SAP couples Fyn to SLAM immune receptors

Nature Cell Biology

Volumn 5, Issue 2, 2003, Pages 155-160

  Chan, Betty ^a,b   Lanyi, Arpad ^b,d   Song, Hyun Kyu ^a,b   Griesbach, Jan ^a   Simarro Grande, Maria ^b   Poy, Florence ^a   Howie, Duncan ^b   Sumegi, Janos ^c   Terhorst, Cox ^b   Eck, Michael J ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD150 ANTIGEN; PHOSPHOTRANSFERASE; PROTEIN KINASE FYN; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; LYMPHOCYTE; LYMPHOPROLIFERATIVE DISEASE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; X CHROMOSOME LINKAGE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; BINDING SITES; CARRIER PROTEINS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; GENES, REPORTER; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOPROLIFERATIVE DISORDERS; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CELL SURFACE; RECEPTORS, VIRUS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; THYMUS GLAND; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA;

EID: 0037320641     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb920     Document Type: Article

References (30)

1. Sayos, J. et al. The X-linked lymphoprofiliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395, 462-469 (1998).
2. Coffey, A. J. et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nature Genet. 20, 129-135 (1998).
3. Nichols, K. E. et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc. Natl Acad. Sci. USA 95, 13765-13770 (1998).
4. Poy, F. et al. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol. Cell 4, 555-561 (1999).
5. Latour, S. et al. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nature Immunol. 2, 681-690 (2001).
6. Morra, M. et al. X-linked lymphoproliferative disease: A progressive immunodeficiency. Annu. Rev. Immunol. 19, 657-682 (2001).
7. Sidorenko, S. P. & Clark, E. A. Characterization of a cell surface glycoprotein IPO-3, expressed on activated human B and T lymphocytes. J. Immunol. 151, 4614-4624 (1993).
8. Wang, N. et al. CD150 is a member of a family of genes that encode glycoprotein on the surface of hematopietic cells. Immunogenetics 53, 382-394 (2001).
9. Cocks, B. G. et a;. A novel receptor involved in T-cell activation. Nature 376, 260-263 (1995).
10. Punnonen, J. et al. Soluble and membrane-bound forms of signalling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. J. Exp. Med. 185, 993-1004 (1997).
11. Mavaddat, N. et al. Signaling lymphocytic activation moleculr (CDw150) is homophilic but self-associates with very low affinity. J. Biol. Chrm. 275, 28100-28109 (2000).
12. Tatsuo, H., Ono, N., Tanaka, K. & Yanagi, Y. SLAM (Cdw150) is a cellular receptor for measles virus. Nature 406, 893-897 (2000).
13. Wu, C. et al. SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nature Immunol. 2, 410-414 (2001).
14. Czar, M. J. et al. Altered lymphocyte response and cytokine production in mice dificient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc. Natl Acad. Sci. USA 98, 7449-7454 (2001).
15. Sayos, J. et al. Potential pathways for regulation of NK and T cells response: Differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4. Int. Immunol. 12, 1749-1757 (2000).
16. Sayos, J. et al. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product. SAP. Blood 97, 3867-3874 (2001).
17. Morra, M. et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptor in hematopoietic cells. EMBO J. 20, 5840-5852 (2001).
18. Morra, M. et al. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J. Biol. Chem. 276, 36809-36816 (2001).
19. Noble, M., E.M., Mustacchio, A., Saraster, M., Courtridge, S.A. & Wierenga, R.K. Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structure of SH3 domains in tyrosine kinases and spectrin. EMBO J. 12, 2617-2624 (1993).
20. Moarefi, I. et al. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385, 650-653 (1997).
21. Holdorf, A. D., Lee K. H., Burack, W. R., Allen, P.M. & Shaw, A. S. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nature Immunol. 3, 259-264 (2002).
22. Xu, W., Harrison, S.C. & Eck, M. J. Three-dimensional structure of tyrosine kinase c-Src. Nature 385, 595-602 (1997).
23. Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M. J. & Shoelson, S. E. Crystal structure of the tyrosine phosphatase SHP-2 Cell 92, 441-450 (1998).
24. Howie, D. et al. Antibodies directed at murine CD150(SLAM) mediate cell co-stimulation in both a SAP-dependent and SAP-independent fashion. Blood (in the press).
25. Howie, D. et al. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood 99, 957-965 (2002).
26. Nagy, N. et al. SH2D1A and SLAM protein expression in human lymphocytes and derived cell lines. Int. J. Cancer 88, 439-447 (2000).
27. Navaza, J. Implementation of molecular replacement in AMoRe. Acta Crystallogr. D Biol. Crystallogr. 57, 1367-1372 (2001).
28. Jones, T.A. & Kjeldgaard, M. Electron-density map interpretation. Methods Enzymol. 277, 173-208 (1997).
29. Brunger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallgr. D, Biol. Crystallogr. 54, 905-921 (1998).
30. Nagy, N. et al. The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells. Immunol. Lett. 82, 141-147 (2002).