Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: Development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin β-lactone

Biochemistry

Volumn 37, Issue 21, 1998, Pages 7792-7800

  McCormack, Teresa A ^a   Cruikshank, Amy A ^a   Grenier, Louis ^a   Melandri, Francesco D ^a   Nunes, Sandra L ^a   Plamondon, Louis ^a   Stein, Ross L ^a   Dick, Lawrence R ^a,b  

^a ProScript Inc   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; BRANCHED CHAIN AMINO ACID; ENZYME INHIBITOR; LACTACYSTIN BETA LACTONE; PEPTIDASE; PROTEASOME; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; HYDROLYSIS; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALDEHYDES; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOPEPTIDASES; KINETICS; LACTONES; MASS SPECTROMETRY; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; RABBITS; SUBSTRATE SPECIFICITY;

EID: 0032568514     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980097q     Document Type: Article

References (35)

1. Ciechanover, A. (1994) Cell. 79, 13-21.
2. Goldberg, A. L., Stein, R. L., and Adams, J. (1995) Chem. and Biol. 2, 503-508.
3. Hochstrasser, M. (1995) Curr. Opin. Biol. 7, 215-223.
4. Peters, J.-M. (1994) Trends Biochem. Sci. 19, 377-382.
5. Rechsteiner, M., Hoffman, L., and Dubiel, W. (1993) J. Biol. Chem. 268, 6065-6068.
6. Murray, A. (1995) Cell 81, 149-152.
7. Rolfe, M., Beer-Romero, P., Glass, S., Eckstein, J., Berdo, I., Theodoras, A., Pagano, M., and Draetta, G. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 3264-3268.
8. Scheffner, M., Huibregste, J. M., Vierstra, R. D., and Howley, P. M. (1993) Cell 75, 495-505.
9. Shkedy, D., Gonen, H., Bercovich, B., and Ciechanover, A. (1994) FEBS Lett. 348, 126-130.
10. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. (1995) Genes Dev. 9, 1586-1597.
11. Palombella, V. J., Rando, A. L., Goldberg, A. L., and Maniatis, T. (1994) Cell. 78, 773-785.
12. Schecter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162.
13. Orlowski, M. (1990) Biochemistry 29, 10289-10297.
14. Orlowski, M., Cardozo, C., and Michaud, C. (1993) Biochemistry 32, 1563-1572.
15. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, S. L. (1995) Science 268, 726-730.
16. Stein, R. L., Melandri, F., and Dick, L. (1996) Biochemistry 35, 3899-3908.
17. Dess, D. B., and Martin, J. C. (1983) J. Org. Chem. 48, 4156-4158.
18. Uno, H., Baldwin, J. E., and Russel, A. T. (1994) J. Am. Chem. Soc. 116, 2139-2140.
19. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301.
20. Nishino, N., and Powers, J. C. (1980) J. Biol. Chem. 255, 3482-3486.
21. Tsubi, S., Kawasaki, H., Saito, Y., Miyashita, N., Inomata, M., and Kawashima, S. (1993) Biochem. Biophys. Res. Commun. 196, 1195-1201.
22. Vinitsky, A., Michaud, C., Powers, J. C., and Orlowski, M. (1992) Biochemistry 31, 9421-9428.
23. Vinitsky, A., Cardozo, C., Sepp-Lorenzino, L., Michaud, C., and Orlowski, M. (1994) J. Biol. Chem. 269, 29860-29866.
24. Cardozo, C., Vinitsky, A., Michaud, C., and Orlowski, M. (1994) Biochemistry 33, 6483-6489.
25. Dick, L. R., Cruikshank, A. A., Grenier, L., Melandri, F. D., Nunes, S. L., and Stein, R. L. (1996) J. Biol. Chem. 271, 7273-7276.
26. Akiyama, K., Yokota, K., Kagawa, S., Shimbara, N., Tamura, T., Akioka, H., Nothwang, H. G., Noda, C., Tanaka, K., and Ichibara, A. (1994) Science 265, 1231-1234.
27. Löwe, J., Stock, D., Jap, B., Zwickl, P., Baumeister, W., and Huber, R. (1995) Science 268, 533-539.
28. Seemüller, E., Lupas, A., Stock, D., Löwe, J., Huber, R., and Baumeister, W. (1995) Science 268, 579-582.
29. Zühl, F., Tamura, T., Dolenc, I., Cejka, Z., Nagy, I., De Mot, R., and Baumeister, W. (1997) FEBS Lett. 400, 83-90.
30. McCormack, T., Baumeister, W., Grenier, L., Moomaw, C., Plamondon, L., Pramanik, B., Slaughter, C., Soucy, F., Stein, R., Zühl, F., and Dick, L. (1997) J. Biol. Chem. 272, 26103-26109.
31. Chen, P., and Hochstrasser, M. (1995) EMBO J. 14, 2620-2630.
32. Morimoto, Y., Mizushima, T., Yagi, A., Tanahashi, N., Tanaka, K., Ichihare, A., and Tsukihara, T. (1995) J. Biochem. 117, 471-474.
33. Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H. D., and Huber, R. (1997) Nature 386, 463-471.
34. Arendt, C. S., and Hochstrasser, M. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 7156-7161.
35. Wilk, S., and Orlowski, M. (1983) J. Neurochem. 40, 842-849.