A novel, specific interaction involving the Csk SH3 domain and its natural ligand

Nature Structural Biology

Volumn 8, Issue 11, 2001, Pages 998-1004

  Ghose, Ranajeet ^a   Shekhtman, Alexander ^a   Goger, Michael J ^a   Ji, Hong ^a   Cowburn, David ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; LIGAND; LYSINE; PROLINE; PROTEIN TYROSINE KINASE; SERINE; THREONINE;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; SEQUENCE ALIGNMENT; SOLUTIONS; SRC HOMOLOGY DOMAINS;

EID: 0034753803     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb1101-998     Document Type: Article

References (50)

1. Src family protein tyrosine kinases and cellular signal transduction pathways
2. Structure-function relationships in Src family and related protein tyrosine kinases
3. Molecular cloning and expression of chicken C-terminal Src kinase: Lack of stable association with c-Src protein
4. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
5. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p 50csk
6. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
7. Three-dimensional structure of the tyrosine kinase c-Src
8. Association of inhibitory tyrosine protein kinase p 50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells
9. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
10. Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP
11. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase
12. Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk)
13. The crystal structure of human CskSH3: Structural diversity near the RT-Src and n-Src loop
14. SH3 domains: Complexity in moderation
15. Structural basis for the binding of proline-rich peptides to SH3 domains
16. Solution structure of the SH3 domain of Src and identification of its ligand-binding site
17. Structural determinants of peptide-binding orientation and of sequence specificity in SH 3 domains
18. Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition
19. Structure-function analysis of SH3 domains: SH 3 binding specificity altered by single amino acid substitutions
20. Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells
21. Chk, a Csk family tyrosine protein kinase, exhibits Csk-like activity in fibroblasts, but not in an antigen-specific T-cell line
22. The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO 7e
23. Protein dynamics from NMR
24. Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 2
25. Determination of the rotational diffusion tensor of macromolecules in solution from NMR relaxation data with a combination of exact and approximate methods - Application to the determination of interdomain orientation in multidomain proteins
26. HYDRONMR: Prediction of NMR relaxation of globular proteins from atomic-level structures and hydrodynamic calculations
27. 15N relaxation with monomer/dimer equilibration
28. Redistribution and loss of side chain entropy upon complex formation of a calmodulin-peptide complex
29. Increased protein backbone conformational entropy upon hydrophobic ligand binding
30. A relaxation -compensated Carr-Purcell-Meiboom-Gill sequence for characterizing chemical exchange by NMR spectroscopy
31. The DNA-binding domain in the Bacillus subtilis transition-state regulator Abr 8 employs significant motion for promiscuous DNA recognition
32. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
33. HIV-2 and SIV Nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution
34. Crystal structure of the conserved core of HIV- 1 Nef complexed with a Src family SH3 domain
35. Two binding orientations for peptides to the Src SH3 domain: Development of a general model for SH3-ligand interactions
36. Formation of a native-like subdomain in a partially folded intermediate of bovine pancreatic tripsin inhibitor
37. Trimerization specificity in HIV-1 gp41: Analysis with a GCN 4 leucine zipper model
38. NMRPipe: A multidimensional spectral processing system based on UNIX pipes
39. A common sense approach to peak picking in two-, three- and four-dimensional spectra using automatic computer analysis of contour diagrams
40. A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments
41. Torsion angle dynamics for NMR structure calculation with the new program DYANA
42. Protein backbone angle restraints from searching a database for chemical shift and sequence homology
43. Optimal sampling strategies for the measurement of relaxation times in proteins
44. 15N nuclear magnetic relaxation of proteins
45. A program for display and analysis of macromolecular structures
46. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
47. AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR