Protein-protein interactions define specificity in signal transduction

Genes and Development

Volumn 14, Issue 9, 2000, Pages 1027-1047

  Pawson, Tony ^a   Nash, Piers ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SERINE THREONINE KINASE;

ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION; HUMANS; MEMBRANE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0034193568     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (199)

1. Aghazadeh, B. and M.K. Rosen. 1999. Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices. Chem. Biol. 6: R241-R246.
2. Alessi, D.R., M. Deak, A. Casamayor, F.B. Caudwell, N. Morrice, D.G. Norman, P. Gaffney, C.B. Reese, C.N. MacDougall, D. Harbison, A. Ashworth, and M. Bownes. 1997. 3-phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7: 776-789.
3. Andjelkovic, M., S.M. Maira, P. Cron, P.J. Parker, and B.A. Hemmings. 1999. Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol. Cell. Biol. 19: 5061-5062.
4. Arch, R.H., R.W. Gedrich, and C.B. Thompson. 1998. Tumor necrosis factor receptor-associated factors (TRAFs) - family of adapter proteins that regulates life and death. Genes & Dev. 12: 2821-2830.
5. Ashkenazi, A. and V.M. Dixit. 1998. Death receptors: Signaling and modulation. Science 281: 1305-1308.
6. Behrens, J., J.P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl, and W. Birchmeier. 1996. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382: 638-642.
7. Behrens, J., B.A. Jerchov, M. Wurtele, J. Grimm, C. Asbrand, R. Wirtz, M. Kuhl, D. Wedlich, and W. Birchmeier. 1998. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β. Science 280: 596-599.
8. Belham, C., S. Wu, and J. Avruch. 1999. Intracellular signalling: PDK1 - a kinase at the hub of things. Curr Biol. 9: R93-R96.
9. Bell, D.W., J.M. Varley, T.E. Szydlo, D.H. Kang, D.C. Wahrer, K.E. Shannon, M. Lubratovich, S.J. Verselis, K.J. Isselbacher, J.F. Fraumeni, J.M. Birch, P.P. Li, J.E. Garber, and D.A. Haber. 1999. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286: 2528-2531.
10. Binns, K., P.P. Taylor, F. Sicheri, T. Pawson, and S.J. Holland. 2000. Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol. Cell. Biol. (in press).
11. Blume-Jensen, P., G. Jiang, R. Hyman, K.F. Lee, S. O'Gorman, and T. Hunter. 2000. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility. Nat. Genet. 24: 157-162.
12. Bokoch, G.M., Y. Wang, B.P. Bohl, M.A. Sells, L.A. Quilliam, and U.G. Knaus. 1996. Interaction of the Nck adapter with p21-activated kinase (PAK1). J. Biol. Chem. 271: 25746-25749.
13. Borg, J.P., J. Ooi, E. Levy, and B. Margolis. 1998. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol. 16: 6229-6241.
14. Boutros, M., N. Paricio, D.I. Strutt, and M. Mlodzik. 1998. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94: 109-118.
15. Brose, K., K.S. Bland, K.H. Wang, D. Arnott, W. Henzel, C.S. Goodman, M. Tessier-Lavigne, and T. Kidd. 1999. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96: 795-806.
16. Brunet, A., A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96: 857-868.
17. Bubeck Wardenburg, J., R. Pappu, J.Y. Bu, B. Mayer, J. Chernoff, D. Straus, and A.C. Chan. 1998. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 9: 607-616.
18. Buday, L. 1999. Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins. Biochem. Biophys. Acta 1422: 187-204.
19. Chan, S.S., H. Zheng, M.W. Su, R. Wilk, M.T. Killen, E.M. Hedgecock, and J.G. Culotti. 1996. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87: 187-195.
20. Cadigan, K.M. and R. Nusse. 1996. wingless signaling in the Drosophila eye and embryonic epidermis. Development 122: 2801-2812.
21. Chen, X., U. Vinkemeier, Y. Zhao, D. Jeruzalmei, J.E. Darnell, Jr., and J. Kuriyan. 1998. Crystal structure of tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93: 827-839.
22. Chinnaiyan, A.M., K. O'Rourke, M. Tewari, and V.M. Dixit. 1995. FADD a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512.
23. Choi, K.Y., B. Satterberg, D.M. Lyons, and E.A. Elion. 1994. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78: 499-512.
24. Colledge, M.S. and J.D. Scott. 1999. AKAPs: From structure to function. Trends Cell Biol. 9: 216-221.
25. Craig, K.L. and M. Tyers. 1999. The F-box: A new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog. Biophys. Molec. Biol. 72: 299-328.
26. Cunningham, B.C. and J.A. Wells. 1991. Rational design of receptor specific variants of human growth hormone. Proc. Natl. Acad. Sci. 88: 3407-3411.
27. Darnell, J.E., Jr. 1997. STATs and gene regulation. Science 277: 1630-1635.
28. Debant, A., C. Serra-Pages, K. Seipel, S. O'Brien, M. Tang, S.H. Park, and M. Streuli. 1996. The multi-domain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. 93: 5466-5471.
29. Drescher, U., C. Kremoser, C. Handwerker, J. Löschinger, M. Noda, and F. Bonhoeffer. 1995. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82: 359-370.
30. Du, K. and M. Montminy. 1998. CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 273: 32377-32379.
31. Durocher, D., J. Henckel, A.R. Fersht, and S.P. Jackson. 1999. The FHA domain is a modular phosphopeptide recognition motif. Mol. Cell 4: 387-394.
32. Eck, M.J., S.K. Atwell, S.E. Shoelson, and S.C. Harrison. 1993. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p561ck. Nature 362: 87-91.
33. Ekman, S., E.R. Thuresson, C.-H. Heldin, and L. Rönnstrand, L. 1999. Increased mitogenecity of an αβ heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. Oncogens 18: 1-8.
34. Elion, E.A. 1998. Routing MAP kinase cascades. Science 281: 1625-1626.
35. Etemad-Moghadam, B., S. Guo, and K.J. Kemphues. 1995. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell 83: 743-752.
36. Fagotto, F., E. Jho, L. Zeng, T. Kurth, T. Joos, C. Kaufmann, and F. Costantini. 1999. Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145: 741-756.
37. Fambrough, D., K. McClure, A. Kazlauskas, and E.S. Lander. 1999. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97: 727-741.
38. Fanning, A.S. and J.M. Anderson. 1999. Protein modules as organizers of membrane structure. Curr. Opin. Cell. Biol. 11: 432-439.
39. Flanagan, J.G. and P. Vanderhaeghen. 1998. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21: 309-345.
40. Frise, E., J.A. Knoblich, S. Younger-Shepherd, L.Y. Ja, and Y.N. Jan. 1996. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc. Natl. Acad. Sci. 93: 11925-11932.
41. Fruman, D.A., L.E. Rameh, and L.C. Cantley. 1999. Phosphoinositide binding domains: Embracing 3-phosphate. Cell 97: 817-820.
42. Gassmann, M., F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein, and G. Lemke. 1995. Aberrant neural and cardiac development in mice lacking the erbB4 neuregulin receptor. Nature 378: 390-394.
43. Gavin, A.C. and A.R. Nebreda. 1999. A MAP kinase decking site is required for phosphorylation and activation of p90(rsk)/ MAPKAP kinase-1. Curr. Biol. 9: 281-284.
44. Gertler, F.B., K. Niebuhr, M. Reinhard, J. Wehland, and P. Sonano. 1996. Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics. Cell 87: 227-239.
45. Hart, M., J.P. Concordet, I. Lassot, I. Albert, R. del los Santos, H. Durand, C. Perret, B. Rubinfeld, F. Margottin, R. Benarous et al 1999. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell. Curr. Biol. 9: 207-210.
46. Heldin, C.H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80: 213-223.
47. Heldin, C.-H., A. Östman, and L. Rönnstrand. 1998. Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378: F79-F113.
48. Heuchel, R., A. Berg, M. Tallquist, K. Ahlen, R.K. Reed, K. Rubin, L. Claesson-Welsh, C.H. Heldin, and P. Soriano. 1999. Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling. Proc. Natl. Acad. Sci. 96: 11410-11415.
49. Hillier, B.J., K.S. Christopherson, K.E. Prehoda, D.S. Bredt, and W.A. Lim. 1999. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 284: 812-815.
50. Hing, H., J. Xiao, N. Harden, L. Lim, and S.L. Zipursky. 1999. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97: 853-863.
51. Hof, P., S. Pluskey, S. Dhe-Paganon, M.J. Eck, and S.E. Shoelson. 1998. Crystal structure of the tyrosine phosphatase SHP-2. Cell 92: 441-450.
