Pancreatic β cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes

Journal of Experimental Medicine

Volumn 188, Issue 8, 1998, Pages 1445-1451

  Hotta, Mizuo ^a,b   Tashiro, Fumi ^a   Ikegami, Hiroshi ^b   Niwa, Hitoshi ^a   Ogihara, Toshio ^b   Yodoi, Junji ^c   Miyazaki, Jun Ichi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Insulitis, cytokine; Nonobese diabetic mouse; Oxidative stress

Indexed keywords

CYTOKINE; GLUCOSE; INSULIN; REACTIVE OXYGEN METABOLITE; THIOREDOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GLUCOSE BLOOD LEVEL; INFLAMMATORY INFILTRATE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, TRANSGENIC; OXIDATIVE STRESS; RABBITS; STREPTOZOCIN; THIOREDOXIN;

EID: 0032547768     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.8.1445     Document Type: Article

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