Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HslV by a new class of inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 13, 1997, Pages 6629-6634

  Bogyo, Matthew ^a   McMaster, John S ^a   Gaczynska, Maria ^a   Tortorella, Domenico ^a   Goldberg, Alfred L ^b   Ploegh, Hidde ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBOXYBENZYLLEUCYLLEUCYLLEUCINE VINYLSULFONE; CHYMOTRYPSIN; IODINE 125; LACTACYSTIN; NITROPHENOL; PEPTIDASE; PROTEASOME; SERINE; SULFONE; THREONINE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTORADIOGRAPHY; BETA CHAIN; CATALYSIS; DOSE RESPONSE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; FLUOROGRAPHY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; ISOELECTRIC FOCUSING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; THERMOPLASMA;

NON-PROGRAMMATIC;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ATP-DEPENDENT PROTEASES; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ENZYME INHIBITORS; ESCHERICHIA COLI; HEAT-SHOCK PROTEINS; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; SERINE ENDOPEPTIDASES; SULFONES; THERMOPLASMA; THREONINE;

ESCHERICHIA COLI; EUKARYOTA; THERMOPLASMA;

EID: 0031010398     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.13.6629     Document Type: Article

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