52. Hofmann, K. and P. Butcher. 1995. The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20: 347-349.
53. Holder, N. and R. Klein. 1999. Eph receptors and ephrins: Effectors of morphogenesis. Development 126: 2033-2044.
54. Holland, P.M. and J.A. Cooper. 1999. Protein modification: Docking sites for kinases. Curr. Biol. 9: R329-R331.
55. Holland, S.J., N.W. Gale, G.D. Gish, R.A. Roth, Z. Songyang, L.C. Cantley, M. Henkemeyer, G.D. Yancopoulos, and T. Pawson. 1997. Juxtamembrane tyrosine residues couple the Eph family receptor Eph B2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 16: 3877-3888.
56. Hong, K., L. Hinck, M. Nishiyama, M.M. Poo, M. Tessier-Lavigne, and E. Stein. 1999. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97: 927-941.
57. Hsu, H., J. Xiong, and D.V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495-504.
58. Huang, D., J. Moffat, W.A. Wilson, L. Moore, C. Cheng, P.J. Roach, and B. Andrews. 1998. Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: Control of glycogen biosynthesis by Pcl8 and Pcl10. Mol. Cell. Biol. 18: 3289-3299.
59. Hubbard, S.R. 1999. Structural analysis of receptor tyrosine kinases. Prog. Biophys. Mol. Biol. 71: 343-358.
60. Hunter, T. 2000. Signaling - 2000 and beyond. Cell 100: 113-127.
61. Itoh, K., A. Antipova, M.J. Ratcliffe, and S. Sokol. 2000. Interaction of dishevelled and xenopus axin-related protein is required for Wnt signal transduction. Mol. Cell. Biol. 20: 2228-2238.
62. Jacobs, D., D. Glossip, H. Xing, A.J. Muslin, and K. Kornfeld. 1999. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes & Dev. 13: 163-175.
63. Joazerio, C.A., S.S. Wing, H. Huang, J.D. Leverson, T. Hunter, and Y.C. Liu. 1999. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309-312.
64. Kaffitz, K.W., C.R. Rose, H. Thoenen, and A. Konnerth. 1999. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 401: 918-921.
65. Kalo, M.S. and E.B. Pasquale. 1999. Multiple in vivo tyrosine phosphorylation sites in EphB receptors. Biochemistry 38: 14396-14408.
66. Karin, M. 1999. The beginning of the end IκB kinase (IKK) and NF-κB activation. J. Biol. Chem. 274: 27339-27342.
67. Kawata, T., A. Shevchenko, M. Fukuzawa, K.A. Jermyn, N.F. Totty, N.V. Zhukovskaya, A.E. Sterling, M. Mann, and J.G. Williams. 1997. SH2 signaling in a lower eukaryote: A STAT protein that regulates stalk cell differentiation in dictyostelium. Cell 89: 909-916.
68. Kay, L.E., D.R. Muhandiram, G. Wolf, S.E. Shoelson, and J.D. Forman-Kay. 1998. Correlation between binding and dynamics at SH2 domain interfaces. Nat. Struct. Biol. 5: 156-163.
69. Kelkar, N., S. Gupta, M. Dickens, and R.J. Davis. 2000. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol. Cell Biol. 20: 1030-1043.
70. Kidd, T., K. Brose, K.J. Mitchell, R.D. Fetter, M. Tessier-Lavigne, CS. Goodman, and G. Tear. 1998. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92: 205-215.
71. Kidd, T., K.S. Bland, and C.S. Goodman. 1999. Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785-794.
72. Kissel, H., I. Timokhina, M.P. Hardy, G. Rothschild, Y. Tajima, V. Soares, M. Angeles, S.R. Whitlow, K. Manova, and P. Besmer. 2000. Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses. EMBO J. 19: 1312-1326.
73. Klein, G. and E. Klein. 1998. Sinking surveillance's flagship. Nature 395: 443-443.
74. Kouhara, H., Y.R. Hadari, T. Spivak-Kroizman, J. Schilling, D. Bar-Sagi, I. Lax, and J. Schlessinger. 1997. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89: 693-702.
75. Kretzschmar, M., J. Doody, I. Timokhina, and J. Massague. 1999. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes & Dev. 13: 804-816.
76. Kuriyan, J. and D. Cowburn. 1997. Modular peptide recognition domains in eukaryotic signaling. Annu. Rev. Biophys. Biomol. Struct. 26: 259-288.
77. Lanier, L.M. and F.B. Gertler. 2000. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility. Curr. Opin. Neurobiol. 10: 80-87.
78. Lanier, L.M., M.A. Gates, W. Witke, A.S. Menzies, A.M. Wehman, J.D. Macklis, D. Kwiatkowski, P. Soriano, and F.B. Gertler. 1999. Mena is required for neurulation and commissure formation. Neuron 22: 313-325.
79. Larose, L., G. Gish, and T. Pawson. 1995. Construction of an SH2 domain-binding site with mixed specificity. J. Biol. Chem. 270: 3858-3862.
80. Lee, K.F., H. Simon, H. Chen, B. Bates, M.C. Hung, and C. Hauser. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394-398.
81. Leonardo, E.D., L. Hinck, M. Masu, K. Keino-Masu, S.L. Ackerman, and M. Tessier-Lavigne. 1997. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386: 833-838.
82. Lesa, G.M. and P.W. Sternberg. 1997. Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor. Mol. Cell. Biol. 8: 779-793.
83. Leuing-Hagesteijn, C., A.M. Spence, B.D. Stern, Y. Zhou, M.W. Su, E.M. Hedgecock, and J.G. Culotti. 1992. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migration in C. elegans. Cell 71: 289-299.
84. Li, N., A. Batzer, R. Daly, E. Skolnik, P. Chardin, D. Bar-Sagi, B. Margolis, and J. Schlessinger. 1993. Guanine nucleotide releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling. Nature 363: 85-88.
85. Li, S.C., C. Zwahlen, S.J. Vincent, C.J. McGlade, L.E. Kay, T. Pawson, and J.D. Forman-Kay. 1998. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat. Struct. Biol. 5: 1075-1083.
86. Li, S.C., G. Gish, D. Yang, A.J. Coffey, J.D. Forman-Kay, I. Ernberg, L.E. Kay, and T. Pawson. 1999. Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A. Curr. Biol. 9: 1355-1362.
87. Liao, H., I.J. Byeon, and M.D. Tsai. 1999. Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53. J. Mol. Biol. 294: 1041-1049.
88. Lin, D., G.D. Gish, Z. Songyang, and T. Pawson. 1999. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J. Biol. Chem. 274: 3726-3733.
89. Liu, F., Q. Wan, Z.B. Pristupa, X.-M. Yu, Y.T. Wang, and H.B. Niznik. 2000. Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors. Nature 403: 274-280.
90. Liu, S.K., N. Fang, G.A. Koretzky, and C.J. McGlade. 1999. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9: 67-75.
91. Lowman, H.B., B.C. Cunnigham, and J.A. Wells. 1991. Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen. J. Biol. Chem. 266: 10982-10988.
92. Lu, P.J., X.Z. Zhou, M. Shen, and K.P. Lu. 1999. Function of WW domains as phosphoserine-or phosphothreonine-binding modules. Science 283: 1325-1328.
93. Lu, W., S. Katz, R. Gupta, and B.J. Mayer. 1997. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr. Biol. 7: 85-94.
94. Maina, F., F. Casagranda, E. Andero, A. Simeone, P.M. Comoglio, G. Klein, and C. Ponzetto. 1996. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 87: 531-542.
95. Manser, E., T.H. Loo, C.G. Koh, Z.S. Zhao, X.Q. Chen, I. Tan, T. Leung, and L. Lim. 1998. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1: 183-192.
96. Mao, Y., A. Nickitenko, X. Duan, T.E. Lloyd, M.N. Wu, H. Bellen, and F.A. Quiocho. 2000. Crystal structure of the VHS and FYVE tandem domains of Hrs a protein involved in membrane trafficking and signal transduction. Cell 100: 447-456.
97. Marengere, L.E.M., Z. Songyang, G.D. Gish, M.D. Schaller, T. Parsons, M.J. Stern, L.C. Cantley, and T. Pawson. 1994. SH2 domain specificity and activity modified by a single residue. Nature 369: 502-505.
98. Marshall, C.J. 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase MAP kinase. Curr. Opin. Genet. Dev. 4: 82-89.
99. Massague, J. 1998. TGF-β signal transduction. Annu. Rev. Biochem. 67: 753-791.
100. Mayer, B.J. 1999. Endocytosis: EH domains lend a hand. Curr. Biol. 9: R70-R73.
101. McWhirter, S.M., S.S. Pullen, J.M. Holton, J.J. Crute, M.R. Kehry, and T. Alber. 1999. Crystallographic analysis of CD40 recognition and signaling by human TRAF2. Proc. Natl. Acad. Sci. 96: 8408-8412.
102. Meyer, D. and C. Birchmeier. 1995. Multiple essential functions of neuregulin in development. Nature 378: 386-390.
103. Meyer, D., A. Liu, and B. Margolis. 1999. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190rhoGEF and its localization in differentiated neurons. J. Biol. Chem. 274: 35113-35118.
104. Muslin, A.J., J.W. Tanner, P.M. Allen, and A.S. Shaw. 1996. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84: 889-897.
