Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells

Biochemical Journal

Volumn 346, Issue 2, 2000, Pages 447-454

  Gardner, Robert C ^a   Assinder, Stephen J ^a   Christie, Gary ^b   Mason, Grant G F ^a   Markwell, Roger ^b   Wadsworth, Harry ^b   McLaughlin, Mark ^b   King, Ron ^b   Chabot Fletcher, Marie C ^c   Breton, John J ^c   Allsop, David ^b,d   Rivett, A Jennifer ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c SmithKline Beecham   (United States)

^d LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Chymotrypsin like activity; NF B; Tight binding inhibitors

Indexed keywords

BORONIC ACID DERIVATIVE; CHYMOTRYPSIN; COUMARIN DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; PROTEASOME INHIBITOR;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; GEL FILTRATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

ANIMALS; BORONIC ACIDS; CELLS, CULTURED; CHYMOTRYPSIN; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX;

ANIMALIA; MAMMALIA;

EID: 0034161929     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3460447     Document Type: Article

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