PAProC: A prediction algorithm for proteasomal cleavages available on the WWW

Immunogenetics

Volumn 53, Issue 2, 2001, Pages 87-94

  Nussbaum, A K ^a   Kuttler, C ^a   Hadeler, K P ^a   Rammensee, H G ^a   Schild, H ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Algorithm; Cleavage prediction; CTL epitope; MHC; Proteasome

Indexed keywords

AMINO ACID; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; PROTEIN;

ALGORITHM; ARTICLE; CYTOTOXIC T LYMPHOCYTE; INTERNET; PREDICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALGORITHMS; AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE ENDOPEPTIDASES; DATABASES, FACTUAL; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGENETICS; INTERNET; LIGANDS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; PHOSPHOPYRUVATE HYDRATASE; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035074032     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510100300     Document Type: Article

References (30)

1. Abrogation of CTL epitope processing by single amino acid substitution flanking the C-terminal proteasome cleavage site
2. Role of the proteasome in Alzheimer's disease
3. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide
4. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
5. Inhibition of proteasomal degradation by the Gly-Ala repeat of Epstein-Barr virus is influenced by the length of the repeat and the strength of the degradation signal
6. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum
7. The human 26S and 20S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate
8. Genes regulating MHC class I processing of antigen
9. Cell death in polyglutamine diseases
10. A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20S proteasome
11. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
12. An algorithm for the prediction of proteasomal cleavages
13. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1
14. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1
15. Cytotoxic T lymphocyte epitopes of HIV-1 nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes
16. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides
17. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
18. Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system
19. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1
20. A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation
21. Mechanisms of MHC class I-restricted antigen processing
22. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER
23. SYFPEITHI: Database for MHC ligands and peptide motifs
24. Degradation of cell proteins and the generation of MHC class I-presented peptides
25. Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities
26. Two new proteases in the MHC class I processing pathway
27. The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope
28. Protein aggregation in Huntington's and Parkinson's disease: Implications for therapy
29. Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
30. Glutamine repeats and neurodegeneration