The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

Cell

Volumn 84, Issue 5, 1996, Pages 769-779

  Wiertz, Emmanuel J H J ^a   Jones, Thomas R ^b   Sun, Lei ^b   Bogyo, Matthew ^a   Geuze, Hans J ^c   Ploegh, Hidde L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b PFIZER INC   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GLUCAN SYNTHASE; GLYCOSIDASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; PROTEASOME; PROTEIN SUBUNIT; PROTEINASE INHIBITOR;

ANTIGEN EXPRESSION; ARTICLE; CELL FRACTIONATION; CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME MECHANISM; GENE EXPRESSION REGULATION; GENE INSERTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; VIRUS GENE;

HUMAN HERPESVIRUS 5;

EID: 0029915568     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81054-5     Document Type: Article

References (43)

1. Beersma, M.F.C., Bijlmakers, M.J.E., and Ploegh, H.L.(1993). Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J. Immunol. 151, 4455-4464.
2. Braakman, I., Hoover-Litty, H., Wagner, K.R., and Helenius, A. (1991). Folding of influenza hemagglutinin in the endoplasmic reticulum. J. Cell Biol. 114, 401-411.
3. Burgert, H.-G., and Kvist, S. (1985). An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens. Cell 41, 987-997.
4. del Val, M., Hengel, H., Hacker, H., Hartlaub, U., Ruppert, T., Lucin, P., and Koszinowski, U.H. (1992). Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-golgi compartment. J. Exp. Med. 176, 729-738.
5. Economou, A., and Wickner, W. (1994). SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion. Cell 78, 835-843.
6. Eichholtz, T., Vossebeld, P., van Overveld, M., and Ploegh, H.L. (1992). Activation of protein kinase C accelerates internalization of transferrin receptor but not major histocompatibility complex class I, independent of their phosphorylation status. J. Biol. Chem. 267, 22490-22495.
7. Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J., and Schreiber, S.L. (1995). Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 286, 726-731.
8. Früh, K., Ahn, K., Djaballah, H., Sempé, P., van Endert, P.M., Tampé, R., Peterson, P.A., and Yang, Y. (1995). A viral inhibitor of peptide transporters for antigen presentation. Nature 375, 415-418.
9. Görlich, D., and Rapoport, T.A. (1993). Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell 75, 615-630.
10. Görlich, D., Prehn, S., Hartmann, E., Kalies, K.U., and Rapoport, T.A. (1992). A mammalian homolog of Sec61p and SecYp is associated with ribosomes and nascent polypeptides during translocation. Cell 71, 489-503.
11. Hammond, C., Braakman, I., and Helenius, A. (1994). Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control. Proc. Natl. Acad. Sci. USA 91, 913-917.
12. Heemels, M.-T., and Ploegh, H.L. (1995). Generation, translocation and presentation of MHC class I-restricted peptides. Annu. Rev. Biochem. 64, 463-491.
13. Hill, A., and Ploegh, H.L. (1995). Getting the inside out: TAP and the presentation of viral antigen. Proc. Natl. Acad. Sci. USA 92, 341-343.
14. Hill, A., Jugovic, P., York, I., Russ, G., Bennink, J., Yewdell, J., Ploegh, H.L., and Johnson, D. (1995). Herpes simplex virus turns off the TAP to evade host immunity. Nature 375, 411-415.
15. Jensen, T.J., Loo, M.A., Pind, S., Williams, D.B., Goldberg, A.L., and Riordan, J.R. (1995). Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83, 129-135.
16. Jones, T.R., Muzithras, V.P., and Gluzman, Y. (1991). Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential. J. Virol. 65, 3742-3752.
17. Jones, T.R., Sun, L., Bebernitz, G.A., Muzithras, V.P., Kim, H.-J., Johnston, S.H., and Baum, E.Z. (1994). Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants. J. Virol. 68, 3742-3752.
18. Jones, T.R., Hanson, L.K., Sun, L., Slater, J.S., Stenberg, R.M., and Campbell, A.E. (1995). Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J. Virol. 69, 4830-4841.
19. Kim, Y.J., Rajapandi, T., and Oliver, D. (1994). SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state. Cell 78, 845-853.