105. Muzio, M., A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P.H. Krammer, M.E. Peter, and V.M. Dixit. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827.
106. Nebreda, A.R. and A.C. Gavin. 1999. Cell survival demands some Rsk. Science 286: 1309-1310.
107. Newlon, M.G., M. Roy, D. Morikis, Z.E. Hausken, V. Coghlan, J.D. Scott, and P.A. Jennings. 1999. The molecular basis for protein kinase A anchoring revealed by solution NMR. Nat. Struct. Biol. 6: 222-227.
108. Nguyen, J.T., C.W. Turck, F.E. Cohen, R.N. Zuckermann, and W. Lim. 1998. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors. Science 282: 2088-2092.
109. Niebuhr, K., F. Ebel, R. Frank, M. Reinhard, F. Domann, U.D. Carl, U. Walter, F.B. Gertler, J. Wehland, and T. Chakraborty. 1997. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. EMBO J. 16: 5433-5444.
110. Nishita, M., M.K. Hashimoto, S. Ogata, M.N. Laurent, N. Ueno, H. Shibuya, and K.W. Cho. 2000. Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer. Nature 403: 781-785.
111. Ong, S.H., G.R. Guy, Y.R. Hadari, S. Laks, N. Gotoh, J. Schlessinger, and I. Lax. 2000. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol. Cell. Biol. 20: 979-989.
112. Ottinger, E.A., M.C. Botfield, and S.E. Shoelson. 1998. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. J. Biol. Chem. 273: 729-735.
113. Park, Y.C., V. Burkit, A.R. Villa, L. Tong, and H. Wu. 1999. Structural basis for self-association and receptor recognition of human TRAF2. Nature 398: 533-538.
114. Pascal, S.M., A.U. Singer, G. Gish, T. Yamazaki, S.E. Shoelson, T. Pawson, I.E. Kay, and J.D. Forman-Kay. 1994. Nuclear magnetic resonance structure of an SH2 domain of pbospholipase C-gammal complexed with a high affinity binding peptide. Cell 77: 461-472.
115. Patton, E.E., A.R. Willems, D. Sa, L. Kuras, D. Thomas, K.L. Craig, and M. Tyers. 1998. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes & Dev. 12: 692-705.
116. Pawson, T. 1995. Protein modules and signalling networks. Nature 373: 573-580.
117. Pawson, T. and J.D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science 278: 2075-2080.
118. Pellicena, P., K.R. Stowen, and W.T. Miller. 1998. Enhanced phosphorylation of src family kinase substrates containing SH2 domain binding sites. J. Biol. Chem. 273: 15325-15328.
119. Peng, C.Y., P.R. Graves, R.S. Thoma, Z. Wu, A.S. Shaw, and H. Piwnica-Worms. 1997. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277: 1501-1505.
120. Pinkas-Kramarski, R., M. Shelly, B.C. Guarino, L.M. Wang, L. Lyass, I. Alroy, M. Alamand, A. Kuo, J.D. Moyer, S. Lavi, M. Eisenstein, B.J. Ratzkin, R. Seger, S.S. Bacus, J.H. Pierce, G.C. Andrews, and Y. Yarden. 1998. ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol. Cell. Biol. 18: 6090-6101.
121. Plotnikov, A.N., J. Schlessinger, S.R. Hubbard, and M. Mohammadi. 1999. Structural basis for FGF receptor dimerization and activation. Cell 98: 641-650.
122. Plowman, G.D., S. Sudarsanam, J. Bingham, D. Whyte, and T. Hunter. 1999. The protein kinases of Caenorhabditis elegans: A model for signal transduction in multicellular organisms. Proc. Natl. Acad. Sci. 96: 13603-13610.
123. Posas, F. and H. Saito. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK. Science 276: 1702-1705.
124. Poy, F., M.B. Yaffe, J. Sayos, K. Saxena, M. Morra, J. Sumegi, L.C. Cantley, C. Terhorst, and M.J. Eck. 1999. Crystal structures of the XLP Protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol. Cell 4: 555-561.
125. Prehoda, K.E., D.J. Lee, and W.A. Lim. 1999. Structure of the enabled/VASP homology 1 domain-peptide complex: A key component in the spatial control of actin assembly. Cell 97: 471-480.
126. Pryciak, P.M. and F.A. Huntress. 1998. Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathway. Genes & Dev. 12: 2684-2697.
127. Qin, B., S.S. Lam, and K. Lin. 1999. Crystal structure of a transcriptionally active Smad4 fragment. Struct. Fold Des. 7: 1493-1503.
