Repulsive axon guidance: Abelson and enabled play opposing roles downstream of the roundabout receptor

Cell

Volumn 101, Issue 7, 2000, Pages 703-715

  Bashaw, Greg J ^a   Kidd, Thomas ^a   Murray, Dave ^b   Pawson, Tony ^b   Goodman, Corey S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ARTICLE; DNA FLANKING REGION; ENZYME SUBSTRATE; GENE MUTATION; GENETIC CONSERVATION; MULTIGENE FAMILY; NERVE FIBER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR GENE; SIGNAL TRANSDUCTION;

ENA;

EID: 0034705292     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80883-1     Document Type: Article

References (31)

1. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding and actin bundle formation
2. Chimenc axon guidance receptors: The cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
3. Negative regulation of fibroblast motility by Ena/VASP proteins
4. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
5. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans
6. Genetic analysis of a Drosophila neural cell adhesion molecule: Interaction of fasciclin I and Abelson tyrosine kinase mutations
7. c-Abl kinase regulates the protein binding activity of c-Crk
8. Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled
9. Enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties
10. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
11. A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization
12. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion
13. N-terminal mutations activate the leukemogenic potential of the myristolated form of c-abl
14. Slit is the midline repellent for the robo receptor in Drosophila
15. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
16. Dosage sensitive and complementary functions of Roundabout and Commissureless control axon crossing of the CNS midline
17. The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila
18. Mena is required for neurulation and commissure formation
19. Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes
20. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
21. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
22. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins
23. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
24. Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein
25. Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
26. Mutations in sidestep lead to defects in pathfinding and synaptic specificity during the development of neuromuscular connectivity in Drosophila
27. Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
28. The molecular biology of axon guidance
29. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
30. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
31. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans