Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes

Journal of Immunology

Volumn 160, Issue 6, 1998, Pages 2684-2691

  Arnush, Marc ^a   Scarim, Anna L ^a   Heitmeier, Monique R ^a   Kelly, Colleen B ^a   Corbett, John A ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CELL FUNCTION; CELL VIABILITY; ENZYME INDUCTION; GENE TARGETING; GLUCOSE OXIDATION; IMMUNOCYTOTOXICITY; INSULIN RELEASE; MACROPHAGE ACTIVATION; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT;

ANIMALS; DIABETES MELLITUS, TYPE 1; INSULIN; INTERLEUKIN-1; ISLETS OF LANGERHANS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032521025     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Lacy, P. E. 1994. The intraislet macrophage and type 1 diabetes. Mount Sinai J. Med. 61:170.
2. Wright, J. R., J. B. Lefkowith, G. Schreiner, and P. E. Lacy. 1988. Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice Proc. Natl. Acad. Sci. USA 85:6137.
3. Lefkowith, J. B., G. Schreiner, J. Cormier, E. S. Handler, H. K. Driscoll, D. Greiner, J. P. Mordes, and A. A. Rossini. 1990. Prevention of diabetes in the BB rat by essential fatty acid deficiency: relationship between physiological and biochemical changes. J. Exp. Med. 171:729.
4. Oschilewski, U., U. Kiesel, and H. Kolb. 1985. Administration of silica prevents diabetes in BB rats. Diabetes. 34:197.
5. Mandrup-Poulsen, T., K. Bendtzen, H. Nielsen, G. Bendixen, and J. Nerup. 1985. Cytokines cause functional and structural damage to isolated islets of Langerhans. Allergy 40:424.
6. Mandrup-Poulsen, T., S. Helqvist, L. D. Wogensen, J. Mølvig, F. Pociot, J. Johannesen, and J. Nerup. 1990. Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr. Top. Microbiol. Immunol. 164:169.
7. Southern, C., D. Schulster, and I. C. Green. 1990. Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an L-arginine-dependent nitric oxide generation mechanism. FEBS. Lett. 276:42.
8. Welsh, N., D. L. Eizirik, K. Bendtzen, and S. Sandler. 1991. Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of Krebs cycle enzyme aconitase. Endocrinology 129:3167.
9. Corbett, J. A., J. R. Lancaster, Jr., M. A. Sweetland, and M. L. McDaniel. 1991. Interleukin-1β-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. J. Biol. Chem. 266:21351.
10. Corbett, J. A., J. L. Wang, J. H. Hughes, B. A. Wolf, M. A. Sweetland, J. R. Lancaster, Jr., and M. L. McDaniel. 1992. Nitric oxide and cyclic GMP formation induced by interleukin-1β in islets of Langerhans. Biochem. J. 287:229.
11. Welsh, N., and S. Sandler. 1992. Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets. Biochem. Biophys. Res. Commun. 182:333.
12. Corbett, J. A., R. G. Tilton, K. Chang, K. S. Hasan, Y. Ido, J. L. Wang, M. A. Sweetland, J. R. Lancaster, Jr., J. R. Williamson, and M. L. McDaniel. 1992. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes 41:552.
13. Corbett, J. A., J. L. Wang, T. P. Misko, W. Zhao, W. F. Mickey, and M. L. McDaniel. 1993. Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone. Autoimmunity 15:145.
14. Corbett, J. A., M. A. Sweetland, J. L. Wang, J. R. Lancaster, Jr., and M. L. McDaniel. 1993. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. USA 90:1731.
15. Corbett, J. A., J. L. Wang, M. A. Sweetland, J. R. Lancaster, Jr., and M. L. McDaniel. 1992. IL-1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans. J. Clin. Invest. 90:2384.
16. Corbett, J. A., and M. L. McDaniel. 1994. Reversibility of interleukin-1β-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. Biochem. J. 299:719.
17. Corbett, J. A., and M. L. McDaniel. 1995. Intraislet release of interleukin-1 ini hibits β-cell function by inducing β-cell expression of inducible nitric oxide synthase. J. Exp. Med. 181:559.
18. Lacy, P. E., and E. H. Finke. 1991. Activation of intraislet lymphoid cells causes destruction of islet cells. Am. J. Pathol. 138:1183.
19. Lacy, P. E., and M. Kostianovsky. 1967. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35.
20. Wright, P. H., D. R. Makulu, D. Vichick, and K. E. Sussman. 1971. Insulin immunoassay by back-titration. Diabetes 20:33.
21. 15N]nitrate in biological fluids. Anal. Biochem. 126:131.
22. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
23. Hill, J. R., J. A. Corbett, G. Kwon, C. A. Marshall, and M. L. McDaniel. 1996. Nitric oxide regulates interleukin-1 bioactivity released from murine macrophages. J. Biol. Chem. 271:22672.
24. Kennedy, M. K., D. S. Torrance, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA correlates with recovery. J. Immunol. 149:2496.
25. Rabinovitch, A., W. L. Suarez-Pinzon, O. Sorensen, and R. C. Bleackley. 1995. Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137:2093.
26. Dower, S. K., J. E. Sims, D. P. Cerretti, and T. A. Bird. 1992. The interleukin-1 system: receptors, ligands and signals. Chem. Immunol. 51:33.
27. Hogquist, K. A., M. A. Nett, E. R. Unanue, and D. D. Chaplin. 1991. Interleukin-1 is processed and released during apoptosis. Proc. Natl. Acad. Sci. USA 88:8485.
28. Bonner-Weir, S. 1988. Morphological evidence for pancreatic polarity of β-cells within islets of Langerhans. Diabetes 37:616.
29. Cailleau, C., A. Diu-Hercend, E. Ruuth, R. Westwood, and C. Carnaud. 1997. Treatment with neutralizing antibodies specific for IL-1β prevents cyclophosphamide-induced diabetes in nonobese diabetic mice. Diabetes 46:937.
30. Zychlinsky, A., C. Fitting, J. M. Cavaillon, and P. J. Sansonetti. 1994. Interleukin-1 is released by murine macrophages during apoptosis induced by Shigella flexneri. J. Clin. Invest. 94:1328.
31. Misko, T. P., W. M. Moore, T. P. Kasten, G. A. Nickols, J. A. Corbett, R. G. Tilton, M. L. McDaniel, J. R. Williamson, and M. G. Currie. 1993. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:119.
32. Heitmeier, M. R., A. L. Scarim, and J. A. Corbett. 1997. IFN-γ increases the sensitivity of islets of Langerhans for iNOS expression induced by IL-1. J. Biol. Chem. 272:13653.
33. Nerup, J., and A. Lernmark. 1981. Autoimmunity in insulin-dependent diabetes mellitus. Am. J. Med. 70:135.
34. Rabinovitch, A. 1993. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1:215.
35. Sarvetnick, N., D. Liggitt, S. L. Pitts, S. E. Hansen, and T. A. Stewart. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52:773.