Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand

Human Gene Therapy

Volumn 13, Issue 3, 2002, Pages 395-406

  Prud'homme, Gerald J ^a   Chang, Yigang ^a   Li, Xiaoying ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CARCINOEMBRYONIC ANTIGEN; CELL SURFACE PROTEIN; COMPLEMENTARY DNA; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA VACCINE; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 4; LIGAND; PLASMID DNA; PREPROINSULIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DIABETES; AUTOIMMUNE DISEASE; CLONAL ANERGY; CONTROLLED STUDY; ELECTROPORATION; FEMALE; GENE TRANSFER; IMMUNITY; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MOUSE; NONHUMAN; PROTEIN BINDING; SPLEEN CELL; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; DNA, COMPLEMENTARY; FEMALE; IMMUNOCONJUGATES; IMMUNOSUPPRESSION; INSULIN; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; SPLEEN; T-LYMPHOCYTES; VACCINES, DNA;

ANIMALIA;

EID: 0036202406     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340252792521     Document Type: Article

References (36)

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3. Diabetes
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8. Selected strategies to augment polynucleotide gene vaccination
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14. Late complication of immune deviation therapy in a nonhuman primate
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23. Treatment of murine lupus with cDNA encoding IFN-γR/Fc
24. The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice
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26. Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors
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34. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
35. Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice
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