Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

Nature

Volumn 396, Issue 6710, 1998, Pages 433-439

  Migaud, Martine ^a   Charlesworth, Paul ^a   Dempster, Maureen ^a   Webster, Lorna C ^a   Watabe, Ayako M ^b   Makhinson, Michael ^b   He, Yong ^c   Ramsay, Mark F ^a   Morris, Richard G M ^a   Morrison, John H ^c   O'Dell, Thomas J ^b   Grant, Seth G N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POSTSYNAPTIC RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; GENE TARGETING; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; MOUSE MUTANT; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPATIAL MEMORY;

ANIMALS; ELECTROPHYSIOLOGY; GENE TARGETING; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEARNING; LEARNING DISORDERS; LONG-TERM POTENTIATION; MAZE LEARNING; MEMBRANE PROTEINS; MEMORY; MICE; MICE, INBRED C57BL; MODELS, NEUROLOGICAL; MUTATION; NERVE TISSUE PROTEINS; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPSES;

ANIMALIA;

EID: 0032481058     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/24790     Document Type: Article

References (38)

1. Bear, M. F. & Malenka, R. C. Synaptic plasticity: LTP and LTD. Curr. Opin. Neurobiol. 4, 389-399 (1994).
2. Bliss, T. V. P. & Collingridge, G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39 (1993).
3. Hollman, M. & Heinemann, S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108 (1994).
4. Nakanishi, S. & Masu, M. Molecular diversity and functions of glutamate receptors. Annu. Rev. Biophys. Biomolec. Struct. 23, 314-348 (1994).
5. Smart, T. G. Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Curr. Opin. Neurobiol. 7, 358-367 (1997).
6. Kornau, H.-C., Schenker, L. T., Kennedy, M. B. & Seeburg, P. H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269, 1737-1740 (1995).
7. Kim, E., Cho, K.-O., Rothschild, A. & Sheng, M. Heteromultimeriozation and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17, 103-113 (1996).
8. Müller, B. M. et al. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17, 255-265 (1996).
9. Niethammer, M., Kim, E. & Sheng, M. Interaction between the C terminus of NMDA receptor subunits and mutliple members of the PSD-95 family of membrane-associated guanylate kinases. J. Neurosci. 16, 2157-2163 (1996).
10. Cho, K. O., Hunt, C. A. & Kennedy, M. B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9, 929-942 (1992).
11. Kistner, U. et al. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J. Biol. Chem. 268, 4580-4583 (1993).
12. + channels by interaction with a family of membrane-associated guanylate kinases. Nature 378, 85-88 (1995).
13. Brenman, J. E. et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84, 757-767 (1996).
14. Hough, C. D., Woods, D. F., Park, S. & Bryant, P. J. Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK discs-large. Genes Dev. 11, 3242-3252 (1997).
15. Müller, B. M. et al. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J. Neurosci. 15, 2354-2366 (1995).
16. Hunt, C. A., Schenker, L. J. & Kennedy, M. B. PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane in forebrain synapses. J. Neurosci. 16, 1380-1388 (1996).
17. Wang, J. H. & Kelly, P. A. T. Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. J. Neurophysiol. 78, 2707-2716 (1997).
18. Irie, M. et al. Binding of neuroligins to PSD-95. Science 277, 1511-1515 (1997).
19. + channels in vivo. J. Neurosci. 17, 152-159 (1997).
20. Mayford, M., Wang, J., Kandel, E. R. & O'Dell, T. J. CaMKII regulates the frequency-response function of hipocampal synapses for the production of both LTD and LTP. Cell 81, 891-904 (1995).
21. Dudek, S. M. & Bear, M. F. Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J. Neurosci. 13, 2910-2918 (1993).
22. Morris, R. G. M., Anderson, E., Lynch, G. S. & Baudry, M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-776 (1986).
23. Tsien, J. Z., Huerta, P. T. & Tonegawa, S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87, 1327-1338 (1996).
24. Allison, D. W., Gelfand, V. I., Spector, I. & Craig, A. M. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: Differential attachment of NMDA versus AMPA receptors. J. Neurosci. 18, 2423-2436 (1998).
25. Wyszynski, M. et al. Competitive binding of α-actinin and calmodulin to the NMDA receptor. Nature 385, 439-442 (1997).
26. Wechsler, A. & Teichberg, V. I. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin. EMBO J. 17, 3931-3939 (1998).
27. Bienenstock, E., Cooper, L. & Munro, P. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J. Neurosci. 2, 32-48 (1982).
28. Kim, J. H., Liao, D., Lau, L.-F. & Huganir, R. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20, 683-691 (1998).
29. Chen, H.-J., Rojas-Soto, M., Oguni, A. & Kennedy, M. B. A synaptic Ras GTPase-activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20, 895-904 (1998).
30. Naisbitt, S. et al. Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90. J. Neurosci. 17, 5687-5696 (1997).
31. Takeuchi, M. et al. SAPAPs: A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J. Biol. Chem. 272, 11943-11951 (1997).
32. Tsunoda, S. et al. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature 388, 243-249 (1997).
33. Sejnowski, T. J. Statistical constraints on synaptic plasticity. J. Theor. Biol. 69, 387-389 (1977).
34. Willshaw, D. & Dayan, P. Optimal plasticity from matrix memories: what goes up must come down. Neural Comp. 2, 85-93 (1990).
35. Hancock, P. J. B., Smith, L. S. & Phillips, W. A. A biologically supported error-correcting learning rule. Neural Comp. 3, 201-212 (1991).
36. Otto, T., Eichenbaum, H., Wiener, S. I. & Wible, C. G. Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation. Hippocampus 1, 181-192 (1991).
37. Morrison, B. M., Janssen, W. G. M., Gordon, J. W. & Morrison, J. H. Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice. J. Comp. Neurol. 395, 523-534 (1998).
38. Rayport, S. et al. Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology. J. Neurosci. 12, 4264-4280 (1992).