Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins

Current Biology

Volumn 11, Issue 23, 2001, Pages 1815-1824

  Harris, Kendra ^a   Lamson, Rachel E ^a   Nelson, Bryce ^b   Hughes, Timothy R ^c   Marton, Matthew J ^c   Roberts, Christopher J ^c   Boone, Charles ^b   Pryciak, Peter M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c ROSETTA INPHARMATICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SACCHAROMYCES CEREVISIAE;

EID: 0035960710     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00567-X     Document Type: Article

References (42)

1. Organization and regulation of mitogen-activated protein kinase signaling pathways
2. MAP kinase pathways in the yeast Saccharomyces cerevisiae
3. The riddle of MAP kinase signaling specificity
4. Signal transduction: Hanging on a scaffold
5. Routing MAP kinase cascades
6. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
7. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade
8. Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module
9. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK
10. MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
11. A mammalian scaffold complex that selectively mediates MAP kinase activation
12. Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11
13. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
14. Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5p
15. Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathway
16. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway
17. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor
18. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
19. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
20. Yeast MEK-dependent signal transduction: Response thresholds and parameters affecting fidelity
21. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation
22. Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation
23. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: Mating and invasive growth
24. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles
25. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
26. The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
27. Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein
28. Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase
29. Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo
30. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission
31. Scaffold proteins may biphasically affect the levels of mitogen- activated protein kinase signaling and reduce its threshold properties
32. An osmosensing signal transduction pathway in yeast
33. Cyclin specificity: How many wheels do you need on a unicycle?
34. Rho GTPases and their effector proteins
35. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
36. A strategy to make constitutively active MAP kinase by fusing with constitutively active MAP kinase kinase
37. Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae
38. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
39. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants
40. Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42
41. Relative dependence of different outputs of the Saccharomyces cerevisiae pheromone response pathway on the MAP kinase Fus3p
42. MAPK specificity in the yeast pheromone response independent of transcriptional activation