Structure and function of a human TAF(II)250 double bromodomain module

Science

Volumn 288, Issue 5470, 2000, Pages 1422-1425

  Jacobson, Raymond H ^a   Ladurner, Andreas G ^a   King, David S ^a   Tjian, Robert ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; PROTEIN;

ACETYLATION; ARTICLE; CHROMATIN STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; GENE TARGETING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

ACETYLATION; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; HISTONES; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; NUCLEOSOMES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TRANSCRIPTION FACTOR TFIID; TRANSCRIPTION, GENETIC;

EID: 0034717183     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5470.1422     Document Type: Article

References (41)

1. G. Orphanides, T. Lagrange, D. Reinberg, Genes Dev. 10, 2657 (1996).
2. J. A. Goodrich and R. Tjian, Curr. Opin. Cell Biol. 6, 403 (1994).
3. S. K. Burley and R. G. Roeder, Annu. Rev. Biochem. 65, 769 (1996); R. Tjian and T. Maniatis, Cell 77, 5 (1994).
4. S. K. Burley and R. G. Roeder, Annu. Rev. Biochem. 65, 769 (1996); R. Tjian and T. Maniatis, Cell 77, 5 (1994).
5. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
6. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
7. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
8. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
9. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
10. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
11. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
12. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
13. P. A. Wade and A. P. Wolffe, Curr. Biol. 7, R82 (1997); M. J. Pazin and J. T. Kadonaga, Cell 89, 325 (1997); P. A. Grant et al., Genes Dev. 11, 1640 (1997); V. V. Ogryzko, R. L. Schiltz, V. Russanova, B. H. Howard, Y. Nakatani, Cell 87, 953 (1996); X. J. Yang, V. V. Ogryzko, J. Nishikawa, B. H. Howard, Y. Nakatani, Nature 382, 319 (1996); T. E. Spencer et al. Nature 389, 194 (1997); H. Chen et al. Cell 90, 569 (1997); V. Allfrey, R. Faulkner, A. Mirsky, Proc. Natl. Acad. Sci. U.S.A. 51, 786 (1964); J. E. Brownell and C. D. Allis, Curr. Opin. Genet. Dev. 6, 176 (1996).
14. A. J. Bannister and T. Kouzarides, Nature 384, 641 (1996).
15. C. A. Mizzen et al., Cell 87, 1261 (1996).
16. F. Jeanmougin, J. M. Wurtz, B. Le Douarin, P. Chambon, R. Losson, Trends Biochem. Sci. 22, 151 (1997).
17. S. R. Haynes et al., Nucleic Acids Res. 20, 2603 (1992).
18. O. Matangkasombut, R. M. Buratowski, N. W. Swilling, S. Buratowski, Genes Dev. 14, 951 (2000).
19. C. Dhalluin et al., Nature 399, 491 (1999).
20. C. A. Johnson, L P. O'Neill, A. Milchell, B. M. Turner, Nucleic Acids. Res. 26, 994 (1998); M. H. Kuo et al., Nature 383, 269 (1996); S. Y. Roth and C. D. Allis, Cell 87, 5 (1996); R. E. Sobel, R. G. Cook, C. A. Perry, A. T. Annunziato, C. D. Allis, Proc. Natl. Acad. Sci. U.S.A. 92, 1237 (1995); B. M. Turner, Cell 75, 5 (1993).
21. C. A. Johnson, L P. O'Neill, A. Milchell, B. M. Turner, Nucleic Acids. Res. 26, 994 (1998); M. H. Kuo et al., Nature 383, 269 (1996); S. Y. Roth and C. D. Allis, Cell 87, 5 (1996); R. E. Sobel, R. G. Cook, C. A. Perry, A. T. Annunziato, C. D. Allis, Proc. Natl. Acad. Sci. U.S.A. 92, 1237 (1995); B. M. Turner, Cell 75, 5 (1993).
22. C. A. Johnson, L P. O'Neill, A. Milchell, B. M. Turner, Nucleic Acids. Res. 26, 994 (1998); M. H. Kuo et al., Nature 383, 269 (1996); S. Y. Roth and C. D. Allis, Cell 87, 5 (1996); R. E. Sobel, R. G. Cook, C. A. Perry, A. T. Annunziato, C. D. Allis, Proc. Natl. Acad. Sci. U.S.A. 92, 1237 (1995); B. M. Turner, Cell 75, 5 (1993).
23. C. A. Johnson, L P. O'Neill, A. Milchell, B. M. Turner, Nucleic Acids. Res. 26, 994 (1998); M. H. Kuo et al., Nature 383, 269 (1996); S. Y. Roth and C. D. Allis, Cell 87, 5 (1996); R. E. Sobel, R. G. Cook, C. A. Perry, A. T. Annunziato, C. D. Allis, Proc. Natl. Acad. Sci. U.S.A. 92, 1237 (1995); B. M. Turner, Cell 75, 5 (1993).
24. C. A. Johnson, L P. O'Neill, A. Milchell, B. M. Turner, Nucleic Acids. Res. 26, 994 (1998); M. H. Kuo et al., Nature 383, 269 (1996); S. Y. Roth and C. D. Allis, Cell 87, 5 (1996); R. E. Sobel, R. G. Cook, C. A. Perry, A. T. Annunziato, C. D. Allis, Proc. Natl. Acad. Sci. U.S.A. 92, 1237 (1995); B. M. Turner, Cell 75, 5 (1993).
25. W. A. Hendrickson and C. M. Ogata, Methods Enzymol. 276, 494 (1997).
26. G. Kleywegt, Acta Crystallogr. D 53, 179 (1994).
27. Amino acid residues are abbreviated as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; Y, Tyr.
28. D. J. Clarke, L. P. O'Neill, B. M. Turner, Biochem. J. 294, 557 (1993).
29. M. Grunstein, Annu. Rev. Cell Biol. 6, 643 (1990).
30. V. V. Ogryzko et al., Cell 94, 35 (1998).
31. J. E. Brownell et al., Cell 84, 843 (1996).
32. S. C. Gill and P. H. von Nippel, Anal. Biochim. 182, 319 (1989).
33. R. Koradi, M. Billeter, K. Wüthrich, J. Mol. Graph. 14, 29, 51 (1996).
34. Collaborative Computational Project, Acta, Crystallogr. D 50, 760 (1994).
35. J. Holton, unpublished program.
36. S. L. Roderick, unpublished program.
37. Z. Otwinowski, in Isomorphous Replacement and Anomalous Scattering, W. Wolf, P. R. Evans, A. C. W. Leslie, Eds. (The CCP4 Study Weekend, SERC Daresbury Laboratory, Daresbury, UK, 1991).
38. K. D. Cowtan and P. Main, Acta Crystallogr. D 52, 43 (1996).
39. T. A. Jones, J. Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta Crystallogr. D 47, 110 (1991).
40. A. T. Brunger et al., Acta Crystallogr. D 54, 905 (1998).
41. Supported in part by grants from the National Institutes of Health, The Wellcome Trust, and the Burroughs Wellcome Fund. We thank J. Endrizzi for assistance maintaining our diffraction facilities and offering helpful advice. We thank J. Holton for the use of ELVES, T. Alber and J. Berger for their insights and observations, and T. Earnest and the staff at the Advanced Light Source for their help. We thank T. Handel and her lab for their support, D. Koshland Jr. and S. Marqusee for use of the MCS-ITC instrument, and M. Haggart for DNA sequencing and oligonucleotide synthesis. We thank D. Rio, M. Botchan, and B. W. Matthews for their comments on the manuscript.