20. Kim, H.-J., Gatz, C., Hillen, W., and Jones, T.R. (1995). Tetracycline repressor-regulated gene expression in recombinant human cytomegalovirus. J. Virol. 69, 2565-2573.
21. Lardy, H.A. (1965). On the direction of pyridine nucleotide oxidation-reduction reactions in gluconeogenesis and lipogenesis. In Control of Energy Metabolism, B. Chance, R. Estabrook, and J. Williamson, eds. (San Diego, CA: Academic Press), pp. 245-248.
22. Liou, W., and Slot, J.W. (1994). Improved fine structure in immunolabeled cryosections after modifying the sectioning and pick-up conditions. ICEM13-Paris, 17-22 July, 1-2.
23. Maudsley, D.J., and Pound, J.D. (1991). Modulation of MHC antigen expression by viruses and oncogenes. Immunol. Today 12, 429-431.
24. Moore, S.E., and Spiro, R.G. (1994). Intracellular compartmentalization and degradation of free polymannose oligosaccharides released during glycoprotein biosynthesis. J. Biol. Chem. 269, 12715-12721.
25. Neefjes, J.J., Doxiadis, I., Stam, N.J., Beckers, C.J., and Ploegh, H.L. (1986). An analysis of class I antigens of Man and other species by one-dimensional IEF and immunoblotting. Immunogenetics 23, 164-171.
26. Neefjes, J.J., Dierx, J., and Ploegh, H.L. (1993). The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions, Eur. J. Immunol. 23, 840-845.
27. Panzner, S., Dreier, L., Hartmann, E., Kostka, S., and Rapoport, T.A. (1995). Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell 81, 561-570.
28. Ploegh, H.L. (1995). One-dimensional isoelectricfocusing of proteins in slab gels. In Current Protocols in Protein Science, J.E. Coligan, B.M. Dunn, H.L. Ploegh, D.W. Speicher, and P.T. Wingfield, eds. (New York: John Wiley & Sons), pp. 10.2.1-10.2.8.
29. Rivett, A.J. (1993). Proteasomes: multicatalytic proteinase complexes. Biochem. J. 291, 1-10.
30. Rock, K.L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., and Goldberg, A.L. (1994). Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771.
31. Sanders, S.L., Whitfield, K.M., Vogel, J.P., Rose, M.D., and Schekman, R.W. (1992). Sec61p and BiP directly facilitate polypeptide translocation into the ER. Cell 69, 353-365.
32. Scheiffele, P., Peränen, J., and Simons, K. (1995). N-glycans as apical sorting signals in epithelial eels. Nature 378, 96-98.
33. Schneider, H.C., Berthold, J., Bauer, M.F., Dietmeier, K., Guiard, B., Brunner, M., and Neupert, W. (1994). Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature 371, 768-774.
34. Sherwood, S.W., Kung, A.L., Roitelman, J., Simoni, R.D., and Schimke, R.T. (1993). In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc. Natl. Acad. Sci. USA 90, 3353-3357.
35. Simon, S.M., and Blobel, G. (1991). A protein-conducting channel in the endoplasmic reticulum. Cell 65, 371-380.
36. Slot, J.W., Geuze, H.J., Gigengack, S., Lienhard, G.E., and James, D.E. (1991). Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. J. Cell Biol. 113, 123-135.
37. Stam, N., Spits, H., and Ploegh, H.L. (1986). Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of some HLA-C locus products. J. Immunol. 137, 2299-2306.
38. Suzuki, T., Seko, A., Kitajima, K., Inoue, Y., and lnoue, S. (1994). Purification and enzymatic properties of peptide: N-glycanase from C3H mouse-derived L-929fibroblast cells of proteins by N-deglycosylation. J. Biol. Chem. 269, 17611-17618.
39. Tarentino, A.L, and Plummer, T.H. (1994). Enzymatic deglycosylation of asparagine-linked glycans: purification, properties, and specificity of oligosaccharide-cleaving enzymes from Flavobacterium meningosepticum. Meth. Enzymol. 230, 44-57.
40. Townsend, A., and Bodmer, H. (1989). Antigen recognition by class I restricted T-lymphocytes. Annu. Rev. Immunol. 7, 601-624.
41. Vogel, J.P., Misra, L.M., and Rose, M.D. (1990). Loss of Bip/Grp78 function blocks translocation of secretory proteins in yeast. J. Cell. Biol. 110, 1885-1895.
42. Ward, C.L, Omura, S., and Kopito, R.R. (1995). Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83, 121-127.
43. York, I.A., Roop, C., Andrews, D.W., Riddell, S.R., Graham, F.L., and Johnson, D.C. (1994). A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell 77, 525-535.