Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain

EMBO Journal

Volumn 21, Issue 18, 2002, Pages 4785-4795

  Jogl, Gerwald ^a   Shen, Yang ^a   Gebauer, Damara ^a   Li, Jiang ^a   Wiegmann, Katja ^a   Kashkar, Hamid ^a   Krönke, Martin ^a   Tong, Liang ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Chediak Higashi syndrome; Protein structure; TNF signaling; Vesicle trafficking

Indexed keywords

NEUROBEACHIN; PLECKSTRIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BONE MARROW TRANSPLANTATION; CHEDIAK HIGASHI SYNDROME; CRYSTAL STRUCTURE; FRAMESHIFT MUTATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CHEDIAK-HIGASHI SYNDROME; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 0037119998     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf502     Document Type: Article

References (39)

1. Adam-Klages, S., Adam, D., Wiegmann, K., Struve, S., Kolanus, W., Schneider-Mergener, J. and Kronke, M. (1996) FAN, a novel WD- repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell, 86, 937-947.
2. Barbosa, M.D.F.S. et al. (1996) Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature, 382, 262-265.
3. Blomberg, N., Baraldi, E., Nilges, M. and Saraste, M. (1999) The PH superfold: a structural scaffold for multiple functions. Trends Biochem. Sci., 24, 441-445.
4. Brunger, A.T. et al. (1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D, 54, 905-921.
5. Carson, M. (1987) Ribbon models of macromolecules. J. Mol. Graph., 5, 103-106.
6. CCP4 (1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D, 50, 760-763.
7. Certain, S. et al. (2000) Protein truncation test of LYST reveals heterogeneous mutations in patients with Chediak-Higashi syndrome. Blood, 95, 979-983.
8. Colledge, M. and Scott, J.D. (1999) AKAPs: from structure to function. Trends Cell Biol., 9, 216-221.
9. Cornillon, S., Dubois, A., Bruckert, F., Lefkir, Y., Marchetti, A., Benghezal, M., de Lozanne, A., Letourneur, F. and Cosson, P. (2002) Two members of the beige/CHS (BEACH) family are involved at different stages in the organization of the endocytic pathway in Dictyostelium. J. Cell Sci., 115, 737-744.
10. Dell'Angelica, E.C., Mullins, C., Caplan, S. and Bonifacino, J.S. (2000) Lysosome-related organelles. FASEB J., 14, 1265-1278.
11. Evans, S.V. (1993) SETOR: hardware lighted three-dimensional solid model representations of macromolecules. J. Mol. Graph., 11, 134-138.
12. Ferguson, K.M., Lemmon, M.A., Schlessinger, J. and Sigler, P.B. (1995) Structure of the high affinity complex of inositol triphosphate with a phospholipase C pleckstrin homology domain. Cell, 83, 1037-1046.
13. Feuchter, A.E., Freeman, J.D. and Mager, D.L. (1992) Strategy for detecting cellular transcripts promoted by human endogenous long terminal repeats: identification of a novel gene (CDC4L) with homology to yeast CDC4. Genomics, 13, 1237-1246.
14. Gilbert, D.J., Engel, H., Wang, X., Grzeschik, K.-H., Copeland, N.G., Jenkins, N.A. and Kilimann, M.W. (1999) The neurobeachin gene (Nbea) identifies a new region of homology between mouse central chromosome 3 and human chromosome 13q13. Mamm. Genome, 10, 1030-1031.
15. Han, J.-D., Baker, N.E. and Rubin, C.S. (1997) Molecular characterization of a novel A kinase anchor protein from Drosophila melanogaster. J. Biol. Chem., 272, 26611-26619.
16. Hendrickson, W.A. (1991) Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science, 254, 51-58.
17. Hendrickson, W.A., Horton, J.R. and LeMaster, D.M. (1990) Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure. EMBO J., 9, 1665-1672.
18. Introne, W., Boissy, R.E. and Gahl, W.A. (1999) Clinical, molecular and cell biological aspects of Chediak-Higashi syndrome. Mol. Gen. Metab., 68, 283-303.
19. Jones, T.A., Zou, J.Y., Cowan, S.W. and Kjeldgaard, M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A, 47, 110-119.
20. Karim, M.A., Nagle, D.L., Kandil, H.H., Burger, J., Moore, K.J. and Spritz, R.A. (1997) Mutations in the Chediak-Higashi syndrome gene (CHS1) indicate requirement for the complete 3801 amino acid CHS protein. Hum. Mol. Gen., 6, 1087-1089.
21. Kraulis, P.J. (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Cryst., 24, 946-950.
22. Kreder, D. et al. (1999) Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J., 18, 2472-2479.
23. Kwak, E., Gerald, N., Larochelle, D.A., Vithalani, K.K., Niswonger, M.L., Maready, M. and de Lozanne, A. (1999) LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium. Mol. Biol. Cell, 10, 4429-4439.
24. Merritt, E.A. and Bacon, D.J. (1997) Raster3D-photorealistic molecular graphics. Methods Enzymol., 277, 505-524.
25. Nagase, T., Kikuno, R., Nakayama, M., Hirosawa, M. and Ohara, O. (2000) Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res., 7, 273-281.
26. Nagle, D.L. et al. (1996) Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat. Genet., 14, 307-311.
27. Neer, E.J., Schmidt, C.J., Narabudripad, R. and Smith, T.F. (1994) The ancient regulatory-protein family of WD-repeat proteins. Nature, 371, 297-300.
28. Nicholls, A., Sharp, K.A. and Honig, B. (1991) Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins, 11, 281-296.
29. Otwinowski, Z. and Minor, W. (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol., 276, 307-326.
30. Perou, C.M. et al. (1996) Identification of the murine beige gene by YAC complementation and positional cloning. Nat. Genet., 13, 303-308.
31. Spritz, R.A. (1998) Genetic defects in Chediak-Higashi syndrome and the beige mouse. J. Clin. Immunol., 18, 97-105.
32. Tong, L. (1993) Replace: a suite of computer programs for molecular-replacement calculations. J. Appl. Crystallogr., 26, 748-751.
33. Tong, L. and Rossmann, M.G. (1990) The locked rotation function. Acta Crystallogr. A, 46, 783-792.
34. Tong, L. and Rossmann, M.G. (1993) Patterson-map interpretation with noncrystallographic symmetry. J. Appl. Crystallogr., 26, 15-21.
35. Tong, L., Choi, H.-K., Minor, W. and Rossmann, M.G. (1992) The structure determination of Sindbis virus core protein using isomorphous replacement and molecular replacement averaging between two crystal forms. Acta Crystallogr. A, 48, 430-442.
36. Wang, B.-C. (1985) Resolution of phase ambiguity in macromolecular crystallography. Methods Enzymol., 115, 90-112.
37. Wang, J.-W., Howson, J., Haller, E. and Ker, W.G. (2001) Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chsl/beige proteins. J. Immunol., 166, 4586-4595.
38. Wang, X., Herberg, F.W., Laue, M.M., Wullner, C., Hu, B., Petrasch-Parwez, E. and Kilimann, M.W. (2000) Neurobeachin: a protein kinase A-anchoring, beige/Chediak-Higashi protein homolog implicated in neuronal membrane traffic. J. Neurosci., 20, 8551-8565.
39. Ward, D.M., Griffiths, G.M., Stinchcombe, J.C. and Kaplan, J. (2000) Analysis of the lysosomal storate disease Chediak-Higashi syndrome. Traffic, 1, 816-822.