Protein degradation and the generation of MHC class I-presented peptides

Advances in Immunology

Volumn 80, Issue , 2002, Pages 1-70

  Rock, Kenneth L ^a   York, Ian A ^a   Saric, Tomo ^a   Goldberg, Alfred L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDASE; PROTEASOME; TRANSMEMBRANE CONDUCTANCE REGULATOR; UBIQUITIN; CYSTEINE PROTEINASE; HLA ANTIGEN CLASS 1; MULTIENZYME COMPLEX; PROTEIN;

ANTIGEN PRESENTATION; CONJUGATION; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HUMAN; IMMUNOREGULATION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CYTOPLASM; METABOLISM; NON-PROGRAMMATIC; PHYSIOLOGY;

NON-PROGRAMMATIC;

ANIMALS; ANTIGEN PRESENTATION; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; ENDOPLASMIC RETICULUM; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERFERON TYPE II; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; UBIQUITIN;

EID: 0036017391     PISSN: 00652776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-2776(02)80012-8     Document Type: Article

References (343)

1. Beta-catenin is a target for the ubiquitin-proteasome pathway
2. Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
3. Proteasome inhibitors: A novel class of potent and effective antitumor agents
4. Primary structures of two homologous subunits of PA28, a γ-interferon-inducible protein activator of the 20S proteasome
5. Interferon-γ induces different subunit organizations and functional diversity of proteasomes
6. Sequence signals for generation of antigenic peptides by the proteasome: Implications for proteasomal cleavage mechanism
7. Novel dipeptidyl proteasome inhibitors overcome bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
8. Heat, heat shock, heat shock proteins and death: A central link in innate and adaptive immune responses
9. The role of tapasin in MHC class I antigen assembly
10. Intracellular localization of proteasomal degradation of a viral antigen
11. Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides
12. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules
13. The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class i molecules
14. Purification, substrate specificity, and classification of tripeptidyl peptidase II
15. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex
16. Thimet oligopeptidase and oligopeptidase m or neurolysin
17. Cd91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
18. The proteasome: Paradigm of a self-compartmentalizing protease
19. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
20. Abrogation of ctl epitope processing by single amino acid substitution flanking the C-terminal proteasome cleavage site
21. Increased efficiency of folding and peptide loading of mutant mhc class i molecules
22. PAN, the Proteasome Activating Nucleotidase from archaebacteria, is a molecular chaperone which unfolds protein substrate
23. Allelic differences in the relationship between proteasome activity and MHC class I peptide loading
24. Proteasome activity limits the assembly of mhc class i molecules after IFN-γ stimulation
25. Interferon-γ can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase
26. Production of a specific major histocompatibility complex class i-restricted epitope by ubiquitin-dependent degradation of modified ovalbumin in lymphocyte lysate
27. 26S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate
28. Interaction of HTLV-I tax with the human proteasome: Implications for NFκB induction
29. Molecular size-fractionation during endocytosis in macrophages
30. Role of cue1p in ubiquitination and degradation at the er surface
31. CD91: A receptor for heat shock protein gp96
32. Interferon γ stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes
33. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HSLV by a new class of inhibitors
34. Proteases and proteolysis in the lysosome
35. Peptide intermediates in the degradation of cellular proteins: Bestatin permits their accumulation in mouse liver in vivo
36. Measurement of muscle protein degradation in live mice by accumulation of bestatin-induced peptides
37. A protein catalytic framework with an N-terminal nucleophile is capable of self-activation
38. The base of the proteasome regulatory particle exhibits chaperone-like activity
39. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
40. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines
41. Biochemical purification of distinct proteasome subsets
42. Sumo-1 modification of mdm2 prevents its self-ubiquitination and increases mdm2 ability to ubiquitinate p53
43. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance
44. Catalytic components of the bovine pituitary multicatalytic proteinase complex (proteasome)
45. Cleavage of pro-x and glu-x bonds catalyzed by the branched chain amino acid preferring activity of the bovine pituitary multicatalytic proteinase complex (20S proteasome)
46. Altered properties of the branched chain amino acidpreferring activity contribute to increased cleavages after branched chain residues by the "immunoproteasome"
47. Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues
48. Differential sensitivity of fos and jun family members to calpains
49. 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
50. The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells
51. Genes encoded in the major histocompatibility complex affecting the generation of peptides for tap transport
52. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
53. Naturally processed peptides longer than nine amino acid residues bind to the class i mhc molecule hla-a2.1 with high affinity and with different conformations
54. Signal-induced site-specific phosphorylation targets IκB alpha to the ubiquitin-proteasome pathway
55. Regulation of cyclin d1 by calpain protease
56. Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85
