Structure of pumilio reveals similarity between RNA and peptide binding motifs

Cell

Volumn 105, Issue 2, 2001, Pages 281-289

  Edwards, Thomas A ^a   Pyle, Scott E ^b   Wharton, Robin P ^b   Aggarwal, Aneel K ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MESSENGER RNA; PEPTIDE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN; PROTEIN HEAT; PUMILIO; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CRYSTAL STRUCTURE; DROSOPHILA; EMBRYO DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN RNA BINDING; STRUCTURE ANALYSIS; TRANSLATION REGULATION;

DROSOPHILA;

EID: 0035917508     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00318-X     Document Type: Article

References (53)

1. Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos
2. Crystallography & NMR system: A software suite for macromolecular structure determination
3. Collaborative computing project no. 4, The CCP4 suite: Programs for protein crystallography
4. Structure of the nuclear transport complex karyopherin-β2-Ran x GppNHp
5. Structure of importin-β bound to the IBB domain of importin-α
6. The 3′ untranslated region of messenger RNA: A molecular 'hotspot' for pathology
7. Crystallographic analysis of the recognition of a nuclear localisation signal by the nuclear import factor karyopherin-a
8. Translational regulation in development
9. Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila
10. Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila
11. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
12. Maximum-likelihood heavy atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
13. Crystallization and characterization of Pumilio: A novel RNA binding protein
14. SETOR: Hardware lighted three dimensional solid model representations of macromolecules
15. PHASES-95: A program package for the processing and analysis of diffraction data from macromolecules
16. Translational regulation of nanos by RNA localization
17. Crystal structure of a b-catenin/Tcf complex
18. Control of translation initiation in animals
19. The structure of a protein phosphatase 2a PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
20. Three dimensional structure of the armadillo repeat region of b-catenin
21. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-kappaB inactivation
22. Structure of an IκBα/NF-κB complex
23. Improved methods for building models in electron density maps and the location of errors in these models
24. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
25. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
26. Procheck: A program to check the stereochemical quality of protein structures
27. Allosteric effects of DNA on transcriptional regulators
28. The Drosophila pumilio gene: An unusually long transcription unit and an unusual protein
29. Translational regulation of maternal mRNAs
30. Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos
31. RNA-protein complexes
32. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
33. The puf3 protein is a transcript-specific regulator of mRNA degradation in yeast
34. Maximum likelihood refinement of heavy atom parameters
35. Processing of X-ray diffraction data collected in oscillation mode
36. Crystal structure of an HIV-binding recombinant fragment of human CD4
37. Allosteric effects of pit-1 DNA sites on long-term repression in cell type specification
38. Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro
39. Recruitment of Nanos to hunchback mRNA by Pumilio
40. Drosophila Brain Tumor is a translational repressor
41. Post-transcriptional regulation through the HO 3′UTR by Mpt5, a yeast homolog of Pumilio and FBF
42. Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres
43. Automated MAD and MIR structure solution
44. Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system
45. Hot spots in β-catenin for interactions with LEF-1, conductin and APC
46. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
47. The Pumilio RNA-binding domain is also a translational regulator
48. RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
49. Translational control of growth factor and proto-oncogene expression
50. Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA
51. The PUMILIO-RNA interaction: A single RNA-binding domain monomer recognizes a bipartite target sequence
52. The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins
53. A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line