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Volumn 296, Issue 5574, 2002, Pages 1886-1889
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Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling
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Author keywords
[No Author keywords available]
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Indexed keywords
CELLS;
HYDROPHOBICITY;
HYDROXYLATION;
MOLECULAR STRUCTURE;
ONCOLOGY;
OXYGEN;
PHYSIOLOGY;
MUTATIONS;
PROTEINS;
HYDROXYPROLINE;
HYPOXIA INDUCIBLE FACTOR 1;
OXYGEN;
PROLINE;
ELONGIN;
HIF1A PROTEIN, HUMAN;
HYPOXIA INDUCIBLE FACTOR 1ALPHA;
LIGASE;
TRANSCRIPTION FACTOR;
TUMOR SUPPRESSOR PROTEIN;
UBIQUITIN PROTEIN LIGASE;
VHL PROTEIN, HUMAN;
VON HIPPEL LINDAU PROTEIN;
BIOCHEMISTRY;
CANCER;
OXYGEN;
SIGNALING;
ARTICLE;
BETA SHEET;
CARCINOGENESIS;
CONFORMATION;
HYDROXYLATION;
MOLECULAR RECOGNITION;
MUTATION;
PRIORITY JOURNAL;
PROTEIN BINDING;
SIGNAL TRANSDUCTION;
VON HIPPEL LINDAU DISEASE;
AMINO ACID SEQUENCE;
ANIMAL;
BINDING SITE;
CHEMICAL STRUCTURE;
CHEMISTRY;
GENETICS;
HUMAN;
HYDROGEN BOND;
HYDROPHOBICITY;
MACROMOLECULE;
METABOLISM;
MOLECULAR GENETICS;
MOUSE;
PROTEIN CONFORMATION;
PROTEIN SECONDARY STRUCTURE;
PROTEIN TERTIARY STRUCTURE;
X RAY CRYSTALLOGRAPHY;
AMINO ACID SEQUENCE;
ANIMALS;
BINDING SITES;
CRYSTALLOGRAPHY, X-RAY;
HUMANS;
HYDROGEN BONDING;
HYDROPHOBICITY;
HYDROXYLATION;
HYDROXYPROLINE;
HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT;
LIGASES;
MACROMOLECULAR SUBSTANCES;
MICE;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
MUTATION;
PROTEIN CONFORMATION;
PROTEIN STRUCTURE, SECONDARY;
PROTEIN STRUCTURE, TERTIARY;
SIGNAL TRANSDUCTION;
TRANSCRIPTION FACTORS;
TUMOR SUPPRESSOR PROTEINS;
UBIQUITIN-PROTEIN LIGASES;
VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;
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EID: 0037035851
PISSN: 00368075
EISSN: None
Source Type: Journal
DOI: 10.1126/science.1073440 Document Type: Article |
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Times cited : (650)
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References (29)
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