128. Radhakrishnan, I., G.C. Perez-Alvarado, D. Parker, H.J. Dyson, M.R. Montminy, and P.E. Wright. 1997. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator-coactivator interactions. Cell 91: 741-752.
129. Rameh, L.E. and L.C. Cantley. 1999. The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274: 8347-8350.
130. Remy, I., I.A. Wilson, and S.W. Michnick. 1999. Erythropoietin receptor activation by a ligand-induced conformation change. Science 283: 990-993.
131. Rhyu, M.S., L.Y. Jan, and Y.N. Jan. 1994. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76: 477-491.
132. Richards, S.A., J. Fu, A. Rommanelli, A. Shimamura, and J. Blenis. 1999. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Curr. Biol. 9: 810-820.
133. Rothe, M., S.C. Wong, W.J. Henzel, and D.V. Goeddel. 1994. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681-692.
134. Rothwarf, D.M., E. Zandi, G. Natoli, and M. Karin. 1998. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395: 297-300.
135. Rozakis-Adcock, M., R. Fernley, J. Wade, T. Pawson, and D. Bowtell. 1993. The SH2 and SH3 domains of mammalian Grb2 couple the EGF-receptor to mSos1, an activator of Ras. Nature 363: 83-85.
136. Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signal-assembler molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13: 3748-3756.
137. Salcini, A.E., S. Confalonieri, M. Doria, E. Santolini, E. Tassi, O. Minenkova, G. Cesareni, P.G. Pelicci, and P.P. Di Fiore. 1997. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes & Dev. 11: 2239-2249.
138. Salvesen, G.S. and V.M. Dixit. 1999. Caspase activation: The induced-proximity model. Proc. Natl. Acad. Sci. 96: 10964-10967.
139. Sanders, L.C., F. Matsumura, G.M. Bokoch, and P. de Lanerolle. 1999. Inhibition of myosin light chain kinase by p21-activated kinase. Science 283: 2083-2085.
140. Sayos, J., C. Wu, M. Morra, N. Wang, X. Zhang, D. Allen, S. van Schaik, L. Notarangelo, R. Geha, M.G. Roncarolo et al. 1998. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395: 462-469.
141. Schober, M., M. Schefer, and J.A. Knoblich. 1999. Bazooka recruits inscuteable to orient asymmetric cell division in Drosophila neuroblasts. Nature 402: 548-551.
142. Schulman, B.A., D.L. Lindstrom, and E. Harlow. 1998. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc. Natl. Acad. Sci. 95: 10453-10458.
143. Schultz, J., R.R. Copley, T. Doerks, C.P. Ponting, and P. Bork. 2000. SMART: A web-based tool for the study of genetically mobile domains. Nucleic Acids Res. 28: 231-234.
144. Sicheri, F., I. Moarefi, and J. Kuriyan. 1997. Crystal structure of the Src family tyrosine kinase Hck. Nature 385: 602-609.
145. Skowyra, D., K.L. Craig, M. Tyers, S.J. Elledge, and J.W. Harper. 1997. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91: 209-219.
146. Song, H., G. Ming, Z. He, M. Lehmann, L. McKerracher, M. Tessier-Lavigne, and M. Poo. 1998. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science 281: 1515-1518.
147. Songyang, Z., S.E. Shoelson, M. Chadhuri, G. Gish, T. Pawson, F. King, T. Roberts, S. Ratnofsky, B. Schaffhausen, and L.C. Cantley. 1993. Identification of phosphotyrosine peptide motifs which bind to SH2 domains. Cell 72: 767-778.
148. Songyang, Z., G. Gish, G. Mbamalu, T. Pawson, and L.C. Cantley. 1995. A single point mutation switches the specificity of group III Src homology (SH)2 domains to that of group I SH2 domains. J. Biol. Chem. 270: 26029-26032.
149. Songyang, Z., A.S. Fanning, C. Fu, J. Xu, S.M. Marfatia, A.H. Chishti, A. Crompton, A.C. Chan, J.M. Anderson, and L.C. Cantley. 1997. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275: 73-77.
150. Stapleton, D., I. Balan, T. Pawson, and F. Sicheri. 1999. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. Nat. Struct. Biol. 6: 44-49.
151. Starr, R. and D.J. Hilton. 1999. Negative regulation of the JAK/ STAT pathway. BioEssays 21: 47-52.
152. Starr, R., T.A. Willson, E.M. Viney, L.J. Murray, J.R. Rayner, B.J. Jenkins, T.J. Gonda, W.S. Alexander, D. Metcalf, N.A. Nicola, and D.J. Hilton. 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387: 917-921.
