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Volumn 286, Issue 5447, 1999, Pages 2162-2165

Impaired immunoproteasome assembly and immune responses in PA28(-/-) mice

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME;

EID: 0032778516     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5447.2162     Document Type: Article
Times cited : (156)

References (30)
  • 2
    • 0038899636 scopus 로고    scopus 로고
    • K. L. Rock and A. L. Goldberg, Annu. Rev. Immunol. 17, 739 (1999); K. Früh and Y. Yang, Curr. Opin. Immunol. 11, 76 (1999).
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 76
    • Früh, K.1    Yang, Y.2
  • 3
    • 0030611045 scopus 로고    scopus 로고
    • C. Realini et al., J. Biol. Chem. 272, 25483 (1997); X. Song, J. Von Kampen, C. A. Slaughter, G. N. Demartino, J. Biol. Chem. 272, 27994 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 25483
    • Realini, C.1
  • 5
    • 0030014843 scopus 로고    scopus 로고
    • K. Ahn et al., J. Biol. Chem. 271, 18237 (1996); Y. Yang, K. Früh, K. Ahn, P. A. Peterson, J. Biol. Chem. 270, 27687 (1995).
    • (1996) J. Biol. Chem. , vol.271 , pp. 18237
    • K, A.1
  • 7
    • 0030602834 scopus 로고    scopus 로고
    • T. P. Dick et al., Cell 86, 253 (1996); M. Groettrup et al., Nature 381, 166 (1996).
    • (1996) Cell , vol.86 , pp. 253
    • Dick, T.P.1
  • 8
    • 0029918289 scopus 로고    scopus 로고
    • T. P. Dick et al., Cell 86, 253 (1996); M. Groettrup et al., Nature 381, 166 (1996).
    • (1996) Nature , vol.381 , pp. 166
    • Groettrup, M.1
  • 10
    • 84920347457 scopus 로고    scopus 로고
    • Supplemental Web figures are available at www. sciencemag.org/feature/data/1043186.shl.
  • 11
    • 0031456970 scopus 로고    scopus 로고
    • J. R. Knowlton et al., Nature 390, 639 (1997).
    • (1997) Nature , vol.390 , pp. 639
    • Knowlton, J.R.1
  • 13
    • 84920343288 scopus 로고    scopus 로고
    • note
    • -/- cells after the temperature challenge decreased to ∼80% of the wild-type levels.
  • 16
  • 18
    • 0000713709 scopus 로고    scopus 로고
    • N. Nathanson, Ed. Lippincott-Raven, Philadelphia
    • P. Borrow and M. B. A. Oldstone, in Viral Pathogenesis, N. Nathanson, Ed. (Lippincott-Raven, Philadelphia, 1997), pp. 593-627; M. J. Buchmeier and A. J. Zajac, in Persistent Virus Infections, R. Ahmed and I. Chen, Eds. ( Wiley, New York, 1999), pp. 575-605.
    • (1997) Viral Pathogenesis , pp. 593-627
    • Borrow, P.1    Oldstone, M.B.A.2
  • 19
    • 0001453074 scopus 로고    scopus 로고
    • R. Ahmed and I. Chen, Eds. Wiley, New York
    • P. Borrow and M. B. A. Oldstone, in Viral Pathogenesis, N. Nathanson, Ed. (Lippincott-Raven, Philadelphia, 1997), pp. 593-627; M. J. Buchmeier and A. J. Zajac, in Persistent Virus Infections, R. Ahmed and I. Chen, Eds. ( Wiley, New York, 1999), pp. 575-605.
    • (1999) Persistent Virus Infections , pp. 575-605
    • Buchmeier, M.J.1    Zajac, A.J.2
  • 20
    • 0030852963 scopus 로고    scopus 로고
    • G. Niedermann et al., J. Exp. Med. 186, 209 (1997); M. Groettrup et al., J. Biol. Chem. 270, 23808 (1995).
    • (1997) J. Exp. Med. , vol.186 , pp. 209
    • Niedermann, G.1
  • 21
    • 0028970626 scopus 로고
    • G. Niedermann et al., J. Exp. Med. 186, 209 (1997); M. Groettrup et al., J. Biol. Chem. 270, 23808 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 23808
    • Groettrup, M.1
  • 24
    • 84920355300 scopus 로고    scopus 로고
    • note
    • Antisera specific to the proteasome subunit C9, LMP2, PA28a, and PA28b have been described (3). Antibodies specific to CD4, CDS, CD3-e, TCR-ab, CD23, CD25, CD28, CD45, CD69, class I, and class II molecules were purchased from PharMingen (San Diego, CA). 25D1.16 (10) and a PA28a-specific antiserum (2) were kindly provided by A. Porgador and M. Rechsteiner, respectively. Metabolic labeling, immunoprecipitation, immunoblotting, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PACE) were performed as described (3).
  • 25
    • 17444369342 scopus 로고    scopus 로고
    • T. Flad et al., Cancer Res. 58, 5803 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 5803
    • Flad, T.1
  • 28
    • 0023902072 scopus 로고
    • H. Bluthmann et al., Nature 334, 156 (1988).
    • (1988) Nature , vol.334 , pp. 156
    • Bluthmann, H.1
  • 30
    • 84920358908 scopus 로고    scopus 로고
    • note
    • All animal experiments were conducted in accordance with institutional guidelines. We thank S. Sutton, J. Culver and S. Courtney for technical assistance and J.-F. Huang, and G. Schoenhals for critical reading. The technical assistance of the DNA, vivarium, and peptide synthesis facilities of the R. W. Johnson Pharmaceutical Research Institute is gratefully acknowledged.


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