Interaction of HTLV-I tax with the human proteasome: Implications for NF-κB induction

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 13, Issue SUPPL. 1, 1996, Pages

  Béraud, Christophe ^a,b   Greene, Warner C ^a  

^a GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^b AMGEN INC   (United States)

Author keywords

HsN3; HTLV I; I B; NF B; Proteasome; Tax

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; TAX PROTEIN;

CELL IMMORTALIZATION; CONFERENCE PAPER; ENHANCER REGION; HUMAN T CELL LEUKEMIA VIRUS 1; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SPASTIC PARAPLEGIA; T CELL LEUKEMIA; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 0029759240     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199600001-00014     Document Type: Conference Paper

References (88)

1. Yoshida M, Miyoshi I, Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 1982;79:2031-5.
2. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980; 77:7415-9.
3. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de The G. Antibodies to the human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis. Lancet 1985;2:407-10.
4. Osame M, Usuku K, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M. HTLV-I associated myelopathy: a new clinical entity. Lancet 1986;1:1031-2.
5. Grassmann R, Berchtold S, Radant I, et al. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J Virol 1992;66:4570-5.
6. Smith MR, Greene WC. Type I human T-cell leukemia virus Tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J Clin Invest 1991;88:1038-42.
7. Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M, Hatanaka M. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc Natl Acad Sci USA 1990;87:1071-5.
8. Hinrichs SH, Nerenberg M, Reynolds K, Khoury G, Jay G. A transgenic mouse model for human neurofibromatosis. Science 1987;237:1340-3.
9. Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G, Jay G. The tat gene of human T-lymphotropic virus type I induces mesenchymal tumors in transgenic mice. Science 1987;237:1324-9.
10. Chen IS, Slamon DJ, Rosenblatt JD, Shah NP, Quan SG, Wachsman W. The x gene is essential for HTLV replication. Science 1985;229:54-8.
11. Sodroski J, Rosen C, Goh WC, Haseltine W. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus. Science 1985;228:1430-4.
12. Béraud C, Lombard-Platet G, Michal Y, Jalinot P. Binding of the HTLV-I Taxi transactivator to the inducible 21 bp enhancer is mediated by the cellular factor HEB1. EMBOJ 1991;10:3795-803.
13. Suzuki T, Fujisawa JI, Toita M, Yoshida M. The transactivator tax of human T-cell leukemia virus type 1 (HTLV-I) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-I. Proc Natl Acad Sci USA 1993;90: 610-4.
14. Zhao LJ, Giam CZ. Interaction of T-cell lymphotropic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer. Proc Natl Acad Sci 1991;88: 445-9.
15. Zhao LJ, Giam CZ. Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc Natl Acad Sci USA 1992;89:7070-4.
16. Franklin AA, Kubik MF, Uittenbogaard MN, et al. Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element binding protein (CREB). J Biol Chem 1993;268:225-31.
17. Armstrong AP, Franklin AA, Uittenbogaard MN, Giebler HA, Nyborg JK. Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors. Proc Natl Acad Sci USA 1993;90:7303-7.
18. Wagner S, Green MR. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science 1993;262:395-9.
19. Caron C, Rousset R, Beraud C, Moncollin V, Egly JM, Jalinot P. Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP. EMBO J 1993;12: 4269-78.
20. Duvall JF, Kashanchi F, Cvekl A, Radonovich MF, Piras G, Brady JN. Transactivation of the human T-cell leukemia virus type 1 Tax1-responsive 21-base-pair repeats requires holo-TFIID and TFIIA. J Virol 1995;69:5077-86.
21. Alexandre C, Verrier B. Four regulatory elements in the human c-fos promoter mediate transactivation by HTLV-I Tax protein. Oncogene 1991;6:543-51.
22. 1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 1988;85:8526-30.
23. tax protein in the human T-cell line, jurkat. J Virol 1989;63:3220-6.
24. Maruyama M, Shibuya H, Harada H, et al. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-I-encoded p40x and T3/Ti complex triggering. Cell 1987;48:343-50.
25. Siekevitz M, Feinberg MB, Holbrook N, Wong-Staal F, Greene WC. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the transactivator (tat) gene product of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 1987;84:5389-93.
26. Cross SL, Feinberg MB, Wolf JB, Holbrook NJ, Wong-Staal F, Leonard WJ. Regulation of the human interleukin-2 receptor α chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell 1987;49: 47-56.
27. x encoded by human T-cell leukemia virus type I. EMBO J 1986; 5:2883-8.
28. Ballard DW, Böhnlein E, Lowenthal JW, Wano Y, Franza BR, Greene WC. HTLV-I Tax induces cellular proteins that activate the κB element in the IL-2 Receptor α gene. Science 1988;241:1652-4.
29. Ruben S, Poteat H, Tan TH, Kawakami K, Roeder R, Haseltine W, Rosen CA. Cellular transcription factors and regulation of the IL-2 receptor gene expression by HTLV-I tax gene product. Science 1988;241:89-92.
30. Baeuerle PA, Baltimore D. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell 1988;53:211-7.
31. Baeuerle PA, Baltimore D. IκB: a specific Inhibitor of the NF-κB transcription factor. Science 1988;242:540-6.
32. Baeuerle PA. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochem Biophys Acta 1991;1072:63-80.
33. Urban MB, Baeuerle PA. The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specificity. Genes Dev 1990;4:1975-84.
34. Haskill S, Beg AA, Tompkins SM, et al. Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity. Cell 1991;65:1281-9.
35. Zabel U, Baeuerle PA. Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA. Cell 1990;61:255-65.
36. Hatada EN, Nieters A, Wulczyn FG, et al. The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding. Proc Natl Acad Sci USA 1992;89:2489-93.
37. Inoue JI, Kerr LD, Kakizuka A, Verma IM. IkBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: a new member of the IκB family. Cell 1992;68:1109-20.
38. Liou H-C, Garry PN, Ghosh S, Fujita T, Baltimore D. The NF-κB p50 precursor, p105, contains an internal IκB-like inhibitor that preferentially inhibits p50. EMBO J 1992;11: 3003-9.
39. Bours V, Villalobos J, Burd PR, Kelly K, Siebenlist U. Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature 1990;348:76-80.
40. Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D. Cloning of the p50 DNA binding subunit of NF-κB: homology to rel and dorsal. Cell 1990;62:1019-29.
41. Kieran M, Blank V, Logeat F, et al. The DNA binding subunit of NF-κB is identical to factor KBF-1 and homologous to the rel oncogene product. Cell 1990;62:1007-18.
42. Meyer R, Hatada EN, Hohmann H-P, et al. Cloning of the DNA-binding subunit of human nuclear factor κB: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor a. Proc Natl Acad Sci USA 1991;88:966-70.
43. Naumann M, Wulczyn GF, Scheidereit C. The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J 1993;12:213-22.
44. Rice NR, MacKichan ML, Israel A. The precursor of NF-κB p50 has IκB-like functions. Cell 1992;71:243-53.
45. Bours V, Burd PR, Brown K et al. A novel mitogeninducible gene product related to p50-p105-NF-κB participates in transactivation through a κB. Mol Cell Biol 1992;12:685-95.
46. Mercurio F, DiDonato J, Rosette C, Karin M. Molecular cloning and characterization of a novel Rel/NF-κB family member displaying structural and functional homology to NF-κB p50/p105. DNA Cell Biol 1992;11:523-37.
47. Neri A, Chang C-C, Lombardi L, et al. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50. Cell 1991;67: 1075-87.
48. Schmid RM, Perkins ND, Duckett CS, Andrews PC, Nabel GJ. Cloning of an NF-κB subunit which stimulates HIV transcription is synergy with p65. Nature 1991;352:733-6.
49. Mercurio F, DiDonato JA, Rosette C, Karin M. p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction. Genes Dev 1993;7:705-18.
50. Sun SC, Ganchi P, Béraud C, Greene WC. Autoregulation of the NF-κB p65 transactivator by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc Natl Acad Sci USA 1994;91:1346-50.
51. Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U. Control of IκBα proteolysis by site specific, signal-induced phosphorylation. Science 1995;267:1485-8.
52. Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, Lee WE, Ballard DW. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. Mol Cell Biol 1995;15:2809-18.
53. Traenckner EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, Baeuerle PA. Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli. EMBO J 1995;14:2876-83.
54. Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D, Maniatis T. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev 1995;9:1586-97.
55. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and activation of NF-κB. Cell 1994;78:773-85.
56. Traenckner EB, Wilk S, Baeuerle PA. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκBα that is still bound to NF-κB. EMBO J 1994;13:5433-41.
57. Goldberg AL. The mechanism and functions of ATP-dependent proteases in bacterial and animal cells. Eur J Biochem 1992;203:9-23.
58. Rivett AJ. Proteasomes: multicatalytic proteinase complexes. Biochem J 1993;291:1-10.
59. Rechsteiner M, Hoffman L, Dubiel W. The multicatalytic and 26 S proteases. J Biol Chem 1993;268:6065-8.
60. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 1994;79:13-21.
61. Hochstrasser M. Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr Opin Cell Biol 1995;7:215-23.
62. Hershko A, Ciechanover A. The ubiquitin system for protein degradation. Annu Rev Biochem 1992;61:761-807.
63. Rock KL, Gramm C, Rothstein L, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994;78:761-71.
64. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
65. Treier M, Staszewski LM, Bohmann D. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain. Cell 1994;78:787-98.
66. Ishida N, Tanaka K, Tamura T, Nishizawa M, Okazaki K, Sagata N, Ichihara A. Mos is degraded by the 26S proteasome in a ubiquitin-dependent fashion. FEBS Lett 1993;324: 345-8.
67. Richter-Ruoff B, Wolf DH, Hochstrasser M. Degradation of the yeast MATα2 transcriptional regulator is mediated by the proteasome. FEBS Lett 1994;354:50-2.
68. Murray A. Cyclin ubiquination: the destructive end of mitosis. Cell 1995;81:149-52.
69. Michalek MT, Grant EP, Gramm C, Goldberg AL, Rock KL. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature 1993;363:552-4.
70. Suzuki T, Hirai H, Fujisawa J, Fujita T, Yoshida M. A transactivator Tax of human T-cell leukemia virus type 1 binds to NF-κB p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-κB site and CArG box. Oncogene 1993;8:2391-7.
71. Murakami T, Hirai H, Suzuki T, Fujisawa J, Yoshida M. HTLV-I Tax enhances NF-κB2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100. Virology 1995;206:1066-74.
72. Lanoix J, Lacoste J, Pepin N, Rice N, Hiscott J. Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-κB signalling pathway. Oncogene 1994;9:841-52.
73. Béraud C, Sun SC, Ganchi P, Ballard DW, Greene WC. HTLV-I Tax associates with and is negatively regulated by the NF-κB2 p100 gene product: implications for viral latency. Mol Cell Biol 1994;14:1374-82.
74. Suzuki T, Hirai H, Yoshida M. Tax protein of HTLV-I interacts with the Rel homology domain of N-κB p65 and c-Rel proteins bound to the NF-κB binding site and activates transcription. Oncogene 1994;9:3099-105.
75. Suzuki T, Hirai H, Murakami T, Yoshida M. Tax protein of HTLV-I destabilizes the complexes of NF-κB and IκB-α and induces nuclear translocation of NF-κB for transcriptional activation. Oncogene 1995;10:1199-207.
76. Hirai H, Suzuki T, Fujisawa J, Inoue J, Yoshida M. Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factors κB and induces nuclear translocation of transcription factor NF-κB proteins for transcriptional activation. Proc Natl Acad Sci USA 1994;91: 3584-8.
77. Hirai H, Fujisawa J, Suzuki T, et al. Transcriptional activator Tax of HTLV-I binds to the NF-κB precursor p105. Oncogene 1992;7:1737-42.
78. Muñoz E, Courtois G, Veschambre P, Jalinot P, Israel A. Tax induces nuclear translocation of NF-κB through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of IκBα/MAD3. J Virol 1994;68:8035-44.
79. Kanno T, Franzoso G, Siebenlist U. Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-κB from p100 (NF-κB2)-inhibited cytoplasmic reservoirs. Proc Natl Acad Sci USA 1994;91:634-8.
80. Watanabe M, Muramatsu M, Tsuboi A, Arai K. Differential response of NF-κB1 p105 and NF-κB2 p100 to HTLV-I encoded Tax. FEBS Lett 1994;342:115-8.
81. Lacoste J, Petropoulos L, Pepin N, Hiscott J. Constitutive phosphorylation and turnover of IκBα in human T-cell leukemia virus type I-infected and Tax-expressing T cells. J Virol 1995;69:564-9.
82. Sun S-C, Elwood J, Béraud C, Greene WC. Human T-cell leukemia virus type I Tax activation of NF-κB/Rel involves phosphorylation and degradation of IκBα and RelA (p65)-mediated induction of c-rel gene. Mol Cell Biol 1994;14: 7377-84.
83. Maggirwar SB, Harhaj E, Sun S-C. Activation of NF-κB/Rel by Tax involves degradation of IκBα and is blocked by a proteasome inhibitor. Oncogene 1995;11:993-8.
84. Nothwang HG, Tamura T, Tanaka K, Ichihara A. Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3 HsC7-I and HsC10-II, confine potential proteolytic active-site residues. Biochim Biophys Acta 1994;1219:361-8.
85. Gerards WLH, Hop FWH, Hendriks ILAM, Bloemendal H. Cloning and expression of a human pro(tea)some β-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity. FEBS Lett 1994;346:151-5.
86. Seemüller E, Lupas A, Stock D, Löwe J, Huber R, Baumeister W. Proteasome from Thermoplasma acidophilum: a threonine protease. Science 1995;268:579-82.
87. Kristensen P, Johnsen AH, Uerkvitz W, Tanaka K, Hendil KB. Human proteasome subunits from 2-dimensional gels identified by partial sequencing. Biochem Biophys Res Commun 1994;205:1785-9.
88. Kopp F, Kristensen P, Hendil KB, Johnsen A, Sobek A, Dahlmann B. The human proteasome subunit HsN3 is located in the inner rings of the complex dimer. J Mol Biol 1995;248:264-72.