Immunotherapy of NOD mice with bone marrow-derived dendritic cells

Diabetes

Volumn 48, Issue 12, 1999, Pages 2300-2308

  Feili Hariri, Maryam ^a,b   Dong, Xin ^a,b   Alber, Sean M ^a,b   Watkins, Simon C ^a,b   Salter, Russell D ^a,b   Morel, Penelope A ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CELL MIGRATION; CELL POPULATION; CELL STIMULATION; DENDRITIC CELL; HEMATOPOIETIC STEM CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0033513456     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.12.2300     Document Type: Article

References (58)

1. Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-296, 1991
2. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM: Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176:1693-1702, 1992
3. Inaba K, Inaba M, Deguchi M, Hagi K, Yasumizu R, Ikehara S, Muramatsu S, Steinman RM: Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci U S A 90:3038-3042, 1993
4. Crowley M, Inaba K, Witmer-Pack M, Steinman RM: The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell Immunol 118:108-125, 1989
5. Wu L, Vremec D, Ardavin C, Winkel K, Suss G, Georgiou H, Maraskovsky E, Cook W, Shortman K: Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation. Eur J Immunol 25:418-425, 1995
6. Saunders D, Lucas K, Ismaili J, Wu L, Maraskovsky E, Dunn A, Shortman K: Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J Exp Med 184:2185-2196, 1996
7. Thomas R, Lipsky PE: Dendritic cells: origin and differentiation. Stem Cells 14:196-206, 1996
8. Schuler G, Steinman RM: Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161:526, 1985
9. Lu L, Woo J, Rao AS, Li Y, Watkins SC, Qian S, Starzl TE, Demetris AJ, Thomson AW: Propagation of dendritic cell progenitors from normal mouse liver using GM-CSF and their maturational development in the presence of type-1 collagen. J Exp Med 179:1823-1833, 1994
10. Carlow DA, van Oers NSC, Teh SJ, Teh HS: Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions. J Immunol 148:1595-1603, 1992
11. Vremec D, Zorbas M, Scollay R, Saunders DJ, Ardavin CF, Wu L, Shortman K: The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med 176:47-58, 1992
12. Lu L, Hsieh M, Oriss TB, Morel PA, Starzl TE, Rao AS, Thomson AW: Generation of DC from mouse spleen cell cultures in response to GM-CSF: immunophenotypic and functional analyses. Immunology 84:127-134, 1995
13. Lu L, Rudert WA, Qian S, McCaslin D, Fu F, Rao AS, Trucco M, Fung JJ, Starzl TE, Thomson AW: Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. J Exp Med 182:379-387, 1995
14. Sallusto F, Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocytes/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med 179:1109-1118, 1994
15. Larsen CP, Steinman RM, Witmer-Pack MD, Hankins DF, Morris PJ, Austyn JM: Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 172:1483, 1990
16. Heufler C, Koch F, Schuler G: Granulocyte/macrophage colony-stimulating factor and interteukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J Exp Med 167:700-705, 1988
17. Marland G, Bakker AB, Adema GJ, Figdor CG: Dendritic cells in immune response induction. Stem Cells 14:501-507, 1996
18. Morel PA, Vasquez C, Feili-Hariri M: Immunobiology of DC in NOD mice. J Leak Biol 66:276-280, 1999
19. Pierre P, Turley SJ, Gatti E, Hull M, Meltzer J, Mirza A, Inaba K, Steinman RM, Mellman I: Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388:787-792, 1997
20. Cella M, Engering A, Pinet V, Pieters J, Lanzavecchia A: Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388:782-787, 1997
21. Tisch R, Yang XD, Singer SM, Liblau RS, Fluger L, McDevvitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72-75, 1993
22. Wegmann DR, Gill RG, Norbury-Glaser M, Schloot N, Daniel D: Analysis of the spontaneous T cell response to insulin in NOD mice. J Autoimmun 7:833-843, 1994
23. Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR: Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci U S A 87:1576-1580, 1990
24. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GSP, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T cell self tolerance to glutamate decarboxylase is a key event in the pathogenesis of murine insulin-dependent diabetes. Nature 366:69-71, 1993
25. Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L: Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes. J Exp Med 181:817-821, 1995
26. + Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest 95:2979-2985, 1995
27. Tian J, Clare-Salzler M, Herschenfeld A, Middleton B, Newman D, Mueller R, Arita S, Evans C, Atkinson M, Mullen Y, Sarvetnick N, Tobin A, Lehmann PV, Kaufman DL: Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med 2:1348-1353, 1996
28. Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Konen-Waisman S, Cohen IR: Hsp60 peptide therapy of NOD mouse diabetes induced a Th2 cytokines burst and downregulates autoimmunity to various β-cell antigens. Diabetes 46:758-764, 1997
29. Serreze DV, Leiter EH: Defective activation of T suppressor cell function in nonobese diabetic mice: potential relation to cytokine deficiencies. J Immunol 140:3801-3807, 1988
30. Serreze DV, Gaskins HR, Leiter EH: Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J Immunol 150:2534-2543, 1993
31. Piganelli JD, Martin T, Haskins K: Splenic macrophages from the NOD mouse are defective in the ability to present antigen. Diabetes 47:1212-1218, 1998
32. Jansen A, Homo-Delarche F, Hooijkaas H, Leenen PJ, Dardenne M, Drexhage HA: Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β-cell destruction in NOD mice. Diabetes 43:667-675, 1994
33. Dahlen E, Dawe K, Ohlsson L, Hedlund G: Dendritic cells and macrophages are the first and major producers of TNF-α in pancreatic islets in the nonobese diabetic mouse. J Immunol 160:3585-3593, 1998
34. Clare-Salzler MJ, Brooks J, Chai A, van Herle K, Anderson C: Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest 90:741-748, 1992
35. Atkinson MA, Maclaren NK: Islet cell autoantigens in insulin-dependent diabetes. J Clin Invest 92:1608-1616, 1993
36. Elias D, Reshef T, Birk OS, van der Zee R, Walker D, Cohen IR: Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-KDa heat shock protein. Proc Natl Acad Sci U S A 88:3088-3091, 1991
37. Feili-Hariri M, Kao H, Mietzner TM, Morel PA: Functional consequences of the binding of the MHC class II-derived peptides to MHC class II. Int Immunol 8:1857-1865, 1996
38. Barratt-Boyes SM, Watkins SC, Finn OJ: In vivo migration of dendritic cells differentiated in vitro: a chimpanzee model. J Immunol 158:4543-4547, 1997
39. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC: The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375:151-155, 1995
40. + T cells. J Immunol 154:5071-5079, 1995
41. Ramiya VK, Shang X-Z, Pharis PG, Wasserfall CH, Stabler TV, Muir AB, Schatz DA, Maclaren NK: Antigen based therapies to prevent diabetes in NOD mice. J Autoimmun 9:349-356, 1996
42. Martin RM, Brady JL, Lew AM: The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice. J Immunol Methods 212:187-192, 1998
43. Zitvogel L, Mayordomo JI, Tjandrawan T, DeLeo A, Clarke MR, Lotze ML, Storkus WJ: Therapy of murine tumors with peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J Exp Med 183:87-98, 1996
44. -) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 66:659-665, 1996
45. Rastellini C, Lu L, Ricordi C, Starzl TE, Rao AS, Thomson AW: Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet cell allograft survival. Transplantation 60:1366-1370, 1995
46. Khoury SJ, Gallon L, Chen W, Betres K, Russell ME, Hancock WW, Carpenter CB, Sayegh MH, Weiner HL: Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 182:357-366, 1995
47. Clare-Salzler M, Mullen Y: Marked dendritic cell-T cell cluster formation in the pancreatic lymph node of the non-obese diabetic mouse. Immunology 76:478-484, 1992
48. Shimuzu J, Carrasco-Marin E, Kanagawa O, Unanue ER: Relationship between β cell injury and antigen presentation in NOD mice. J Immunol 155:4095-4099, 1995
49. Sallusto F, Cella M, Danieli C, Lanzavecchia A: Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 182:389-400, 1995
50. Lanzavecchia A: Mechanisms of antigen uptake for presentation. Curr Opinion Immunol 8:348-354, 1996
51. Ulaeto D, Lacy PE, Kipnis DM, Kanagawa O, Unanue ER: A T cell dormant state in the autoimmmune process of non-obese diabetic mice treated with complete Freund's adjuvant. Proc Natl Acad Sci U S A 89:3927-3931, 1992
52. Gazda LS, Baxter AG, Lafferty KJ: Regulation of autoimmune diabetes: characteristics of non-islet antigen-specific therapies. Immunol Cell Biol 74:401-407, 1996
53. Lenschow D, Herold KC, Rhee L, Patel B, Koons A, Qin H-Y, Fuchs E, Singh B, Thompson CB, Bluestone J: CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 5:285-293, 1996
54. Yoon J-W, Yoon C-S, Lim H-W, Huang QQ, Kang Y, Pyun KH, Hirasawa K, Sherwin RS, Jun H-S: Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells. Science 284:1183-1187, 1999
55. Serreze DV, Hamaguchi K, Leiter EH: Immunostimulation circumvents diabetes in NOD/Lt mice. J Autoimmun 2:759-776, 1989
56. Rabinovitch L: Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Diabetes 43:613-621, 1994
57. Rapoport MJ, Jaramillo A, Zipris D, Lazarus AH, Serreze DV, Leiter EH, Cyopock P, Danska JS, Delovitch TL: IL-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in NOD mice. J Exp Med 178:87-99, 1993
58. Boitard C, Yasunami R, Dardenne M, Bach J-F: The cell mediated inhibition of the transfer of autoimmune diabetes in the NOD mice. J Exp Med 169: 1669-1680, 1989