Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

Cell

Volumn 97, Issue 6, 1999, Pages 727-741

  Fambrough, D ^a   McClure, K ^a   Kazlauskas, A ^a   Lander, E S ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; GENE INDUCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE;

EID: 0033001953     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80785-0     Document Type: Article

References (60)

1. A.-K. Arvidsson E. Rupp E. Nanberg J. Downward L. Rönnstrand S. Wennstrom J. Schlessinger C.-H. Heldin L. Claesson-Welsh Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation Mol. Cell. Biol. 14 1994 6715 6726
2. M.V. Barone S.A. Courtneidge Myc but not Fos rescue of PDGF signaling block caused by kinase-inactive Src Nature 378 1995 509 512
3. U. Boehm T. Klamp M. Groot J.C. Howard Cellular responses to interferon-γ Annu. Rev. Immunol. 15 1997 749 795
4. T. Bondeva L. Pirola G. Bulgarelli-Leva I. Rubio R. Wetzker M.P. Wymann Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK Science 282 1998 293 296
5. S6k activation mediated by phosphatidylinositol-3-OH kinase Nature 370 1994 71 75
6. J. Chung E. Uchida T.C. Grammer J. Blenis STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation Mol. Cell. Biol. 17 1997 6508 6516
7. J.E. Darnell Jr. STATs and gene regulation Science 277 1997 1630 1635
8. M. David E. Petricoin III C. Benjamin R. Pine M.J. Weber A.C. Larner Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins Science 269 1995 1721 1723
9. K.A. DeMali C.C. Whiteford E.T. Ulug A. Kazlauskas Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cγ or phosphatidylinositol 3 kinase J. Biol. Chem. 272 1997 9011 9018
10. I. Dikic J. Schlessinger I. Lax PC12 cells overexpressing the insulin receptor undergo insulin dependent neuronal differentiation Curr. Biol. 4 1994 702 708
11. W.J. Fantl J.A. Escobedo G.A. Martin C.W. Turck M. del Rosario F. McCormick L.T. Williams Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways Cell 69 1992 413 423
12. T.F. Franke S.-I. Yang T.O. Chan K. Datta A. Kazlauskas D.K. Morrison D.R. Kaplan P.N. Tsichlis The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase Cell 81 1995 727 736
13. M. Freeman Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye Cell 87 1996 651 660
14. C.-H. Heldin Simultaneous induction of stimulatory and inhibitory signals by PDGF FEBS Lett. 410 1997 17 21
15. C.-H. Heldin A. Östman L. Rönnstrand Signal transduction via platelet-derived growth factor receptors Biochim. Biophys. Acta 1378 1998 79 113
16. H.R. Herschman Primary response genes induced by growth factors and tumor promoters Annu. Rev. Biochem. 60 1991 281 319
17. C.S. Hill R. Treisman Differential activation of c- fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors EMBO J. 14 1995 5037 5047
18. V.R. Iyer M.B. Eisen D.T. Ross G. Schuler T. Moore J.C.F. Lee J.M. Trent L.M. Staudt J. Hudson Jr. M.S. Boguski The transcriptional program in the response of human fibroblasts to serum Science 283 1999 83 87
19. N. Jain T. Zhang S.L. Fong C.P. Lim X. Cao Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK) Oncogene 17 1997 3157 3167
20. M. Joly A. Kazlauskas F.S. Fay S. Corvera Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites Science 263 1994 684 687
21. A. Kashishian J.A. Cooper Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1 Mol. Biol. Cell 4 1993 49 57
22. A. Kashishian A. Kazlauskas J.A. Cooper Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo EMBO J. 11 1992 1373 1382
23. A. Kazlauskas A. Kashishian J.A. Cooper M. Valius GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit Mol. Cell. Biol. 12 1992 2534 2544
24. A. Kazlauskas G.S. Feng T. Pawson M. Valius The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp Proc. Natl. Acad. Sci. USA 90 1993 6939 6943
25. L. Kim T.W. Wong The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors Mol. Cell. Biol. 15 1995 4553 4561
26. V. Kundra J.A. Escobedo A. Kazlauskas H.K. Kim S.G. Rhee L.T. Williams B.R. Zetter Regulation of chemotaxis by the platelet-derived growth factor receptor β Nature 367 1994 474 476
27. D.J. Lockhart H. Dong M.C. Byrne M.T. Follettie M.V. Gallo M.S. Chee M. Mittmann C. Wang M. Kobayashi H. Horton E.L. Brown Expression monitoring by hybridization to high-density oligonucleotide arrays Nature Biotech. 14 1996 1675 1680
28. A.D. Miller G.J. Rosman Improved retroviral vectors for gene transfer and expression BioTechniques 7 1989 980 990
29. J.-P. Montmayeur M. Valius J. Vandenheede A. Kazlauskas The platelet-derived growth factor β receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs J. Biol. Chem. 272 1997 32670 32678
30. S. Mori L. Rönnstrand K. Yokote Å. Engström S.A. Courtneidge L. Claesson-Welsh C.-H. Heldin Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases EMBO J. 12 1993 2257 2264
