Assembly of cell regulatory systems through protein interaction domains

Science

Volumn 300, Issue 5618, 2003, Pages 445-452

  Pawson, Tony ^a,b   Nash, Piers ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; NUCLEIC ACIDS; POLYPEPTIDES;

CELL REGULATORY SYSTEMS;

PROTEINS;

ANKYRIN; BCR ABL PROTEIN; BETA CATENIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; ELONGATION FACTOR 3; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HISTONE ACETYLTRANSFERASE; HUNTINGTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOLIPID; PHOSPHOPROTEIN PHOSPHATASE 2A; POLYPEPTIDE; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; RAS PROTEIN; REGULATOR PROTEIN; RHO FACTOR; SYNTROPHIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR PROTEIN; UBIQUITIN; VIRUS PROTEIN;

GENOME; PROTEIN;

BINDING SITE; CELL POLARITY; CHROMOSOME REARRANGEMENT; DNA DAMAGE; DROSOPHILA; DRUG TARGETING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL PHYSIOLOGY; CELL POLARITY; ENZYMES; EVOLUTION, MOLECULAR; KINETICS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEINS; PROTEOMICS; RECEPTORS, CELL SURFACE; REPETITIVE SEQUENCES, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0037453510     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083653     Document Type: Review

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149. We thank J. Scott, D. Durocher, J. Forman-Kay, J. Dennis, M. Toone, B. Seet, and J, Wrana for comments on the manuscript. We apologize to authors of the many important concepts and papers not discussed here for want of space. T.P. is a Distinguished Scientist of the Canadian Institutes of Health Research (CIHR). P.N. is a Postdoctoral Senior Research Fellow of the CIHR.