Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2DIA

Current Biology

Volumn 9, Issue 23, 1999, Pages 1355-1362

  Li, Shun Cheng ^a,e   Gish, Gerald ^a,e   Yang, Daiwen ^e,f   Coffey, Alison J ^b   Forman Kay, Julie D ^c,e   Ernberg, Ingemar ^d   Kay, Lewis E ^e,f   Pawson, Tony ^a,e  

^a MOUNT SINAI HOSPITAL   (Canada)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033518296     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(00)80080-9     Document Type: Article

References (38)

1. Pawson T: Protein modules and signaling networks. Nature 1995, 373:573-580.
2. Cohen GB, Ren R, Baltimore D: Modular binding domains in signal transduction proteins. Cell 1995, 80:237-248.
3. Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, et al.: Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry 1993, 32:3197-3202.
4. Bradshaw JM, Waksman G: Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: Dissection of the phosphopeptide sequence specificity and coupling energetics. Biochemistry 1999, 38:5147-5154.
5. Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J: Binding of a high affinity phosphotyrosyl peptide in the src SH2 domain: Crystal structures of the complexed and peptide-free forms. Cell 1993, 72:779-790.
6. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, et al.: SH2 domains recognize specific phosphopeptide sequences. Cell 1993, 72:767-778.
7. Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, et al.: Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell 1994, 77:461-472.
8. Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, et al.: SH2 domain specificity and activity modified by a single residue. Nature 1994, 369:502-505.
9. Bubeck-Wardenburg J, Wong J, Futterer K, Pappu R, Fu C, Waksman G, et al.: Regulation of antigen receptor function by protein tyrosine kinases. Prog Biophys Mol Biol 1999, 71:373-392.
10. Samelson LE: Adaptor proteins and T-cell antigen receptor signaling. Prog Biophys Mol Biol 1999, 71:393-403.
11. Scharenberg AM, Kinet JP: The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? Cell 1996, 87:961-964.
12. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, et al.: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 1998, 395:462-469.
13. Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, et al.: Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet 1998, 20:129-131.
14. Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, et al.: Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci USA 1998, 95:13765-13770.
15. Purtilo DT, Grierson HL, Davis JR, Okano M: The X-linked lymphoproliferative disease: From autopsy toward cloning the gene 1975-1990. Pediatr Pathol 1991, 11:685-710.
16. Harrington DS, Weisenburger DD, Purtilo DT: Malignant lymphoma in the X-linked lymphoproliferative syndrome. Cancer 1987, 59:1419-1429.
17. Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, et al.: Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol 1994, 14:2777-2785.
18. Wishart DS, Sykes BD: The 13C chemical-shift index: A simple method for the identification of protein secondary structure using 13C chemical-shift data. J Biomol NMR 1994, 4:171-180.
19. Wishart DS, Sykes BD, Richards FM: The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy. Biochemistry 1992, 31:1647-1651.
20. Overduin M, Rios CB, Mayer BJ, Baltimore D, Cowburn D: Three-dimensional solution structure of the src homology 2 domain of c-abl. Cell 1992, 70:697-704.
21. Burshtyn DN, Yang W, Yi T, Long EO: A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem 1997, 272:13066-13072.
22. Chung E, Henriques D, Renzoni D, Zvelebil M, Bradshaw JM, Waksman G, et al.: Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides. Structure 1998, 6:1141-1151.
23. Kay LE, Muhandiram DR, Wolf G, Shoelson SE, Forman-Kay JD: Correlation between binding and dynamics at SH2 domain interfaces. Nat Struct Biol 1998, 5:156-163.
24. Larose L, Gish G, Pawson T: Construction of an SH2 domain-binding site with mixed specificity. J Biol Chem 1995, 270:3858-3862.
25. Yoakim L, Hou W, Songyang Z, Liu Y, Cantley L, Schaffhausen B: Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity. Mol Cell Biol 1994, 14:5929-5938.
26. Songyang Z, Gish G, Mbamalu G, Pawson T, Cantley LC: A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains. J Biol Chem 1995, 270:26029-26032.
27. Huyer G, Ramachandran C: The specificity of the N-terminal SH2 domain of SHP-2 is modified by a single point mutation. Biochemistry 1998, 37:2741-2747.
28. Ladbury JE, Lemmon MA, Zhou M, Green J, Botfield MC, Schlessinger J: Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: A reappraisal. Proc Natl Acad Sci USA 1995, 92:3199-3203.
29. Waksman G, Kominos D, Robertson SC, Pant N, Baltimore D, Birge RB, et al.: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosinephosphorylated peptides. Nature 1992, 358:646-653.
30. Bradshaw JM, Grucza RA, Ladbury JE, Waksman G: Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: A thermodynamic study. Biochemistry 1998, 37:9083-9090.
31. ZHang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, et al.: Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J 1997, 16:6141-6150.
32. Li SC, Zwahlen C, Vincent SJ, McGlade CJ, Kay LE, Pawson T, et al.: Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat Struct Biol 1998, 5:1075-1083.
33. Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, et al.: Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell 4:555-561.
34. Pace CN, Vajdos F, Fee L, Grimsley G, Gray T: How to measure and predict the molar absorption coefficient of a protein. Protein Sci 1995, 4:2411-2423.
35. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A: NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 1995, 6:277-293.
36. Johnson BA, Blevins RA: NMRView: A computer program for the visualization and analysis of NMR data. J Biomol NMR 1994, 4:603-614.
37. Muhandiram DR, Kay LE: Gradient-enhanced triple-resonance three-dimensional NMR experiments with enhanced sensitivity. J Mag Res Series B 1994, 103:203-216.
38. Sattler M, Schleucher J, Griesinger C: Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients. Prog NMR Spectro 1999, 34:93-158.