A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

Cell

Volumn 101, Issue 7, 2000, Pages 777-787

  Park, Young Chul ^a   Ye, Hong ^a   Hsia, Constance ^a   Segal, Deena ^a   Rich, Rebecca L ^b   Liou, Hsiou Chi ^a   Myszka, David G ^b   Wu, Hao ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN TRADD; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL SURVIVAL; EMBRYO; ENZYME ACTIVATION; ENZYME SPECIFICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034705271     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80889-2     Document Type: Article

References (65)

1. Tumor necrosis factor receptor-associated factors (TRAFs) - A family of adapter proteins that regulates life and death
2. Death receptors: Signaling and modulation
3. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
4. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
5. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
6. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
7. Crystallography and NMR system: A new software suite for macromolecular structure determination
8. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes
9. CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival
10. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
11. SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules
12. Tumor necrosis factor receptor family members in the immune system
13. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
14. Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: A role for TNF-R1 activation by endogenous membrane-anchored TNF
15. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation
16. The p70 tumor necrosis factor receptor mediates cytotoxicity
17. Determination of macromolecular structures from anamalous diffraction of synchrotron radiation
18. Selenomethionyl proteins produced for analysis by multiwavelength anamalous diffraction (MAD): A vehicle for direct determination of three dimensional structure
19. The importance of efficacy and partial agonism in evaluating models of B lymphocyte activation
20. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
21. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
22. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
23. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
24. Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors
25. Improved methods for building models in electron density maps and the location of errors in those models
26. Regulation of CD40 ligand expression and use of recombinant CD40 ligand for studying B cell growth and differentiation
27. The death-domain kinase RIP mediates the TNF-induced NF-(κ)B signal
28. Modular peptide recognition domains in eukaryotic signaling
29. TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival
30. Editorial overview: CD27 and (TNFR) relatives in the immune system: Their role in health and disease
31. The ubiquitin-homology protein, DAP-1, associates with TNF receptor (p60) death domain and induces apoptosis
32. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase
33. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
34. Crystallographic analysis of CD40 recognition and signaling by human TRAF2
35. Regulation and function of the JNK subgroup of MAP kinases
36. Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
37. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
38. Improving biosensor analysis
39. CLAMP: A biosensor kinetic data analysis program
40. Apoptosis by death factor
41. Therapeutic potential and strategies for inhibiting tumor necrosis factor-α
42. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
43. ASK1 is essential for JNK/ SAPK activation by TRAF2
44. Alpha plus beta folds revisited: Some favoured motifs
45. Structural basis for self-association and receptor recognition of human TRAF2
46. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
47. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma
48. Combining evolutionary information and neural networks to predict protein secondary structure
49. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
50. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
51. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
52. Cytotoxic effect in TNF and lymphotoxin on T lymphoblasts
53. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
54. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation and death
55. REPLACE, a suite of computer programs for molecular-replacement calculations
56. Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
57. Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans
58. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
59. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: Requirement of the TNF receptor-associated factor-2 binding site
60. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60
61. Thermodynamic characterization of the interaction between TRAF2 and receptor peptides by isothermal titration calorimetry
62. The Structural basis for recognition of diverse receptor sequences by TRAF2
63. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
64. Induction of apoptosis in mature T cells by tumour necrosis factor