Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors

Science

Volumn 282, Issue 5396, 1998, Pages 2088-2092

  Nguyen, Jack T ^a   Turck, Christoph W ^b   Cohen, Fred E ^a   Zuckermann, Ronald N ^c   Lim, Wendell A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN;

AMINO ACID COMPOSITION; ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GRB2 ADAPTOR PROTEIN; HELMINTH PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHOSPHOPROTEINS; PROLINE; PROTEIN ENGINEERING; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CRK; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS;

CAENORHABDITIS ELEGANS;

EID: 0032509175     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5396.2088     Document Type: Article

References (1)

1. M. Sudot, Prog. Biophys. Mol. Biol. 65, 113 (1996).