Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

New England Journal of Medicine

Volumn 344, Issue 14, 2001, Pages 1038-1042

  Druker, Brian J ^a,e   Sawyers, Charles L ^b   Kantarjian, Hagop ^c   Resta, Debra J ^d   Reese, Sofia Fernandes ^d   Ford, John M ^d   Capdeville, Renaud ^d   Talpaz, Moshe ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BCR ABL TYROSINE KINASE INHIBITOR; IMATINIB; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; BLAST CELL CRISIS; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG TOLERABILITY; EDEMA; ENZYME ACTIVITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; RELAPSE; REMISSION; THROMBOCYTOPENIA; VOMITING;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BLAST CRISIS; BLOOD CELL COUNT; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; PHILADELPHIA CHROMOSOME; PILOT PROJECTS; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; RECURRENCE; REMISSION INDUCTION;

EID: 0035810142     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200104053441402     Document Type: Article

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