Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus

Current Biology

Volumn 12, Issue 9, 2002, Pages 740-745

  Scaplehorn, Niki ^a,b   Holmström, Anna ^a   Moreau, Violaine ^a   Frischknecht, Freddy ^a   Reckmann, Inge ^a   Way, Michael ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GRB2 PROTEIN, HUMAN; GREEN FLUORESCENT PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYBRID PROTEIN; NCK PROTEIN; ONCOPROTEIN; PHOTOPROTEIN; PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WAS PROTEIN, HUMAN; WISKOTT ALDRICH SYNDROME PROTEIN;

ARTICLE; CELL LINE; CHEMISTRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HELA CELL; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; VACCINIA VIRUS;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; GRB2 ADAPTOR PROTEIN; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; ONCOGENE PROTEINS; PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; VACCINIA VIRUS; WISKOTT-ALDRICH SYNDROME PROTEIN;

VACCINIA VIRUS;

EID: 0037197805     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00812-6     Document Type: Article

References (18)

1. WASP and WAVE family proteins: Key molecules for rapid rearrangement of cortical actin filaments and cell movement
2. Regulation of actin filament network formation through ARP2/3 complex: Activation by a diverse array of proteins
3. Regulation of Wiskott-Aldrich syndrome protein and related molecules
4. WIP regulates N-WASP-mediated actin polymerization and filopodium formation
5. Actin based motility of vaccinia virus mimics receptor tyrosine kinase signalling
6. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
7. Surfing pathogens and the lessons learned for actin polymerization
8. Vaccinia virus utilizes microtubules for movement to the cell surface
9. Kinesin dependent movement on microtubules precedes actin based motility of vaccinia virus
10. Vaccinia virus intracellular movement is associated with microtubules and independent of actin tails
11. SH2 domains recognize specific phosphopeptide sequences
12. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins
13. Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus
14. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange
15. The GTPase dynamin binds to and is activated by a subset of SH3 domains
16. GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
17. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
18. Protein-protein interactions define specificity in signal transduction