153. Steven, R., T. Kubiseski, H. Zheng, S. Kulkarni, J. Mancillas, A. Ruiz Morales, C.M.V. Hogue, T. Pawson, and J. Culotti. 1998. UNC-73 activates the Rac GTPase and is required for cell and growth cone migration in C. elegans. Cell 92: 785-795.
154. Sun, X.J., D.L. Crimmins, M.G. Myers, M. Miralpeix, and M.F. White. 1993. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell. Biol. 13: 7418-7428.
155. Sun, Z., J. Hsiao, D.S. Fay, and D.F. Stern. 1998. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281: 272-274.
156. Tabuse, Y., Y. Izumi, F. Piano, K.J. Kemphues, J. Miwa, and S. Ohno. 1998. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development 125: 3607-3614.
157. Tamagnone, L., S. Artigiani, H. Chen, Z. He, G.I. Ming, H. Song, A. Chedotal, M.L. Winberg, C.S. Goodman, M. Poo, M. Tessier-Lavigne, and P.M. Comoglio. 1999. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99: 71-80.
158. Tang, H.Y., J. Xu, and M. Cai. 2000. Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis. Mol. Cell. Biol. 20: 12-25.
159. Tanoue, T., M. Adachi, T. Moriguchi, and E. Nishida. 2000. A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell. Biol. 2: 110-116.
160. Tessier-Lavigne, M. and C.S. Goodman. 1996. The molecular biology of axon guidance. Science 274: 1123-1133.
161. Thanos, C.D., K.E. Goodwill, and J.U. Bowie. 1999. Oligomeric structure of the human EphB2 receptor SAM domain. Science 283: 833-836.
162. Thorson, J.A., L.W. Yu, A.L. Hsu, N.Y. Shih, P.R. Graves, J.W. Tanner, P.M. Allen, H. Piwnica-Worms, and A.S. Shaw. 1998. 14-3-3 protein are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol. Cell. Biol. 18: 5229-5238.
163. Trub, T., W.E. Choi, G. Wolf, E. Ottinger, Y. Chen, M. Weiss, and S.E. Sholeson. 1995. Specificity of the PTB domain of Shc for β turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J. Biol. Chem. 270: 18205-18208.
164. Tsukazaki, T., T.A. Chiang, A.F. Davison, L. Attisano, and J.L. Wrana. 1998. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 95: 779-791.
165. Tu, J.C., B. Xiao, S. Naisbitt, J.P. Yuan, R.S. Petralia, P. Brakeman, A. Doan, V.K. Aakalu, A.A. Lanahan, M. Sheng, and P.P. Worley. 1999. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583-592.
166. Tyers, M. and A.R. Willems. 1999. One ring to rule a superfamily of E3 ubiquitin ligases. Science 284: 603-604.
167. Ulloa, L., J. Doody, and J. Massague. 1999. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 397: 710-713.
168. van der Geer, P., S. Wiley, V.K.M. Lai, J.P. Olivier, G.D. Gish, T. Stephens, D. Kaplan, S. Shoelson, and T. Pawson. 1995. A conserved amino-terminal SHC domain binds to activated growth factor receptors and phosphotyrosine-containing peptides. Curr. Biol. 5: 404-412.
169. van der Geer, P., S. Wiley, G.D. Gish, V.K. Lai, R. Stephens, M.F. White, D. Kaplan, and T. Pawson. 1996. Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. Proc. Natl. Acad. Sci. 93: 963-968.
170. Vetter, I.R., C. Nowak, T. Nishimoto, J. Kuhlmann, and A. Wittinghofer. 1999. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: Implications for nuclear transport. Nature 398: 39-46.
171. Waksman, G., S.E. Shoelson, N. Pant, D. Cowburn, and J. Kuriyan. 1993. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms. Cell 72:779-790.
172. Wasikiewicz, A.J., A. Flynn, G.G. Proud, and J.A. Cooper. 1997. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16: 1909-1920.
173. Waterman, H., I. Alroy, S. Strano, R. Seger, and Y. Yarden. 1999. The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing. EMBO J. 18: 3348-3358.
174. Westphal, R.S., S.J. Tavalin, J.W. Lin, N.M. Alto, I.D. Fraser, L.K. Langeberg, M. Sheng, and J.D. Scott. 1999. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285: 93-96.
175. Whitmarsh, A.J. and R.J. Davis. 1998. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23: 481-485.
176. _. 2000. A central control for cell growth. Nature 403: 255-256.
177. Willems, A.R., S. Lanker, E.E. Patton, K.L. Craig, T.F. Nason, N. Mathias, R. Kobayashi, C. Wittenberg, and M. Tyers. 1996. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86: 453-463.
178. Winston, J.T., P. Strack, P. Beer-Romero, C.Y. Chu, S.J. Elledge, and J.W. Harper. 1999. The SCFβ-TCRP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro. Genes & Dev. 15: 270-283.
179. Wodarz, A., A. Ramrath, U. Kuchinke, and E. Knust. 1999. Bazooka provides an apical cue for inscuteable localization in Drosophila neuroblasts. Nature 402: 544-547.
180. Wrana, J. 2000. Regulation of Smad activity. Cell 100: 189-192.
181. Wu, G., Y.G. Chen, B. Ozdamar, C.A. Gyuricza, P.A. Chong, J.L. Wrana, J. Massague, and Y. Shi. 2000. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science 287: 92-97.
182. Wu, H., U. Klingmuller, P. Besmer, and H.F. Lodish. 1995. Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377: 242-246.
183. Xing, H., S. Zhang, C. Weinheimer, A. Kovacs, and A.J. Muslin. 2000. 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J. 19: 349-358.
184. Xing, J., D.D. Ginty, and M.E. Greenberg. 1996. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273: 959-963.
185. Xu, W., S.C. Harrison, and M.J. Eck. 1997. Three-dimensional structure of the tyrosine kinase c-Src. Nature 385: 595-602.
186. Yaffe, M.B., K. Rittinger, S. Volina, P.R. Caron, A. Aitken, H. Leffers, S.J. Gamblin, S.J. Smerdon, and L.C. Cantley. 1997. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 91: 961-971.
187. Yaron, A., A. Hatzubai, M. Davis, I. Lavon, S. Amit, A.M. Manning, J.S. Andersen, M. Mann, F. Mercurio, and Y. Ben-Neriah. 1998. Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 396: 590-594.
188. Yasuda, J., A.J. Whitmarsh, J. Cavanagh, M. Sharma, and R.J. Davis. 1999. The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell. Biol. 19: 7245-7254.
189. Ye, H., Y.C. Park, M. Kreishman, E. Kieff, and H. Wu. 1999. The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol. Cell 4: 321-330.
190. Yoon, H.S., P.J. Hajduk, A.M. Petros, E.T. Olejczak, R.P. Meadows, and S.W. Fesik. 1994. Solution structure of a pleckstrin-homology domain. Nature 369: 672-675.
191. Zeng, L., F. Fagotto, T. Zhang, W. Hsu, T.J. Vasicek, W.L. Perry, III, J.J. Lee, S.M. Tilghman, B.M. Gumbiner, and F. Costantini. 1997. The mouse fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90: 181-192.
192. Zeng, W., K.A. Wharton, Jr., J.A. Mack, K. Wang, M. Gadbaw, K. Suyama, P.S. Klein, and M.P. Scott. 2000. naked cuticle encodes an inducible antagonist of Wnt signalling. Nature 403: 789-795.
193. Zeng, Y. and H. Piwnica-Worms. 1999. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol. Cell. Biol. 19: 7410-7419.
194. Zeng, Y., K.C. Forbes, Z. Wu, S. Moreno, H. Piwnica-Worms, and T. Enoch. 1998. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature 395: 507-510.
195. L. Cell 87: 619-628.
196. Zhang, J.G., A. Farley, S.E. Nicholson, T.A. Willson, L.M. Zugaro, R.J. Simpson, R.L. Mortiz, D. Gary, R. Richardson, G. Hausmann, B.J. Kile, S.B. Kent, W.S. Alexander, D. Metcalf, D.J. Hilton, N.A. Nicola, and M. Baca. 1999. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. 96: 2071-2076.
197. Zhou, M.-M., K.S. Ravichandran, E.T. Olejniczak, A.M. Petros, R.P. Meadows, M. Sattler, J.E. Harlan, W.S. Wade, S.J. Burakoff, and S.W. Fesik. 1995. Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature 378: 584-592.
198. Zhu, H., P. Kavsak, S. Abdollah, J.L. Wrana, and G.H. Thomsen. 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400: 687-693.
199. Zisch, A.H., C. Pazzagli, A.L. Freeman, M. Schneller, M. Hadman, J.W. Smith, E. Ruoslahti, and E.B. Pasquale. 2000. Replacing two conserved tyrosines of the EphB2 receptors with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene 19: 177-187.