Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

Current Opinion in Immunology

Volumn 13, Issue 2, 2001, Pages 147-153

  Van den Eynde, B J ^a   Morel, S ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; IMMUNOPROTEASOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PROTEIN EXPRESSION; REVIEW;

EID: 0035314002     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00197-7     Document Type: Review

References (53)

1. Degradation of cell proteins and the generation of MHC class I-presented peptides
2. Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution
3. Structure of 20S proteasome from yeast at 2.4 Å resolution
4. The proteasome: Paradigm of a self-compartmentalizing protease
5. The MHC class I ligand-generating system: Roles of immunoproteasomes and the interferon-γ-inducible proteasome activator PA28
6. Interferon γ stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes
7. The interferon-γ-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro
8. Altered properties of the branched chain amino acid-preferring activity contribute to increased cleavages after branched chain residues by the 'immunoproteasome'
9. Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: Reciprocally regulated tissue expression of interferon-γ-modulated proteasome subunits
10. Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation
11. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
12. Constitutive and interferon-γ-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1
13. Control of LMP7 expression in human endothelial cells by cytokines regulating cellular and humoral immunity
14. Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma
15. Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: Evidence for deficiencies associated with transformation and progression
16. A ubiquitin-like protein which is synergistically inducible by interferon-γ and tumor necrosis factor-α
17. The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome
18. Immunoproteasome assembly: Cooperative incorporation of interferon γ (IFN-γ)-inducible subunits
19. Novel propeptide function in 20S proteasome assembly influences β subunit composition
20. Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7
21. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands
22. -/- mice
23. The function of the proteasome system in MHC class I antigen processing
24. Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28α/β, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
25. Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
26. Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-γ for acquirement of the functional diversity responsible for antigen processing
27. MHC class I expression in mice lacking the proteasome subunit LMP-7
28. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
29. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes
30. A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes
31. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma
32. Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes
33. MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells
34. Proteasomes can either generate or destroy MHC class I epitopes: Evidence for nonproteasomal epitope generation in the cytosol
35. Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein
36. IFN-γ exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase
37. Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3
38. 271-279
39. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
40. Thymic dendritic cells
41. Differential effects of peptide diversity and stromal cell type in positive and negative selection in the thymus
42. Identification of NY-ESO-1 peptide analogues capable of improved stimulation of tumor-reactive CTL
43. Retroviral transduction of human dendritic cells with a tumor-associated antigen gene
44. Dendritic cells infected with poxviruses encoding MART-1/Melan A sensitize T lymphocytes in vitro
45. Genetic immunization for the melanoma antigen MART-1/Melan-A using recombinant adenovirus-transduced murine dendritic cells
46. Generation of melanoma-specific cytotoxic T lymphocytes by dendritic cells transduced with a MART-1 adenovirus
47. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes
48. Identification of human cancers deficient in antigen processing
49. Antigen-processing machinery breakdown and tumor growth
50. Down-regulation of HLA class I antigen-processing molecules in malignant melanoma. Association with disease progression
51. Down-regulation of the transporter for antigen presentation, proteasome subunits, and class I major histocompatibility complex in tumor cell lines
52. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport
53. The major-histocompatibility-complex-encoded β-type proteasome subunits LMP2 and LMP7