57. Atp-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation
58. A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes
59. Ubiquitin-mediated proteolysis: Biological regulation via destruction
60. Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization
61. Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines
62. Two distinct proteolytic processes in the generation of a major histocompatibility complex class i-presented peptide
63. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
64. The nature of the MHC class I peptide loading complex
65. The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria
66. Inhibition of proteasomal degradation by the gly-ala repeat of Epstein-Barr virus is influenced by the length of the repeat and the strength of the degradation signal
67. Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to yield antigenic peptides
68. Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants
69. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands
70. P53-dependent cell cycle arrest induced by n-acetyl-1-leucinyl-1-leucinyl-1-norleucinal in platelet-derived growth factor-stimulated human fibroblasts
71. Activation of the cell death program by inhibition of proteasome function
72. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
73. The proteasome (multicatalytic protease) is a component of the 1500-kda proteolytic complex which degrades ubiquitin-conjugated proteins
74. Purification of an 11 S regulator of the multicatalytic protease
75. The cleavage preference of the proteasome governs the yield of antigenic peptides
76. Effects of major-histocompatibility-complex-encoded subunits on the peptidase and proteolytic activities of human 20S proteasomes: Cleavage of proteins and antigenic peptides
77. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes
78. Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes
79. Bovine spleen multicatalytic proteinase complex (proteasome) - Replacement of x, y, and z subunits by LMP7, LMP2, and mec11 and changes in properties and specificity
80. The human 26S and 20S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate
81. GFP-labelling of 26S proteasomes in living yeast: Insight into proteasomal functions at the nuclear envelope/rough er
82. Structure of peptides associated with MHC class I molecules
83. A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes
84. Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear pml bodies
85. Cellular peptide composition governed by major histocompatibility complex class I molecules
86. Mhc class I expression in mice lacking the proteasome subunit LMP-7
87. Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells
88. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
89. Regulatory subunit interactions of the 26S proteasome, a complex problem
90. A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell
91. Ubiquitination
92. Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85
93. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle
94. Hbx protein of hepatitis b virus interacts with the c-terminal portion of a novel human proteasome alpha-subunit
95. Proteasome subunits x and y alter peptidase activities in opposite ways to the interferon-γ-induced subunits LMP2 and LMP7
96. Γ-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
97. Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7
98. The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader-derived T cell epitope
99. Characterization of peptidyl boronic acid inhibitors of mammalian 20S and 26S proteasomes and their inhibition of proteasomes in cultured cells
100. c-myc over-expression activates alternative pathways for intracellular proteolysis in lymphoma cells
101. A giant protease with potential to substitute for some functions of the proteasome
102. A proteolytic system that compensates for loss of proteasome function
103. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and EIF3
104. Functional analysis of the proteasome regulatory particle
105. Cyclin is degraded by the ubiquitin pathway
106. A proteasome-related gene between the two abc transporter loci in the class II region of the human MHC
107. Intracellular protein degradation in mammalian and bacterial cells: Part 2
108. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha
109. Generation of naturally processed peptide/MHC class I complexes is independent of the stability of endogenously synthesized precursors
110. Tapasin: An ER chaperone that controls MHC class I assembly with peptide
111. Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation
112. Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why?
113. The interferon-γ-inducible 11S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20S proteasome in vitro
114. The interferon-γ-inducible 11S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20S proteasome in vitro
115. A role for the proteasome regulator PA28a in antigen presentation
116. A gated channel into the proteasome core particle
117. Structure of 20S proteasome from yeast at 2.4-angstrom resolution
118. Crystal structure of epoxomicin: 20S proteasome reveals a molecular basis for selectivity of alpha, beta-epoxyketone proteasome inhibitors
119. The ATP dependence of the degradation of short-and long-lived proteins in growing fibroblasts
120. Sequence of the AFG3 gene encoding a new member of the FTSH/YME1/TMA subfamily of the AAA-protein family
121. Identification of endogenous peptides recognized by in vivo or in vitro generated alloreactive cytotoxic T lymphocytes: Distinct characteristics correlated with CD8 dependence
122. Role of 26S proteasome and hrd genes in the degradation of 3-hydroxy-3-methylglutaryl-coa reductase, an integral endoplasmic reticulum membrane protein
123. Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway
124. Induction of leucine aminopeptidase by interferon-γ: Identification by protein microsequencing after purification by preparative two-dimensional gel electrophoresis
125. Cross-presentation, dendritic cells, tolerance and immunity
126. HLA-A2.1-associated peptides from a mutant cell line: A second pathway of antigen presentation
127. Simultaneous binding of PA28 and PA700 activators to 20S proteasomes
128. Comparison of human COP9 signalsome and 26S proteasome lid
129. Lessons from the discovery of the ubiquitin system
130. The ubiquitin system
131. Proposed role of ATP in protein breakdown: Conjugation of protein with multiple chains of the polypeptide of ATP- dependent proteolysis
132. The ubiquitin system
133. Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins
134. Gettin down with ubiquitin: Turning off cell-surface receptors, transporters and channels
135. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
136. Proteasomes of the yeast S. cerevisiae: Genes, structure and functions
137. Anti-peptide antibody blocks peptide binding to MHC class I molecules in the endoplasmic reticulum
138. Newly identified pair of proteasomal subunits regulated reciprocally by interferon γ
139. Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111
140. Covalent modification of all members of human cullin family proteins by nedd8
141. Ubiquitin-lysozyme conjugates: Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysate
142. Purification of two high molecular weight proteases from rabbit reticulocyte lysate
143. Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex
144. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
145. Proteasome complex as a potential cellular target of hepatitis B virus X protein
146. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry
147. Proteasome beta-type subunits: Unequal roles of propeptides in core particle maturation and a hierarchy of active site function
148. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
149. Herpesvirus evasion of the immune system
150. Noncaspase proteases in apoptosis
151. Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A
152. Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown
153. Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes
154. The sizes of peptides generated from protein by mammalian 26 and 20S proteasomes: Implications for understanding the degradative mechanism and antigen presentation
155. Proteasome inhibitors: From research tools to drug candidates
156. Structure of the proteasome activator regalpha (PA28α)
157. The substrate translocation channel of the proteasome
158. The axial channel of the proteasome core particle is gated by the rpt2 ATPase and controls both substrate entry and product release
159. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
160. 20S proteasome biogenesis
161. Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability
162. A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1
163. Constitutive class I-restricted exogenous presentation of self antigens in vivo
164. Yeast mitochondrial ATP-dependent protease: Purification and comparison with the homologous rat enzyme and the bacterial ATP-dependent protease la
165. An algorithm for the prediction of proteasomal cleavages
166. The mouse and human genes encoding the recognition component of the N-end rule pathway
167. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to t cells
168. Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae
169. Proteasome inhibitors cause induction of heat shock proteins and trehalose, which together confer thermotolerance in Saccharomyces cerevisiae
170. Proteasome inhibitors: Valuable new tools for cell biologists
171. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line 220
172. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1
173. Inhibition of ubiquitin/proteasome-dependent protein degradation by the gly-ala repeat domain of the Epstein-Barr virus nuclear antigen 1
174. Molecular dissection of the 11S reg (PA28) proteasome activators
175. p53-dependent induction of apoptosis by proteasome inhibitors
176. Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation
177. Crystal structure of the 20S proteasome from the archaeon t. acidophilum at 3.4 a resolution
178. Cytotoxic T lymphocyte epitopes of hiv-1 nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes
179. Proteasomes can either generate or destroy MHC class I epitopes: Evidence for nonproteasomal epitope generation in the cytosol
180. The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome
181. Eubacterial proteasomes
182. Lysosome-endosome fusion and lysosome biogenesis
183. Promotion of nedd8-cull conjugate cleavage by COP9 signalosome
184. Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)
185. An asparaginyl endopeptidase processes a microbial antigen for class Ii MHC presentation
186. Homology of proteasome subunits to major histocompatibility complex-linked LMP gene
187. Sensitization of MHC class I-restricted T cells to exogenous proteins: Evidence for an alternative class I-restricted antigen presentation pathway
188. Identification and characterization of a Drosophila nuclear proteasome regulator - A homolog of human 11S reg γ (PA28 γ)
189. Late events in the assembly of 20S proteasomes
190. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: Development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone
191. Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases
192. Protein degradation in MHC class II antigen presentation: Opportunities for immunomodulation
193. Eponemycin exerts its antitumor effect through the inhibition of proteasome function
194. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
195. Proteasome inhibitors activate stress kinases and induce hsp72: Diverse effects on apoptosis
196. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
197. Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation
198. Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: Effects on replication, transcription, translation, and the cellular stress response
199. Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides
200. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides
201. Processing of some antigens by the standard proteasome but not by the immunoprotea-some results in poor presentation by dendritic cells
202. Difference in antigen presentation to MHC class I- and class II-restricted influenza virus-specific cytolytic T lymphocyte clones
203. The class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol
204. ATP-dependent inactivation and sequestration of ornithine decarboxylase by the 26S proteasome are prerequisites for degradation
205. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
206. Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta
207. Cyclin ubiquitination: The destructive end of mitosis
208. Cloning and heterogeneous in vivo expression of tat binding protein-1 (TBP-1) in the mouse
209. Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
210. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
211. The specificity of proteasomes: Impact on MHC class I processing and presentation of antigens
212. The proteolytic fragments generated by vertebrate proteasomes: Structural relationships to major histocompatibility complex class I binding peptides
213. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1
214. Paproc: A prediction algorithm for proteasomal cleavages available on the www
215. Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease
216. The efficiency of antigen delivery from macrophage phagosomes into cytoplasm for MHC class I-restricted antigen presentation
217. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells
218. Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex
219. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex: Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids
220. Subunit of the 20S proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex
221. Covalent modifier nedd8 is essential for scf ubiquitin-ligase in fission yeast
222. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
223. Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol
224. Mhc class I antigen processing of listeria monocytogenes proteins: Implications for dominant and subdominant CTL responses
225. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC i-dependent peptide trimming in the ER
226. Targeting of substrates to the 26S proteasome
227. Endoplasmic reticulum degradation: Reverse protein transport and its end in the proteasome
228. Retrograde protein translocation: Eradication of secretory proteins in health and disease
229. Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol
230. Impaired immunoproteasome assembly and immune responses in PA28-/-mice
231. Cells adapted to the proteasome inhibitor 4-hydroxy5-iodo-3-nitrophenylacetyl-leu-leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival
232. Degradation of a mutant secretory protein, alpha1-antitrypsin z, in the endoplasmic reticulum requires proteasome activity
233. Chemistry of peptides associated with MHC class I and class II molecules
234. MHC ligands and peptide motifs: First listing
235. Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease
236. Characterization of recombinant REGα, REGβ, and REGγ proteasome activators
237. The proteasome activator 11S reg (PA28) and class I antigen presentation
238. Dynamics of proteasome distribution in living cells
239. The major substrates for TAP in vivo are derived from newly synthesized proteins
240. The transporter associated with antigen processing (TAP): Structural integrity, expression, function, and its clinical relevance
241. Degradation of cell proteins and the generation of MHC class I-presented peptides
242. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
243. Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling
244. HSLV-HSLU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome
245. Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
246. ATPase and ubiquitin-binding proteins of the yeast proteasome
247. Caspases: Intracellular signaling by proteolysis
248. Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase
249. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
250. The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells
251. Structure and mechanism of ATP-dependent proteases
252. Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein
253. Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20S proteasome
254. Analysis of mammalian 20S proteasome biogenesis - The maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis
255. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
256. The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses
257. Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 α/β, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
258. tirI in mediating auxin response
259. HIV-1 tat inhibits the 20S proteasome and its 11S regulator-mediated activation
260. Autocatalytic processing of the 20S proteasome
261. Proteasome from thermoplasma acidophilum - A threonine protease
262. Proteasome from thermoplasma acidophilum: A threonine protease
263. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
264. A minimal glycinealanine repeat prevents the interaction of ubiquitinated IκB alpha with the proteasome: A new mechanism for selective inhibition of proteolysis
265. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules
266. Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
267. Double-cleavage production of the CTL epitope by proteasomes and PA28: Role of the flanking region
268. Contribution of proline residue for efficient production of MHC class I ligands by proteasomes
269. LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes
270. Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation
271. Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes
272. MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells
273. Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation
274. Class I MHC molecules: Assembly and antigen presentation
275. Roles of proteasomes, transporter for antigen presentation (TAP), and β2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway
276. Structure and physiological function of calpains
277. Properties of the caspases
278. 20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences
279. Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28
280. Pa2Sαβ double and PA28β single transfectant mouse B8 cell lines reveal enhanced presentation of a mouse cytomegalovirus (MCMV) pp89 MHC class I epitope
281. Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities
282. Two new proteases in the MHC class I processing pathway
283. P45(skp2) promotes p27(kip1) degradation and induces S phase in quiescent cells
284. Proteasomes generate in vitro a natural peptide of influenza-A nucleoprotein functional in HAL-B27 antigen assembly
285. The role of tricorn protease and its aminopeptidase-interacting factors in cellular protein degradation
286. Tricorn protease - The core of a modular proteolytic system
287. Hybrid proteasomes: Induction by interferon-γ and contribution to ATP-dependent proteolysis
288. Molecular properties of the proteasome activator PAE8 family proteins and γ-interferon regulation
289. Control of i kappa b alpha proteolysis by the ubiquitin-proteasome pathway
290. Aminopeptidases: Towards a mechanism of action
291. The proteasome inhibitor PS-341 in cancer therapy
292. The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope
293. Cathepsins x and b can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities
294. Generation of cytotoxic T-lymphocytes to a self-peptide/class I complex: A model for peptide-mediated tumor rejection
295. Cutting edge: Induction of enhanced CTL-dependent protective immunity in vivo by n-end rule targeting of a model tumor antigen
296. Targeting of hiv-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization
297. Atp- and antizyme-dependent endoproteolysis of ornithine decarboxylase to ohgopeptides by the 26S proteasome
298. Tripeptidyl peptidases: Enzymes that count
299. Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome
300. Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
301. Ubiquitin-dependent c-jun degradation in vivo is mediated by the delta domain
302. Downregulation of g protein-coupled receptors
303. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine
304. Lysosomal cysteine proteases: More than scavengers
305. Regulation of the 26S proteasome by adenovirus E1A
306. Inhibition of TNF-induced apoptosis by NFκB
307. Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome
308. Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
309. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
310. Proteasomal proteomics: Identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes
311. Proteases involved in MHC class II antigen presentation
312. The generation of MHC class I associated peptides is only partially inhibited by proteasome inhibitors - Involvement of nonproteasomal cytosolic proteases in antigen processing
313. Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes
314. Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex
315. The 26S proteasome: A molecular machine designed for controlled proteolysis
316. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
317. Calpain inhibition - An overview of its therapeutic potential
318. Lysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): Evidence for a nonprocessive mode of degradation
319. Molecular mechanisms underlying endocytosis and sorting of erbb receptor tyrosine kinases
320. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
321. Making sense of the COP9 signalosome: A regulatory protein complex conserved from arabidopsis to human
322. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex
323. Themes and variations on ubiquitylation
324. Existence of a molecular ruler in proteasomes suggested by analysis of degradation products
325. Structural basis for the activation of 20S proteasomes by 11S regulators
326. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
327. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
328. Evidence that pituitary cation-sensitive neutral endopeptidase is a multicatalytic protease complex
329. Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes
330. Metabolism of ubiquitinated histones
331. Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane
332. Epitope selection in major histocompatibility complex class I-mediated pathway is affected by the intracellular localization of an antigen
333. Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: Importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes
334. MHC class I presentation of an exogenous polypeptide antigen encoded by the murine aids defective virus
335. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses
336. Defective ribosomal products (DRiPs): A major source of antigenic peptides for MHC class I molecules?
337. Whose end is destruction: Cell division and the anaphasepromoting complex
338. Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex
339. Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators atf3, gadd153 and madl
340. Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells
341. Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase
342. An archaebacterial ATPase, homologous to ATPases in the eukaryotic 26S proteasome, activates protein breakdown by 20S proteasomes