Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1143-1150

  Sigal, Luis J ^a,b   Rock, Kenneth L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

Immunity, cellular; Influenza virus; Lymphocytic choriomeningitis virus; Mice; T lymphocytes, cytotoxic

Indexed keywords

EPITOPE; NUCLEOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; INFLUENZA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; VACCINIA VIRUS; VIRUS INFECTION; VIRUS LOAD;

ANIMALS; ANTIGEN-PRESENTING CELLS; BONE MARROW CELLS; BONE TRANSPLANTATION; CROSSES, GENETIC; CYTOTOXICITY, IMMUNOLOGIC; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; POLIOVIRUS; T-LYMPHOCYTES, CYTOTOXIC; TRANSPLANTATION CHIMERA; TUMOR CELLS, CULTURED; VACCINIA VIRUS;

EID: 0034676087     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1143     Document Type: Article

References (30)

1. Antigen recognition by class I-restricted T lymphocytes
2. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter
3. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter
4. Antigen processing and presentation by the class I major histocompatibility complex
5. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
6. A new foreign policy: MHC class I molecules monitor the outside world
7. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
8. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules
9. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
10. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
11. Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes
12. Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: An immunodominant region which induces nonreciprocal CTL cross-reactivity
13. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
14. Duration of TCR stimulation determines costimulatory requirement of T cells
15. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter
16. 8+ T cells developing in parent→F1 chimeras prepared with supralethal irradiation: Step-wise induction of tolerance in the intrathymic and extrathymic environments
17. Strong T cell tolerance in parent→F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy
18. T cell specificity in twice-irradiated F1→parent bone marrow chimeras: Failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction
19. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
20. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
21. Dendritic cells in genetic immunization
22. DNA vaccination: Transfection and activation of dendritic cells as key events for immunity
23. 8+ T cells after gene gun immunization
24. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells
25. DNA-based immunization by in vivo transfection of dendritic cells
26. Requirements for bone marrow-derived antigen presenting cells in priming cytotoxic T cell responses to intracellular pathogens
27. Lymphohemopoietic origin of the immunogenic, virus-antigen-presenting cells triggering anti-viral T-cell responses
28. Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing
29. Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein
30. Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway