loop-helix transcription factors. E2A and BETA1, form separate DNA binding complexes on the insulin gene E box
    • Peyton M, Moss LG, Tsai MJ (1994) Two distinct class A helix-loop-helix transcription factors. E2A and BETA1, form separate DNA binding complexes on the insulin gene E box. J Biol Chem 269:25936-25941
    • (1994) J Biol Chem , vol.269 , pp. 25936-25941
    • Peyton, M.1    Moss, L.G.2    Tsai, M.J.3
  • 38
    • 0026020867 scopus 로고
    • An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers
    • erratum in Cell 66:423
    • Sun XH, Baltimore D (1991) An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell 64:459-470 (erratum in Cell 66:423)
    • (1991) Cell , vol.64 , pp. 459-470
    • Sun, X.H.1    Baltimore, D.2
  • 39
    • 0027141207 scopus 로고
    • HLH proteins, fly neurogenesis, and vertebrate myogenesis
    • Jan YN, Jan LY (1993) HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell 75:827-830
    • (1993) Cell , vol.75 , pp. 827-830
    • Jan, Y.N.1    Jan, L.Y.2
  • 40
    • 0027420712 scopus 로고
    • Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    • Guillemot D, Lo L-X, Johnson JE, Auerbach A, Anderson DJ, Joyner AL (1993) Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75:463-476
    • (1993) Cell , vol.75 , pp. 463-476
    • Guillemot, D.1    Lo, L.-X.2    Johnson, J.E.3    Auerbach, A.4    Anderson, D.J.5    Joyner, A.L.6
  • 41
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • Naya FJ, Stellrecht CM, Tsai MJ (1995) Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019
    • (1995) Genes Dev , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3
  • 42
    • 0029068316 scopus 로고
    • Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
    • Lee JH, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H (1995) Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836-844
    • (1995) Science , vol.268 , pp. 836-844
    • Lee, J.H.1    Hollenberg, S.M.2    Snider, L.3    Turner, D.L.4    Lipnick, N.5    Weintraub, H.6
  • 43
    • 0028358092 scopus 로고
    • The insulin gene contains multiple transcriptional elements that respond to glucose
    • German MS, Wang J (1994) The insulin gene contains multiple transcriptional elements that respond to glucose. Mol Cell Biol 14:4067-4075
    • (1994) Mol Cell Biol , vol.14 , pp. 4067-4075
    • German, M.S.1    Wang, J.2
  • 44
    • 0027944249 scopus 로고
    • Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
    • Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD (1994) Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci USA 91:10465-10469
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10465-10469
    • Petersen, H.V.1    Serup, P.2    Leonard, J.3    Michelsen, B.K.4    Madsen, O.D.5
  • 46
    • 0025923288 scopus 로고
    • Two proteins act as the IUF1 insulin gene enhancer binding factor
    • Scott V, Clark AR, Hutton JC, Docherty K (1991) Two proteins act as the IUF1 insulin gene enhancer binding factor. FEBS Lett 290:27-30
    • (1991) FEBS Lett , vol.290 , pp. 27-30
    • Scott, V.1    Clark, A.R.2    Hutton, J.C.3    Docherty, K.4
  • 47
    • 0026386775 scopus 로고
    • Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells
    • Ohlsson H, Thor S, Edlund T (1991) Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells. Mol Endocrinol 5:897-904
    • (1991) Mol Endocrinol , vol.5 , pp. 897-904
    • Ohlsson, H.1    Thor, S.2    Edlund, T.3
  • 48
    • 0026471057 scopus 로고
    • Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
    • German MS, Wang J, Chadwick RB, Rutter WJ (1992) Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev 6:2165-2176
    • (1992) Genes Dev , vol.6 , pp. 2165-2176
    • German, M.S.1    Wang, J.2    Chadwick, R.B.3    Rutter, W.J.4
  • 49
    • 0025280050 scopus 로고
    • Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
    • Karlsson O, Thor S, Norberg T, Ohlsson H, Edlund T (1990) Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344:879-882
    • (1990) Nature , vol.344 , pp. 879-882
    • Karlsson, O.1    Thor, S.2    Norberg, T.3    Ohlsson, H.4    Edlund, T.5
  • 50
    • 0026742624 scopus 로고
    • Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin 1 gene
    • Emens LA, Landers DW, Moss LG (1992) Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin 1 gene. Proc Natl Acad Sci USA 89:7300-7304
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7300-7304
    • Emens, L.A.1    Landers, D.W.2    Moss, L.G.3
  • 51
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. Embo J 12:4251-4259
    • (1993) Embo J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 52
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MR (1993) Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7:1275-1283
    • (1993) Mol Endocrinol , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.R.6
  • 53
    • 0028314969 scopus 로고
    • IDX-1:A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller CP, McGehec RE, Jr., Habener JF (1994) IDX-1:a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. Embo J 13:1145-1156
    • (1994) Embo J , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehec Jr., R.E.2    Habener, J.F.3
  • 55
    • 0028567837 scopus 로고
    • Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
    • Peers B, Leonard J, Sharma S, Teitelman G, Montminy MR (1994) Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol 8:1798-1806
    • (1994) Mol Endocrinol , vol.8 , pp. 1798-1806
    • Peers, B.1    Leonard, J.2    Sharma, S.3    Teitelman, G.4    Montminy, M.R.5
  • 56
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CVE, Teitelman G (1995) Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11-18
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.E.6    Teitelman, G.7
  • 57
    • 0028134697 scopus 로고
    • The LIM domain is a modular protein-binding interface
    • Schmeichel KL, Beckerle MC (1994) The LIM domain is a modular protein-binding interface. Cell 79:211-219
    • (1994) Cell , vol.79 , pp. 211-219
    • Schmeichel, K.L.1    Beckerle, M.C.2
  • 58
    • 0027439276 scopus 로고
    • The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1
    • Sanchez-Garcia I, Osada H, Forster A, Rabbitts TH (1993) The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. Embo J 12:4243-4250
    • (1993) Embo J , vol.12 , pp. 4243-4250
    • Sanchez-Garcia, I.1    Osada, H.2    Forster, A.3    Rabbitts, T.H.4
  • 59
    • 0028587878 scopus 로고
    • Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus
    • erratum in Nature 373:451
    • Taira M, Otani H, Saint-Jeannet JP, Dawid IB (1994) Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus. Nature 372:677-679 (erratum in Nature 373:451)
    • (1994) Nature , vol.372 , pp. 677-679
    • Taira, M.1    Otani, H.2    Saint-Jeannet, J.P.3    Dawid, I.B.4
  • 60
    • 0026335927 scopus 로고
    • The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat
    • Thor S, Ericson J, Brannstrom T, Edlund T (1991) The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7:881-889
    • (1991) Neuron , vol.7 , pp. 881-889
    • Thor, S.1    Ericson, J.2    Brannstrom, T.3    Edlund, T.4
  • 61
    • 0025794399 scopus 로고
    • Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1
    • Dong J, Asa SL, Drucker DJ (1991) Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1. Mol Endocrinol 5:1633-1641
    • (1991) Mol Endocrinol , vol.5 , pp. 1633-1641
    • Dong, J.1    Asa, S.L.2    Drucker, D.J.3
  • 62
    • 0026687778 scopus 로고
    • Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells
    • Shelton KD, Franklin AJ, Khoor A, Beechem J, Magnuson MA (1992) Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol 12:4578-4589
    • (1992) Mol Cell Biol , vol.12 , pp. 4578-4589
    • Shelton, K.D.1    Franklin, A.J.2    Khoor, A.3    Beechem, J.4    Magnuson, M.A.5
  • 63
    • 0026602931 scopus 로고
    • The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes
    • German MS, Moss LG, Wang J, Rutter WJ (1992) The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol Cell Biol 12:1777-1788
    • (1992) Mol Cell Biol , vol.12 , pp. 1777-1788
    • German, M.S.1    Moss, L.G.2    Wang, J.3    Rutter, W.J.4
  • 64
    • 0023723641 scopus 로고
    • Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins
    • Philippe J, Drucker DJ, Knepel W, Jepeal L, Misulovin Z, Habener JF (1988) Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol 8:4877-4888
    • (1988) Mol Cell Biol , vol.8 , pp. 4877-4888
    • Philippe, J.1    Drucker, D.J.2    Knepel, W.3    Jepeal, L.4    Misulovin, Z.5    Habener, J.F.6
  • 65
    • 0026628841 scopus 로고
    • The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells
    • Leonard J, Serup P, Gonzalez G, Edlund T, Montminy M (1992) The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. Proc Natl Acad Sci USA 89:6247-6251
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6247-6251
    • Leonard, J.1    Serup, P.2    Gonzalez, G.3    Edlund, T.4    Montminy, M.5
  • 66
    • 0029047865 scopus 로고
    • The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
    • Wang M, Drucker DJ (1995) The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. J Biol Chem 270:12646-12652
    • (1995) J Biol Chem , vol.270 , pp. 12646-12652
    • Wang, M.1    Drucker, D.J.2
  • 67
    • 0029878794 scopus 로고    scopus 로고
    • Activation of amylin gene transcription by the LIM domain homeobox gene isl-1
    • Wang M, Drucker DJ (1996) Activation of amylin gene transcription by the LIM domain homeobox gene isl-1. Mol Endocrinol 10:243-251
    • (1996) Mol Endocrinol , vol.10 , pp. 243-251
    • Wang, M.1    Drucker, D.J.2
  • 68
    • 0029655778 scopus 로고    scopus 로고
    • Activation of proglucagon gene transcription through a novel promoter element by the caudal-related liomeodomain protein cdx-2/3
    • Jin T, Drucker DJ (1996) Activation of proglucagon gene transcription through a novel promoter element by the caudal-related liomeodomain protein cdx-2/3. Mol Cell Biol 16:19-28
    • (1996) Mol Cell Biol , vol.16 , pp. 19-28
    • Jin, T.1    Drucker, D.J.2
  • 69
    • 84995839584 scopus 로고
    • Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells
    • Turque N, Plaza S, Radvanyi F, Carriere C, Saule S (1994) Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol Endocrinol 8:929-938
    • (1994) Mol Endocrinol , vol.8 , pp. 929-938
    • Turque, N.1    Plaza, S.2    Radvanyi, F.3    Carriere, C.4    Saule, S.5
  • 71
    • 0027750830 scopus 로고
    • Characterization and developmental expression of Tlx-1, the murine homolog of HOX11
    • Raju K, Tang S, Dube ID, Kamel-Reid S, Bryce DM, Breitman ML (1993) Characterization and developmental expression of Tlx-1, the murine homolog of HOX11. Mech Dev 44:51-64
    • (1993) Mech Dev , vol.44 , pp. 51-64
    • Raju, K.1    Tang, S.2    Dube, I.D.3    Kamel-Reid, S.4    Bryce, D.M.5    Breitman, M.L.6
  • 72
    • 0024566960 scopus 로고
    • Negative regulation of human insulin gene expression by the 5′-flanking region in non-pancreatic cells
    • Takeda J, Ishii S, Seino Y, Imamoto F, Imura H (1989) Negative regulation of human insulin gene expression by the 5′-flanking region in non-pancreatic cells. FEBS Lett 247:41-45
    • (1989) FEBS Lett , vol.247 , pp. 41-45
    • Takeda, J.1    Ishii, S.2    Seino, Y.3    Imamoto, F.4    Imura, H.5
  • 73
    • 0006492784 scopus 로고
    • Regulation of rat insulin 1 gene expression: Evidence for negative regulation in nonpancreatic cells
    • Nir U, Walker MD, Rutter WJ (1986) Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. Proc Natl Acad Sci USA 83:3180-3184
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3180-3184
    • Nir, U.1    Walker, M.D.2    Rutter, W.J.3
  • 74
    • 0029147620 scopus 로고
    • A silencer and an adjacent positive element interact to modulate the activity of the human insulin promoter
    • Clark AR, Wilson MH, Leibiger I, Scott V, Docherty K (1995) A silencer and an adjacent positive element interact to modulate the activity of the human insulin promoter. Eur J Biochem 232:627-632
    • (1995) Eur J Biochem , vol.232 , pp. 627-632
    • Clark, A.R.1    Wilson, M.H.2    Leibiger, I.3    Scott, V.4    Docherty, K.5
  • 75
    • 8244227432 scopus 로고    scopus 로고
    • Novel glucose response element in the distal human insulin promotor
    • International Society of Endocrinology, and Endocrine Society, San Francisco, USA
    • Sander M, German MS (1996) Novel glucose response element in the distal human insulin promotor. Program of the 10th International Congress of Endocrinology, International Society of Endocrinology, and Endocrine Society, San Francisco, USA, pp 802
    • (1996) Program of the 10th International Congress of Endocrinology , pp. 802
    • Sander, M.1    German, M.S.2
  • 76
    • 0025246260 scopus 로고
    • Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene
    • Hwung YP, Gu YZ, Tsai MJ (1990) Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene. Mol Cell Biol 10:1784-1788
    • (1990) Mol Cell Biol , vol.10 , pp. 1784-1788
    • Hwung, Y.P.1    Gu, Y.Z.2    Tsai, M.J.3
  • 77
    • 0024471574 scopus 로고
    • XIHbox 8: A novel Xenopus homeo protein restricted to a narrow band of endoderm
    • Wright CV, Schnegelsberg P, De Robertis EM (1988) XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development 104:787-794
    • (1988) Development , vol.104 , pp. 787-794
    • Wright, C.V.1    Schnegelsberg, P.2    De Robertis, E.M.3
  • 79
    • 0028848301 scopus 로고
    • Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb
    • Riddle RD, Ensini M, Nelson C, Tsuchida T, Jessell TM, Tabin C (1995) Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83:631-640
    • (1995) Cell , vol.83 , pp. 631-640
    • Riddle, R.D.1    Ensini, M.2    Nelson, C.3    Tsuchida, T.4    Jessell, T.M.5    Tabin, C.6
  • 80
    • 0029563650 scopus 로고
    • Dorsal cell fate specified by chick Lmx1 during vertebrate limb development
    • Vogel A, Rodriguez C, Warnken W, Izpisua Belmonte JC (1995) Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378:716-720
    • (1995) Nature , vol.378 , pp. 716-720
    • Vogel, A.1    Rodriguez, C.2    Warnken, W.3    Izpisua Belmonte, J.C.4
  • 81
    • 0027966927 scopus 로고
    • The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
    • Chan SK, Jaffe L, Capovilla M, Botas J, Mann RS (1994) The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78:603-615
    • (1994) Cell , vol.78 , pp. 603-615
    • Chan, S.K.1    Jaffe, L.2    Capovilla, M.3    Botas, J.4    Mann, R.S.5
  • 82
    • 0028084337 scopus 로고
    • Ternary complex factors: Growth factor regulated transcriptional activators
    • Treisman R (1994) Ternary complex factors: growth factor regulated transcriptional activators. Curr Opin Genet Dev 4:96-101
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 96-101
    • Treisman, R.1
  • 83
    • 0024494832 scopus 로고
    • Individual protein-binding domains of the insulin gene enhancer positively activate β-cell-specific transcription
    • Karlsson O, Walker MD, Rutter WJ, Edlund T (1989) Individual protein-binding domains of the insulin gene enhancer positively activate β-cell-specific transcription. Mol Cell Biol 9:823-827
    • (1989) Mol Cell Biol , vol.9 , pp. 823-827
    • Karlsson, O.1    Walker, M.D.2    Rutter, W.J.3    Edlund, T.4
  • 84
    • 8244225950 scopus 로고    scopus 로고
    • A structural basis for synergistic activation of insulin gene transcription
    • International Society of Endocrinology, and Endocrine Society, San Francisco, USA
    • Zhang W, Johnson JD, German MS (1996) A structural basis for synergistic activation of insulin gene transcription. Program of the 10th International Congress of Endocrinology, International Society of Endocrinology, and Endocrine Society, San Francisco, USA, pp 717
    • (1996) Program of the 10th International Congress of Endocrinology , pp. 717
    • Zhang, W.1    Johnson, J.D.2    German, M.S.3
  • 85
    • 0028127761 scopus 로고
    • Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression
    • Sharma A, Stein R (1994) Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression. Mol Cell Biol 14:871-879
    • (1994) Mol Cell Biol , vol.14 , pp. 871-879
    • Sharma, A.1    Stein, R.2
  • 86
    • 0028169993 scopus 로고
    • Extrudenticle raises the DNA binding specificity of homeotic selector gene products
    • van Dijk MA, Murre C (1994) extrudenticle raises the DNA binding specificity of homeotic selector gene products. Cell 78:617-624
    • (1994) Cell , vol.78 , pp. 617-624
    • Van Dijk, M.A.1    Murre, C.2
  • 87
    • 0028868441 scopus 로고
    • The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: Importance of the FPWMK motif and of the homeodomain
    • Peers B, Sharma S, Johnson T, Kamps M, Montminy M (1995) The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol Cell Biol 15:7091-7097
    • (1995) Mol Cell Biol , vol.15 , pp. 7091-7097
    • Peers, B.1    Sharma, S.2    Johnson, T.3    Kamps, M.4    Montminy, M.5
  • 88
    • 0001216801 scopus 로고
    • Early pancreas organogenesis: Morphogenesis, tissue interactions and mass effects
    • Wessells NK, Cohen JH (1967) Early pancreas organogenesis: morphogenesis, tissue interactions and mass effects. Dev Biol 15:237-270
    • (1967) Dev Biol , vol.15 , pp. 237-270
    • Wessells, N.K.1    Cohen, J.H.2
  • 89
    • 0002923914 scopus 로고
    • Development of the embryonic endocrine pancreas
    • Steiner DF, Frenkel N (eds) Williams and Wilkins, Washington
    • Pictet R, Rutter WJ (1972) Development of the embryonic endocrine pancreas. In: Steiner DF, Frenkel N (eds) Handbook of physiology, vol 1. Williams and Wilkins, Washington, pp 25-66
    • (1972) Handbook of Physiology , vol.1 , pp. 25-66
    • Pictet, R.1    Rutter, W.J.2
  • 90
    • 0026321596 scopus 로고
    • Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene
    • Herrera PL, Huarte J, Sanvito F, Meda P, Orci L, Vassalli JD (1991) Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113:1257-1265
    • (1991) Development , vol.113 , pp. 1257-1265
    • Herrera, P.L.1    Huarte, J.2    Sanvito, F.3    Meda, P.4    Orci, L.5    Vassalli, J.D.6
  • 91
    • 0024042759 scopus 로고
    • The pancreatic duct cell: Proliferative capabilities, specific characteristics, metaplasia, isolation, and culture
    • Githens S (1988) The pancreatic duct cell: proliferative capabilities, specific characteristics, metaplasia, isolation, and culture, J Pediatr Gastroenterol Nutr 7:486-506
    • (1988) J Pediatr Gastroenterol Nutr , vol.7 , pp. 486-506
    • Githens, S.1
  • 94
    • 0026518591 scopus 로고
    • Onset of cell-specific gene expression in the developing mouse pancreas
    • Gittes GK, Rutter WJ (1992) Onset of cell-specific gene expression in the developing mouse pancreas. Proc Natl Acad Sci USA 89:1128-1132
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1128-1132
    • Gittes, G.K.1    Rutter, W.J.2
  • 95
    • 0028864433 scopus 로고
    • Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis
    • Tabata T, Schwartz C, Gustavson E, Ali Z, Kornberg TB (1995) Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. Development 121:3359-3369
    • (1995) Development , vol.121 , pp. 3359-3369
    • Tabata, T.1    Schwartz, C.2    Gustavson, E.3    Ali, Z.4    Kornberg, T.B.5
  • 96
    • 0029079881 scopus 로고
    • Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
    • Zecca M, Basler K, Struhl G (1995) Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121:2265-2278
    • (1995) Development , vol.121 , pp. 2265-2278
    • Zecca, M.1    Basler, K.2    Struhl, G.3
  • 97
    • 0026083212 scopus 로고
    • Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head
    • Lai E, Prezioso VR, Tao WF, Chen WS, Darnell JE, Jr. (1991) Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev 5:416-427
    • (1991) Genes Dev , vol.5 , pp. 416-427
    • Lai, E.1    Prezioso, V.R.2    Tao, W.F.3    Chen, W.S.4    Darnell Jr., J.E.5
  • 98
    • 0026089359 scopus 로고
    • Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro
    • Liu JK, DiPersio CM, Zaret KS (1991) Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro. Mol Cell Biol 11:773-784
    • (1991) Mol Cell Biol , vol.11 , pp. 773-784
    • Liu, J.K.1    DiPersio, C.M.2    Zaret, K.S.3
  • 99
    • 0027425313 scopus 로고
    • Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm
    • Monaghan AP, Kaestner KH, Grau E, Schutz G (1993) Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119:567-578
    • (1993) Development , vol.119 , pp. 567-578
    • Monaghan, A.P.1    Kaestner, K.H.2    Grau, E.3    Schutz, G.4
  • 100
    • 0027425136 scopus 로고
    • The formation and maintenance of the definitive endoderm lineage in the mouse: Involvement of HNF3/forkhead proteins
    • Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS (1993) The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119:1301-1315
    • (1993) Development , vol.119 , pp. 1301-1315
    • Ang, S.L.1    Wierda, A.2    Wong, D.3    Stevens, K.A.4    Cascio, S.5    Rossant, J.6    Zaret, K.S.7
  • 101
    • 0027318791 scopus 로고
    • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
    • Sasaki H, Hogan BL (1993) Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118:47-59
    • (1993) Development , vol.118 , pp. 47-59
    • Sasaki, H.1    Hogan, B.L.2
  • 102
    • 0028979933 scopus 로고
    • Induction and patterning of the vertebrate nervous system
    • Kelly OG, Melton DA (1995) Induction and patterning of the vertebrate nervous system. Trends Genet 11:273-278
    • (1995) Trends Genet , vol.11 , pp. 273-278
    • Kelly, O.G.1    Melton, D.A.2
  • 103
    • 0028630689 scopus 로고
    • Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
    • Fan CM, Tessier-Lavigne M (1994) Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79:1175-1186
    • (1994) Cell , vol.79 , pp. 1175-1186
    • Fan, C.M.1    Tessier-Lavigne, M.2
  • 104
    • 0028946524 scopus 로고
    • Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos
    • Berl
    • Ebensperger C, Wilting J, Brand-Saberi B, Mizutani Y, Christ B, Balling R, Koseki H (1995) Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos. Anat Embryol (Berl) 191:297-310
    • (1995) Anat Embryol , vol.191 , pp. 297-310
    • Ebensperger, C.1    Wilting, J.2    Brand-Saberi, B.3    Mizutani, Y.4    Christ, B.5    Balling, R.6    Koseki, H.7
  • 105
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409-1416
    • (1996) Development , vol.122 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 106
    • 0001763783 scopus 로고
    • Epitheliomesenchymal interaction in pancreatic morphogenesis
    • Golosow N, Grobstein C (1962) Epitheliomesenchymal interaction in pancreatic morphogenesis. Dev Biol 4:242-255
    • (1962) Dev Biol , vol.4 , pp. 242-255
    • Golosow, N.1    Grobstein, C.2
  • 108
    • 0030041280 scopus 로고    scopus 로고
    • Lineage-specific morphogenesis in the developing pancreas: Role of mesenchymal factors
    • Gittes GK, Galante PE, Hanahan D, Rutter WJ, Debase HT (1996) Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development 122:439-447
    • (1996) Development , vol.122 , pp. 439-447
    • Gittes, G.K.1    Galante, P.E.2    Hanahan, D.3    Rutter, W.J.4    Debase, H.T.5
  • 110
    • 0023176967 scopus 로고
    • Cell lineage analysis of pancreatic islet development: Glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct
    • Teitelman G, Lee JK (1987) Cell lineage analysis of pancreatic islet development: glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct. Dev Biol 121:454-466
    • (1987) Dev Biol , vol.121 , pp. 454-466
    • Teitelman, G.1    Lee, J.K.2
  • 111
    • 0027308108 scopus 로고
    • Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide
    • Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D (1993) Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118:1031-1039
    • (1993) Development , vol.118 , pp. 1031-1039
    • Teitelman, G.1    Alpert, S.2    Polak, J.M.3    Martinez, A.4    Hanahan, D.5
  • 112
    • 0027952880 scopus 로고
    • Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor
    • Upchurch BH, Aponte GW, Leiter AB (1994) Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development 120:245-252
    • (1994) Development , vol.120 , pp. 245-252
    • Upchurch, B.H.1    Aponte, G.W.2    Leiter, A.B.3
  • 113
    • 0023949396 scopus 로고
    • Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons
    • Alpert S, Hanahan D, Teitelman G (1988) Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53:295-308
    • (1988) Cell , vol.53 , pp. 295-308
    • Alpert, S.1    Hanahan, D.2    Teitelman, G.3
  • 114
    • 0024632456 scopus 로고
    • Dissecting mouse development with toxigenics
    • Evans GA (1989) Dissecting mouse development with toxigenics. Genes Dev 3:259-263
    • (1989) Genes Dev , vol.3 , pp. 259-263
    • Evans, G.A.1
  • 116
    • 0015811815 scopus 로고
    • Dynamics of insulin release from the foetal and neonatal rat pancreas
    • Asplund K (1973) Dynamics of insulin release from the foetal and neonatal rat pancreas. Eur J Clin Invest 3:338-344
    • (1973) Eur J Clin Invest , vol.3 , pp. 338-344
    • Asplund, K.1
  • 117
    • 0023853539 scopus 로고
    • Development of the biphasic response to glucose in fetal and neonatal rat pancreas
    • Hole R, Pian-Smith M, Sharp G (1988) Development of the biphasic response to glucose in fetal and neonatal rat pancreas. Am J Physiol 254:E167-E174
    • (1988) Am J Physiol , vol.254
    • Hole, R.1    Pian-Smith, M.2    Sharp, G.3
  • 118
    • 0023872502 scopus 로고
    • Maturation of insulin response to glucose during human fetal and neonatal development
    • Otonkoski T, Andersson S, Knip M, Simell O (1988) Maturation of insulin response to glucose during human fetal and neonatal development. Diabetes 37:286-291
    • (1988) Diabetes , vol.37 , pp. 286-291
    • Otonkoski, T.1    Andersson, S.2    Knip, M.3    Simell, O.4
  • 120
    • 0025334163 scopus 로고
    • Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes
    • Matschinsky FM (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes 39:647-652
    • (1990) Diabetes , vol.39 , pp. 647-652
    • Matschinsky, F.M.1
  • 121
    • 0027479441 scopus 로고
    • Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediates
    • German MS (1993) Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates. Proc Natl Acad Sci USA 90:1781-1785
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1781-1785
    • German, M.S.1
  • 122
    • 0028136475 scopus 로고
    • Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas
    • Pang K, Mukonoweshuro C, Wong GG (1994) Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas. Proc Natl Acad Sci USA 91:9559-9563
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9559-9563
    • Pang, K.1    Mukonoweshuro, C.2    Wong, G.G.3
  • 123
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack JM (1995) Developmental biology of the pancreas. Development 121:1569-1580
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.1
  • 124
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 125
    • 84866477180 scopus 로고    scopus 로고
    • Development of the endocrine pancreas of the rat related to the homeobox-gene products PDX-1 and Nkx 6.1
    • International Society of Endocrinology, Endocrine Society, San Francisco, USA
    • Øster A, Jensen J, Serup P, Madsen OD, Larsson LI (1996) Development of the endocrine pancreas of the rat related to the homeobox-gene products PDX-1 and Nkx 6.1. Program of the 10th International Congress of Endocrinology, International Society of Endocrinology, Endocrine Society, San Francisco, USA, pp 414
    • (1996) Program of the 10th International Congress of Endocrinology , pp. 414
    • Øster, A.1    Jensen, J.2    Serup, P.3    Madsen, O.D.4    Larsson, L.I.5
  • 126
    • 0002135521 scopus 로고    scopus 로고
    • Insulin gene regulation
    • LeRoith D, Olefsky J, Taylor S (eds) Lippincott-Raven, Philadelphia
    • Kennedy G, German M (1996) Insulin gene regulation. In: LeRoith D, Olefsky J, Taylor S (eds) Diabetes mellitus: a fundamental and clinical text. Lippincott-Raven, Philadelphia, pp 20-26
    • (1996) Diabetes Mellitus: A Fundamental and Clinical Text , pp. 20-26
    • Kennedy, G.1    German, M.2
  • 127
    • 0027422291 scopus 로고
    • Site-specific recombinases: Tools for genome engineering
    • Kilby NJ, Snaith MR, Murray JA (1993) Site-specific recombinases: tools for genome engineering. Trends Genet 9:413-421
    • (1993) Trends Genet , vol.9 , pp. 413-421
    • Kilby, N.J.1    Snaith, M.R.2    Murray, J.A.3
  • 128
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP - Mediated gene targeting
    • Gu H, Zou YR, Rajewsky K (1993) Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP - mediated gene targeting Cell 73:1155-1164
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.R.2    Rajewsky, K.3
  • 129
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
    • Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265:103-106
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.