31. R. Nishimura W. Li A. Kashishian A. Mondino M. Zhou J. Cooper J. Schlessinger Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor Mol. Cell. Biol. 13 1993 6889 6896
32. A. Olivera S. Spiegel Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens Nature 365 1993 557 560
33. T. Pawson J.D. Scott Signaling through scaffold, anchoring, and adaptor proteins Science 278 1997 2075 2080
34. M.A. Price C. Hill R. Treisman Integration of growth factor signals at the c-fos serum response element Phil. Trans. R. Soc. Lond. B 351 1996 551 559
35. C.S.S. Rani F. Wang E. Fuior A. Berger J. Wu T.W. Sturgill D. Beitner-Johnson D. LeRoith L. Varticovski S. Spiegel Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors J. Biol. Chem. 272 1997 10777 10783
36. S. Roche J. McGlade M. Jones G.D. Gish T. Pawson S.A. Courtneidge Requirement of phospholipase Cγ, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis evidence for the existence of Ras-dependent and Ras-independent pathways EMBO J. 15 1996 4940 4948
37. B.J. Rollins C.D. Stiles Serum-inducible genes Adv. Cancer Res. 53 1989 1 32
38. L. Rönnstrand S. Mori A.-K. Arvidsson A. Eriksson C. Wernstedt U. Hellman L. Claesson-Welsh C.-H. Heldin Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor involvement in the interaction with phospholipase C-gamma EMBO J. 11 1992 3911 3919
39. Y. Sasai E.M. De Robertis Ectodermal patterning in vertebrate embryos Dev. Biol. 182 1997 5 20
40. M. Schena D. Shalon R.W. Davis P.O. Brown Quantitative monitoring of gene expression patterns with a complementary DNA microarray Science 270 1995 467 470
41. O. Silvennoinen C. Schindler J. Schlessinger D.E. Levy Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation Science 261 1993 1736 1739
42. M. Socolovsky I. Dusanter-Fourt H.F. Lodish The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors J. Biol. Chem. 272 1997 14009 14012
43. D. St. Johnston C. Nüsslein-Volhard The origin of pattern and polarity in the Drosophila embryo Cell 68 1992 201 219
44. K. Symes M. Mercola Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase Proc. Natl. Acad. Sci. USA 93 1996 9641 9644
45. P. Tamayo D. Slonim J. Mesirov Q. Zhu S. Kitareewan E. Dmitrovsky E.S. Lander T.R. Golub Interpreting patterns of gene expression with self-organizing maps methods and application to hematopoietic differentiation Proc. Natl. Acad. Sci. USA in press 1999
46. S. Taverse K. Seedorf H. Paterson C.J. Marchall P. Cohen A. Ullrich EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor Curr. Biol. 4 1994 694 701
47. H. Ueno J.A. Escobedo L.T. Williams Dominant-negative mutations of platelet-derived growth factor (PDGF) receptors J. Biol. Chem. 268 1993 22814 22819
48. R.R. Vaillancourt A.M. Gardner A. Kazlauskas G.L. Johnson The kinase-inactive PDGF β-receptor mediates activation of the MAP kinase cascade via the endogenous PDGF α-receptor in HepG2 cells Oncogene 13 1996 151 159
49. S. Valgeirsdóttir K. Paukku O. Silvennoinen C.-H. Heldin L. Claesson-Welsh Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in the PDGF β-receptor juxtamembrane and kinase insert domains Oncogene 16 1998 505 515
50. M. Valius A. Kazlauskas Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal Cell 73 1993 321 334
51. M. Valius C. Bazenet A. Kazlauskas Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively Mol. Cell. Biol. 13 1993 133 143
52. M. Valius J.P. Secrist A. Kazlauskas The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1 Mol. Cell. Biol. 15 1995 3058 3071
53. P. van der Geer T. Hunter R.A. Lindberg Receptor protein-tyrosine kinases and their signal transduction pathways Annu. Rev. Cell Biol. 10 1994 251 337
54. M.L. Vignais H.B. Sadowski D. Watling N.C. Rogers M. Gilman Platelet-derived growth factor induced phosphorylation of multiple JAK family kinases and STAT proteins Mol. Cell. Biol. 16 1996 1759 1769
55. T.M. Wright J.M. Farber 5′ regulatory region of a novel cytokine gene mediates selective activation by interferon gamma J. Exp. Med. 173 1991 417 422
56. H. Yamamoto M. Crow L. Cheng E. Lakatta J. Kinsella PDGF receptor-to-nucleus signaling of p91 (STAT1α) transcription factor in rat smooth muscle cells Exp. Cell Res. 222 1996 125 130
57. K. Yokote S. Mori K. Hansen J. McGlade T. Pawson C.-H. Heldin L. Claesson-Welsh Direct interaction between Shc and the platelet-derived growth factor beta-receptor J. Biol. Chem. 269 1994 15337 15343
58. K. Yokote B. Margolis C.-H. Heldin L. Claesson-Welsh Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors J. Biol. Chem. 271 1996 30942 30949
59. X. Zhu Z. Wen L.Z. Xu J.E. Darnell Jr. Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires and activated Jak2 kinase Mol. Cell. Biol. 17 1997 6618 6623
60. M. Zubiaur J. Sancho C. Terhorst D.V. Faller A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-β receptor upon ligand binding J. Biol. Chem. 270 1995 17221 17228